{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:06:21Z","timestamp":1740107181721,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03660-3","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T14:33:52Z","timestamp":1734618832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is vitamin D deficiency a more frequent finding in hirsutism or not?"],"prefix":"10.1007","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-5551","authenticated-orcid":false,"given":"Hojat","family":"Eftekhari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-6574","authenticated-orcid":false,"given":"Abbas","family":"Darjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-488X","authenticated-orcid":false,"given":"Narges","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-3021","authenticated-orcid":false,"given":"Kaveh Gharaei","family":"Nejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-3700","authenticated-orcid":false,"given":"Rana","family":"Rafiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-3884","authenticated-orcid":false,"given":"Elahe","family":"Rafiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"3660_CR1","first-page":"168","volume":"100","author":"E Matheson","year":"2019","unstructured":"Matheson E, Bain J (2019) Hirsutism in women. Am Fam Physician 100:168\u2013175","journal-title":"Am Fam Physician"},{"key":"3660_CR2","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.2174\/1381612822666160720151243","volume":"22","author":"PM Spritzer","year":"2016","unstructured":"Spritzer PM, Barone CR, Oliveira FB (2016) de: Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management. Curr Pharm Des 22:5603\u20135613. https:\/\/doi.org\/10.2174\/1381612822666160720151243","journal-title":"Curr Pharm Des"},{"key":"3660_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4103\/ejdv.ejdv_36_23","volume":"44","author":"KG Nejad","year":"2024","unstructured":"Nejad KG, Rafiei R, Eftekhari H, Dibayi F, Rafiei E (2024) Hirsutism in patients with lichen planopilaris (LPP). Egypt J Dermatology Venerol 44:50\u201354","journal-title":"Egypt J Dermatology Venerol"},{"key":"3660_CR4","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1016\/j.ijwd.2017.02.007","volume":"3","author":"J Mihailidis","year":"2017","unstructured":"Mihailidis J, Dermesropian R, Taxel P, Luthra P, Grant-Kels JM (2017) Endocrine evaluation of hirsutism. Int J women\u2019s dermatology 3:S6\u201310. https:\/\/doi.org\/10.1016\/j.ijwd.2017.02.007","journal-title":"Int J women\u2019s dermatology"},{"key":"3660_CR5","doi-asserted-by":"publisher","first-page":"e0123608","DOI":"10.1371\/journal.pone.0123608","volume":"10","author":"MB Khomami","year":"2015","unstructured":"Khomami MB, Tehrani FR, Hashemi S, Farahmand M, Azizi F (2015) Of PCOS symptoms, hirsutism has the most significant impact on the quality of life of Iranian women. PLoS ONE 10:e0123608. https:\/\/doi.org\/10.1371\/journal.pone.0123608","journal-title":"PLoS ONE"},{"key":"3660_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.12998\/wjcc.v11.i2.292","volume":"11","author":"K Unluhizarci","year":"2023","unstructured":"Unluhizarci K, Hacioglu A, Taheri S, Karaca Z, Kelestimur F (2023) Idiopathic hirsutism: Is it really idiopathic or is it misnomer? World J Clin cases 11:292\u2013298. https:\/\/doi.org\/10.12998\/wjcc.v11.i2.292","journal-title":"World J Clin cases"},{"key":"3660_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cca.2022.03.011","volume":"531","author":"RWPM de Kroon","year":"2022","unstructured":"de Kroon RWPM, den Heijer M, Heijboer AC (2022) Is idiopathic hirsutism idiopathic? Clin Chim Acta 531:17\u201324. https:\/\/doi.org\/10.1016\/j.cca.2022.03.011","journal-title":"Clin Chim Acta"},{"key":"3660_CR8","doi-asserted-by":"publisher","unstructured":"Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, Kumar M (2023) Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. J Clin Med 12. https:\/\/doi.org\/10.3390\/jcm12041454","DOI":"10.3390\/jcm12041454"},{"key":"3660_CR9","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.fertnstert.2013.04.001","volume":"100","author":"SB Christensen","year":"2013","unstructured":"Christensen SB, Black MH, Smith N, Martinez MM, Jacobsen SJ, Porter AH, Koebnick C (2013) Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril 100:470\u2013477. https:\/\/doi.org\/10.1016\/j.fertnstert.2013.04.001","journal-title":"Fertil