{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:46:46Z","timestamp":1793119606972,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-025-03982-w","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T15:50:17Z","timestamp":1739634617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring the psychodermatologic burden and associated psychiatric manifestations in rosacea: a systematic review"],"prefix":"10.1007","volume":"317","author":[{"given":"Sheila","family":"Sharifi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Katamanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jafferany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"issue":"4","key":"3982_CR1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1067\/mjd.2002.120625","volume":"46","author":"J Wilkin","year":"2002","unstructured":"Wilkin J, Dahl M, Detmar M et al (2002) Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of Rosacea. J Am Acad Dermatol 46(4):584\u2013587. https:\/\/doi.org\/10.1067\/mjd.2002.120625","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"3982_CR2","first-page":"348","volume":"6","author":"TT Huynh","year":"2013","unstructured":"Huynh TT (2013) Burden of Disease: the Psychosocial Impact of Rosacea on a patient\u2019s quality of life. Am Health Drug Benefits 6(6):348\u2013354","journal-title":"Am Health Drug Benefits"},{"issue":"2","key":"3982_CR3","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/bjd.16481","volume":"179","author":"L Gether","year":"2018","unstructured":"Gether L, Overgaard LK, Egeberg A, Thyssen JP (2018) Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol 179(2):282\u2013289. https:\/\/doi.org\/10.1111\/bjd.16481","journal-title":"Br J Dermatol"},{"issue":"6","key":"3982_CR4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/jamadermatol.2022.0526","volume":"158","author":"YA Barakji","year":"2022","unstructured":"Barakji YA, R\u00f8nnstad ATM, Christensen MO et al (2022) Assessment of frequency of Rosacea subtypes in patients with Rosacea: a systematic review and Meta-analysis. JAMA Dermatol 158(6):617\u2013625. https:\/\/doi.org\/10.1001\/jamadermatol.2022.0526","journal-title":"JAMA Dermatol"},{"issue":"4","key":"3982_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s13555-019-00322-5","volume":"9","author":"HE Baldwin","year":"2019","unstructured":"Baldwin HE, Harper J, Baradaran S, Patel V (2019) Erythema of Rosacea affects Health-Related Quality of Life: results of a Survey conducted in collaboration with the National Rosacea Society. Dermatol Ther (Heidelb) 9(4):725\u2013734. https:\/\/doi.org\/10.1007\/s13555-019-00322-5","journal-title":"Dermatol Ther (Heidelb)"},{"key":"3982_CR6","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2147\/PPA.S345258","volume":"16","author":"Y Huang","year":"2022","unstructured":"Huang Y, Yan S, Xie H et al (2022) Health Related Quality of Life of Rosacea Patients in China assessed by Dermatology Life Quality Index and willingness to pay. Patient Prefer Adherence 16:659\u2013670 Published 2022 Mar 6. https:\/\/doi.org\/10.2147\/PPA.S345258","journal-title":"Patient Prefer Adherence"},{"key":"3982_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jad.2021.12.008","volume":"299","author":"HC Chang","year":"2022","unstructured":"Chang HC, Huang YC, Lien YJ, Chang YS (2022) Association of rosacea with depression and anxiety: a systematic review and meta-analysis. J Affect Disord 299:239\u2013245. https:\/\/doi.org\/10.1016\/j.jad.2021.12.008","journal-title":"J Affect Disord"},{"key":"3982_CR8","doi-asserted-by":"publisher","unstructured":"Chen M, Deng Z, Huang Y, Li J (2021) Prevalence and Risk Factors of Anxiety and Depression in Rosacea Patients: A Cross-Sectional Study in China. Front Psychiatry.;12:659171. Published 2021 Jun 16. https:\/\/doi.org\/10.3389\/fpsyt.2021.659171","DOI":"10.3389\/fpsyt.2021.659171"},{"issue":"4","key":"3982_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000506627","volume":"236","author":"L Lukaviciute","year":"2020","unstructured":"Lukaviciute L, Ganceviciene R, Navickas P, Navickas A, Grigaitiene J, Zouboulis CC (2020) Anxiety, Depression, and suicidal ideation amongst patients with facial dermatoses (Acne, Rosacea, Perioral Dermatitis, and Folliculitis) in Lithuania. Dermatology 