{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:02:04Z","timestamp":1793037724622,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the science and technology department\u2019s major program of Henan, China","award":["161100311100"],"award-info":[{"award-number":["161100311100"]}]},{"name":"the national health and family planning commission in China","award":["201601010"],"award-info":[{"award-number":["201601010"]}],"id":[{"id":"https:\/\/ror.org\/052eegr76","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00404-017-4588-1","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:33:47Z","timestamp":1510706027000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic performance of HPV E6\/E7 mRNA assay for detection of cervical high-grade intraepithelial neoplasia and cancer among women with ASCUS Papanicolaou smears"],"prefix":"10.1007","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-2759","authenticated-orcid":false,"given":"Chenchen","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7490-1712","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"4588_CR1","doi-asserted-by":"publisher","unstructured":"Moyer VA (2012) Screening for cervical cancer: US preventive services task force recommendation statement. Ann Intern Med 156(12):880\u2013891, W312. \n                        https:\/\/doi.org\/10.7326\/0003-4819-156-12-201206190-00424","DOI":"10.7326\/0003-4819-156-12-201206190-00424"},{"issue":"16","key":"4588_CR2","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","volume":"287","author":"D Solomon","year":"2002","unstructured":"Solomon D, Davey D, Kurman R et al (2002) The 2001 bethesda system: terminology for reporting results of cervical cytology. JAMA 287(16):2114\u20132119","journal-title":"JAMA"},{"key":"4588_CR3","doi-asserted-by":"publisher","first-page":"536495","DOI":"10.1155\/2014\/536495","volume":"2014","author":"X Catteau","year":"2014","unstructured":"Catteau X, Simon P, No\u00ebl JC (2014) Evaluation of the oncogenic human papillomavirus DNA test with liquid-based cytology in primary cervical cancer screening and the importance of the ASC\/SIL ratio: a Belgian study. ISRN Obstet Gynecol 2014:536495. \n                        https:\/\/doi.org\/10.1155\/2014\/536495","journal-title":"ISRN Obstet Gynecol"},{"key":"4588_CR4","doi-asserted-by":"publisher","unstructured":"Arbyn M, Sasieni P, Meijer CJ, Clavel C, Koliopoulos G, Dillner J (2006) Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses. Vaccine 24(Suppl 3):S3\/78\u201389. \n                        https:\/\/doi.org\/10.1016\/j.vaccine.2006.05.117","DOI":"10.1016\/j.vaccine.2006.05.117"},{"issue":"4","key":"4588_CR5","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","volume":"197","author":"TC Wright","year":"2007","unstructured":"Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D (2007) 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol 197(4):346\u2013355. \n                        https:\/\/doi.org\/10.1016\/j.ajog.2007.07.047","journal-title":"Am J Obstet Gynecol"},{"issue":"9295","key":"4588_CR6","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/S0140-6736(01)06809-X","volume":"358","author":"MA Nobbenhuis","year":"2001","unstructured":"Nobbenhuis MA, Helmerhorst TJ, van den Brule AJ, Rozendaal L, Voorhorst FJ, Bezemer PD, Verheijen RH, Meijer CJ (2001) Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear. Lancet 358(9295):1782\u20131783. \n                        https:\/\/doi.org\/10.1016\/S0140-6736(01)06809-X","journal-title":"Lancet"},{"key":"4588_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4137\/BMI.S14296","volume":"9","author":"MG Discacciati","year":"2014","unstructured":"Discacciati MG, da SID, Villa LL, Reis L, Hayashi P, Costa MC, Rabelo-Santos SH, Zeferino LC (2014) Prognostic value of DNA and mRNA e6\/e7 of human papillomavirus in the evolution of cervical intraepithelial neoplasia grade 2. Biomark Insights 9:15\u201322. \n                        https:\/\/doi.org\/10.4137\/BMI.S14296","journal-title":"Biomark Insights"},{"key":"4588_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jviromet.2013.10.032","volume":"196","author":"TY Liu","year":"2014","unstructured":"Liu TY, Xie R, Luo L, Reilly KH, He C, Lin YZ, Chen G, Zheng XW, Zhang LL, Wang HB (2014) Diagnostic validity of human papillomavirus E6\/E7 mRNA test in cervical cytological samples. J Virol Methods 196:120\u2013125. \n                        https:\/\/doi.org\/10.1016\/j.jviromet.2013.10.032","journal-title":"J Virol Methods"},{"issue":"2","key":"4588_CR9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/LGT.0000000000000306","volume":"21","author":"JL