{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:03:39Z","timestamp":1785873819245,"version":"3.56.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Cumhuriyet University CUBAP","award":["T-603"],"award-info":[{"award-number":["T-603"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00404-015-3803-1","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T06:16:38Z","timestamp":1435817798000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls"],"prefix":"10.1007","volume":"293","author":[{"given":"Savas","family":"Karakus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Bozoklu Akkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caglar","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"Sancakdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"issue":"10","key":"3803_CR1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1600-0412.2011.01152.x","volume":"90","author":"IK Prusac","year":"2011","unstructured":"Prusac IK, Zekic Tomas S, Roje D (2011) Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia. Acta Obstet Gynecol Scand 90(10):1157\u20131163","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"9","key":"3803_CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2393-9-8","volume":"26","author":"K Haram","year":"2009","unstructured":"Haram K, Svendsen E, Abildgaard U (2009) The HELLP syndrome: clinical issues and management. A Review. BMC Pregnancy Childbirth 26(9):8","journal-title":"A Review. BMC Pregnancy Childbirth"},{"key":"3803_CR3","first-page":"1960","volume":"12","author":"J Jebbink","year":"1822","unstructured":"Jebbink J, Wolters A, Fernando F, Afink G, van der Post J (1822) Ris-Stalpers C (2012) Molecular genetics of preeclampsia and HELLP syndrome\u2014a review. Biochim Biophys Acta 12:1960\u20131969","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3803_CR4","doi-asserted-by":"crossref","first-page":"e886","DOI":"10.1038\/cddis.2013.408","volume":"24","author":"K John","year":"2013","unstructured":"John K, Wielgosz S, Schulze-Osthoff K, Bantel H, Hass R (2013) Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome. Cell Death Dis 24(4):e886","journal-title":"Cell Death Dis"},{"issue":"2","key":"3803_CR5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00404-001-0283-2","volume":"267","author":"T Shinagawa","year":"2002","unstructured":"Shinagawa T, Suzuki S, Sawa R, Yoneyama Y, Asakura H, Araki T (2002) Maternal plasma adenosine and endothelin-1 levels in twin gestation complicated by preeclampsia. Arch Gynecol Obstet 267(2):72\u201375","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"3803_CR6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12098-009-0079-0","volume":"76","author":"MA Nezar","year":"2009","unstructured":"Nezar MA, el-Baky AM, Soliman OA, Abdel-Hady HA, Hammad AM, Al-Haggar MS (2009) Endothelin-1 and leptin as markers of intrauterine growth restriction. Indian J Pediatr 76(5):485\u2013488","journal-title":"Indian J Pediatr"},{"issue":"6","key":"3803_CR7","first-page":"371","volume":"22","author":"LJ Zhang","year":"2010","unstructured":"Zhang LJ, Han YH, Han YZ (2010) Serum soluble Endoglin, plasma endothelin-1 and coagulation function in early onset severe preeclampsia with organ dysfunction. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22(6):371\u2013374","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"4","key":"3803_CR8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/01443615.2013.769944","volume":"33","author":"H Celik","year":"2013","unstructured":"Celik H, Avci B, I\u015fik Y (2013) Vascular endothelial growth factor and endothelin-1 levels in normal pregnant women and pregnant women with pre-eclampsia. J Obstet Gynaecol 33(4):355\u2013358","journal-title":"J Obstet Gynaecol"},{"issue":"3","key":"3803_CR9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1078\/0171-9335-00154","volume":"80","author":"H Bantel","year":"2001","unstructured":"Bantel H, Ruck P, Gregor M, Schulze-Osthoff K (2001) Detection of elevated caspase activation and early apoptosis in liver diseases. Eur J Cell Biol 80(3):230\u2013239","journal-title":"Eur J Cell Biol"},{"issue":"3","key":"3803_CR10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1071-5576(01)00108-3","volume":"8","author":"LA Hefler","year":"2001","unstructured":"Hefler LA, Tempfer CB, Bancher-Todesca D, Schatten C, Husslein P, Heinze G, Gregg AR (2001) Placental expression and serum levels of cytokeratin-18 are increased in women with preeclampsia. J Soc Gynecol Investig 8(3):169\u2013173","journal-title":"J Soc Gynecol Investig"},{"issue":"5","key":"3803_CR11","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/hep.20411","volume":"40","author":"H Bantel","year":"2004","unstructured":"Bantel H, L\u00fcgering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP, Manns MP, Schulze-Osthoff K (2004) Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 40(5):1078\u20131087","journal-title":"Hepatology"},{"issue":"2","key":"3803_CR12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/00365510802474384","volume":"69","author":"RR Hamad","year":"2009","unstructured":"Hamad