{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:23:58Z","timestamp":1779301438599,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ningbo Top Medical and Health Research Program","award":["2023030514"],"award-info":[{"award-number":["2023030514"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03700-y","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T22:21:45Z","timestamp":1736029305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study"],"prefix":"10.1007","volume":"317","author":[{"given":"Linrong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"3700_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41598-023-49306-8","volume":"14","author":"S Kim","year":"2024","unstructured":"Kim S, Lee DK, Kim H-R, Park JM, Kim SB, Yu H (2024) Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients. Sci Rep 14:360. https:\/\/doi.org\/10.1038\/s41598-023-49306-8","journal-title":"Sci Rep"},{"key":"3700_CR2","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.3390\/jpm13121708","volume":"13","author":"N Arsovi\u0107","year":"2023","unstructured":"Arsovi\u0107 N, Jovanovi\u0107 M, Babac S, \u010cvorovi\u0107 L, Radivojevi\u0107 N, Arsovi\u0107 K (2023) Cochlear implantation in patients with bilateral Sudden Sensorineural hearing loss after COVID-19 infection. J Pers Med 13:1708. https:\/\/doi.org\/10.3390\/jpm13121708","journal-title":"J Pers Med"},{"key":"3700_CR3","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1038\/ncomms4983","volume":"5","author":"A Ko","year":"2014","unstructured":"Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PMVL, Sinsheimer JS et al (2014) Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun 5:3983. https:\/\/doi.org\/10.1038\/ncomms4983","journal-title":"Nat Commun"},{"key":"3700_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1194\/jlr.P063461","volume":"57","author":"B Gombojav","year":"2016","unstructured":"Gombojav B, Lee SJ, Kho M, Song Y-M, Lee K, Sung J (2016) Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East asians. J Lipid Res 57:318\u2013324. https:\/\/doi.org\/10.1194\/jlr.P063461","journal-title":"J Lipid Res"},{"key":"3700_CR5","doi-asserted-by":"publisher","first-page":"e37056","DOI":"10.1371\/journal.pone.0037056","volume":"7","author":"TR Braun","year":"2012","unstructured":"Braun TR, Been LF, Singhal A, Worsham J, Ralhan S, Wander GS et al (2012) A replication study of GWAS-derived lipid genes in Asian indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. PLoS ONE 7:e37056. https:\/\/doi.org\/10.1371\/journal.pone.0037056","journal-title":"PLoS ONE"},{"key":"3700_CR6","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1093\/hmg\/ddu346","volume":"23","author":"LE Wolber","year":"2014","unstructured":"Wolber LE, Girotto G, Buniello A, Vuckovic D, Pirastu N, Lorente-C\u00e1novas B et al (2014) Salt-inducible kinase 3, SIK3, is a new gene associated with hearing. Hum Mol Genet 23:6407\u20136418. https:\/\/doi.org\/10.1093\/hmg\/ddu346","journal-title":"Hum Mol Genet"},{"key":"3700_CR7","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1111\/jdv.14949","volume":"32","author":"KM Hoegler","year":"2018","unstructured":"Hoegler KM, John AM, Handler MZ, Schwartz RA (2018) Generalized pustular psoriasis: a review and update on treatment. J Eur Acad Dermatol Venereol 32:1645\u20131651. https:\/\/doi.org\/10.1111\/jdv.14949","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3700_CR8","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3390\/genes14061297","volume":"14","author":"S-F Yang","year":"2023","unstructured":"Yang S-F, Lin M-H, Chou P-C, Hu S-K, Shih S-Y, Yu H-S et al (2023) Genetics of Generalized Pustular Psoriasis: current understanding and implications for future therapeutics. Genes (Basel) 14:1297. https:\/\/doi.org\/10.3390\/genes14061297","journal-title":"Genes (Basel)"},{"key":"3700_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jdermsci.2015.11.007","volume":"81","author":"L Yang","year":"2016","unstructured":"Yang L, Li B, Dang E, Jin L, Fan X, Wang G (2016) Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3. J Dermatol Sci 81:85\u201392. https:\/\/doi.org\/10.1016\/j.jdermsci.2015.11.007","journal-title":"J Dermatol Sci"},{"key":"3700_CR10","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","volume":"2","author":"JE Greb","year":"2016","unstructured":"Greb JE, Goldminz AM, Elder JT, Lebwohl MG, Gladman DD, Wu JJ et al (2016) Psoriasis Nat Rev Dis Primers 2:16082. https:\/\/doi.org\/10.1038\/nrdp.2016.82","journal-title":"Psoriasis Nat Rev Dis Primers"},{"key":"3700_CR11","doi-asserted-by":"publisher","first-page":"9310","DOI":"10.3390\/ijerph17249310","volume":"17","author":"HG Choi","year":"2020","unstructured":"Choi HG, Park B, Hong SM, Park I-S, Kim SK (2020) Psoriasis increases the risk of Sudden Sensorineural hearing loss: a Longitudinal Follow up Study using a National Sample Cohort. Int J Environ Res Public Health 17:9310. https:\/\/doi.org\/10.3390\/ijerph17249310","journal-title":"Int J Environ Res Public Health"},{"key":"3700_CR12","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/sim.3034","volume":"27","author":"DA Lawlor","year":"2008","unstructured":"Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Davey Smith G (2008) Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 27:1133\u20131163. https:\/\/doi.org\/10.1002\/sim.3034","journal-title":"Stat Med"},{"key":"3700_CR13","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1001\/jama.2022.2505","volume":"327","author":"ML Maciejewski","year":"2022","unstructured":"Maciejewski