{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:45:00Z","timestamp":1780339500583,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,5,12]],"date-time":"2013-05-12T00:00:00Z","timestamp":1368316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00404-013-2879-8","type":"journal-article","created":{"date-parts":[[2013,5,11]],"date-time":"2013-05-11T13:51:06Z","timestamp":1368280266000},"page":"1149-1152","source":"Crossref","is-referenced-by-count":17,"title":["Role of initial and day 4 human chorionic gonadotropin levels in predicting the outcome of single-dose methotrexate treatment in women with tubal ectopic pregnancy"],"prefix":"10.1007","volume":"288","author":[{"given":"Em\u0131n","family":"Ustunyurt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzeyyen","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem Basak","family":"Ustunyurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,12]]},"reference":[{"issue":"4","key":"2879_CR1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bpobgyn.2008.12.007","volume":"23","author":"NM Mello van","year":"2009","unstructured":"van Mello NM, Mol F, Mol BW, Hajenius PJ (2009) Conservative management of tubal ectopic pregnancy. Best Pract Res Clin Obstet Gynaecol 23(4):509\u2013518","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"9485","key":"2879_CR2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(05)67103-6","volume":"366","author":"CM Farquhar","year":"2005","unstructured":"Farquhar CM (2005) Ectopic pregnancy. Lancet 366(9485):583\u2013591. Review","journal-title":"Lancet"},{"issue":"4","key":"2879_CR3","first-page":"778","volume":"101","author":"KT Barnhart","year":"2003","unstructured":"Barnhart KT, Gosman G, Ashby R, Sammel M (2003) The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens. Obstet Gynecol 101(4):778\u2013784","journal-title":"Obstet Gynecol"},{"issue":"6","key":"2879_CR4","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","volume":"85","author":"A Alleyassin","year":"2006","unstructured":"Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Hamed EA (2006) Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril 85(6):1661\u20131666","journal-title":"Fertil Steril"},{"issue":"7","key":"2879_CR5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/00016349.2010.486825","volume":"89","author":"ES Guvendag Guven","year":"2010","unstructured":"Guvendag Guven ES, Dilbaz S, Dilbaz B, Aykan Yildirim B, Akdag D, Haberal A (2010) Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study. Acta Obstet Gynecol Scand 89(7):889\u2013895","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"2879_CR6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.fertnstert.2006.06.054","volume":"87","author":"K Barnhart","year":"2007","unstructured":"Barnhart K, Hummel AC, Sammel MD, Menon S, Jain J, Chakhtoura N (2007) Use of \u201c2-dose\u201d regimen of methotrexate to treat ectopic pregnancy. Fertil Steril 87(2):250\u2013256","journal-title":"Fertil Steril"},{"issue":"4","key":"2879_CR7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0029-7844(02)03158-7","volume":"101","author":"KT Barnhart","year":"2003","unstructured":"Barnhart KT, Gosman G, Ashby R, Sammel M (2003) The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens. Obstet Gynecol 101(4):778\u2013784","journal-title":"Obstet Gynecol"},{"key":"2879_CR8","unstructured":"Lipscomb GH, Givens VM, Meyer NL, Bran D (2005) Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy. Am J Obstet Gynecol 192(6):1844\u20131847; discussion 1847\u20131848"},{"issue":"2","key":"2879_CR9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijgo.2011.09.023","volume":"116","author":"R Sagiv","year":"2012","unstructured":"Sagiv R, Debby A, Feit H, Cohen-Sacher B, Keidar R, Golan A (2012) The optimal cutoff serum level of human chorionic gonadotropin for efficacy of methotrexate treatment in women with extrauterine pregnancy. Int J Gynaecol Obstet 116(2):101\u2013104","journal-title":"Int J Gynaecol Obstet"},{"issue":"5","key":"2879_CR10","first-page":"754","volume":"77","author":"TG Stovall","year":"1991","unstructured":"Stovall TG, Ling FW, Gray LA (1991) Single-dose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol 77(5):754\u2013757","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2879_CR11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0015-0282(01)03256-3","volume":"77","author":"R Gamzu","year":"2002","unstructured":"Gamzu R, Almog B, Levin Y, Avni A, Jaffa A, Lessing JB, Baram A (2002) Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations. Fertil Steril 77(4):761\u2013765","journal-title":"Fertil Steril"},{"issue":"10","key":"2879_CR12","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/oxfordjournals.humrep.a135774","volume":"10","author":"GH Corsan","year":"1995","unstructured":"Corsan GH, Karacan