{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:18:22Z","timestamp":1784675902108,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s00404-016-4277-5","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T17:21:05Z","timestamp":1482600065000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The expression of Foxp3 and TLR4 in cervical cancer: association with immune escape and clinical pathology"],"prefix":"10.1007","volume":"295","author":[{"given":"Huijie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"issue":"3","key":"4277_CR1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s10637-009-9240-x","volume":"28","author":"M Singh","year":"2010","unstructured":"Singh M, Tyagi S, Bhui K, Prasad S, Shukla Y (2010) Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols. Invest New Drugs 28(3):216\u2013224. doi: 10.1007\/s10637-009-9240-x","journal-title":"Invest New Drugs"},{"issue":"1","key":"4277_CR2","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s00464-010-1174-z","volume":"25","author":"Moreira A Luz da","year":"2011","unstructured":"da Luz Moreira A, Mor I, Geisler DP, Remzi FH, Kiran RP (2011) Laparoscopic resection for rectal cancer: a case-matched study. Surg Endosc 25(1):278\u2013283. doi: 10.1007\/s00464-010-1174-z","journal-title":"Surg Endosc"},{"key":"4277_CR3","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.2741\/2840","volume":"13","author":"JR Wilczynski","year":"2008","unstructured":"Wilczynski JR, Radwan M, Kalinka J (2008) The characterization and role of regulatory T cells in immune reactions. Front Biosci J Virtual Library 13:2266\u20132274","journal-title":"Front Biosci J Virtual Library"},{"issue":"3","key":"4277_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","volume":"22","author":"JD Fontenot","year":"2005","unstructured":"Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (2005) Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329\u2013341. doi: 10.1016\/j.immuni.2005.01.016","journal-title":"Immunity"},{"issue":"5609","key":"4277_CR5","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"S Hori","year":"2003","unstructured":"Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Sci (New York, NY) 299(5609):1057\u20131061. doi: 10.1126\/science.1079490","journal-title":"Sci (New York, NY)"},{"key":"4277_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1479-5876-6-19","volume":"6","author":"V Karanikas","year":"2008","unstructured":"Karanikas V, Speletas M, Zamanakou M, Kalala F, Loules G, Kerenidi T, Barda AK, Gourgoulianis KI, Germenis AE (2008) Foxp3 expression in human cancer cells. J Trans Med 6:19. doi: 10.1186\/1479-5876-6-19","journal-title":"J Trans Med"},{"key":"4277_CR7","doi-asserted-by":"crossref","unstructured":"Cunha LL, Morari EC, Nonogaki S, Soares FA, Vassallo J, Ward LS (2012) Foxp3 expression is associated with aggressiveness in differentiated thyroid carcinomas. Clinics (Sao Paulo, Brazil) 67(5):483\u2013488","DOI":"10.6061\/clinics\/2012(05)13"},{"issue":"7","key":"4277_CR8","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.ejca.2014.02.016","volume":"50","author":"P Weller","year":"2014","unstructured":"Weller P, Bankfalvi A, Gu X, Dominas N, Lehnerdt GF, Zeidler R, Lang S, Brandau S, Dumitru CA (2014) The role of tumour FoxP3 as prognostic marker in different subtypes of head and neck cancer. Euro J Cancer 50(7):1291\u20131300. doi: 10.1016\/j.ejca.2014.02.016 (Oxford, England: 1990)","journal-title":"Euro J Cancer"},{"issue":"24","key":"4277_CR9","first-page":"3545","volume":"123","author":"LH Wang","year":"2010","unstructured":"Wang LH, Su L, Wang JT (2010) Correlation between elevated FOXP3 expression and increased lymph node metastasis of gastric cancer. Chin Med J 123(24):3545\u20133549","journal-title":"Chin Med J"},{"issue":"3","key":"4277_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00262-008-0570-x","volume":"58","author":"M Ohara","year":"2009","unstructured":"Ohara M, Yamaguchi Y, Matsuura K, Murakami S, Arihiro K, Okada M (2009) Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer. Cancer Immunol Immunotherapy: CII 58(3):441\u2013447. doi: 10.1007\/s00262-008-0570-x","journal-title":"Cancer Immunol Immunotherapy: