{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:03:13Z","timestamp":1775242993574,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-025-04169-z","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T11:47:13Z","timestamp":1743335233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of rosacea on neurodegenerative and neuropsychiatric diseases: a two-sample Mendelian randomization study"],"prefix":"10.1007","volume":"317","author":[{"given":"Xiangjun","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangren","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"4169_CR1","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.jaad.2018.08.049","volume":"80","author":"AF Alexis","year":"2019","unstructured":"Alexis AF, Callender VD, Baldwin HE et al (2019) Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience. J Am Acad Dermatol 80:1722\u20131729.e7. https:\/\/doi.org\/10.1016\/j.jaad.2018.08.049","journal-title":"J Am Acad Dermatol"},{"key":"4169_CR2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16481","author":"L Gether","year":"2018","unstructured":"Gether L, Overgaard LK, Egeberg A, Thyssen JP (2018) Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. https:\/\/doi.org\/10.1111\/bjd.16481","journal-title":"Br J Dermatol"},{"key":"4169_CR3","doi-asserted-by":"publisher","first-page":"e10874","DOI":"10.1016\/j.heliyon.2022.e10874","volume":"8","author":"X-M Hu","year":"2022","unstructured":"Hu X-M, Li Z-X, Zhang D-Y et al (2022) Current research and clinical trends in rosacea pathogenesis. Heliyon 8:e10874. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e10874","journal-title":"Heliyon"},{"key":"4169_CR4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.clindermatol.2019.07.032","volume":"37","author":"U Wollina","year":"2019","unstructured":"Wollina U (2019) Is rosacea a systemic disease? Clin Dermatol 37:629\u2013635. https:\/\/doi.org\/10.1016\/j.clindermatol.2019.07.032","journal-title":"Clin Dermatol"},{"key":"4169_CR5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/jnnp.18.1.72","volume":"18","author":"EA Davidson","year":"1955","unstructured":"Davidson EA, Robertson EE (1955) Alzheimer\u2019s disease with acne rosacea in one of identical twins. J Neurol Neurosurg Psychiatry 18:72\u201377. https:\/\/doi.org\/10.1136\/jnnp.18.1.72","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4169_CR6","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1002\/ana.24645","volume":"79","author":"A Egeberg","year":"2016","unstructured":"Egeberg A, Hansen PR, Gislason GH, Thyssen JP (2016) Patients with rosacea have increased risk of dementia. Ann Neurol 79:921\u2013928. https:\/\/doi.org\/10.1002\/ana.24645","journal-title":"Ann Neurol"},{"key":"4169_CR7","doi-asserted-by":"publisher","first-page":"756550","DOI":"10.3389\/fimmu.2021.756550","volume":"12","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zhang Y, Li Y et al (2021) Bioinformatics and network pharmacology identify the therapeutic role and potential mechanism of melatonin in AD and rosacea. Front Immunol 12:756550. https:\/\/doi.org\/10.3389\/fimmu.2021.756550","journal-title":"Front Immunol"},{"issue":"3","key":"4169_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00403-007-0816-z","volume":"300","author":"K Aroni","year":"2008","unstructured":"Aroni K et al (2008) A study of the pathogenesis of rosacea: how angiogenesis and mast cells may participate in a complex multifactorial process. Arch Dermatol Res 300(3):125\u2013131. https:\/\/doi.org\/10.1007\/s00403-007-0816-z","journal-title":"Arch Dermatol Res"},{"key":"4169_CR9","doi-asserted-by":"publisher","first-page":"653334","DOI":"10.3389\/fnagi.2021.653334","volume":"13","author":"S Bandyopadhyay","year":"2021","unstructured":"Bandyopadhyay S (2021) Role of neuron and glia in Alzheimer\u2019s disease and associated vascular dysfunction. Front Aging Neurosci 13:653334. https:\/\/doi.org\/10.3389\/fnagi.2021.653334","journal-title":"Front Aging Neurosci"},{"key":"4169_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/jidsymp.2011.6","volume":"15","author":"VD Schwab","year":"2011","unstructured":"Schwab VD, Sulk M, Seeliger S et al (2011) Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc 15:53\u201362. https:\/\/doi.org\/10.1038\/jidsymp.2011.6","journal-title":"J Investig Dermatol Symp Proc"},{"key":"4169_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s007020170088","volume":"108","author":"M Fischer","year":"2001","unstructured":"Fischer M, Gemende I, Marsch WCh, Fischer PA (2001) Skin function and skin disorders in Parkinson\u2019s disease. J Neural Transm 108:205\u2013213. https:\/\/doi.org\/10.1007\/s007020170088","journal-title":"J Neural Transm"},{"issue":"5","key":"4169_CR12","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jaad.2014.05.036","volume":"71","author":"F Moustafa","year":"2014","unstructured":"Moustafa F et al (2014) The psychological impact of rosacea and the influence of current management options. J Am Acad Dermatol 71(5):973\u2013980. https:\/\/doi.org\/10.1016\/j.jaad.2014.05.036","journal-title":"J Am Acad Dermatol"},{"key":"4169_CR13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/jdv.13748","volume":"31","author":"B Halioua","year":"2017","unstructured":"Halioua B, Cribier B, Frey M, Tan J (2017) Feelings of stigmatization in patients with rosacea. J Eur Acad Dermatol Venereol 31:163\u2013168. https:\/\/doi.org\/10.1111\/jdv.13748","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"4169_CR14","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.abd.2019.03.002","volume":"94","author":"P Incel Uysal","year":"2019","unstructured":"Incel Uysal P, Akdogan N, Hayran Y et al (2019) Rosacea associated with increased risk of generalized anxiety disorder: a case-control study of prevalence and risk of anxiety in patients with rosacea. An Bras Dermatol 94:704\u2013709. https:\/\/doi.org\/10.1016\/j.abd.2019.03.002","journal-title":"An Bras Dermatol"},{"key":"4169_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2233","volume":"375","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR et al (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ 375:n2233. https:\/\/doi.org\/10.1136\/bmj.n2233","journal-title":"BMJ"},{"key":"4169_CR16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00403-024-03331-3","volume":"316","author":"W Wu","year":"2024","unstructured":"Wu W, Tong H, Li Y, Cui J (2024) Rosacea and autoimmune liver diseases: a two-sample Mendelian randomization study. Arch Dermatol Res 316:549. https:\/\/doi.org\/10.1007\/s00403-024-03331-3","journal-title":"Arch Dermatol Res"},{"key":"4169_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12863-022-01082-6","volume":"23","author":"R Feng","year":"2022","unstructured":"Feng R, Lu M, Xu J et al (2022) Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study. BMC Genom Data 23:69. https:\/\/doi.org\/10.1186\/s12863-022-01082-6","journal-title":"BMC Genom Data"},{"key":"4169_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000535034","volume":"240","author":"S-P Sinikumpu","year":"2024","unstructured":"Sinikumpu S-P, Jokelainen J, Tasanen K et al (2024) Association of rosacea with depressive and anxiety symptoms: a general population study. Dermatology 240:189\u2013194. https:\/\/doi.org\/10.1159\/000535034","journal-title":"Dermatology"},{"issue":"2","key":"4169_CR19","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1159\/000444082","volume":"232","author":"A Egeberg","year":"2016","unstructured":"Egeberg A et al (2016) Patients with rosacea have increased risk of depression and anxiety disorders: a Danish nationwide cohort study. Dermatology (Basel, Switzerland) 232(2):208\u2013213. https:\/\/doi.org\/10.1159\/000444082","journal-title":"Dermatology (Basel, Switzerland)"},{"key":"4169_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jad.2021.12.008","volume":"299","author":"H-C Chang","year":"2022","unstructured":"Chang H-C, Huang Y-C, Lien Y-J, Chang Y-S (2022) Association of rosacea with depression and anxiety: a systematic review and meta-analysis. J Affect Disord 299:239\u2013245. https:\/\/doi.org\/10.1016\/j.jad.2021.12.008","journal-title":"J Affect Disord"},{"issue":"4","key":"4169_CR21","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jaad.2017.09.016","volume":"78","author":"R Haber","year":"2018","unstructured":"Haber R, El Gemayel M (2018) Comorbidities in rosacea: a systematic review and update. J Am Acad Dermatol 78(4):786\u2013792.e8. https:\/\/doi.org\/10.1016\/j.jaad.2017.09.016","journal-title":"J Am Acad Dermatol"},{"key":"4169_CR22","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1001\/jamaneurol.2016.0022","volume":"73","author":"A Egeberg","year":"2016","unstructured":"Egeberg A, Hansen PR, Gislason GH, Thyssen JP (2016) Exploring the association between rosacea and Parkinson disease: a Danish nationwide cohort study. JAMA Neurol 73:529. https:\/\/doi.org\/10.1001\/jamaneurol.2016.0022","journal-title":"JAMA Neurol"},{"key":"4169_CR23","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s13555-020-00458-9","volume":"10","author":"FMN Forton","year":"2020","unstructured":"Forton FMN (2020) The pathogenic role of demodex mites in rosacea: a potential therapeutic target already in erythematotelangiectatic rosacea? Dermatol Ther (Heidelb) 10:1229\u20131253. https:\/\/doi.org\/10.1007\/s13555-020-00458-9","journal-title":"Dermatol