{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:03:25Z","timestamp":1789574605870,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["70948"],"award-info":[{"award-number":["70948"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03664-z","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T14:16:04Z","timestamp":1734704164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the efficacy of combination treatment of microneedling and topical Bleomycin with cryotherapy for the management of hand and foot refractory warts"],"prefix":"10.1007","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5010-5612","authenticated-orcid":false,"given":"Roya","family":"Vatankhah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-1413","authenticated-orcid":false,"given":"Afsaneh","family":"Radmehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-9916","authenticated-orcid":false,"given":"Hamideh Azimi","family":"Alamdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1957-0626","authenticated-orcid":false,"given":"Faeghe Sheikhalizadeh","family":"Nobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-4776","authenticated-orcid":false,"given":"Mobina","family":"Oladghaffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"issue":"3","key":"3664_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jcv.2013.02.021","volume":"57","author":"SC Bruggink","year":"2013","unstructured":"Bruggink SC, Gussekloo J, de Koning MN, Feltkamp MC, Bavinck JN, Quint WG et al (2013) HPV type in plantar warts influences natural course and treatment response: secondary analysis of a randomised controlled trial. J Clin Virol 57(3):227\u2013232","journal-title":"J Clin Virol"},{"issue":"1","key":"3664_CR2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/bjd.15758","volume":"178","author":"GK Hogendoorn","year":"2018","unstructured":"Hogendoorn GK, Bruggink SC, de Koning MNC, Eekhof JAH, Hermans KE, Rissmann R et al (2018) Morphological characteristics and human papillomavirus genotype predict the treatment response in cutaneous warts. Br J Dermatol 178(1):253\u2013260","journal-title":"Br J Dermatol"},{"key":"3664_CR3","doi-asserted-by":"crossref","unstructured":"Skubic L, Ho\u0161njak L, Breznik V, Fujs Komlo\u0161 K, Luzar B, Poljak M (2022) An Improved Protocol for Comprehensive Etiological Characterization of Skin Warts and Determining Causative Human Papillomavirus Types in 128 Histologically Confirmed Common Warts. Viruses.;14(10)","DOI":"10.3390\/v14102266"},{"issue":"1","key":"3664_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/rmv.1822","volume":"25","author":"J Doorbar","year":"2015","unstructured":"Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I (2015) Human papillomavirus molecular biology and disease association. Rev Med Virol 25(1):2\u201323","journal-title":"Rev Med Virol"},{"issue":"6","key":"3664_CR5","doi-asserted-by":"publisher","first-page":"700","DOI":"10.5858\/arpa.2017-0572-RA","volume":"142","author":"P Bacaj","year":"2018","unstructured":"Bacaj P, Burch D (2018) Human Papillomavirus Infection of the Skin. Arch Pathol Lab Med 142(6):700\u2013705","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"3664_CR6","first-page":"145","volume":"20","author":"JC Cardoso","year":"2011","unstructured":"Cardoso JC, Calonje E (2011) Cutaneous manifestations of human papillomaviruses: a review. Acta Dermatovenerol Alp Pannonica Adriat 20(3):145\u2013154","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"2","key":"3664_CR7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.12966\/ijei.07.01.2013","volume":"1","author":"SK Krishna","year":"2013","unstructured":"Krishna SK, Jethwa AS (2013) Human papillomavirus infections in adults and children. Am J Epidemiol Infect Dis 1(2):11\u201319","journal-title":"Am J Epidemiol Infect Dis"},{"key":"3664_CR8","unstructured":"Sudhakar G, Vasudev Pai VP, Arvind Pai AP, Venkatesh Kamath VK (2013) Therapeutic approaches in the management of plantar warts by human papillomaviruses: a