CII"},{"issue":"2","key":"4277_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00384-008-0588-8","volume":"24","author":"N Stanilov","year":"2009","unstructured":"Stanilov N, Miteva L, Mintchev N, Stanilova S (2009) High expression of Foxp 3, IL-23p19 and survivin mRNA in colorectal carcinoma. Int J Colorectal Dis 24(2):151\u2013157. doi: 10.1007\/s00384-008-0588-8","journal-title":"Int J Colorectal Dis"},{"issue":"12","key":"4277_CR12","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1172\/jci32538","volume":"117","author":"T Zuo","year":"2007","unstructured":"Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y (2007) FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Investig 117(12):3765\u20133773. doi: 10.1172\/jci32538","journal-title":"J Clin Investig"},{"issue":"6","key":"4277_CR13","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s11033-008-9338-9","volume":"36","author":"YB Zhang","year":"2009","unstructured":"Zhang YB, He FL, Fang M, Hua TF, Hu BD, Zhang ZH, Cao Q, Liu RY (2009) Increased expression of Toll-like receptors 4 and 9 in human lung cancer. Mol Biol Rep 36(6):1475\u20131481. doi: 10.1007\/s11033-008-9338-9","journal-title":"Mol Biol Rep"},{"key":"4277_CR14","doi-asserted-by":"publisher","unstructured":"Petricevic B, Vrbanec D, Jakic-Razumovic J, Brcic I, Rabic D, Badovinac T, Ozimec E, Bali V (2012) Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer. Med Oncol (Northwood, London, England) 29(2):486\u2013494. doi: 10.1007\/s12032-011-9885-0","DOI":"10.1007\/s12032-011-9885-0"},{"key":"4277_CR15","doi-asserted-by":"publisher","first-page":"712561","DOI":"10.1155\/2013\/712561","volume":"2013","author":"S Dang","year":"2013","unstructured":"Dang S, Peng Y, Ye L, Wang Y, Qian Z, Chen Y, Wang X, Lin Y, Zhang X, Sun X, Wu Q, Cheng Y, Nie H, Jin M, Xu H (2013) Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7. Clinical Dev Immunol 2013:712561. doi: 10.1155\/2013\/712561","journal-title":"Clinical Dev Immunol"},{"issue":"4","key":"4277_CR16","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/jclinpath-2011-200402","volume":"65","author":"J Hagstrom","year":"2012","unstructured":"Hagstrom J, Heikkila A, Siironen P, Louhimo J, Heiskanen I, Maenpaa H, Arola J, Haglund C (2012) TLR-4 expression and decrease in chronic inflammation: indicators of aggressive follicular thyroid carcinoma. J Clin Pathol 65(4):333\u2013338. doi: 10.1136\/jclinpath-2011-200402","journal-title":"J Clin Pathol"},{"issue":"7","key":"4277_CR17","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00232-014-9675-7","volume":"247","author":"Y Wang","year":"2014","unstructured":"Wang Y, Weng Y, Shi Y, Xia X, Wang S, Duan H (2014) Expression and functional analysis of Toll-like receptor 4 in human cervical carcinoma. J Membrane Biol 247(7):591\u2013599. doi: 10.1007\/s00232-014-9675-7","journal-title":"J Membrane Biol"},{"issue":"11","key":"4277_CR18","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1158\/1535-7163.mct-08-0582","volume":"7","author":"Y Goto","year":"2008","unstructured":"Goto Y, Arigami T, Kitago M, Nguyen SL, Narita N, Ferrone S, Morton DL, Irie RF, Hoon DS (2008) Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther 7(11):3642\u20133653. doi: 10.1158\/1535-7163.mct-08-0582","journal-title":"Mol Cancer Ther"},{"issue":"11","key":"4277_CR19","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1016\/j.molimm.2007.01.022","volume":"44","author":"W He","year":"2007","unstructured":"He W, Liu Q, Wang L, Chen W, Li N, Cao X (2007) TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol 44(11):2850\u20132859. doi: 10.1016\/j.molimm.2007.01.022","journal-title":"Mol Immunol"},{"issue":"1","key":"4277_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-0625.2009.00953.x","volume":"19","author":"L Milkova","year":"2010","unstructured":"Milkova L, Voelcker V, Forstreuter I, Sack U, Anderegg U, Simon JC, Maier-Simon C (2010) The NF-kappaB signalling pathway is involved in the LPS\/IL-2-induced upregulation of FoxP3 expression in human CD4+ CD25 high regulatory T cells. Exp Dermatol 19(1):29\u201337. doi: 10.1111\/j.1600-0625.2009.00953.x","journal-title":"Exp