{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T18:10:40Z","timestamp":1740247840302,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.662\/2021"],"award-info":[{"award-number":["E-26\/210.662\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-025-04029-w","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T17:38:12Z","timestamp":1740245892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The expression of NLR family pyrin domain containing receptor 1 in Brazilian psoriatic patients is associated with increased disease severity and pro-inflammatory cytokine release"],"prefix":"10.1007","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-8694","authenticated-orcid":false,"given":"Bruna","family":"Romana-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4152-0851","authenticated-orcid":false,"given":"Victoria","family":"Mendes-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-1050","authenticated-orcid":false,"given":"Ana Luisa","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-7792","authenticated-orcid":false,"given":"Haizza Cristina","family":"de Almeida Cabral Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-6845","authenticated-orcid":false,"given":"Camila Oliveira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-2278","authenticated-orcid":false,"given":"Jeane","family":"de Souza Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-009X","authenticated-orcid":false,"given":"Vincent","family":"Lagente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-1821","authenticated-orcid":false,"given":"Lu\u00eds Crist\u00f3v\u00e3o","family":"Porto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7515-2365","authenticated-orcid":false,"given":"Sueli","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"4029_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths CEM, Armstrong AW, Gudjonsson JE et al (2021) Psoriasis 397:1301\u20131315. https:\/\/doi.org\/10.1016\/S0140-6736(20)32549-6","journal-title":"Psoriasis"},{"key":"4029_CR2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of Psoriasis. Rev 323:1945\u20131960. https:\/\/doi.org\/10.1001\/jama.2020.4006","journal-title":"Rev"},{"key":"4029_CR3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/1346-8138.15840","volume":"48","author":"F Yamazaki","year":"2021","unstructured":"Yamazaki F (2021) Psoriasis: Comorbidities 48:732\u2013740. https:\/\/doi.org\/10.1111\/1346-8138.15840","journal-title":"Psoriasis: Comorbidities"},{"key":"4029_CR4","doi-asserted-by":"publisher","first-page":"e24704","DOI":"10.7759\/cureus.24704","volume":"14","author":"CK Seguro","year":"2022","unstructured":"Seguro CK, Demory Beckler M, Kesselman MM (2022) Targeting the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3. Inflammasome Psoriasis Fatigue 14:e24704. https:\/\/doi.org\/10.7759\/cureus.24704","journal-title":"Inflammasome Psoriasis Fatigue"},{"key":"4029_CR5","doi-asserted-by":"publisher","unstructured":"Ciazynska M, Olejniczak-Staruch I, Sobolewska-Sztychny D et al (2021) The role of NLRP1, NLRP3, and AIM2 inflammasomes in Psoriasis. Review 22:5898. https:\/\/doi.org\/10.3390\/ijms22115898","DOI":"10.3390\/ijms22115898"},{"key":"4029_CR6","doi-asserted-by":"publisher","unstructured":"Ciazynska M, Narbutt J, Skibinska M et al (2022) The role of inflammasomes in cutaneous pathology. 39:39\u201346. https:\/\/doi.org\/10.5114\/ada.2022.113802","DOI":"10.5114\/ada.2022.113802"},{"key":"4029_CR7","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.3390\/cells12131766","volume":"12","author":"D Bulte","year":"2023","unstructured":"Bulte D, Rigamonti C, Romano A et al (2023) Inflammasomes: mechanisms of action and involvement in. Hum Dis 12:1766. https:\/\/doi.org\/10.3390\/cells12131766","journal-title":"Hum Dis"},{"key":"4029_CR8","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T). Method 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Method"},{"key":"4029_CR9","doi-asserted-by":"publisher","first-page":"e3465","DOI":"10.21769\/BioProtoc.3465","volume":"9","author":"AR Crowe","year":"2019","unstructured":"Crowe AR, Yue W (2019) Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis. Integr Protoc 9:e3465. https:\/\/doi.org\/10.21769\/BioProtoc.3465","journal-title":"Integr Protoc"},{"key":"4029_CR10","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1177\/0146621618758290","volume":"42","author":"EAO Zijlmans","year":"2018","unstructured":"Zijlmans EAO, van der Ark LA, Tijmstra J et al (2018) Methods Estimating Item-Score Reliab 42:553\u2013570. https:\/\/doi.org\/10.1177\/0146621618758290","journal-title":"Methods Estimating Item-Score Reliab"},{"key":"4029_CR11","doi-asserted-by":"publisher","unstructured":"Duarte GV, Porto-Silva L, de Oliveira MFP (2015) Epidemiology and treatment of psoriasis: a Brazilian perspective. 5:55\u201364. https:\/\/doi.org\/10.2147\/PTT.S51725","DOI":"10.2147\/PTT.S51725"},{"key":"4029_CR12","doi-asserted-by":"publisher","unstructured":"Romiti R, Amone M, Menter A et al (2017) Prevalence of psoriasis in Brazil - a geographical survey. 56:e167\u2013e168. https:\/\/doi.org\/10.1111\/ijd.13604","DOI":"10.1111\/ijd.13604"},{"key":"4029_CR13","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1007\/s12325-019-01049-7","volume":"36","author":"N Lopes","year":"2019","unstructured":"Lopes N, Dias LLS, Azulay-Abulafia L et al (2019) Humanistic and economic impact of moderate to severe plaque. Psoriasis Brazil 36:2849\u20132865. https:\/\/doi.org\/10.1007\/s12325-019-01049-7","journal-title":"Psoriasis Brazil"},{"key":"4029_CR14","doi-asserted-by":"publisher","unstructured":"Gicquel T, Robert S, Loyer P et al (2015) IL-1beta production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages. 29:4162\u20134173. https:\/\/doi.org\/10.1096\/fj.14-267393","DOI":"10.1096\/fj.14-267393"},{"key":"4029_CR15","doi-asserted-by":"publisher","unstructured":"Ekman AK, Verma D, Fredrikson M et al (2014) Genetic variations of NLRP1: susceptibility in psoriasis. 