RR, Bremme K, Kallner A, Sten-Linder M (2009) Increased levels of an apoptotic product in the sera from women with pre-eclampsia. Scand J Clin Lab Invest 69(2):204\u2013208","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"3803_CR13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/hep.20747","volume":"42","author":"N Seidel","year":"2005","unstructured":"Seidel N, Volkmann X, L\u00e4nger F, Flemming P, Manns MP, Schulze-Osthoff K, Bantel H (2005) The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology 42(1):113\u2013120","journal-title":"Hepatology"},{"issue":"2","key":"3803_CR14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/hep.24734","volume":"55","author":"D Joka","year":"2012","unstructured":"Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ, Manns MP, Schulze-Osthoff K, Bantel H (2012) Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 55(2):455\u2013464","journal-title":"Hepatology"},{"issue":"6","key":"3803_CR15","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1083\/jcb.148.6.1239","volume":"148","author":"M MacFarlane","year":"2000","unstructured":"MacFarlane M, Merrison W, Dinsdale D, Cohen GM (2000) Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J Cell Biol 148(6):1239\u20131254","journal-title":"J Cell Biol"},{"issue":"1","key":"3803_CR16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pathophys.2012.02.004","volume":"20","author":"P Chittiboina","year":"2013","unstructured":"Chittiboina P, Ganta V, Monceaux CP, Scott LK, Nanda A, Alexander JS (2013) Angiopoietins as promising biomarkers and potential therapeutic targets in brain injury. Pathophysiology 20(1):15\u201321","journal-title":"Pathophysiology"},{"issue":"9","key":"3803_CR17","doi-asserted-by":"crossref","first-page":"a006550","DOI":"10.1101\/cshperspect.a006650","volume":"2","author":"G Thurston","year":"2012","unstructured":"Thurston G, Daly C (2012) The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med 2(9):a006550","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"9","key":"3803_CR18","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2013.03.011","volume":"319","author":"L Eklund","year":"2013","unstructured":"Eklund L, Saharinen P (2013) Angiopoietin signaling in the vasculature. Exp Cell Res 319(9):1271\u20131280","journal-title":"Exp Cell Res"},{"issue":"6","key":"3803_CR19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4161\/viru.24530","volume":"4","author":"AV Page","year":"2013","unstructured":"Page AV, Liles WC (2013) Biomarkers of endothelial activation\/dysfunction in infectious diseases. Virulence 4(6):507\u2013516","journal-title":"Virulence"},{"issue":"8","key":"3803_CR20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/ajh.2009.97","volume":"22","author":"M Bolin","year":"2009","unstructured":"Bolin M, Wiberg-Itzel E, Wikstr\u00f6m AK, Goop M, Larsson A, Olovsson M, Akerud H (2009) Angiopoietin-1\/angiopoietin-2 ratio for prediction of preeclampsia. Am J Hypertens 22(8):891\u2013895","journal-title":"Am J Hypertens"},{"issue":"1","key":"3803_CR21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5468\/ogs.2015.58.1.10","volume":"58","author":"SS Shim","year":"2015","unstructured":"Shim SS, Lee CH, Jun JK (2015) Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor in pregnant women who subsequently develop preeclampsia. Obstet Gynecol Sci. 58(1):10\u201316","journal-title":"Obstet Gynecol Sci."},{"issue":"1","key":"3803_CR22","doi-asserted-by":"crossref","first-page":"IX","DOI":"10.3109\/10641950109152635","volume":"20","author":"MA Brown","year":"2001","unstructured":"Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM (2001) The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 20(1):IX\u2013XIV","journal-title":"Hypertens Pregnancy"},{"issue":"3","key":"3803_CR23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0002-9378(86)90266-8","volume":"155","author":"BM Sibai","year":"1986","unstructured":"Sibai BM, Taslimi MM, el-Nazer A, Amon E, Mabie BC, Ryan GM (1986) Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 155(3):501\u2013509","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"3803_CR24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejogrb.2012.09.026","volume":"166","author":"U Abildgaard","year":"2013","unstructured":"Abildgaard U, Heimdal K (2013) Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol 166(2):117\u2013123","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3803_CR25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-385855-9.00004-7","volume":"53","author":"C Benedetto","year":"2011","unstructured":"Benedetto C, Marozio L, Tancredi A, Picardo E, Nardolillo P, Tavella AM, Salton L (2011) Biochemistry of HELLP syndrome. Adv Clin Chem 53:85\u2013104","journal-title":"Adv Clin Chem"},{"issue":"2","key":"3803_CR26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00404-015-3659-4","volume":"292","author":"M Kalinderis","year":"2015","unstructured":"Kalinderis M, Papanikolaou A, Kalinderi K, Vyzantiadis TA, Ioakimidou A, Tarlatzis BC (2015) Serum levels of leptin and IP-10 in preeclampsia compared to controls. Arch Gynecol