236(4):314\u2013322. https:\/\/doi.org\/10.1159\/000506627","journal-title":"Dermatology"},{"key":"3982_CR10","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.2147\/CCID.S390921","volume":"15","author":"F Yang","year":"2022","unstructured":"Yang F, Zhang Q, Song D, Liu X, Wang L, Jiang X (2022) A cross-sectional study on the Relationship between Rosacea Severity and Quality of Life or Psychological State. Clin Cosmet Investig Dermatol 15:2807\u20132816 Published 2022 Dec 20. https:\/\/doi.org\/10.2147\/CCID.S390921","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"3","key":"3982_CR11","doi-asserted-by":"publisher","first-page":"e13616","DOI":"10.1111\/srt.13616","volume":"30","author":"Z Yang","year":"2024","unstructured":"Yang Z, Zhao W, Hu M et al (2024) Quality of life, sleep and anxiety status among patients with rosacea in the Yunnan plateau region: a 2-year retrospective study. Skin Res Technol 30(3):e13616. https:\/\/doi.org\/10.1111\/srt.13616","journal-title":"Skin Res Technol"},{"key":"3982_CR12","doi-asserted-by":"publisher","unstructured":"Ozcan Y, Sungur MA, Ozcan BY, Eyup Y, Ozlu E (2023) The Psychosocial Impact of Chronic Facial Dermatoses in Adults. Dermatol Pract Concept.;13(1):e2023029. Published 2023 Jan 1. https:\/\/doi.org\/10.5826\/dpc.1301a29","DOI":"10.5826\/dpc.1301a29"},{"issue":"3","key":"3982_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/jocd.15470","volume":"22","author":"F Yang","year":"2023","unstructured":"Yang F, Wang L, Shucheng H, Jiang X (2023) Differences in clinical characteristics of rosacea across age groups: a retrospective study of 840 female patients. J Cosmet Dermatol 22(3):949\u2013957. https:\/\/doi.org\/10.1111\/jocd.15470","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"3982_CR14","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jaad.2021.09.020","volume":"87","author":"JZ Yi","year":"2022","unstructured":"Yi JZ, Pagani K, Lukac D, Li S, Chung HJ, McGee JS (2022) Racial differences in psychiatric comorbidities of rosacea: a large, urban academic center case-control study. J Am Acad Dermatol 87(2):448\u2013451. https:\/\/doi.org\/10.1016\/j.jaad.2021.09.020","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"3982_CR15","doi-asserted-by":"publisher","first-page":"466","DOI":"10.5021\/ad.2020.32.6.466","volume":"32","author":"JH Kim","year":"2020","unstructured":"Kim JH, Oh YW, Kim DH, Seo BH, Suh HS, Choi YSA, Randomized (2020) Placebo-controlled trial of Gamma Linolenic Acid as an add-on therapy to Minocycline for the Treatment of Rosacea. Ann Dermatol 32(6):466\u2013472. https:\/\/doi.org\/10.5021\/ad.2020.32.6.466","journal-title":"Ann Dermatol"},{"issue":"2","key":"3982_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.abd.2023.01.008","volume":"99","author":"JY Tang","year":"2024","unstructured":"Tang JY, Chen ML, Wan M et al (2024) Associations of serum gamma-linolenic acid levels with erythema severity and anxiety\/depression status in patients with rosacea. Bras Dermatol 99(2):189\u2013195. https:\/\/doi.org\/10.1016\/j.abd.2023.01.008","journal-title":"Bras Dermatol"},{"issue":"1","key":"3982_CR17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12888-019-2182-8","volume":"19","author":"H-Y He","year":"2019","unstructured":"He H-Y, Tian J-L, Deng Y-Q et al (2019) Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris. BMC Psychiatr 19(1):193. https:\/\/doi.org\/10.1186\/s12888-019-2182-8","journal-title":"BMC Psychiatr"},{"issue":"4","key":"3982_CR18","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3889\/oamjms.2019.142","volume":"7","author":"M Sjahrir","year":"2019","unstructured":"Sjahrir M, Roesyanto-Mahadi ID, Effendy E (2019) Correlation between serum brain-derived neurotrophic factor level and Depression Severity in Psoriasis Vulgaris patients. Open Access Maced J Med Sci 7(4):583\u2013586 Published 2019 Feb 25. https:\/\/doi.org\/10.3889\/oamjms.2019.142","journal-title":"Open Access Maced J Med Sci"},{"key":"3982_CR19","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.2147\/CCID.S367545","volume":"15","author":"T Wang","year":"2022","unstructured":"Wang T, Liu F, Jia X et al (2022) Serum level of brain-derived neurotrophic factor (BDNF) Associated with Depression in patients with Rosacea: a candidate predictive biomarker. Clin Cosmet Investig Dermatol 15:1029\u20131036 Published 2022 Jun 