Mueller","year":"2017","unstructured":"Mueller JL, Asma E, Lam CT et al (2017) International image concordance study to compare a point-of-care tampon colposcope with a standard-of-care colposcope. J Low Genit Tract Dis 21(2):112\u2013119. \n                        https:\/\/doi.org\/10.1097\/LGT.0000000000000306","journal-title":"J Low Genit Tract Dis"},{"issue":"6","key":"4588_CR10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.vaccine.2015.12.011","volume":"34","author":"M Fakhreldin","year":"2016","unstructured":"Fakhreldin M, Elmasry K (2016) Improving the performance of reflex Human Papilloma Virus (HPV) testing in triaging women with atypical squamous cells of undetermined significance (ASCUS): a restrospective study in a tertiary hospital in United Arab Emirates (UAE). Vaccine 34(6):823\u2013830. \n                        https:\/\/doi.org\/10.1016\/j.vaccine.2015.12.011","journal-title":"Vaccine"},{"issue":"3","key":"4588_CR11","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1086\/653826","volume":"202","author":"K Louvanto","year":"2010","unstructured":"Louvanto K, Rintala MA, Syrj\u00e4nen KJ, Gr\u00e9nman SE, Syrj\u00e4nen SM (2010) Genotype-specific persistence of genital human papillomavirus (HPV) infections in women followed for 6\u00a0years in the Finnish Family HPV Study. J Infect Dis 202(3):436\u2013444. \n                        https:\/\/doi.org\/10.1086\/653826","journal-title":"J Infect Dis"},{"issue":"9312","key":"4588_CR12","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0140-6736(02)08151-5","volume":"359","author":"N Mu\u00f1oz","year":"2002","unstructured":"Mu\u00f1oz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, Shah KV, Meijer CJ, Bosch FX (2002) Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet 359(9312):1093\u20131101. \n                        https:\/\/doi.org\/10.1016\/S0140-6736(02)08151-5","journal-title":"Lancet"},{"issue":"2","key":"4588_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.canlet.2004.03.039","volume":"210","author":"W Settheetham-Ishida","year":"2004","unstructured":"Settheetham-Ishida W, Singto Y, Yuenyao P, Tassaneeyakul W, Kanjanavirojkul N, Ishida T (2004) Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand. Cancer Lett 210(2):205\u2013211. \n                        https:\/\/doi.org\/10.1016\/j.canlet.2004.03.039","journal-title":"Cancer Lett"},{"issue":"5","key":"4588_CR14","first-page":"2411","volume":"17","author":"S Heng","year":"2016","unstructured":"Heng S, Sirichaisutdhikorn D (2016) Incidence of high grade squamous intraepithelial lesions in patients with atypical squamous cells of undetermined significance papanicolaou smears at Naresuan University Hospital. Asian Pac J Cancer Prev 17(5):2411\u20132414","journal-title":"Asian Pac J Cancer Prev"},{"key":"4588_CR15","doi-asserted-by":"crossref","first-page":"d2757","DOI":"10.1136\/bmj.d2757","volume":"342","author":"M Rebolj","year":"2011","unstructured":"Rebolj M, Bonde J, Njor SH, Lynge E (2011) Human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests: systematic review. BMJ 342:d2757","journal-title":"BMJ"},{"issue":"Suppl 3","key":"4588_CR16","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/S1386-6532(02)00184-1","volume":"25","author":"A Vince","year":"2002","unstructured":"Vince A, Kutela N, Iscic-Bes J, Harni V, Ivanisevic M, Sonicki Z, Culig Z, Poljak M (2002) Clinical utility of molecular detection of human papillomavirus in cervical samples by hybrid capture technology. J Clin Virol 25(Suppl 3):S109\u2013S112","journal-title":"J Clin Virol"},{"issue":"9328","key":"4588_CR17","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0140-6736(02)09463-1","volume":"360","author":"AT Lorincz","year":"2002","unstructured":"Lorincz AT, Castle PE, Sherman ME, Scott DR, Glass AG, Wacholder S, Rush BB, Gravitt PE, Schussler JE, Schiffman M (2002) Viral load of human papillomavirus and risk of CIN3 or cervical cancer. Lancet 360(9328):228\u2013229. \n                        https:\/\/doi.org\/10.1016\/S0140-6736(02)09463-1","journal-title":"Lancet"},{"issue":"5","key":"4588_CR18","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1097\/PAS.0000000000000800","volume":"41","author":"AM Mills","year":"2017","unstructured":"Mills AM, Dirks DC, Poulter MD, Mills SE, Stoler MH (2017) HR-HPV E6\/E7 mRNA in situ hybridization: validation Against PCR, DNA in situ hybridization, and p16 immunohistochemistry in 102 samples of cervical, vulvar, anal, and head and neck neoplasia. Am J Surg Pathol 41(5):607\u2013615. \n                        