review"},{"key":"3664_CR9","doi-asserted-by":"publisher","first-page":"7989817","DOI":"10.1155\/2016\/7989817","volume":"2016","author":"SS Ghadgepatil","year":"2016","unstructured":"Ghadgepatil SS, Gupta S, Sharma YK (2016) Clinicoepidemiological Study of Different Types of Warts. Dermatol Res Pract 2016:7989817","journal-title":"Dermatol Res Pract"},{"issue":"3","key":"3664_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cpm.2016.02.003","volume":"33","author":"TC Vlahovic","year":"2016","unstructured":"Vlahovic TC, Khan MT (2016) The Human Papillomavirus and Its Role in Plantar Warts: A Comprehensive Review of Diagnosis and Management. Clin Podiatr Med Surg 33(3):337\u2013353","journal-title":"Clin Podiatr Med Surg"},{"issue":"4","key":"3664_CR11","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/bjd.13310","volume":"171","author":"JC Sterling","year":"2014","unstructured":"Sterling JC, Gibbs S, Haque Hussain SS, Mohd Mustapa MF, Handfield-Jones SE (2014) British Association of Dermatologists\u2019 guidelines for the management of cutaneous warts 2014. Br J Dermatol 171(4):696\u2013712","journal-title":"Br J Dermatol"},{"key":"3664_CR12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.31128\/AJGP-01-22-6305","volume":"51","author":"K Truong","year":"2022","unstructured":"Truong K, Joseph J, Manago B, Wain T (2022) Destructive therapies for cutaneous warts: A review of the evidence. Australian J Gen Practitioners 51:799\u2013803","journal-title":"Australian J Gen Practitioners"},{"issue":"3","key":"3664_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2133.1995.tb08678.x","volume":"132","author":"JF Bourke","year":"1995","unstructured":"Bourke JF, Berth-Jones J, Hutchinson PE (1995) Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. Br J Dermatol 132(3):433\u2013436","journal-title":"Br J Dermatol"},{"issue":"6","key":"3664_CR14","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/j.1365-2133.1994.tb08594.x","volume":"131","author":"J Berth-Jones","year":"1994","unstructured":"Berth-Jones J, Bourke J, Eglitis H, Harper C, Kirk P, Pavord S et al (1994) Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol 131(6):883\u2013886","journal-title":"Br J Dermatol"},{"issue":"3","key":"3664_CR15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1529-8019.2011.01425.x","volume":"24","author":"JR Lee","year":"2011","unstructured":"Lee JR, Youn JH, Roh JY (2011) Intralesional vincristine combined with cryotherapy for recalcitrant verrucas. Dermatol Ther 24(3):380\u2013383","journal-title":"Dermatol Ther"},{"issue":"10","key":"3664_CR16","first-page":"1299","volume":"34","author":"P Saitta","year":"2008","unstructured":"Saitta P, Krishnamurthy K, Brown LH (2008) Bleomycin in dermatology: a review of intralesional applications. Dermatol Surg 34(10):1299\u20131313","journal-title":"Dermatol Surg"},{"issue":"6","key":"3664_CR17","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0190-9622(93)70133-E","volume":"28","author":"MP James","year":"1993","unstructured":"James MP, Collier PM, Aherne W, Hardcastle A, Lovegrove S (1993) Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts. J Am Acad Dermatol 28(6):933\u2013937","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"3664_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/j.1365-2133.2006.07474.x","volume":"155","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T (2006) Bleomycin and the skin. Br J Dermatol 155(5):869\u2013875","journal-title":"Br J Dermatol"},{"issue":"11","key":"3664_CR19","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1001\/archderm.143.11.1423","volume":"143","author":"T Saida","year":"2007","unstructured":"Saida T, Koga H (2007) Dermoscopic patterns of acral melanocytic nevi: their variations, changes, and significance. Arch Dermatol 143(11):1423\u20131426","journal-title":"Arch Dermatol"},{"issue":"2","key":"3664_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1365-2133.1984.tb04044.x","volume":"111","author":"MH Bunney","year":"1984","unstructured":"Bunney