171:1517\u20131520. https:\/\/doi.org\/10.1111\/bjd.13178","DOI":"10.1111\/bjd.13178"},{"key":"4029_CR16","doi-asserted-by":"publisher","unstructured":"Carlstrom M, Ekman AK, Petersson S et al (2012) Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility. 21:932\u2013937. https:\/\/doi.org\/10.1111\/exd.12049","DOI":"10.1111\/exd.12049"},{"key":"4029_CR17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1042\/CS20160645","volume":"131","author":"N Irrera","year":"2017","unstructured":"Irrera N, Vaccaro M, Bitto A et al (2017) BAY 11-7082 inhibits the NF-kappaB and NLRP3 inflammasome pathways and protects against. IMQ-induced Psoriasis 131:487\u2013498. https:\/\/doi.org\/10.1042\/CS20160645","journal-title":"IMQ-induced Psoriasis"},{"key":"4029_CR18","doi-asserted-by":"publisher","unstructured":"Yang BY, Cheng YG, Liu Y et al (2019) Datura Metel L. Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis and inhibits inflammatory cytokines production through TLR7\/8-MyD88-NF-kappaB-NLRP3 inflammasome pathway. 24:2157. https:\/\/doi.org\/10.3390\/molecules24112157","DOI":"10.3390\/molecules24112157"},{"key":"4029_CR19","doi-asserted-by":"publisher","unstructured":"Netea MG, Nold-Petry CA, Nold MF et al (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. 113:2324\u20132335. https:\/\/doi.org\/10.1182\/blood-2008-03-146720","DOI":"10.1182\/blood-2008-03-146720"},{"key":"4029_CR20","doi-asserted-by":"publisher","unstructured":"Su F, Xia Y, Huang M et al (2018) Expression of NLPR3 in psoriasis is Associated with Enhancement of Interleukin-1beta and Caspase-. 1 24:7909\u20137913. https:\/\/doi.org\/10.12659\/MSM.911347","DOI":"10.12659\/MSM.911347"},{"key":"4029_CR21","doi-asserted-by":"publisher","unstructured":"Sollberger G, Strittmatter GE, Grossi S et al (2015) Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes. 135:1395\u20131404. https:\/\/doi.org\/10.1038\/jid.2014.551","DOI":"10.1038\/jid.2014.551"},{"key":"4029_CR22","doi-asserted-by":"publisher","unstructured":"Johansen C, Moeller K, Kragballe K et al (2007) The activity of caspase-1 is increased in lesional psoriatic epidermis. 127:2857\u20132864. https:\/\/doi.org\/10.1038\/sj.jid.5700922","DOI":"10.1038\/sj.jid.5700922"},{"key":"4029_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cell.2016.09.001","volume":"167","author":"FL Zhong","year":"2016","unstructured":"Zhong FL, Mamai O, Sborgi L et al (2016) Germline NLRP1 mutations cause skin inflammatory and Cancer susceptibility syndromes. Via Inflammasome Activation 167:187\u2013202e117. https:\/\/doi.org\/10.1016\/j.cell.2016.09.001","journal-title":"Via Inflammasome Activation"},{"key":"4029_CR24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jid.2020.07.012","volume":"141","author":"D Verma","year":"2021","unstructured":"Verma D, Fekri SZ, Sigurdardottir G et al (2021) Enhanced inflammasome activity in patients with psoriasis. Promotes Systemic Inflamm 141:586\u2013595e585. https:\/\/doi.org\/10.1016\/j.jid.2020.07.012","journal-title":"Promotes Systemic Inflamm"},{"key":"4029_CR25","doi-asserted-by":"publisher","unstructured":"Singh R, Koppu S, Perche PO et al (2021) The cytokine mediated Molecular Pathophysiology of Psoriasis and. Its Clin Implications 22. https:\/\/doi.org\/10.3390\/ijms222312793","DOI":"10.3390\/ijms222312793"},{"key":"4029_CR26","doi-asserted-by":"publisher","unstructured":"Liu XQ, Zhou PL, Yin XY et al (2023) Circulating inflammatory cytokines and psoriasis risk: a systematic review and meta-analysis. 18:e0293327. https:\/\/doi.org\/10.1371\/journal.pone.0293327","DOI":"10.1371\/journal.pone.0293327"},{"key":"4029_CR27","doi-asserted-by":"publisher","unstructured":"Yawalkar N, Karlen S, Hunger R et al (1998) Expression of interleukin-12 is increased in psoriatic skin. 111:1053\u20131057. https:\/\/doi.org\/10.1046\/j.1523-1747.1998.00446.x","DOI":"10.1046\/j.1523-1747.1998.00446.x"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-04029-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-025-04029-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-04029-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T17:38:14Z","timestamp":1740245894000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-025-04029-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4029"],"URL":"https:\/\/doi.org\/10.1007\/s00403-025-04029-w","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"27 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article was approved by the Ethics Committee for Human Studies of the University of Grande Rio and Pedro Ernesto University Hospital (CAAE: 18267619.7.0000.5259, 46799215.1.0000.5283, and 49561321.0.2003.5282). All patients agreed to participate in the study and signed the consent form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"During the preparation of this work, the authors used ChatGPT-assisted technologies solely to enhance the readability and presentation of the English language.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Generative AI and AI-assisted technologies in the writing process"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"476"}}