Ther (Heidelb)"},{"key":"4169_CR24","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/ddg.14849","volume":"20","author":"BM Clanner-Engelshofen","year":"2022","unstructured":"Clanner-Engelshofen BM, Bernhard D, Dargatz S et al (2022) S2k guideline: rosacea. J Deutsche Derma Gesell 20:1147\u20131165. https:\/\/doi.org\/10.1111\/ddg.14849","journal-title":"J Deutsche Derma Gesell"},{"key":"4169_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/jid.2010.351","volume":"131","author":"K Yamasaki","year":"2011","unstructured":"Yamasaki K, Kanada K, Macleod DT et al (2011) TLR2 Expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688\u2013697. https:\/\/doi.org\/10.1038\/jid.2010.351","journal-title":"J Invest Dermatol"},{"key":"4169_CR26","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.2147\/CCID.S413237","volume":"16","author":"X Yang","year":"2023","unstructured":"Yang X, Cai M (2023) New insights into the mutual promotion of rosacea, anxiety, and depression from neuroendocrine immune aspects. CCID 16:1363\u20131371. https:\/\/doi.org\/10.2147\/CCID.S413237","journal-title":"CCID"},{"key":"4169_CR27","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/ijms24055001","volume":"24","author":"L Marek-Jozefowicz","year":"2023","unstructured":"Marek-Jozefowicz L, Nedoszytko B, Grochocka M et al (2023) Molecular mechanisms of neurogenic inflammation of the skin. Int J Mol Sci 24:5001. https:\/\/doi.org\/10.3390\/ijms24055001","journal-title":"Int J Mol Sci"},{"key":"4169_CR28","doi-asserted-by":"publisher","first-page":"e15976","DOI":"10.7717\/peerj.15976","volume":"11","author":"Y Huang","year":"2023","unstructured":"Huang Y, Liu D, Chen M et al (2023) TLR7 promotes skin inflammation via activating NF\u03baB-mTORC1 axis in rosacea. PeerJ 11:e15976. https:\/\/doi.org\/10.7717\/peerj.15976","journal-title":"PeerJ"},{"key":"4169_CR29","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","volume":"35","author":"M Maes","year":"2011","unstructured":"Maes M (2011) Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 35:664\u2013675. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.06.014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"4169_CR30","doi-asserted-by":"publisher","first-page":"107322","DOI":"10.1016\/j.phrs.2024.107322","volume":"207","author":"Y Yin","year":"2024","unstructured":"Yin Y, Ju T, Zeng D et al (2024) \u201cInflamed\u201d depression: a review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression. Pharmacol Res 207:107322. https:\/\/doi.org\/10.1016\/j.phrs.2024.107322","journal-title":"Pharmacol Res"},{"key":"4169_CR31","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.2147\/JIR.S468773","volume":"17","author":"X Yang","year":"2024","unstructured":"Yang X, Feng Z, Cai M (2024) Elevated specific pro-inflammatory cytokines in peripheral circulation indicate an increased risk of anxiety and depression in rosacea. J Inflamm Res 17:4443\u20134452. https:\/\/doi.org\/10.2147\/JIR.S468773","journal-title":"J Inflamm Res"},{"key":"4169_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/jidsymp.2011.9","volume":"15","author":"PA Gerber","year":"2011","unstructured":"Gerber PA, Buhren BA, Steinhoff M, Homey B (2011) Rosacea: the cytokine and chemokine network. J Investig Dermatol Symp Proc 15:40\u201347. https:\/\/doi.org\/10.1038\/jidsymp.2011.9","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"1","key":"4169_CR33","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/s0190-9622(08)80863-8","volume":"28","author":"FC Powell","year":"1993","unstructured":"Powell FC et al (1993) Substance P and rosacea. J Am Acad Dermatol 28(1):132\u2013133. https:\/\/doi.org\/10.1016\/s0190-9622(08)80863-8","journal-title":"J Am Acad Dermatol"},{"key":"4169_CR34","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/S0006-3223(02)01544-5","volume":"53","author":"B Bondy","year":"2003","unstructured":"Bondy B, Baghai TC, Minov C et al (2003) Substance P serum levels are increased in major depression: preliminary results. Biol Psychiat 53:538\u2013542. https:\/\/doi.org\/10.1016\/S0006-3223(02)01544-5","journal-title":"Biol Psychiat"},{"key":"4169_CR35","doi-asserted-by":"publisher","first-page":"5905","DOI":"10.3390\/ijms25115905","volume":"25","author":"C Humes","year":"2024","unstructured":"Humes C, Sic A, Knezevic NN (2024) Substance P\u2019s impact on chronic pain and psychiatric conditions-a narrative review. Int J Mol Sci 25:5905. https:\/\/doi.org\/10.3390\/ijms25115905","journal-title":"Int J Mol Sci"},{"key":"4169_CR36","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s11154-016-9390-z","volume":"17","author":"G Nikolakis","year":"2016","unstructured":"Nikolakis