Dermatol"},{"issue":"4","key":"4277_CR21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.20021633","volume":"197","author":"I Caramalho","year":"2003","unstructured":"Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J (2003) Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 197(4):403\u2013411","journal-title":"J Exp Med"},{"key":"4277_CR22","doi-asserted-by":"publisher","first-page":"w14066","DOI":"10.4414\/smw.2015.14066","volume":"145","author":"SI Rothschild","year":"2015","unstructured":"Rothschild SI, Thommen DS, Moersig W, Muller P, Zippelius A (2015) Cancer immunology\u2014development of novel anti-cancer therapies. Swiss Med Weekly 145:w14066. doi: 10.4414\/smw.2015.14066","journal-title":"Swiss Med Weekly"},{"issue":"5","key":"4277_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrc1359","volume":"4","author":"E Gilboa","year":"2004","unstructured":"Gilboa E (2004) The promise of cancer vaccines. Nat Rev Cancer 4(5):401\u2013411. doi: 10.1038\/nrc1359","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"4277_CR24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrc1586","volume":"5","author":"W Zou","year":"2005","unstructured":"Zou W (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 5(4):263\u2013274. doi: 10.1038\/nrc1586","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"4277_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/ni.1760","volume":"10","author":"M Feuerer","year":"2009","unstructured":"Feuerer M, Hill JA, Mathis D, Benoist C (2009) Foxp3\u00a0+\u00a0regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 10(7):689\u2013695. doi: 10.1038\/ni.1760","journal-title":"Nat Immunol"},{"issue":"12","key":"4277_CR26","doi-asserted-by":"publisher","first-page":"e8109","DOI":"10.1371\/journal.pone.0008109","volume":"4","author":"KP Koh","year":"2009","unstructured":"Koh KP, Sundrud MS, Rao A (2009) Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. PLoS One 4(12):e8109. doi: 10.1371\/journal.pone.0008109","journal-title":"PLoS One"},{"issue":"20","key":"4277_CR27","doi-asserted-by":"publisher","first-page":"7788","DOI":"10.1158\/0008-5472.can-10-1736","volume":"70","author":"K Klages","year":"2010","unstructured":"Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T (2010) Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 70(20):7788\u20137799. doi: 10.1158\/0008-5472.can-10-1736","journal-title":"Cancer Res"},{"issue":"5","key":"4277_CR28","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00404-015-3712-3","volume":"292","author":"J Khalil","year":"2015","unstructured":"Khalil J, El Kacemi H, Afif M, Kebdani T, Benjaafar N (2015) Five years\u2019 experience treating locally advanced cervical cancer with concurrent chemoradiotherapy: results from a single institution. Arch Gynecol Obstet 292(5):1091\u20131099. doi: 10.1007\/s00404-015-3712-3","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"4277_CR29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11(5):373\u2013384. doi: 10.1038\/ni.1863","journal-title":"Nat Immunol"},{"issue":"6640","key":"4277_CR30","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/41131","volume":"388","author":"R Medzhitov","year":"1997","unstructured":"Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640):394\u2013397. doi: 10.1038\/41131","journal-title":"Nature"},{"issue":"2","key":"4277_CR31","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/sj.onc.1210904","volume":"27","author":"B Huang","year":"2008","unstructured":"Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H (2008) TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 27(2):218\u2013224. doi: 10.1038\/sj.onc.1210904","journal-title":"Oncogene"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-016-4277-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-016-4277-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-016-4277-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T02:43:15Z","timestamp":1498358595000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-016-4277-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,24]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["4277"],"URL":"https:\/\/doi.org\/10.1007\/s00404-016-4277-5","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,24]]}}}