{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:54:38Z","timestamp":1781888078514,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00404-017-4596-1","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T05:22:00Z","timestamp":1511500920000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hyperandrogenemia and ovarian reserve in patients with Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser syndrome type 1 and 2: potential influences on ovarian stimulation"],"prefix":"10.1007","volume":"297","author":[{"given":"Melanie","family":"Henes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Jurow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitt","family":"Schoenfisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin Andrei","family":"Taran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Yvonne","family":"Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-9438","authenticated-orcid":false,"given":"Kristin Katharina","family":"Rall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"4596_CR1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0015-0282(01)01963-X","volume":"76","author":"K Aittomaki","year":"2001","unstructured":"Aittomaki K, Eroila H, Kajanoja P (2001) A population-based study of the incidence of Mullerian aplasia in Finland. Fertil Steril 76:624\u2013625","journal-title":"Fertil Steril"},{"key":"4596_CR2","unstructured":"Anonymous (2016) Deutsches IVF Register (DIR), Jahrbuch 2015. modif. Reprint from J Reproduktionsmed Endokrinol 13"},{"key":"4596_CR3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bpobgyn.2004.05.004","volume":"18","author":"A Balen","year":"2004","unstructured":"Balen A (2004) The pathophysiology of polycystic ovary syndrome: trying to understand PCOS and its endocrinology. Best Pract Res Clin Obstet Gynaecol 18:685\u2013706","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"4596_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1750-1172-4-25","volume":"4","author":"L Bernardini","year":"2009","unstructured":"Bernardini L, Gimelli S, Gervasini C et al (2009) Recurrent microdeletion at 17q12 as a cause of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome: two case reports. Orphanet J Rare Dis 4:25","journal-title":"Orphanet J Rare Dis"},{"key":"4596_CR5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/humrep\/del360","volume":"22","author":"A Biason-Lauber","year":"2007","unstructured":"Biason-Lauber A, De Filippo G, Konrad D et al (2007) WNT4 deficiency\u2013a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum Reprod 22:224\u2013229","journal-title":"Hum Reprod"},{"key":"4596_CR6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJMoa040533","volume":"351","author":"A Biason-Lauber","year":"2004","unstructured":"Biason-Lauber A, Konrad D, Navratil F et al (2004) A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46, XX woman. N Engl J Med 351:792\u2013798","journal-title":"N Engl J Med"},{"key":"4596_CR7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fertnstert.2016.04.001","volume":"106","author":"M Brannstrom","year":"2016","unstructured":"Brannstrom M, Bokstrom H, Dahm-Kahler P et al (2016) One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation. Fertil Steril 106:261\u2013266","journal-title":"Fertil Steril"},{"key":"4596_CR8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0140-6736(14)61728-1","volume":"385","author":"M Brannstrom","year":"2015","unstructured":"Brannstrom M, Johannesson L, Bokstrom H et al (2015) Livebirth after uterus transplantation. Lancet 385:607\u2013616","journal-title":"Lancet"},{"key":"4596_CR9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0140-6736(14)61728-1","volume":"385","author":"M Brannstrom","year":"2015","unstructured":"Brannstrom M, Johannesson L, Bokstrom H et al (2015) Livebirth after uterus transplantation. Lancet 385:607\u2013616","journal-title":"Lancet"},{"key":"4596_CR10","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.fertnstert.2007.08.070","volume":"90","author":"SY Brucker","year":"2008","unstructured":"Brucker SY, Gegusch M, Zubke W et al (2008) Neovagina creation in vaginal agenesis: development of a new laparoscopic Vecchietti-based procedure and optimized instruments in a prospective comparative interventional study in 101 patients. Fertil Steril 90:1940\u20131952","journal-title":"Fertil Steril"},{"key":"4596_CR11","first-page":"250","volume":"44","author":"S Carranza-Lira","year":"1999","unstructured":"Carranza-Lira S, Forbin K, Martinez-Chequer JC (1999) Rokitansky syndrome and MURCS association\u2014clinical features and basis for diagnosis. Int J Fertil Womens Med 44:250\u2013255","journal-title":"Int J Fertil Womens Med"},{"key":"4596_CR12","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/humrep\/dev095","volume":"30","author":"MJ Chen","year":"2015","unstructured":"Chen MJ, Wei SY, Yang WS et al (2015) Concurrent exome-targeted next-generation sequencing and single nucleotide polymorphism array to identify the causative genetic aberrations of isolated Mayer-Rokitansky-Kuster-Hauser syndrome. Hum Reprod 30:1732\u20131742","journal-title":"Hum Reprod"},{"key":"4596_CR13","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/humrep\/deh404","volume":"19","author":"E Cicinelli","year":"2004","unstructured":"Cicinelli E, Einer-Jensen N, Cignarelli M et al (2004) Preferential transfer of endogenous