2. https:\/\/doi.org\/10.2147\/CCID.S367545","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"21","key":"3982_CR20","doi-asserted-by":"publisher","first-page":"12035","DOI":"10.3390\/ijms222112035","volume":"22","author":"HJ Lee","year":"2021","unstructured":"Lee HJ, Hong YJ, Kim M (2021) Angiogenesis in chronic inflammatory skin disorders. Int J Mol Sci 22(21):12035 Published 2021 Nov 7. https:\/\/doi.org\/10.3390\/ijms222112035","journal-title":"Int J Mol Sci"},{"key":"3982_CR21","doi-asserted-by":"publisher","first-page":"996680","DOI":"10.3389\/fsurg.2022.996680","volume":"9","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Yu K (2022) Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients. Front Surg 9:996680 Published 2022 Oct 25. https:\/\/doi.org\/10.3389\/fsurg.2022.996680","journal-title":"Front Surg"},{"key":"3982_CR22","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.2147\/JIR.S468773","volume":"17","author":"X Yang","year":"2024","unstructured":"Yang X, Feng Z, Cai M (2024) Elevated specific pro-inflammatory cytokines in peripheral circulation indicate an increased risk of anxiety and depression in Rosacea. J Inflamm Res 17:4443\u20134452 Published 2024 Jul 9. https:\/\/doi.org\/10.2147\/JIR.S468773","journal-title":"J Inflamm Res"},{"issue":"4","key":"3982_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3897\/rrpharmacology.6.60161","volume":"6","author":"AA Bobrakova","year":"2021","unstructured":"Bobrakova AA (2021) Psychophysiological parameters in rosacea patients after complex therapy with Cortexin. Res Results Pharmacol 6(4):59\u201364. https:\/\/doi.org\/10.3897\/rrpharmacology.6.60161","journal-title":"Res Results Pharmacol"},{"issue":"11","key":"3982_CR24","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1345\/aph.1A476","volume":"36","author":"C Maebara","year":"2002","unstructured":"Maebara C, Ohtani H, Sugahara H, Mine K, Kubo C, Sawada Y (2002) Nightmares and panic disorder associated with carvedilol overdose. Ann Pharmacother 36(11):1736\u20131740. https:\/\/doi.org\/10.1345\/aph.1A476","journal-title":"Ann Pharmacother"},{"key":"3982_CR25","doi-asserted-by":"publisher","unstructured":"Zhang J, Jiang P, Sheng L et al (2022) A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages [published correction appears in Front Immunol.;13:881277. doi: 10.3389\/fimmu.2022.881277]. Front Immunol. 2021;12:609615. Published 2021 Jul 12. https:\/\/doi.org\/10.3389\/fimmu.2021.609615","DOI":"10.3389\/fimmu.2021.609615"},{"issue":"11","key":"3982_CR26","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/1346-8138.16525","volume":"49","author":"J Li","year":"2022","unstructured":"Li J, Tang JY, Fu J et al (2022) Carvedilol ameliorates persistent erythema of erythematotelangiectatic rosacea by regulating the status of anxiety\/depression. J Dermatol 49(11):1139\u20131147. https:\/\/doi.org\/10.1111\/1346-8138.16525","journal-title":"J Dermatol"},{"issue":"5","key":"3982_CR27","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/bjd.18420","volume":"182","author":"M Schaller","year":"2020","unstructured":"Schaller M, Almeida LMC, Bewley A et al (2020) Recommendations for rosacea diagnosis, classification and management: update from the global ROSacea COnsensus 2019 panel. Br J Dermatol 182(5):1269\u20131276. https:\/\/doi.org\/10.1111\/bjd.18420","journal-title":"Br J Dermatol"},{"issue":"6","key":"3982_CR28","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jaad.2023.01.044","volume":"88","author":"B Wang","year":"2023","unstructured":"Wang B, Huang Y, Tang Y et al (2023) Paroxetine is an effective treatment for refractory erythema of rosacea: primary results from the prospective Rosacea Refractory Erythema Randomized Clinical Trial. J Am Acad Dermatol 88(6):1300\u20131307. https:\/\/doi.org\/10.1016\/j.jaad.2023.01.044","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"3982_CR29","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/s0165-6147(99)01389-9","volume":"20","author":"MR MacLean","year":"1999","unstructured":"MacLean MR (1999) Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action? Trends Pharmacol Sci 20(12):490\u2013495. https:\/\/doi.org\/10.1016\/s0165-6147(99)01389-9","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"3982_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13104-020-04952-3","volume":"13","author":"MPZ Emon","year":"2020","unstructured":"Emon MPZ, Das R, Nishuty NL, Shalahuddin Qusar MMA, Bhuiyan MA, Islam MR (2020) Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case-control study with or without antidepressant therapy. BMC Res Notes 13(1):83 Published 2020 Feb 21. https:\/\/doi.org\/10.1186\/s13104-020-04952-3","journal-title":"BMC Res Notes"},{"issue":"6","key":"3982_CR31","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1111\/jocd.12940","volume":"18","author":"NW Mikhael","year":"2019","unstructured":"Mikhael NW, Hamed AM, Mansour AI, Abdelrahman ES (2019) Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris. J Cosmet Dermatol 18(6):1998\u20132003. https:\/\/doi.org\/10.1111\/jocd.12940","journal-title":"J Cosmet Dermatol"},{"issue":"9","key":"3982_CR32","doi-asserted-by":"publisher","first-page":"e24643","DOI":"10.1002\/jcla.24643","volume":"36","author":"N Tong","year":"2022","unstructured":"Tong N, Zhang Y, Yang A, Dai X, Hao S (2022) The potency of common proinflammatory cytokines measurement for revealing the risk and severity of anxiety and depression in psoriasis patients. J Clin Lab Anal 36(9):e24643. https:\/\/doi.org\/10.1002\/jcla.24643","journal-title":"J Clin Lab Anal"},{"key":"3982_CR33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bbi.2019.02.021","volume":"79","author":"L Wang","year":"2019","unstructured":"Wang L, Wang R, Liu L, Qiao D, Baldwin DS, Hou R (2019) Effects of SSRIs on peripheral inflammatory markers in patients with major depressive disorder: a systematic review and meta-analysis. Brain Behav Immun 79:24\u201338. https:\/\/doi.org\/10.1016\/j.bbi.2019.02.021","journal-title":"Brain Behav Immun"},{"issue":"3","key":"3982_CR34","doi-asserted-by":"publisher","first-page":"e1003583","DOI":"10.1371\/journal.pmed.1003583","volume":"18","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med 18(3):e1003583. https:\/\/doi.org\/10.1371\/journal.pmed.1003583","journal-title":"PLoS Med"},{"issue":"4","key":"3982_CR35","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/ced\/llad417","volume":"49","author":"P Abdi","year":"2024","unstructured":"Abdi P, Haq Z, Diaz MJ, Maibach HI (2024) Psychiatric comorbidities associated with rosacea: a propensity score-matched case-control study in the all of us database. Clin Exp Dermatol 49(4):400\u2013403. https:\/\/doi.org\/10.1093\/ced\/llad417","journal-title":"Clin Exp Dermatol"},{"issue":"11","key":"3982_CR36","doi-asserted-by":"publisher","first-page":"e737","DOI":"10.1111\/jdv.16576","volume":"34","author":"Q Chen","year":"2020","unstructured":"Chen Q, Tang Y, Shi X et al (2020) Prevalence, clinical characteristics and health-related quality of life of rosacea in Chinese adolescents: a population-based study. J Eur Acad Dermatol Venereol 34(11):e737\u2013e739. https:\/\/doi.org\/10.1111\/jdv.16576","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"3982_CR37","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000535034","volume":"240","author":"SP Sinikumpu","year":"2024","unstructured":"Sinikumpu SP, Jokelainen J, Tasanen K, Timonen M, Huilaja L (2024) Association of Rosacea with depressive and anxiety symptoms: a General Population Study. Dermatology 240(2):189\u2013194. https:\/\/doi.org\/10.1159\/000535034","journal-title":"Dermatology"},{"issue":"12","key":"3982_CR38","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/1346-8138.16596","volume":"49","author":"K Yamasaki","year":"2022","unstructured":"Yamasaki K, Miyachi Y (2022) Perspectives on rosacea patient characteristics and quality of life using baseline data from a phase 3 clinical study conducted in Japan. J Dermatol 49(12):1221\u20131227. https:\/\/doi.org\/10.1111\/1346-8138.16596","journal-title":"J Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-03982-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-025-03982-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-03982-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T13:36:03Z","timestamp":1747402563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-025-03982-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3982"],"URL":"https:\/\/doi.org\/10.1007\/s00403-025-03982-w","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]},"assertion":[{"value":"7 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"427"}}