{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:51:50Z","timestamp":1789750310261,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:00:00Z","timestamp":1254787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s00404-009-1234-6","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T04:31:56Z","timestamp":1254717116000},"page":"371-375","source":"Crossref","is-referenced-by-count":54,"title":["Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia"],"prefix":"10.1007","volume":"282","author":[{"given":"Dongwei","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,10,6]]},"reference":[{"key":"1234_CR1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","volume":"365","author":"B Sibai","year":"2005","unstructured":"Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785\u2013799","journal-title":"Lancet"},{"key":"1234_CR2","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","volume":"308","author":"CW Redman","year":"2005","unstructured":"Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308:1592\u20131594","journal-title":"Science"},{"issue":"5","key":"1234_CR3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/0003-4819-131-5-199909070-00006","volume":"131","author":"AG Bostom","year":"1999","unstructured":"Bostom AG, Rosenberg IH, Silbershatz H, Jacques PF, Selhub J, D\u2019Agostino RB, Wilson PW, Wolf PA (1999) Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framington study. Ann Intern Med 131(5):352\u2013355","journal-title":"Ann Intern Med"},{"issue":"6","key":"1234_CR4","first-page":"319","volume":"13","author":"J Drzewoski","year":"2000","unstructured":"Drzewoski J, Czupryniak L, Chwatko G et al (2000) Hyperhomocysteinemia in poorly controlled type 2 diabetes patients. Diabetes Nutr Metab 13(6):319\u2013324","journal-title":"Diabetes Nutr Metab"},{"issue":"8","key":"1234_CR5","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2337\/diacare.24.8.1403","volume":"24","author":"JB Meigs","year":"2001","unstructured":"Meigs JB, Jacques PF, Selhub J et al (2001) Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 24(8):1403\u20131410","journal-title":"Diabetes Care"},{"key":"1234_CR6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1471-0528.2000.tb11095.x","volume":"107","author":"J Wang","year":"2000","unstructured":"Wang J, Trudinger B, Duarte N, Wilcken D, Wang X (2000) Elevated circulating homocysteine levels in placental vascular disease and associated preeclampsia. Br J Obstet Gynecol 107:935\u2013938","journal-title":"Br J Obstet Gynecol"},{"issue":"2","key":"1234_CR7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.0001-6349.2004.00291.x","volume":"83","author":"R D\u2019Anna","year":"2004","unstructured":"D\u2019Anna R, Baviera G, Corrado F, Ientile R, Granese D, Stella NC (2004) Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction. Acta Obstet Gynecol Scand 83(2):155\u2013158","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"10","key":"1234_CR8","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1515\/CCLM.2004.228","volume":"42","author":"W Herrmann","year":"2004","unstructured":"Herrmann W, Hubner U, Koch I, Obeid R, Retzke U, Geisel J (2004) Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. Clin Chem Lab Med 42(10):1109\u20131116","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"1234_CR9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000074824","volume":"56","author":"A Var","year":"2003","unstructured":"Var A, Yildirim Y, Onur E et al (2003) Endothelial dysfunction in preeclampsia. Increased homocysteine and decreased nitric oxide levels. Gynecol Obstet Invest 56(4):221\u2013224","journal-title":"Gynecol Obstet Invest"},{"issue":"1","key":"1234_CR10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2005-918889","volume":"23","author":"A Baksu","year":"2006","unstructured":"Baksu A, Taskin M, Goker N, Baksu B, Uluocak A (2006) Plasma homocysteine in late pregnancies complicated with preeclampsia and in newborns. Am J Perinatol 23(1):31\u201335","journal-title":"Am J Perinatol"},{"issue":"21","key":"1234_CR11","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","volume":"104","author":"MC St\u00fchlinger","year":"2001","unstructured":"St\u00fchlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP (2001) Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 104(21):2569\u20132575","journal-title":"Circulation"},{"issue":"10","key":"1234_CR12","first-page":"1139","volume":"43","author":"W Herrmann","year":"2005","unstructured":"Herrmann W, Isber S, Obeid R, Herrmann M, Jouma M (2005) Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status. Clin Chem Lab Med 43(10):1139\u20131146","journal-title":"Clin Chem Lab Med"},{"key":"1234_CR13","first-page":"567","volume-title":"Williams obstetrics","author":"FG Cunningham","year":"2001","unstructured":"Cunningham FG, Gant NF, Leveno KJ et al (2001) Williams obstetrics, 21st edn. McGraw-Hill Book, New York, pp 567\u2013618 [International Edition]","edition":"21"},{"issue":"4","key":"1234_CR14","first-page":"196","volume":"13","author":"WJ Korzun","year":"2000","unstructured":"Korzun WJ, Ho OV (2000) Stability of plasma total homocysteine concentrations in EDTA-whole blood kept on ice. Clin Lab Sci 13(4):196\u2013198","journal-title":"Clin Lab Sci"},{"issue":"20","key":"1234_CR15","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1021\/ac990541a","volume":"71","author":"MJ MacCoss","year":"1999","unstructured":"MacCoss MJ, Fukagawa NK, Matthews DE (1999) Measurement of homocysteine concentrations and stable isotope tracer enrichments in human plasma. Anal Chem 71(20):4527\u20134533","journal-title":"Anal Chem"},{"issue":"1","key":"1234_CR16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-4347(00)00399-6","volume":"748","author":"K