ovarian steroid hormones to the uterus during both the follicular and luteal phases. Hum Reprod 19:2001\u20132004","journal-title":"Hum Reprod"},{"key":"4596_CR14","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00006254-200010000-00023","volume":"55","author":"M Folch","year":"2000","unstructured":"Folch M, Pigem I, Konje JC (2000) Mullerian agenesis: etiology, diagnosis, and management. Obstet Gynecol Surv 55:644\u2013649","journal-title":"Obstet Gynecol Surv"},{"key":"4596_CR15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1210\/jcem-36-4-634","volume":"36","author":"IS Fraser","year":"1973","unstructured":"Fraser IS, Baird DT, Hobson BM et al (1973) Cyclical ovarian function in women with congenital absence of the uterus and vagina. J Clin Endocrinol Metab 36:634\u2013637","journal-title":"J Clin Endocrinol Metab"},{"key":"4596_CR16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.rbmo.2015.09.006","volume":"32","author":"S Friedler","year":"2016","unstructured":"Friedler S, Grin L, Liberti G et al (2016) The reproductive potential of patients with Mayer-Rokitansky-Kuster-Hauser syndrome using gestational surrogacy: a systematic review. Reprod Biomed Online 32:54\u201361","journal-title":"Reprod Biomed Online"},{"key":"4596_CR17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpurol.2011.11.003","volume":"9","author":"MA Hall-Craggs","year":"2013","unstructured":"Hall-Craggs MA, Kirkham A, Creighton SM (2013) Renal and urological abnormalities occurring with Mullerian anomalies. J Pediatr Urol 9:27\u201332","journal-title":"J Pediatr Urol"},{"key":"4596_CR18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humrep\/dem408","volume":"23","author":"KR Hansen","year":"2008","unstructured":"Hansen KR, Knowlton NS, Thyer AC et al (2008) A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 23:699\u2013708","journal-title":"Hum Reprod"},{"key":"4596_CR19","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1093\/humrep\/dew220","volume":"31","author":"M Herlin","year":"2016","unstructured":"Herlin M, Bjorn AM, Rasmussen M et al (2016) Prevalence and patient characteristics of Mayer-Rokitansky-Kuster-Hauser syndrome: a nationwide registry-based study. Hum Reprod 31:2384\u20132390","journal-title":"Hum Reprod"},{"key":"4596_CR20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1471-0528.1959.tb01999.x","volume":"66","author":"B Jb","year":"1959","unstructured":"Jb B (1959) Preliminary observation on urinary oestrogen excretion in certain gynaecological disorders. J Obstet Gynaecol Br Commonw 66:177\u2013211","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"4596_CR21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.fertnstert.2012.11.034","volume":"99","author":"S Kallio","year":"2013","unstructured":"Kallio S, Puurunen J, Ruokonen A et al (2013) Antimullerian hormone levels decrease in women using combined contraception independently of administration route. Fertil Steril 99:1305\u20131310","journal-title":"Fertil Steril"},{"key":"4596_CR22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jadohealth.2016.10.015","volume":"60","author":"JY Kim","year":"2017","unstructured":"Kim JY, Tfayli H, Michaliszyn SF et al (2017) Anti-Mullerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome. J Adolesc Health 60:333\u2013339","journal-title":"J Adolesc Health"},{"key":"4596_CR23","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.fertnstert.2010.07.1062","volume":"95","author":"S Ledig","year":"2011","unstructured":"Ledig S, Schippert C, Strick R et al (2011) Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril 95:1589\u20131594","journal-title":"Fertil Steril"},{"key":"4596_CR24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1172-6-9","volume":"6","author":"K Morcel","year":"2011","unstructured":"Morcel K, Watrin T, Pasquier L et al (2011) Utero-vaginal aplasia (Mayer-Rokitansky-Kuster-Hauser syndrome) associated with deletions in known DiGeorge or DiGeorge-like loci. Orphanet J Rare Dis 6:9","journal-title":"Orphanet J Rare Dis"},{"key":"4596_CR25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/jmg.2010.082412","volume":"48","author":"S Nik-Zainal","year":"2011","unstructured":"Nik-Zainal S, Strick R, Storer M et al (2011) High incidence of recurrent copy number variants in patients with isolated and syndromic Mullerian aplasia. J Med Genet 48:197\u2013204","journal-title":"J Med Genet"},{"key":"4596_CR26","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/humrep\/dei381","volume":"21","author":"P Oppelt","year":"2006","unstructured":"Oppelt P, Renner SP, Kellermann A et al (2006) Clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging. Hum Reprod 21:792\u2013797","journal-title":"Hum Reprod"},{"key":"4596_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/humrep\/deh547","volume":"20","author":"P Oppelt","year":"2005","unstructured":"Oppelt P, Strissel PL, Kellermann A et al (2005) DNA sequence variations of the entire anti-Mullerian hormone (AMH) gene promoter and AMH protein expression in patients with the Mayer-Rokitanski-Kuster-Hauser syndrome. Hum Reprod 20:149\u2013157","journal-title":"Hum Reprod"},{"key":"4596_CR28","doi-asserted-by":"crossref","unstructured":"Oppelt PG, Mueller A, Stephan L et al. (2017) Hyperandrogenemia and high prolactin in congenital utero-vaginal aplasia