{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:28:28Z","timestamp":1784971708012,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03755-x","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T07:45:09Z","timestamp":1737186309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IL-7 secreted by keratinocytes induces melanogenesis via c-kit\/MAPK signaling pathway in Melan-a melanocytes"],"prefix":"10.1007","volume":"317","author":[{"given":"Ji Min","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Youn","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-030X","authenticated-orcid":false,"given":"Jae Sung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"3755_CR1","doi-asserted-by":"publisher","unstructured":"Walters KA, Roberts MS (2002) The structure and function of skin. Dermatological and transdermal formulations. Edited by Kenneth A. Walters. New York, United States: CRC Press.1\u201340. https:\/\/doi.org\/10.1201\/9780824743239.ch1","DOI":"10.1201\/9780824743239.ch1"},{"issue":"1","key":"3755_CR2","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/s0169-409x(02)00121-7","volume":"54","author":"GK Menon","year":"2002","unstructured":"Menon GK (2002) New insights into skin structure: scratching the surface. Adv Drug Deliv Rev 54(1):S3\u2013S17. https:\/\/doi.org\/10.1016\/s0169-409x(02)00121-7","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"3755_CR3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","volume":"84","author":"M Brenner","year":"2008","unstructured":"Brenner M, Hearing VJ (2008) The protective role of melanin against UV damage in human skin. Photochem Photobiol 84(3):539\u2013549. https:\/\/doi.org\/10.1111\/j.1751-1097.2007.00226.x","journal-title":"Photochem Photobiol"},{"issue":"1","key":"3755_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1590\/s0365-05962013000100009","volume":"88","author":"IF Videira","year":"2013","unstructured":"Videira IF, Moura DF, Magina S (2013) Mechanisms regulating melanogenesis. An Bras Dermatol 88(1):76\u201383. https:\/\/doi.org\/10.1590\/s0365-05962013000100009","journal-title":"An Bras Dermatol"},{"issue":"7","key":"3755_CR5","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/ijms17071144","volume":"17","author":"SA D\u2019Mello","year":"2016","unstructured":"D\u2019Mello SA, Finlay GJ, Baguley BC, Askarian-Amiri ME (2016) Signaling pathways in Melanogenesis. Int J Mol Sci 17(7):1144. https:\/\/doi.org\/10.3390\/ijms17071144","journal-title":"Int J Mol Sci"},{"key":"3755_CR6","doi-asserted-by":"publisher","unstructured":"Speeckaert R, van Geel N (2018) Melanocyte and melanogenesis: applied anatomy and physiology. In S. Gupta, M. J. Olsson, D. Parsad, H. W. Lim, N. van Geel, & A. G. Pansdya (Eds.), Vitiligo: medical and surgical managment of vitiligo (pp. 9\u201313). https:\/\/doi.org\/10.1002\/9781118937303.ch3","DOI":"10.1002\/9781118937303.ch3"},{"issue":"1","key":"3755_CR7","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/bjd.12111","volume":"168","author":"HE Teulings","year":"2013","unstructured":"Teulings HE, Overkamp M, Ceylan E, Nieuweboer-Krobotova L, Bos JD, Nijsten T, Wolkerstorfer AW, Luiten RM, van der Veen JP (2013) Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey among 1307 patients and their partners. Br J Dermatol 168(1):162\u2013171. https:\/\/doi.org\/10.1111\/bjd.12111","journal-title":"Br J Dermatol"},{"issue":"3","key":"3755_CR8","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.3892\/mmr.2020.10950","volume":"21","author":"C Fu","year":"2020","unstructured":"Fu C, Chen J, Lu J, Yi L, Tong X, Kang L, Pei S, Ouyang Y, Jiang L, Ding Y, Zhao X, Li S, Yang Y, Huang J, Zeng Q (2020) Roles of inflammation factors in melanogenesis (review). Mol Med Rep 21(3):1421\u20131430. https:\/\/doi.org\/10.3892\/mmr.2020.10950","journal-title":"Mol Med Rep"},{"issue":"4","key":"3755_CR9","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","volume":"84","author":"A Slominski","year":"2004","unstructured":"Slominski A, Tobin DJ, Shibahara