Vishwanathan","year":"2000","unstructured":"Vishwanathan K, Tackett RL, Stewart JT et al (2000) Determination of arginine and methylated arginines in human plasma by liquid chromatography\u2013tandem mass spectrometry. J Chromatogr B Biomed Sci 748(1):157\u2013166","journal-title":"J Chromatogr B Biomed Sci"},{"issue":"2","key":"1234_CR17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-4347(94)00374-2","volume":"661","author":"D Tsikas","year":"1994","unstructured":"Tsikas D, B\u00f6ger RH, Bode-B\u00f6ger SM et al (1994) Quantification of nitrite and nitrate in human urine and plasma as pentafluorobenzyl derivatives by gas chromatography\u2013mass spectrometry using their 15N-labeled analogs. J Chromatogr B Biomed Appl 661(2):185\u2013191","journal-title":"J Chromatogr B Biomed Appl"},{"key":"1234_CR18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ajcn\/76.3.614","volume":"76","author":"MM Murphy","year":"2002","unstructured":"Murphy MM, Scott JM, McPartlin JM, Fernandez-Ballart JD (2002) The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study. Am J Clin Nutr 76:614\u2013619","journal-title":"Am J Clin Nutr"},{"key":"1234_CR19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/S0002-9378(03)00669-0","volume":"189","author":"AM Cotter","year":"2003","unstructured":"Cotter AM, Molloy AM, Scott JM, Daly SF (2003) Elevated plasma homocysteine in early pregnancy: a risk factor for the development of non severe preeclampsia. Am J Obstet Gynecol 189:391\u2013394 discussion 394\u2013396","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"1234_CR20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/14767050400009287","volume":"16","author":"CK Yu","year":"2004","unstructured":"Yu CK, Lakasing L, Papageorghiou AT, Spencer K, Nicolaides KH (2004) Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia. J Matern Fetal Neonatal Med 16(2):134\u2013139","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"3","key":"1234_CR21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000090432","volume":"61","author":"R Onalan","year":"2006","unstructured":"Onalan R, Onalan G, Gunenc Z, Karabulut E (2006) Combining 2nd-trimester maternal serum homocysteine levels and uterine artery Doppler for prediction of preeclampsia and isolated intrauterine growth restriction. Gynecol Obstet Invest 61(3):142\u2013148","journal-title":"Gynecol Obstet Invest"},{"key":"1234_CR22","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","volume":"329","author":"S Moncada","year":"1993","unstructured":"Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002\u20132012","journal-title":"N Engl J Med"},{"key":"1234_CR23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/01.ATV.14.5.753","volume":"14","author":"AJ Cayatte","year":"1994","unstructured":"Cayatte AJ, Palacino JJ, Horten K, Cohen RA (1994) Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14:753\u2013759","journal-title":"Arterioscler Thromb"},{"issue":"8","key":"1234_CR24","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1476-5381.1996.tb16069.x","volume":"119","author":"RJ MacAllister","year":"1996","unstructured":"MacAllister RJ, Parry H, Kimoto M et al (1996) Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 119(8):1533\u20131540","journal-title":"Br J Pharmacol"},{"key":"1234_CR25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.CIR.0000105764.22626.B1","volume":"109","author":"JT Kielstein","year":"2004","unstructured":"Kielstein JT, Impraim B, Simmel S et al (2004) Cardio vascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation 109:172\u2013177","journal-title":"Circulation"},{"key":"1234_CR26","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0140-6736(03)13177-7","volume":"361","author":"MD Savvidou","year":"2003","unstructured":"Savvidou MD, Hingorani AD, Tsikas D, Fr\u00f6lich JC, Vallance P, Nicolaides KH (2003) Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop preeclampsia. Lancet 361:1511\u20131517","journal-title":"Lancet"},{"key":"1234_CR27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0002-9378(98)70437-5","volume":"178","author":"DP Holden","year":"1998","unstructured":"Holden DP, Fickling SA, Whitley GS, Nussey SS (1998) Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 178:551\u2013556","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1234_CR28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1172\/JCI115937","volume":"90","author":"JP Cooke","year":"1992","unstructured":"Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME (1992) Antiatherogenic effects of l-arginine in the hypercholesterolemic rabbit. J Clin Invest 90(3):1168\u20131172","journal-title":"J Clin Invest"},{"issue":"11","key":"1234_CR29","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1093\/jn\/130.11.2626","volume":"130","author":"G Wu","year":"2000","unstructured":"Wu G, Meininger CJ (2000) Arginine, nutrition and cardiovascular function. J Nutr 130(11):2626\u20132629","journal-title":"J Nutr"},{"issue":"5","key":"1234_CR30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0002-9343(99)00396-4","volume":"108","author":"Y Ohtsuka","year":"2000","unstructured":"Ohtsuka Y, Nakaya J (2000) Effect of oral administration of l-arginine on senile dementia. Am J Med 108(5):439","journal-title":"Am J Med"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-009-1234-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-009-1234-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-009-1234-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:53:55Z","timestamp":1559066035000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-009-1234-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["1234"],"URL":"https:\/\/doi.org\/10.1007\/s00404-009-1234-6","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,6]]}}}