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All participants signed an informed consent form. All animal experiments and the study protocol were approved by the Ethics Committee of Laboratory Animals of the Peking Union Medical College in Beijing, China (approval number 003249, April 2023). All experimental procedures were conducted following our institutional guidelines and with international standards for the manipulation and care of laboratory animals (Guide for the Care and Use of Laboratory, Animals, U.S. National Research Council, 1996).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"360"}}