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To assess the efficacy and safety of 598\/1319\u00a0nm SSDW laser as an adjunctive treatment to conventional treatment, 18 patients with bilateral facial acne, with inflammatory papules or pustules, were recruited. Patients were instructed to apply 2.5% benozoyl peroxide (BPO), the drug for inflammatory acne, to their entire face throughout the study. One side of the face was randomly assigned to receive 4 sessions of 589\/1319\u00a0nm SSDW laser treatments, administered every 2\u00a0weeks. After the last laser treatment, 3 monthly follow-ups were scheduled. Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and skin roughness were measured. Adverse events (AEs) and patients\u2019 satisfaction were assessed. At the 3-month follow-up, the ILC reduced by 46% on the adjunctive laser (BPO\u2009+\u2009laser) side (<jats:italic>p<\/jats:italic>\u2009=\u20090.0080), compared with a 29% reduction on the BPO monotherapy side (<jats:italic>p<\/jats:italic>\u2009=\u20090.1875). On the adjunctive laser side, the change in ILC positively correlated with the change in melanin level (<jats:italic>r<\/jats:italic>\u2009=\u20090.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.0301) and showed a trend towards a positive correlation with the change in depression volume (<jats:italic>r<\/jats:italic>\u2009=\u20090.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.0606) and roughness level (<jats:italic>r<\/jats:italic>\u2009=\u20090.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.0806). The patients reported a pain score of 3.4\u2009\u00b1\u20092.3 on scale of 10. No serious AEs occurred. Patients\u2019 satisfaction scores were higher with the adjunctive laser therapy, although this was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.2758). In conclusion, the 589\/1319\u00a0nm SSDW laser provided a synergistic effect as an adjunctive treatment to BPO in inflammatory acne in terms of reducing ILC and improving post inflammatory hyperpigmentation without causing discomfort or downtime.<\/jats:p>","DOI":"10.1007\/s00403-025-04146-6","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:25:39Z","timestamp":1743287139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of the 589\/1319\u00a0nm solid-state dual-wavelength laser combined with topical benzoyl peroxide for inflammatory acne vulgaris: a split-face randomized controlled trial"],"prefix":"10.1007","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-5062","authenticated-orcid":false,"given":"Suphagan","family":"Boonpethkaew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-3323","authenticated-orcid":false,"given":"Yanisa","family":"Ratanapokasatit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonphet","family":"Chirasuthat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-8344","authenticated-orcid":false,"given":"Penpun","family":"Wattanakrai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"3","key":"4146_CR1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/bjd.12149","volume":"168","author":"K Bhate","year":"2013","unstructured":"Bhate K, Williams HC (2013) Epidemiology of acne vulgaris. 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