ML, Dowd BE, Norton EC (2022) Instrumental variables and Heterogeneous Treatment effects. JAMA 327:1177\u20131178. https:\/\/doi.org\/10.1001\/jama.2022.2505","journal-title":"JAMA"},{"key":"3700_CR14","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG, CRP CHD Genetics Collaboration (2011) Avoiding bias from weak instruments in mendelian randomization studies. Int J Epidemiol 40:755\u2013764. https:\/\/doi.org\/10.1093\/ije\/dyr036","journal-title":"Int J Epidemiol"},{"key":"3700_CR15","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37:658\u2013665. https:\/\/doi.org\/10.1002\/gepi.21758","journal-title":"Genet Epidemiol"},{"key":"3700_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess S, Thompson SG (2017) Interpreting findings from mendelian randomization using the MR-Egger method. Eur J Epidemiol 32:377\u2013389. https:\/\/doi.org\/10.1007\/s10654-017-0255-x","journal-title":"Eur J Epidemiol"},{"key":"3700_CR17","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46:1985\u20131998. https:\/\/doi.org\/10.1093\/ije\/dyx102","journal-title":"Int J Epidemiol"},{"key":"3700_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol 40:304\u2013314. https:\/\/doi.org\/10.1002\/gepi.21965","journal-title":"Genet Epidemiol"},{"key":"3700_CR19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet 50:693\u2013698. https:\/\/doi.org\/10.1038\/s41588-018-0099-7","journal-title":"Nat Genet"},{"key":"3700_CR20","doi-asserted-by":"publisher","unstructured":"Harrison SR, Aung Din BNR, Marzo-Ortega H, Helliwell PS Recent advances in the management of psoriatic arthritis: practical considerations. Pol Arch Intern Med 2024:16639. https:\/\/doi.org\/10.20452\/pamw.16639","DOI":"10.20452\/pamw.16639"},{"key":"3700_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s40257-015-0117-9","volume":"16","author":"Y-C Yen","year":"2015","unstructured":"Yen Y-C, Lin Y-S, Weng S-F, Lai F-J (2015) Risk of sudden sensorineural hearing loss in patients with psoriasis: a retrospective cohort study. Am J Clin Dermatol 16:213\u2013220. https:\/\/doi.org\/10.1007\/s40257-015-0117-9","journal-title":"Am J Clin Dermatol"},{"key":"3700_CR22","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/lary.20873","volume":"120","author":"JK Chau","year":"2010","unstructured":"Chau JK, Lin JRJ, Atashband S, Irvine RA, Westerberg BD (2010) Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope 120:1011\u20131021. https:\/\/doi.org\/10.1002\/lary.20873","journal-title":"Laryngoscope"},{"key":"3700_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/brainsci12010091","volume":"12","author":"YL Man","year":"2022","unstructured":"Man YL, Sanna G (2022) Neuropsychiatric manifestations of Antiphospholipid Syndrome-A Narrative Review. Brain Sci 12:91. https:\/\/doi.org\/10.3390\/brainsci12010091","journal-title":"Brain Sci"},{"issue":"Suppl 6","key":"3700_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1468-3083.2010.03829.x","volume":"24","author":"JC Prinz","year":"2010","unstructured":"Prinz JC (2010) From bench to bedside\u2013translational research in psoriasis. J Eur Acad Dermatol Venereol 24(Suppl 6):1\u20134. https:\/\/doi.org\/10.1111\/j.1468-3083.2010.03829.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3700_CR25","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1161\/ATVBAHA.114.304108","volume":"34","author":"S Karbach","year":"2014","unstructured":"Karbach S, Croxford AL, Oelze M, Sch\u00fcler R, Minwegen D, Wegner J et al (2014) Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol 34:2658\u20132668. https:\/\/doi.org\/10.1161\/ATVBAHA.114.304108","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3700_CR26","doi-asserted-by":"publisher","first-page":"976","DOI":"10.2174\/1386207323999201124204755","volume":"24","author":"Q Liu","year":"2021","unstructured":"Liu Q, Wu L, Lu C, Wu D (2021) Analysis of miRNA-mRNA Interaction Network Reveals Gap Junction Beta 2 as a potential candidate gene involved in psoriatic hearing loss pathogenesis. Comb Chem High Throughput Screen 24:976\u2013985. https:\/\/doi.org\/10.2174\/1386207323999201124204755","journal-title":"Comb Chem High Throughput Screen"},{"key":"3700_CR27","doi-asserted-by":"publisher","first-page":"9721","DOI":"10.1074\/jbc.M116.770917","volume":"292","author":"ER Press","year":"2017","unstructured":"Press ER, Shao Q, Kelly JJ, Chin K, Alaga A, Laird DW (2017) Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. J Biol Chem 292:9721\u20139732. https:\/\/doi.org\/10.1074\/jbc.M116.770917","journal-title":"J Biol Chem"},{"key":"3700_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbamem.2012.06.024","volume":"1828","author":"J Xu","year":"2013","unstructured":"Xu J, Nicholson BJ (2013) The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta 1828:167\u2013178. https:\/\/doi.org\/10.1016\/j.bbamem.2012.06.024","journal-title":"Biochim Biophys Acta"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03700-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03700-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03700-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T12:02:03Z","timestamp":1736078523000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03700-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,4]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3700"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03700-y","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,4]]},"assertion":[{"value":"26 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"167"}}