G, Stratakis CA, Kanaki T et al (2016) Skin steroidogenesis in health and disease. Rev Endocr Metab Disord 17:247\u2013258. https:\/\/doi.org\/10.1007\/s11154-016-9390-z","journal-title":"Rev Endocr Metab Disord"},{"key":"4169_CR37","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/mp.2016.120","volume":"22","author":"J Keller","year":"2017","unstructured":"Keller J, Gomez R, Williams G et al (2017) HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry 22:527\u2013536. https:\/\/doi.org\/10.1038\/mp.2016.120","journal-title":"Mol Psychiatry"},{"key":"4169_CR38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.psyneuen.2013.12.004","volume":"41","author":"M Belvederi Murri","year":"2014","unstructured":"Belvederi Murri M, Pariante C, Mondelli V et al (2014) HPA axis and aging in depression: systematic review and meta-analysis. Psychoneuroendocrinology 41:46\u201362. https:\/\/doi.org\/10.1016\/j.psyneuen.2013.12.004","journal-title":"Psychoneuroendocrinology"},{"key":"4169_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jad.2017.09.052","volume":"233","author":"MF Juruena","year":"2018","unstructured":"Juruena MF, Bocharova M, Agustini B, Young AH (2018) Atypical depression and non-atypical depression: is HPA axis function a biomarker? A systematic review. J Affect Disord 233:45\u201367. https:\/\/doi.org\/10.1016\/j.jad.2017.09.052","journal-title":"J Affect Disord"},{"key":"4169_CR40","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.2147\/CCID.S367545","volume":"15","author":"T Wang","year":"2022","unstructured":"Wang T, Liu F, Jia X et al (2022) Serum level of brain-derived neurotrophic factor (BDNF) associated with depression in patients with rosacea: a candidate predictive biomarker. Clin Cosmet Investig Dermatol 15:1029\u20131036. https:\/\/doi.org\/10.2147\/CCID.S367545","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"4169_CR41","doi-asserted-by":"publisher","first-page":"8427","DOI":"10.3390\/ijms21228427","volume":"21","author":"YR Woo","year":"2020","unstructured":"Woo YR, Han YJ, Kim HS et al (2020) Updates on the risk of neuropsychiatric and gastrointestinal comorbidities in rosacea and its possible relationship with the gut-brain-skin axis. Int J Mol Sci 21:8427. https:\/\/doi.org\/10.3390\/ijms21228427","journal-title":"Int J Mol Sci"},{"key":"4169_CR42","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3389\/fmicb.2018.01459","volume":"9","author":"I Salem","year":"2018","unstructured":"Salem I, Ramser A, Isham N, Ghannoum MA (2018) The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol 9:1459. https:\/\/doi.org\/10.3389\/fmicb.2018.01459","journal-title":"Front Microbiol"},{"key":"4169_CR43","doi-asserted-by":"publisher","first-page":"14910","DOI":"10.1038\/s41598-023-42073-6","volume":"13","author":"M Li","year":"2023","unstructured":"Li M, He SX, He YX et al (2023) Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization. Sci Rep 13:14910. https:\/\/doi.org\/10.1038\/s41598-023-42073-6","journal-title":"Sci Rep"},{"key":"4169_CR44","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.jaad.2015.11.004","volume":"74","author":"A Egeberg","year":"2016","unstructured":"Egeberg A, Hansen PR, Gislason GH, Thyssen JP (2016) Clustering of autoimmune diseases in patients with rosacea. J Am Acad Dermatol 74:667\u2013672.e1. https:\/\/doi.org\/10.1016\/j.jaad.2015.11.004","journal-title":"J Am Acad Dermatol"},{"key":"4169_CR45","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1111\/jocd.13587","volume":"19","author":"T Searle","year":"2020","unstructured":"Searle T, Al-Niaimi F, Ali FR (2020) Rosacea and the cardiovascular system. J Cosmet Dermatol 19:2182\u20132187. https:\/\/doi.org\/10.1111\/jocd.13587","journal-title":"J Cosmet Dermatol"},{"key":"4169_CR46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13555-020-00461-0","volume":"11","author":"H Zhang","year":"2021","unstructured":"Zhang H, Tang K, Wang Y et al (2021) Rosacea treatment: review and update. Dermatol Ther (Heidelb) 11:13\u201324. https:\/\/doi.org\/10.1007\/s13555-020-00461-0","journal-title":"Dermatol Ther (Heidelb)"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-04169-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-025-04169-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-025-04169-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T11:47:14Z","timestamp":1743335234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-025-04169-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4169"],"URL":"https:\/\/doi.org\/10.1007\/s00403-025-04169-z","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"18 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"641"}}