Obstet 292(2):343\u2013347","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"3803_CR27","doi-asserted-by":"crossref","first-page":"e63546","DOI":"10.1371\/journal.pone.0063546","volume":"8","author":"S Kuc","year":"2013","unstructured":"Kuc S, Koster MP, Franx A, Schielen PC, Visser GH (2013) Maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia. PLoS One 8(5):e63546","journal-title":"PLoS One"},{"issue":"1","key":"3803_CR28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00404-014-3610-0","volume":"292","author":"B Artunc-Ulkumen","year":"2015","unstructured":"Artunc-Ulkumen B, Guvenc Y, Goker A, Gozukara C (2015) Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia. Arch Gynecol Obstet 292(1):97\u2013102","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"3803_CR29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.transci.2014.12.009","volume":"52","author":"O Simetka","year":"2015","unstructured":"Simetka O, Klat J, Gumulec J, Dolezalkova E, Salounova D, Kacerovsky M (2015) Early identification of women with HELLP syndrome who need plasma exchange after delivery. Transfus Apher Sci 52(1):54\u201359","journal-title":"Transfus Apher Sci"},{"issue":"5","key":"3803_CR30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2174\/1570161111311050004","volume":"11","author":"A Paradis","year":"2013","unstructured":"Paradis A, Zhang L (2013) Role of endothelin in uteroplacental circulation and fetal vascular function. Curr Vasc Pharmacol 11(5):594\u2013605","journal-title":"Curr Vasc Pharmacol"},{"issue":"8","key":"3803_CR31","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","volume":"86","author":"A Inoue","year":"1989","unstructured":"Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 86(8):2863\u20132867","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3803_CR32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1152\/physrev.00032.2009","volume":"90","author":"Y Gao","year":"2010","unstructured":"Gao Y, Raj JU (2010) Regulation of the pulmonary circulation in the fetus and newborn. Physiol Rev 90(4):1291\u20131335","journal-title":"Physiol Rev"},{"issue":"1","key":"3803_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3317\/jraas.2002.001","volume":"3","author":"AV Agapitov","year":"2002","unstructured":"Agapitov AV, Haynes WG (2002) Role of endothelin in cardiovascular disease. J Renin Angiotensin Aldosterone Syst 3(1):1\u201315","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"3\u20134","key":"3803_CR34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s004040050238","volume":"62","author":"S Bussen","year":"1999","unstructured":"Bussen S, S\u00fctterlin M, Steck T (1999) Plasma endothelin and big endothelin levels in women with severe preeclampsia or HELLP-syndrome. Arch Gynecol Obstet 62(3\u20134):113\u2013119","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"3803_CR35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1210\/jcem-71-6-1675","volume":"71","author":"RN Taylor","year":"1990","unstructured":"Taylor RN, Varma M, Teng NN, Roberts JM (1990) Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies. J Clin Endocrinol Metab 71(6):1675\u20131677","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3803_CR36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijgo.2005.04.018","volume":"90","author":"B Baksu","year":"2005","unstructured":"Baksu B, Davas I, Baksu A, Akyol A, Gulbaba G (2005) Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women. Int J Gynaecol Obstet 90(2):112\u2013117","journal-title":"Int J Gynaecol Obstet"},{"issue":"12","key":"3803_CR37","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0024-3205(00)00736-0","volume":"67","author":"S Nishikawa","year":"2000","unstructured":"Nishikawa S, Miyamoto A, Yamamoto H, Ohshika H, Kudo R (2000) The relationship between serum nitrate and endothelin-1 concentrations in preeclampsia. Life Sci 67(12):1447\u20131454","journal-title":"Life Sci"},{"issue":"2","key":"3803_CR38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/CS20040340","volume":"109","author":"T Maltaris","year":"2005","unstructured":"Maltaris T, Scalera F, Schlembach D, Hoffmann I, Mueller A, Binder H, Goecke T, Hothorn T, Schild RL, Beckmann MW, Dittrich R (2005) Increased uterine arterial pressure and contractility of perfused swine uterus after treatment with serum from pre-eclamptic women and endothelin-1. Clin Sci (Lond) 109(2):209\u2013215","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"3803_CR39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/jhep.2002.31165","volume":"35","author":"MB Omary","year":"2002","unstructured":"Omary MB, Ku NO, Toivola DM (2002) Keratins: guardians of the liver. Hepatology 35(2):251\u2013257","journal-title":"Hepatology"},{"issue":"4","key":"3803_CR40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcv.2013.10.008","volume":"58","author":"CB Bae","year":"2013","unstructured":"Bae CB, Kim SS, Ahn SJ, Cho HJ, Kim SR, Park SY, Song GW, Kim DJ, Hwang SG, Yang JM, Kim YB, Park YN, Shin SJ, Cho SW, Cheong JY (2013) Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection. J Clin Virol 