{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:03:33Z","timestamp":1790406213788,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00404-014-3367-5","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T09:00:04Z","timestamp":1405414804000},"page":"1109-1114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Would it be too late? A retrospective case\u2013control analysis to evaluate maternal\u2013fetal outcomes in advanced maternal age"],"prefix":"10.1007","volume":"290","author":[{"given":"Leonarda","family":"Ciancimino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito","family":"Chiofalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Granese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onofrio","family":"Triolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"3367_CR1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.midw.2010.07.006","volume":"27","author":"M Carolan","year":"2011","unstructured":"Carolan M, Frankowska D (2011) Advanced maternal age and adverse perinatal outcome: a review of the evidence. Midwifery 27:793\u2013801","journal-title":"Midwifery"},{"key":"3367_CR2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijgo.2008.05.004","volume":"102","author":"BC Chan","year":"2008","unstructured":"Chan BC, Lao TT (2008) Effect of parity and advanced maternal age on obstetric outcome. Int J Gynaecol Obstet 102:237\u2013241","journal-title":"Int J Gynaecol Obstet"},{"key":"3367_CR3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/01.AOG.0000140682.63746.be","volume":"104","author":"B Jacobsson","year":"2004","unstructured":"Jacobsson B, Ladfors L, Milsom I (2004) Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 104:727\u2013733","journal-title":"Obstet Gynecol"},{"key":"3367_CR4","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1097\/01.AOG.0000163256.83313.36","volume":"105","author":"KS Joseph","year":"2005","unstructured":"Joseph KS, Allen AC, Dodds L, Turner LA, Scott H, Liston R (2005) The perinatal effects of delayed childbearing. Obstet Gynecol 105:1410\u20131418","journal-title":"Obstet Gynecol"},{"key":"3367_CR5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00404-007-0529-8","volume":"278","author":"MH Aliyu","year":"2008","unstructured":"Aliyu MH, Salihu HM, Wilson RE, Alio AP, Kirby RS (2008) The risk of intrapartum stillbirth among smokers of advanced maternal age. Arch Gynecol Obstet 278:39\u201345","journal-title":"Arch Gynecol Obstet"},{"key":"3367_CR6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejogrb.2006.10.030","volume":"135","author":"I Delbaere","year":"2007","unstructured":"Delbaere I, Verstraelen H, Goetgeluk S, Martens G, De Backer G, Temmerman M (2007) Pregnancy outcome in primiparae of advanced maternal age. Eur J Obstet Gynecol Reprod Biol 135:41\u201346","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3367_CR7","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.ajog.2006.10.862","volume":"196","author":"MC Hoffman","year":"2007","unstructured":"Hoffman MC, Jeffers S, Carter J, Duthely L, Cotter A, Gonz\u00e1lez-Quintero VH (2007) Pregnancy at or beyond age 40\u00a0years is associated with an increased risk of fetal death and other adverse outcomes. Am J Obstet Gynecol 196:e11\u2013e13","journal-title":"Am J Obstet Gynecol"},{"key":"3367_CR8","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1136\/bmj.320.7251.1708","volume":"320","author":"AM Nybo Andersen","year":"2000","unstructured":"Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320:1708\u20131712","journal-title":"BMJ"},{"key":"3367_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000086889","volume":"111","author":"A Kuliev","year":"2005","unstructured":"Kuliev A, Cieslak J, Verlinsky Y (2005) Frequency and distribution of chromosome abnormalities in human oocytes. Cytogenet Genome Res 111:193\u2013198","journal-title":"Cytogenet Genome Res"},{"key":"3367_CR10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000086891","volume":"111","author":"F Pellestor","year":"2005","unstructured":"Pellestor F, Anahory T, Hamamah S (2005) Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes. Cytogenet Genome Res 111:206\u2013212","journal-title":"Cytogenet Genome Res"},{"key":"3367_CR11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tig.2007.11.010","volume":"24","author":"PA Hunt","year":"2008","unstructured":"Hunt PA, Hassold TJ (2008) Human female meiosis: what makes a good egg go bad? Trends Genet 24:86\u201393","journal-title":"Trends Genet"},{"key":"3367_CR12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1479-828X.2008.00920.x","volume":"48","author":"S Janssens","year":"2008","unstructured":"Janssens S, Wallace KL, Chang AM (2008) Prepartum and intrapartum caesarean section rates at Mater Mothers\u2019 Hospital Brisbane 1997\u20132005. Aust N Z J Obstet Gynaecol 48:564\u2013569","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"3367_CR13","first-page":"910","volume":"108","author":"JS Bell","year":"2001","unstructured":"Bell JS, Campbell DM, Graham WJ, Penney GC, Ryan M, Hall MH (2001) Can obstetric complications explain the high levels of obstetric interventions and maternity service use among older women? A retrospective analysis of routinely collected data. BJOG 108:910\u2013918","journal-title":"BJOG"},{"key":"3367_CR14","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1471-0528.1998.tb09937.x","volume":"105","author":"AN Rosenthal","year":"1998","unstructured":"Rosenthal AN, Paterson-Brown S (1998) Is there an incremental rise in the risk of obstetric intervention with increasing maternal age? Br J Obstet Gynaecol 105:1064\u20131069","journal-title":"Br J Obstet Gynaecol"},{"key":"3367_CR15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jgyn.2008.08.007","volume":"37","author":"B Khoshnood","year":"2008","unstructured":"Khoshnood B, Bouvier-Colle MH, Leridon H, Blondel B (2008) Impact of advanced maternal age on fecundity and women\u2019s and children\u2019s health. J Gynecol Obstet Biol Reprod (Paris) 