Steril"},{"key":"3660_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fphys.2016.00124","volume":"7","author":"S El Hayek","year":"2016","unstructured":"El Hayek S, Bitar L, Hamdar LH, Mirza FG, Daoud G (2016) Poly Cystic Ovarian Syndrome: An Updated Overview. Front Physiol 7:124. https:\/\/doi.org\/10.3389\/fphys.2016.00124","journal-title":"Front Physiol"},{"key":"3660_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.18502\/jri.v23i4.10815","volume":"23","author":"SA Pourhoseini","year":"2022","unstructured":"Pourhoseini SA, Babazadeh R, Mazlom SR (2022) Prevalence of Polycystic Ovary Syndrome in Iranian Adolescent Girls Based on Adults and Adolescents\u2019 Diagnostic Criteria in Mashhad City. J Reprod Infertil 23:288\u2013295. https:\/\/doi.org\/10.18502\/jri.v23i4.10815","journal-title":"J Reprod Infertil"},{"key":"3660_CR12","doi-asserted-by":"publisher","unstructured":"Mesinovic J, Teede HJ, Shorakae S, Lambert GW, Lambert EA, Naderpoor N, de Courten B (2020) The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome. Nutrients 12. https:\/\/doi.org\/10.3390\/nu12051219","DOI":"10.3390\/nu12051219"},{"key":"3660_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/metabo11020116","volume":"11","author":"F Di Bari","year":"2021","unstructured":"Di Bari F, Catalano A, Bellone F, Martino G, Benvenga S (2021) Vitamin D, bone metabolism, and fracture risk in polycystic ovary syndrome. Metabolites 11:116","journal-title":"Metabolites"},{"key":"3660_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1530\/REP-12-0064","volume":"144","author":"M Blomberg Jensen","year":"2012","unstructured":"Blomberg Jensen M (2012) Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 144:135\u2013152. https:\/\/doi.org\/10.1530\/REP-12-0064","journal-title":"Reproduction"},{"key":"3660_CR15","doi-asserted-by":"publisher","unstructured":"Morgante G, Darino I, Span\u00f2 A et al (2022) PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment. J Clin Med 11. https:\/\/doi.org\/10.3390\/jcm11154509","DOI":"10.3390\/jcm11154509"},{"key":"3660_CR16","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/jog.13516","volume":"44","author":"C Karada\u011f","year":"2018","unstructured":"Karada\u011f C, Yoldemir T, Yavuz DG (2018) Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients. J Obstet Gynaecol Res 44:270\u2013277. https:\/\/doi.org\/10.1111\/jog.13516","journal-title":"J Obstet Gynaecol Res"},{"key":"3660_CR17","doi-asserted-by":"publisher","first-page":"e14291","DOI":"10.1016\/j.heliyon.2023.e14291","volume":"9","author":"B Zhang","year":"2023","unstructured":"Zhang B, Yao X, Zhong X, Hu Y, Xu J (2023) Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials. Heliyon 9:e14291. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e14291","journal-title":"Heliyon"},{"key":"3660_CR18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4161\/derm.19829","volume":"4","author":"JD Ringe","year":"2012","unstructured":"Ringe JD, Kipshoven C (2012) Vitamin D-insufficiency: An estimate of the situation in Germany. Dermatoendocrinol 4:72\u201380. https:\/\/doi.org\/10.4161\/derm.19829","journal-title":"Dermatoendocrinol"},{"key":"3660_CR19","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.clnu.2020.09.024","volume":"40","author":"N Al-Bayyari","year":"2021","unstructured":"Al-Bayyari N, Al-Domi H, Zayed F, Hailat R, Eaton A (2021) Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial. Clin Nutr 40:870\u2013878. https:\/\/doi.org\/10.1016\/j.clnu.2020.09.024","journal-title":"Clin Nutr"},{"key":"3660_CR20","first-page":"202","volume":"5","author":"R Ghadimi","year":"2014","unstructured":"Ghadimi R, Esmaeilzadeh S, Firoozpour M, Ahmadi A (2014) Does vitamin D status correlate with clinical and biochemical features of polycystic ovarysyndrome in high school girls? Casp J Intern Med 5:202\u2013208","journal-title":"Casp J Intern Med"},{"key":"3660_CR21","doi-asserted-by":"publisher","first-page":"e0204748","DOI":"10.1371\/journal.pone.0204748","volume":"13","author":"YHM Krul-Poel","year":"2018","unstructured":"Krul-Poel YHM, Koenders PP, Steegers-Theunissen RP et al (2018) Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study. PLoS ONE 13:e0204748. https:\/\/doi.org\/10.1371\/journal.pone.0204748","journal-title":"PLoS