58(4):641\u2013646","journal-title":"J Clin Virol"},{"issue":"1","key":"3803_CR41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00441-003-0749-6","volume":"314","author":"G Thurston","year":"2003","unstructured":"Thurston G (2003) Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis. Cell Tissue Res 314(1):61\u201368","journal-title":"Cell Tissue Res"},{"issue":"5322","key":"3803_CR42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","volume":"277","author":"PC Maisonpierre","year":"1997","unstructured":"Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277(5322):55\u201360","journal-title":"Science"},{"issue":"2","key":"3803_CR43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/bbrc.2000.2296","volume":"269","author":"I Kim","year":"2000","unstructured":"Kim I, Kim JH, Ryu YS, Liu M, Koh GY (2000) Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun 269(2):361\u2013365","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3803_CR44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","volume":"10","author":"HG Augustin","year":"2009","unstructured":"Augustin HG, Koh GY, Thurston G, Alitalo K (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10(3):165\u2013177","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"29","key":"3803_CR45","doi-asserted-by":"crossref","first-page":"18514","DOI":"10.1074\/jbc.273.29.18514","volume":"273","author":"B Witzenbichler","year":"1998","unstructured":"Witzenbichler B, Maisonpierre PC, Jones P, Yancopoulos GD, Isner JM (1998) Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie 2. J Biol Chem 273(29):18514\u201318521","journal-title":"J Biol Chem"},{"issue":"11","key":"3803_CR46","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1111\/j.1572-0241.2007.01377.x","volume":"102","author":"A Scholz","year":"2007","unstructured":"Scholz A, Rehm VA, Rieke S, Derkow K, Schulz P, Neumann K, Koch I, Pascu M, Wiedenmann B, Berg T, Schott E (2007) Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. Am J Gastroenterol 102(11):2471\u20132481","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"3803_CR47","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1158\/1078-0432.CCR-11-2175","volume":"18","author":"JM Llovet","year":"2012","unstructured":"Llovet JM, Pe\u00f1a CE, Lathia CD, Shan M, Meinhardt G, Bruix J (2012) SHARP Investigators Study Group. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin Cancer Res 18(8):2290\u20132300","journal-title":"Clin Cancer Res"},{"issue":"5","key":"3803_CR48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s13224-013-0388-0","volume":"63","author":"S Aref","year":"2013","unstructured":"Aref S, Goda H, Abdelaal E (2013) Circulating vascular growth factor (VEGF) Angiopoietin-1 (Angi-1) and soluble Tie-2 receptor in pregnancy complicated with pre-eclampsia: a prospective study. J Obstet Gynaecol India 63(5):316\u2013320","journal-title":"J Obstet Gynaecol India"},{"issue":"1","key":"3803_CR49","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/10641955.2010.507844","volume":"31","author":"SY Han","year":"2012","unstructured":"Han SY, Jun JK, Lee CH, Park JS, Syn HC (2012) Angiopoietin-2: a promising indicator for the occurrence of severe preeclampsia. Hypertens Pregnancy 31(1):189\u2013199","journal-title":"Hypertens Pregnancy"},{"issue":"4","key":"3803_CR50","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/uog.13439","volume":"44","author":"A Khalil","year":"2014","unstructured":"Khalil A, Maiz N, Garcia-Mandujano R, Elkhouli M, Nicolaides KH (2014) Longitudinal changes in maternal soluble endoglin and angiopoietin-2 in women at risk for pre-eclampsia. Ultrasound Obstet Gynecol 44(4):402\u2013410","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"9","key":"3803_CR51","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.placenta.2014.07.001","volume":"35","author":"D Kappou","year":"2014","unstructured":"Kappou D, Sifakis S, Androutsopoulos V, Konstantinidou A, Spandidos DA, Papantoniou N (2014) Placental mRNA expression of angiopoietins (Ang)-1, Ang-2 and their receptor Tie-2 is altered in pregnancies complicated by preeclampsia. Placenta 35(9):718\u2013723","journal-title":"Placenta"},{"issue":"7","key":"3803_CR52","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2310\/JIM.0b013e31822c5bdf","volume":"59","author":"M Kamal","year":"2011","unstructured":"Kamal M, El-Khayat W (2011) Do serum angiopoietin-1, angiopoietin-2, and their receptor Tie-2 and 4G\/5G variant of PAI-1 gene have a role in the pathogenesis of preeclampsia? J Investig Med 59(7):1147\u20131150","journal-title":"J Investig Med"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-015-3803-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-015-3803-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-015-3803-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:56:02Z","timestamp":1559066162000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-015-3803-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["3803"],"URL":"https:\/\/doi.org\/10.1007\/s00404-015-3803-1","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]}}}