M, Qasim S, Bohrer MK, Ransom MX, Kemmann E (1995) Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod 10(10):2719\u20132722","journal-title":"Hum Reprod"},{"issue":"2","key":"2879_CR13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/uog.9","volume":"21","author":"A Nazac","year":"2003","unstructured":"Nazac A, Gervaise A, Bouyer J, de Tayrac R, Capella-Allouc S, Fernandez H (2003) Predictors of success in methotrexate treatment of women with unruptured tubal pregnancies. Ultrasound Obstet Gynecol 21(2):181\u2013185","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2879_CR14","doi-asserted-by":"crossref","unstructured":"Nguyen Q, Kapitz M, Downes K, Silva C (2010) Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy? Am J Obstet Gynecol 202(6):630\u2013632","DOI":"10.1016\/j.ajog.2010.03.022"},{"issue":"4","key":"2879_CR15","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.fertnstert.2008.07.1775","volume":"92","author":"E Nowak-Markwitz","year":"2009","unstructured":"Nowak-Markwitz E, Michalak M, Olejnik M, Spaczynski M (2009) Cutoff value of human chorionic gonadotropin in relation to the number of methotrexate cycles in the successful treatment of ectopic pregnancy. Fertil Steril 92(4):1203\u20131207","journal-title":"Fertil Steril"},{"key":"2879_CR16","doi-asserted-by":"crossref","unstructured":"Practice committee of American society for reproductive medicine. Medical treatment of ectopic pregnancy (2008) Fertil Steril 90(5 Suppl):S206\u2013S212. Review","DOI":"10.1016\/j.fertnstert.2008.08.049"},{"issue":"6","key":"2879_CR17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/GCO.0b013e3280105886","volume":"18","author":"E Kirk","year":"2006","unstructured":"Kirk E, Bourne T (2006) The nonsurgical management of ectopic pregnancy. Curr Opin Obstet Gynecol 18(6):587\u2013593. Review","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"26","key":"2879_CR18","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","volume":"341","author":"GH Lipscomb","year":"1999","unstructured":"Lipscomb GH, McCord ML, Stovall TG, Huff G, Portera SG, Ling FW (1999) Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med 341(26):1974\u20131978","journal-title":"N Engl J Med"},{"issue":"2","key":"2879_CR19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0301-2115(01)00480-8","volume":"100","author":"A Natale","year":"2002","unstructured":"Natale A, Busacca M, Candiani M, Gruft L, Izzo S, Felicetta I, Vignali M (2002) Human chorionic gonadotropin patterns after a single dose of methotrexate for ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol 100(2):227\u2013230","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"2879_CR20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.fertnstert.2010.10.014","volume":"95","author":"I Levin","year":"2011","unstructured":"Levin I, Tsafrir Z, Sa\u2019ar N, Lessing J, Avni A, Gamzu R, Almog B (2011) \u201cWatchful waiting\u201d in ectopic pregnancies: a balance between reduced success rates and less methotrexate. Fertil Steril 95(3):1159\u20131160","journal-title":"Fertil Steril"},{"issue":"3","key":"2879_CR21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-0412.2010.01053.x","volume":"90","author":"E Kirk","year":"2011","unstructured":"Kirk E, VAN Calster B, Condous G, Papageorghiou AT, Gevaert O, VAN Huffel S, DE Moor B, Timmerman D, Bourne T (2011) Ectopic pregnancy: using the hCG ratio to select women for expectant or medical management. Acta Obstet Gynecol Scand 90(3):264\u2013272","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"2879_CR22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/0974-1208.69333","volume":"3","author":"A Baxi","year":"2010","unstructured":"Baxi A, Kaushal M, Karmalkar H, Sahu P, Kadhi P, Daval B (2010) Successful expectant management of tubal heterotopic pregnancy. J Hum Reprod Sci 3(2):108\u2013110","journal-title":"J Hum Reprod Sci"},{"issue":"2","key":"2879_CR23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.fertnstert.2006.11.138","volume":"88","author":"A Agostini","year":"2007","unstructured":"Agostini A, Blanc K, Ronda I, Romain F, Capelle M, Blanc B (2007) Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. Fertil Steril 88(2):504\u2013506","journal-title":"Fertil Steril"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-013-2879-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-013-2879-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-013-2879-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T14:13:06Z","timestamp":1715350386000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-013-2879-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,12]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["2879"],"URL":"https:\/\/doi.org\/10.1007\/s00404-013-2879-8","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,12]]}}}