ONE"},{"key":"3660_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1530\/EJE-11-0134","volume":"164","author":"E Wehr","year":"2011","unstructured":"Wehr E, Trummer O, Giuliani A, Gruber H-J, Pieber TR, Obermayer-Pietsch B (2011) Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol 164:741\u2013749","journal-title":"Eur J Endocrinol"},{"key":"3660_CR23","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1016\/j.metabol.2011.03.002","volume":"60","author":"HWR Li","year":"2011","unstructured":"Li HWR, Brereton RE, Anderson RA, Wallace AM, Ho CKM (2011) Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism 60:1475\u20131481","journal-title":"Metabolism"},{"key":"3660_CR24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5653\/cerm.2014.41.2.80","volume":"41","author":"JJ Kim","year":"2014","unstructured":"Kim JJ, Choi YM, Chae SJ et al (2014) Vitamin D deficiency in women with polycystic ovary syndrome. Clin Exp Reprod Med 41:80","journal-title":"Clin Exp Reprod Med"},{"key":"3660_CR25","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.fertnstert.2008.11.031","volume":"93","author":"T Mahmoudi","year":"2010","unstructured":"Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z (2010) Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil Steril 93:1208\u20131214","journal-title":"Fertil Steril"},{"key":"3660_CR26","doi-asserted-by":"publisher","first-page":"176","DOI":"10.23736\/S0391-1977.18.02824-9","volume":"44","author":"EM Davis","year":"2019","unstructured":"Davis EM, Peck JD, Hansen KR, Neas BR, Craig LB (2019) Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes. Minerva Endocrinol 44:176","journal-title":"Minerva Endocrinol"},{"key":"3660_CR27","first-page":"2","volume":"8","author":"SH Khan","year":"2019","unstructured":"Khan SH, Manzoor R, Shahid R, Shah Bukhari SAR, Anwar R (2019) Comparison of vitamin D status for hirsutism, biochemical hyperandrogenism, glycemia and dyslipidemia among subjects with polycystic ovarian syndrome (PCOS). J Womens Heal Issues Care 8:2","journal-title":"J Womens Heal Issues Care"},{"key":"3660_CR28","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1007\/s11845-023-03366-x","volume":"192","author":"A Darjani","year":"2023","unstructured":"Darjani A, Alizadeh N, Gharaei Nejad K, Eftekhari H, Rafiei R, Kazemi H, Rafiei E (2023) Testosterone or dihydrotestosterone: what should be evaluated in hirsutism? Ir J Med Sci 192:2823\u20132827","journal-title":"Ir J Med Sci"},{"issue":"2","key":"3660_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1530\/JME-17-0187","volume":"60","author":"SR Lee","year":"2018","unstructured":"Lee SR, Park MY, Yang H, Lee GS, An BS, Park BK, Jeung EB, Hong EJ (2018) 5\u03b1-dihydrotestosterone reduces renal Cyp24a1 expression via suppression of progesterone receptor. J Mol Endocrinol 60(2):159\u2013170","journal-title":"J Mol Endocrinol"},{"key":"3660_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12881-019-0763-5","volume":"20","author":"X-Y Shi","year":"2019","unstructured":"Shi X-Y, Huang A-P, Xie D-W, Yu X-L (2019) Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med Genet 20:1\u201311","journal-title":"BMC Med Genet"},{"key":"3660_CR31","doi-asserted-by":"crossref","unstructured":"Alizadeh N, Rafiei R, Darjani A, Eftekhari H, Nejad KG, Rafiei E, Vishkaei MS. Chronic telogen effluvium in women: role of micronutrients, a case\u2013control study in north of Iran. J Egypt Women Dermatol Soc 18(3):205\u20139","DOI":"10.4103\/jewd.jewd_34_21"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03660-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03660-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03660-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T15:04:04Z","timestamp":1734620644000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03660-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3660"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03660-3","relation":{},"ISSN":["1432-069X"],"issn-type":[{"type":"electronic","value":"1432-069X"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"19 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research project was approved by Ethics committee of Guilan University of Medical Sciences (Code: IR.GUMS.REC.1399.078) and supported by the Vice Chancellor of Research and Technology, Guilan University of Medical Sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"136"}}