37:733\u2013747","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"3367_CR16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1542\/peds.109.3.399","volume":"109","author":"SC Tough","year":"2002","unstructured":"Tough SC, Newburn-Cook C, Johnston DW, Svenson LW, Rose S, Belik J (2002) Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery. Pediatrics 109:399\u2013403","journal-title":"Pediatrics"},{"key":"3367_CR17","volume-title":"Trends in Europe and North America: the statistical yearbook of the Economic Commission for Europe 2005","author":"United Nations Economic Commission for Europe","year":"2005","unstructured":"United Nations Economic Commission for Europe (2005) Trends in Europe and North America: the statistical yearbook of the Economic Commission for Europe 2005. The Commission, Geneva"},{"key":"3367_CR18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1701-2163(16)35138-6","volume":"34","author":"JA Johnson","year":"2012","unstructured":"Johnson JA, Tough S, Society of Obstetricians and Gynaecologists of Canada (2012) Delayed child-bearing. J Obstet Gynaecol Can 34:80\u201393","journal-title":"J Obstet Gynaecol Can"},{"key":"3367_CR19","first-page":"91","volume":"13","author":"M Carolan","year":"2004","unstructured":"Carolan M (2004) First time mothers over 35\u00a0years: challenges for care? Birth Issues 13:91\u201397","journal-title":"Birth Issues"},{"key":"3367_CR20","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1056\/NEJMp048087","volume":"351","author":"LJ Heffner","year":"2004","unstructured":"Heffner LJ (2004) Advanced maternal age: how old is too old? N Engl J Med 351:1927\u20131929","journal-title":"N Engl J Med"},{"key":"3367_CR21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.rbmo.2009.04.002","volume":"19","author":"A Hourvitz","year":"2009","unstructured":"Hourvitz A, Machtinger R, Maman E, Baum M, Dor J, Levron J (2009) Assisted reproduction in women over 40\u00a0years of age: how old is too old? Reprod Biomed Online 19:599\u2013603","journal-title":"Reprod Biomed Online"},{"key":"3367_CR22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E Elm von","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, STROBE Initiative (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453\u20131457","journal-title":"Lancet"},{"key":"3367_CR23","first-page":"87","volume":"15","author":"A Giri","year":"2013","unstructured":"Giri A, Srivastav VR, Suwal A, Tuladhar AS (2013) Advanced maternal age and obstetric outcome. Nepal Med Coll J 15:87\u201390","journal-title":"Nepal Med Coll J"},{"key":"3367_CR24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1503\/cmaj.071577","volume":"178","author":"KM Benzies","year":"2008","unstructured":"Benzies KM (2008) Advanced maternal age: are decisions about the timing of child-bearing a failure to understand the risks? CMAJ 178:183\u2013184","journal-title":"CMAJ"},{"key":"3367_CR25","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/01.olq.0000258130.07476.e3","volume":"34","author":"S Mario Di","year":"2007","unstructured":"Di Mario S, Say L, Lincetto O (2007) Risk factors for stillbirth in developing countries: a systematic review of the literature. Sex Transm Dis 34:S11\u2013S21","journal-title":"Sex Transm Dis"},{"key":"3367_CR26","first-page":"277","volume":"40","author":"J Stojnic","year":"2013","unstructured":"Stojnic J, Radunovic N, Jeremic K, Kotlica BK, Mitrovic M, Tulic I (2013) Perinatal outcome of singleton pregnancies following in vitro fertilization. Clin Exp Obstet Gynecol 40:277\u2013283","journal-title":"Clin Exp Obstet Gynecol"},{"key":"3367_CR27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","volume":"19","author":"A Pinborg","year":"2013","unstructured":"Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, S\u00f6derstr\u00f6m-Anttila V, Nygren KG, Hazekamp J, Bergh C (2013) Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update 19:87\u2013104","journal-title":"Hum Reprod Update"},{"key":"3367_CR28","first-page":"282","volume":"58","author":"EB Hook","year":"1981","unstructured":"Hook EB (1981) Rates of chromosome abnormalities at different maternal ages. Obstet Gynecol 58:282\u2013285","journal-title":"Obstet Gynecol"},{"key":"3367_CR29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejogrb.2013.12.011","volume":"174","author":"D Caserta","year":"2014","unstructured":"Caserta D, Bordi G, Stegagno M, Filippini F, Podagrosi M, Roselli D, Moscarini M (2014) Maternal and perinatal outcomes in spontaneous versus assisted conception twin pregnancies. Eur J Obstet Gynecol Reprod Biol 174:64\u201369","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3367_CR30","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/1471-0528.12415","volume":"121","author":"R Klemetti","year":"2014","unstructured":"Klemetti R, Gissler M, Sainio S, Hemminki E (2014) Associations of maternal age with maternity care use and birth outcomes in primiparous women: a comparison of results in 1991 and 2008 in Finland. BJOG 121:356\u2013362","journal-title":"BJOG"},{"key":"3367_CR31","first-page":"888","volume":"39","author":"CM Houlihan","year":"1994","unstructured":"Houlihan CM, Knuppel RA (1994) Meconium-stained amniotic fluid. Current controversies. J Reprod Med 39:888\u2013898","journal-title":"J Reprod Med"},{"key":"3367_CR32","first-page":"U2859","volume":"120","author":"M Battin","year":"2007","unstructured":"Battin M, Bevan C, Knight D (2007) Neonatal intensive care utilisation by infants born to mothers older than 40\u00a0years of age: a 10-year review. N Z Med J 120:U2859","journal-title":"N Z Med J"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-014-3367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-014-3367-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-014-3367-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:55:51Z","timestamp":1559051751000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-014-3367-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["3367"],"URL":"https:\/\/doi.org\/10.1007\/s00404-014-3367-5","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}