https:\/\/doi.org\/10.1097\/PAS.0000000000000800","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"4588_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/CS20050369","volume":"110","author":"J Doorbar","year":"2006","unstructured":"Doorbar J (2006) Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond) 110(5):525\u2013541. \n                        https:\/\/doi.org\/10.1042\/CS20050369","journal-title":"Clin Sci (Lond)"},{"issue":"8","key":"4588_CR20","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/jmv.24157","volume":"87","author":"C Baron","year":"2015","unstructured":"Baron C, Henry M, Tamalet C, Villeret J, Richet H, Carcopino X (2015) Relationship between HPV 16, 18, 31, 33, 45 DNA detection and quantitation and E6\/E7 mRNA detection among a series of cervical specimens with various degrees of histological lesions. J Med Virol 87(8):1389\u20131396. \n                        https:\/\/doi.org\/10.1002\/jmv.24157","journal-title":"J Med Virol"},{"issue":"4","key":"4588_CR21","doi-asserted-by":"publisher","first-page":"e0124460","DOI":"10.1371\/journal.pone.0124460","volume":"10","author":"H Johansson","year":"2015","unstructured":"Johansson H, Bjelkenkrantz K, Darlin L, Dilllner J, Forslund O (2015) Presence of high-risk HPV mRNA in relation to future high-grade lesions among high-risk HPV DNA positive women with minor cytological abnormalities. PLoS One 10(4):e0124460. \n                        https:\/\/doi.org\/10.1371\/journal.pone.0124460","journal-title":"PLoS One"},{"issue":"1","key":"4588_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/ijc.27636","volume":"132","author":"M Arbyn","year":"2013","unstructured":"Arbyn M, Roelens J, Cuschieri K, Cuzick J, Szarewski A, Ratnam S, Reuschenbach M, Belinson S, Belinson JL, Monsonego J (2013) The APTIMA HPV assay versus the hybrid capture 2 test in triage of women with ASC-US or LSIL cervical cytology: a meta-analysis of the diagnostic accuracy. Int J Cancer 132(1):101\u2013108. \n                        https:\/\/doi.org\/10.1002\/ijc.27636","journal-title":"Int J Cancer"},{"issue":"3","key":"4588_CR23","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1631\/jzus.B1600288","volume":"18","author":"YL Yao","year":"2017","unstructured":"Yao YL, Tian QF, Cheng B, Cheng YF, Ye J, Lu WG (2017) Human papillomavirus (HPV) E6\/E7 mRNA detection in cervical exfoliated cells: a potential triage for HPV-positive women. J Zhejiang Univ Sci B 18(3):256\u2013262. \n                        https:\/\/doi.org\/10.1631\/jzus.B1600288","journal-title":"J Zhejiang Univ Sci B"},{"issue":"3","key":"4588_CR24","first-page":"261","volume":"33","author":"M Origoni","year":"2012","unstructured":"Origoni M, Carminati G, Sideri M, Clementi M, Rolla S, Candiani M (2012) \u201cLow-grade positivity\u201d of HPV viral load after atypical squamous cells of undetermined significance (ASC-US) cytology identifies women at low-risk for cervical intraepithelial neoplasia grade 2 and 3. Eur J Gynaecol Oncol 33(3):261\u2013264","journal-title":"Eur J Gynaecol Oncol"},{"issue":"10","key":"4588_CR25","doi-asserted-by":"publisher","first-page":"e26022","DOI":"10.1371\/journal.pone.0026022","volume":"6","author":"SW S\u00f8rbye","year":"2011","unstructured":"S\u00f8rbye SW, Arbyn M, Fismen S, Gutteberg TJ, Mortensen ES (2011) HPV E6\/E7 mRNA testing is more specific than cytology in post-colposcopy follow-up of women with negative cervical biopsy. PLoS One 6(10):e26022. \n                        https:\/\/doi.org\/10.1371\/journal.pone.0026022","journal-title":"PLoS One"},{"issue":"11","key":"4588_CR26","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/cncy.21463","volume":"122","author":"JC Gage","year":"2014","unstructured":"Gage JC, Katki HA, Schiffman M et al (2014) The low risk of precancer after a screening result of human papillomavirus-negative\/atypical squamous cells of undetermined significance papanicolaou and implications for clinical management. Cancer Cytopathol 122(11):842\u2013850. \n                        https:\/\/doi.org\/10.1002\/cncy.21463","journal-title":"Cancer Cytopathol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-017-4588-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-017-4588-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-017-4588-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T23:16:41Z","timestamp":1516576601000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-017-4588-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4588"],"URL":"https:\/\/doi.org\/10.1007\/s00404-017-4588-1","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}