S, Wortsman J (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84(4):1155\u20131228. https:\/\/doi.org\/10.1152\/physrev.00044.2003","journal-title":"Physiol Rev"},{"issue":"2","key":"3755_CR10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/1523-1747.ep12460991","volume":"96","author":"VB Swope","year":"1991","unstructured":"Swope VB, Abdel-Malek Z, Kassem LM, Nordlund JJ (1991) Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis. J Invest Dermatol 96(2):180\u2013185. https:\/\/doi.org\/10.1111\/1523-1747.ep12460991","journal-title":"J Invest Dermatol"},{"issue":"2","key":"3755_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/jid.2012.331","volume":"133","author":"H Choi","year":"2013","unstructured":"Choi H, Choi H, Han J, Jin SH, Park JY, Shin DW, Lee TR, Kim K, Lee AY, Noh M (2013) IL-4 inhibits the melanogenesis of normal human melanocytes through the JAK2-STAT6 signaling pathway. J Invest Dermatol 133(2):528\u2013536. https:\/\/doi.org\/10.1038\/jid.2012.331","journal-title":"J Invest Dermatol"},{"issue":"11","key":"3755_CR12","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1182\/blood.v99.11.3892","volume":"99","author":"TJ Fry","year":"2002","unstructured":"Fry TJ, Mackall CL (2002) Interleukin-7: from bench to clinic. Blood 99(11):3892\u20133904. https:\/\/doi.org\/10.1182\/blood.v99.11.3892","journal-title":"Blood"},{"issue":"3","key":"3755_CR13","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1084\/jem.178.3.1109","volume":"178","author":"C Heufler","year":"1993","unstructured":"Heufler C, Topar G, Grasseger A, Stanzl U, Koch F, Romani N, Namen AE, Schuler G (1993) Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 178(3):1109\u20131114. https:\/\/doi.org\/10.1084\/jem.178.3.1109","journal-title":"J Exp Med"},{"issue":"2","key":"3755_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nri2023","volume":"7","author":"R Mazzucchelli","year":"2007","unstructured":"Mazzucchelli R, Durum SK (2007) Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 7(2):144\u2013154. https:\/\/doi.org\/10.1038\/nri2023","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"3755_CR15","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1038\/leu.2016.83","volume":"30","author":"K Cant\u00e9-Barrett","year":"2016","unstructured":"Cant\u00e9-Barrett K, Spijkers-Hagelstein JA, Buijs-Gladdines JG, Uitdehaag JC, Smits WK, van der Zwet J, Buijsman RC, Zaman GJ, Pieters R, Meijerink JP (2016) MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia 30(9):1832\u20131843. https:\/\/doi.org\/10.1038\/leu.2016.83","journal-title":"Leukemia"},{"issue":"6","key":"3755_CR16","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1182\/blood-2005-12-028019","volume":"110","author":"T Jahn","year":"2007","unstructured":"Jahn T, Sindhu S, Gooch S, Seipel P, Lavori P, Leifheit E, Weinberg K (2007) Direct interaction between kit and the interleukin-7 receptor. Blood 110(6):1840\u20131847. https:\/\/doi.org\/10.1182\/blood-2005-12-028019","journal-title":"Blood"},{"issue":"34","key":"3755_CR17","doi-asserted-by":"publisher","first-page":"31461","DOI":"10.1074\/jbc.C300186200","volume":"278","author":"CD Mol","year":"2003","unstructured":"Mol CD, Lim KB, Sridhar V, Zou H, Chien EY, Sang BC, Nowakowski J, Kassel DB, Cronin CN, McRee DE (2003) Structure of a c-kit product complex reveals the basis for kinase transactivation. J Biol Chem 278(34):31461\u201331464. https:\/\/doi.org\/10.1074\/jbc.C300186200","journal-title":"J Biol Chem"},{"issue":"4","key":"3755_CR18","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","volume":"92","author":"J Lennartsson","year":"2012","unstructured":"Lennartsson J, R\u00f6nnstrand L (2012) Stem cell factor receptor\/c-Kit: from basic science to clinical implications. Physiol Rev 92(4):1619\u20131649. https:\/\/doi.org\/10.1152\/physrev.00046.2011","journal-title":"Physiol Rev"},{"issue":"1","key":"3755_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.cr.7290105","volume":"12","author":"W Zhang","year":"2002","unstructured":"Zhang