MH, Nolan MW, Buxton PK, Going SM, Prescott RJ (1984) The treatment of resistant warts with intralesional bleomycin: a controlled clinical trial. Br J Dermatol 111(2):197\u2013207","journal-title":"Br J Dermatol"},{"issue":"1","key":"3664_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0190-9622(83)70112-X","volume":"9","author":"SM Shumer","year":"1983","unstructured":"Shumer SM, O\u2019Keefe EJ (1983) Bleomycin in the treatment of recalcitrant warts. J Am Acad Dermatol 9(1):91\u201396","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"3664_CR22","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/S0190-9622(88)70140-1","volume":"18","author":"M Amer","year":"1988","unstructured":"Amer M, Diab N, Ramadan A, Galal A, Salem A (1988) Therapeutic evaluation for intralesional injection of bleomycin sulfate in 143 resistant warts. J Am Acad Dermatol 18(6):1313\u20131316","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"3664_CR23","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1046\/j.1365-2133.1996.d01-1104.x","volume":"135","author":"SE Munn","year":"1996","unstructured":"Munn SE, Higgins E, Marshall M, Clement M (1996) A new method of intralesional bleomycin therapy in the treatment of recalcitrant warts. Br J Dermatol 135(6):969\u2013971","journal-title":"Br J Dermatol"},{"issue":"2","key":"3664_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/09546630600621987","volume":"17","author":"E Agius","year":"2006","unstructured":"Agius E, Mooney JM, Bezzina AC, Yu RC (2006) Dermojet delivery of bleomycin for the treatment of recalcitrant plantar warts. J Dermatolog Treat 17(2):112\u2013116","journal-title":"J Dermatolog Treat"},{"issue":"5 Pt 1","key":"3664_CR25","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S0190-9622(86)70264-8","volume":"15","author":"ME Hayes","year":"1986","unstructured":"Hayes ME, O\u2019Keefe EJ (1986) Reduced dose of bleomycin in the treatment of recalcitrant warts. J Am Acad Dermatol 15(5 Pt 1):1002\u20131006","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"3664_CR26","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1001\/archderm.1984.01650430153030","volume":"120","author":"RA Miller","year":"1984","unstructured":"Miller RA (1984) Nail dystrophy following intralesional injections of bleomycin for a periungual wart. Arch Dermatol 120(7):963\u2013964","journal-title":"Arch Dermatol"},{"issue":"9","key":"3664_CR27","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1001\/archderm.1986.01660210022008","volume":"122","author":"F Urbina Gonz\u00e1lez","year":"1986","unstructured":"Urbina Gonz\u00e1lez F, Cristobal Gil MC, Aguilar Martinez A, Guerra Rodriguez P, S\u00e1nchez de Paz F, Garc\u00eda-P\u00e9rez A (1986) Cutaneous toxicity of intralesional bleomycin administration in the treatment of periungual warts. Arch Dermatol 122(9):974\u2013975","journal-title":"Arch Dermatol"},{"issue":"1","key":"3664_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11095-016-2042-x","volume":"34","author":"HS Lee","year":"2017","unstructured":"Lee HS, Ryu HR, Roh JY, Park JH (2017) Bleomycin-Coated Microneedles for Treatment of Warts. Pharm Res 34(1):101\u2013112","journal-title":"Pharm Res"},{"issue":"1","key":"3664_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jconrel.2005.02.002","volume":"104","author":"JH Park","year":"2005","unstructured":"Park JH, Allen MG, Prausnitz MR (2005) Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release 104(1):51\u201366","journal-title":"J Control Release"},{"issue":"2","key":"3664_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10544-015-9944-y","volume":"17","author":"Y Ma","year":"2015","unstructured":"Ma Y, Boese SE, Luo Z, Nitin N, Gill HS (2015) Drug coated microneedles for minimally-invasive treatment of oral carcinomas: development and in vitro evaluation. Biomed Microdevices 17(2):44","journal-title":"Biomed Microdevices"},{"key":"3664_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mser.2016.03.001","volume":"104","author":"E