patients. Reproduction","DOI":"10.1530\/REP-16-0408"},{"key":"4596_CR29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fertnstert.2015.04.022","volume":"104","author":"M Ozekinci","year":"2015","unstructured":"Ozekinci M, Erman Akar M, Senol Y et al (2015) Comparison of markers of ovarian reserve between patients with complete mullerian agenesis and age-matched fertile and infertile controls. Fertil Steril 104:176\u2013179","journal-title":"Fertil Steril"},{"key":"4596_CR30","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/j.fertnstert.2011.01.152","volume":"95","author":"P Philibert","year":"2011","unstructured":"Philibert P, Biason-Lauber A, Gueorguieva I et al (2011) Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-Kuster-Hauser syndrome). Fertil Steril 95:2683\u20132686","journal-title":"Fertil Steril"},{"key":"4596_CR31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1210\/jc.2007-2023","volume":"93","author":"P Philibert","year":"2008","unstructured":"Philibert P, Biason-Lauber A, Rouzier R et al (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and mullerian duct abnormalities: a French collaborative study. J Clin Endocrinol Metab 93:895\u2013900","journal-title":"J Clin Endocrinol Metab"},{"key":"4596_CR32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1477-7827-12-23","volume":"12","author":"K Rall","year":"2014","unstructured":"Rall K, Conzelmann G, Schaffeler N et al (2014) Acne and PCOS are less frequent in women with Mayer-Rokitansky-Kuster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study. Reprod Biol Endocrinol 12:23","journal-title":"Reprod Biol Endocrinol"},{"key":"4596_CR33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/humrep\/der356","volume":"27","author":"A Raziel","year":"2012","unstructured":"Raziel A, Friedler S, Gidoni Y et al (2012) Surrogate in vitro fertilization outcome in typical and atypical forms of Mayer-Rokitansky-Kuster-Hauser syndrome. Hum Reprod 27:126\u2013130","journal-title":"Hum Reprod"},{"key":"4596_CR34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1750-1172-6-53","volume":"6","author":"M Sandbacka","year":"2011","unstructured":"Sandbacka M, Halttunen M, Jokimaa V et al (2011) Evaluation of SHOX copy number variations in patients with Mullerian aplasia. Orphanet J Rare Dis 6:53","journal-title":"Orphanet J Rare Dis"},{"key":"4596_CR35","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.fertnstert.2009.07.1674","volume":"94","author":"M Sowers","year":"2010","unstructured":"Sowers M, Mcconnell D, Gast K et al (2010) Anti-Mullerian hormone and inhibin B variability during normal menstrual cycles. Fertil Steril 94:1482\u20131486","journal-title":"Fertil Steril"},{"key":"4596_CR36","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-0028-1105918","volume":"41","author":"PL Strissel","year":"2009","unstructured":"Strissel PL, Oppelt P, Cupisti S et al (2009) Assessment of pituitary and steroid hormones and members of the TGF-beta superfamily for ovarian function in patients with congenital uterus and vaginal aplasia (MRKH syndrome). Horm Metab Res 41:408\u2013413","journal-title":"Horm Metab Res"},{"key":"4596_CR37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2214\/ajr.160.2.8424345","volume":"160","author":"EH Strubbe","year":"1993","unstructured":"Strubbe EH, Willemsen WN, Lemmens JA et al (1993) Mayer-Rokitansky-Kuster-Hauser syndrome: distinction between two forms based on excretory urographic, sonographic, and laparoscopic findings. AJR Am J Roentgenol 160:331\u2013334","journal-title":"AJR Am J Roentgenol"},{"key":"4596_CR38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/09513590802288291","volume":"25","author":"C Sultan","year":"2009","unstructured":"Sultan C, Biason-Lauber A, Philibert P (2009) Mayer-Rokitansky-Kuster-Hauser syndrome: recent clinical and genetic findings. Gynecol Endocrinol 25:8\u201311","journal-title":"Gynecol Endocrinol"},{"key":"4596_CR39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0301-2115(95)02157-3","volume":"62","author":"M Ugur","year":"1995","unstructured":"Ugur M, Karakaya S, Zorlu G et al (1995) Polycystic ovaries in association with mullerian anomalies. Eur J Obstet Gynecol Reprod Biol 62:57\u201359","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"4596_CR40","first-page":"QC10","volume":"10","author":"AK Verma","year":"2016","unstructured":"Verma AK, Rajbhar S, Mishra J et al (2016) Anti-mullerian hormone: a marker of ovarian reserve and its association with polycystic ovarian syndrome. J Clin Diagn Res 10:QC10\u2013QC12","journal-title":"J Clin Diagn Res"},{"key":"4596_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/rep.1.00529","volume":"131","author":"JA Visser","year":"2006","unstructured":"Visser JA, De Jong FH, Laven JS et al (2006) Anti-Mullerian hormone: a new marker for ovarian function. Reproduction 131:1\u20139","journal-title":"Reproduction"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-017-4596-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-017-4596-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-017-4596-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T23:16:59Z","timestamp":1516576619000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-017-4596-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4596"],"URL":"https:\/\/doi.org\/10.1007\/s00404-017-4596-1","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]}}}