W, Liu HT (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12(1):9\u201318. https:\/\/doi.org\/10.1038\/sj.cr.7290105","journal-title":"Cell Res"},{"issue":"5600","key":"3755_CR20","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1126\/science.1072682","volume":"298","author":"GL Johnson","year":"2002","unstructured":"Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Sci (New York N Y) 298(5600):1911\u20131912. https:\/\/doi.org\/10.1126\/science.1072682","journal-title":"Sci (New York N Y)"},{"issue":"3","key":"3755_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4062\/biomolther.2022.092","volume":"31","author":"T Huang","year":"2023","unstructured":"Huang T, Zhao D, Lee S, Keum G, Yang HO (2023) Sinapic acid attenuates the Neuroinflammatory response by targeting AKT and MAPK in LPS-Activated microglial models. Biomolecules Ther 31(3):276\u2013284. https:\/\/doi.org\/10.4062\/biomolther.2022.092","journal-title":"Biomolecules Ther"},{"issue":"3","key":"3755_CR22","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4062\/biomolther.2023.041","volume":"31","author":"SB Rho","year":"2023","unstructured":"Rho SB, Byun HJ, Kim BR, Lee CH (2023) Liver kinase B1 mediates its Anti-tumor function by binding to the N-Terminus of malic enzyme 3. Biomolecules Ther 31(3):330\u2013339. https:\/\/doi.org\/10.4062\/biomolther.2023.041","journal-title":"Biomolecules Ther"},{"issue":"9","key":"3755_CR23","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1089\/AID.2014.0062","volume":"30","author":"L Feller","year":"2014","unstructured":"Feller L, Chandran R, Kramer B, Khammissa RA, Altini M, Lemmer J (2014) Melanocyte biology and function with reference to oral melanin hyperpigmentation in HIV-seropositive subjects. AIDS Res Hum Retroviruses 30(9):837\u2013843. https:\/\/doi.org\/10.1089\/AID.2014.0062","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"5","key":"3755_CR24","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1038\/jid.2012.66","volume":"132","author":"F Cevikbas","year":"2012","unstructured":"Cevikbas F, Steinhoff M (2012) IL-33: a novel danger signal system in atopic dermatitis. J Invest Dermatol 132(5):1326\u20131329. https:\/\/doi.org\/10.1038\/jid.2012.66","journal-title":"J Invest Dermatol"},{"issue":"6","key":"3755_CR25","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.4049\/jimmunol.159.6.3044","volume":"159","author":"IR Williams","year":"1997","unstructured":"Williams IR, Rawson EA, Manning L, Karaoli T, Rich BE, Kupper TS (1997) IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. J Immunol (Baltimore Md: 1950) 159(6):3044\u20133056","journal-title":"J Immunol (Baltimore Md: 1950)"},{"issue":"1\u20132","key":"3755_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0165-2427(02)00136-8","volume":"88","author":"A Gr\u00f6ne","year":"2002","unstructured":"Gr\u00f6ne A (2002) Keratinocytes and cytokines. Vet Immunol Immunopathol 88(1\u20132):1\u201312. https:\/\/doi.org\/10.1016\/s0165-2427(02)00136-8","journal-title":"Vet Immunol Immunopathol"},{"issue":"3","key":"3755_CR27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s1074-7613(00)80329-5","volume":"6","author":"HR Rodewald","year":"1997","unstructured":"Rodewald HR, Ogawa M, Haller C, Waskow C, DiSanto JP (1997) Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity 6(3):265\u2013272. https:\/\/doi.org\/10.1016\/s1074-7613(00)80329-5","journal-title":"Immunity"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03755-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03755-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03755-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T19:38:19Z","timestamp":1737229099000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03755-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3755"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03755-x","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]},"assertion":[{"value":"30 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"275"}}