Larra\u00f1eta","year":"2016","unstructured":"Larra\u00f1eta E, Lutton REM, Woolfson AD, Donnelly RF (2016) Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Mater Sci Engineering: R: Rep 104:1\u201332","journal-title":"Mater Sci Engineering: R: Rep"},{"issue":"1","key":"3664_CR32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s11095-011-0524-4","volume":"29","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Brown K, Siebenaler K, Determan A, Dohmeier D, Hansen K (2012) Development of lidocaine-coated microneedle product for rapid, safe, and prolonged local analgesic action. Pharm Res 29(1):170\u2013177","journal-title":"Pharm Res"},{"key":"3664_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2017.03.015","volume":"265","author":"X Zhao","year":"2017","unstructured":"Zhao X, Coulman SA, Hanna SJ, Wong FS, Dayan CM, Birchall JC (2017) Formulation of hydrophobic peptides for skin delivery via coated microneedles. J Control Release 265:2\u201313","journal-title":"J Control Release"},{"key":"3664_CR34","doi-asserted-by":"crossref","unstructured":"Graham GF, Barham KL, Cryosurgery (2003) Curr Probl Dermatol 15(6):229\u2013250","DOI":"10.1016\/S1040-0486(03)00077-2"},{"issue":"5","key":"3664_CR35","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1046\/j.1365-2133.2001.04190.x","volume":"144","author":"I Ahmed","year":"2001","unstructured":"Ahmed I, Agarwal S, Ilchyshyn A, Charles-Holmes S, Berth-Jones J (2001) Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud. Br J Dermatol 144(5):1006\u20131009","journal-title":"Br J Dermatol"},{"issue":"2","key":"3664_CR36","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1001\/archderm.1991.01680020102014","volume":"127","author":"WB Shelley","year":"1991","unstructured":"Shelley WB, Shelley ED (1991) Intralesional bleomycin sulfate therapy for warts. A novel bifurcated needle puncture technique. Arch Dermatol 127(2):234\u2013236","journal-title":"Arch Dermatol"},{"issue":"9","key":"3664_CR37","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1001\/archderm.1985.01660090022008","volume":"121","author":"M Takigawa","year":"1985","unstructured":"Takigawa M, Oku T, Ginoza M, Yamada M, Yamamoto T, Kobayashi I (1985) Treatment of viral warts with pressure-sensitive adhesive tape containing bleomycin sulfate. Arch Dermatol 121(9):1108","journal-title":"Arch Dermatol"},{"issue":"1","key":"3664_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s13346-017-0458-4","volume":"8","author":"HR Ryu","year":"2018","unstructured":"Ryu HR, Jeong HR, Seon-Woo HS, Kim JS, Lee SK, Kim HJ et al (2018) Efficacy of a bleomycin microneedle patch for the treatment of warts. Drug Deliv Transl Res 8(1):273\u2013280","journal-title":"Drug Deliv Transl Res"},{"issue":"5","key":"3664_CR39","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1177\/1203475415576860","volume":"19","author":"L Kruter","year":"2015","unstructured":"Kruter L, Saggar V, Akhavan A, Patel P, Umanoff N, Viola KV et al (2015) Intralesional Bleomycin for Warts: Patient Satisfaction and Treatment Outcomes. J Cutan Med Surg 19(5):470\u2013476","journal-title":"J Cutan Med Surg"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03664-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03664-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03664-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T15:02:58Z","timestamp":1734706978000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03664-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3664"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03664-z","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"15 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Tabriz University of Medical Sciences, following the ethical principles of the Helsinki Declaration and Good Clinical Practices (Protocol number, IR.TBZMED.REC.1401.1004, and was prospectively registered at IRCT.ir, clinical trials registry, with identifier number: IRCT20221109056452N1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"145"}}