{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:00:56Z","timestamp":1780452056091,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00404-018-4861-y","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T05:49:05Z","timestamp":1533361745000},"page":"675-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1007","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2802","authenticated-orcid":false,"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amerigo","family":"Vitagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Noventa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"D\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,4]]},"reference":[{"key":"4861_CR1","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1080\/17425255.2016.1206887","volume":"12","author":"M Bizzarri","year":"2016","unstructured":"Bizzarri M, Fuso A, Dinicola S, Cucina A, Bevilacqua A (2016) Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol 12:1181\u20131196. \n                    https:\/\/doi.org\/10.1080\/17425255.2016.1206887","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1030\u20131030","key":"4861_CR2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.cell.2010.11.045","volume":"143","author":"AJ Hatch","year":"2010","unstructured":"Hatch AJ, York JD (2010) SnapShot: inositol phosphates. Cell 143(1030\u20131030):e1. \n                    https:\/\/doi.org\/10.1016\/j.cell.2010.11.045","journal-title":"Cell"},{"key":"4861_CR3","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature05185","volume":"443","author":"G Paolo Di","year":"2006","unstructured":"Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651\u2013657. \n                    https:\/\/doi.org\/10.1038\/nature05185","journal-title":"Nature"},{"key":"4861_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3389\/fphar.2017.00341","volume":"8","author":"MA Sortino","year":"2017","unstructured":"Sortino MA, Salomone S, Carruba MO, Drago F (2017) Polycystic ovary syndrome: insights into the therapeutic approach with inositols. Front Pharmacol 8:341. \n                    https:\/\/doi.org\/10.3389\/fphar.2017.00341","journal-title":"Front Pharmacol"},{"key":"4861_CR5","doi-asserted-by":"publisher","first-page":"re1","DOI":"10.1126\/scisignal.2001958","volume":"4","author":"A Chakraborty","year":"2011","unstructured":"Chakraborty A, Kim S, Snyder SH (2011) Inositol pyrophosphates as mammalian cell signals. Sci Signal 4:re1. \n                    https:\/\/doi.org\/10.1126\/scisignal.2001958","journal-title":"Sci Signal"},{"key":"4861_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/1933719115594018","volume":"23","author":"M Noventa","year":"2016","unstructured":"Noventa M, Vitagliano A, Quaranta M, Borgato S, Abdulrahim B, Gizzo S (2016) Preventive and therapeutic role of dietary inositol supplementation in periconceptional period and during pregnancy: a summary of evidences and future applications. Reprod Sci 23:278\u2013288. \n                    https:\/\/doi.org\/10.1177\/1933719115594018","journal-title":"Reprod Sci"},{"key":"4861_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3109\/09513590.2016","volume":"32","author":"C Paul","year":"2016","unstructured":"Paul C, Lagan\u00e0 AS, Maniglio P, Triolo O, Brady DM (2016) Inositol\u2019s and other nutraceuticals\u2019 synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives. Gynecol Endocrinol 32:431\u2013438. \n                    https:\/\/doi.org\/10.3109\/09513590.2016","journal-title":"Gynecol Endocrinol"},{"key":"4861_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10815-014-0412-z","volume":"32","author":"A Vitagliano","year":"2015","unstructured":"Vitagliano A, Noventa M, Gizzo S (2015) Is it time to consider patients suffering from endometriosis-related infertility as \u201cnovel candidates\u201d for targeted peri-conceptional d-chiro inositol supplementation? Hypothesis, rationale and some considerations. J Assist Reprod Genet 32:407\u2013408. \n                    https:\/\/doi.org\/10.1007\/s10815-014-0412-z","journal-title":"J Assist Reprod Genet"},{"key":"4861_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3109\/09513590.2013.860120","volume":"30","author":"A Pizzo","year":"2014","unstructured":"Pizzo A, Lagan\u00e0 AS, Barbaro L (2014) Comparison between effects of myo-inositol and d-chiro-inositol on ovarian function and metabolic factors in women with PCOS. Gynecol Endocrinol 30:205\u2013208. \n                    https:\/\/doi.org\/10.3109\/09513590.2013.860120","journal-title":"Gynecol Endocrinol"},{"key":"4861_CR10","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.fertnstert.2008.01.088","volume":"91","author":"E Papaleo","year":"2009","unstructured":"Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L (2009) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril 91:1750\u20131754. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2008.01.088","journal-title":"Fertil Steril"},{"key":"4861_CR11","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s00404-013-2855-3","volume":"288","author":"S Colazingari","year":"2013","unstructured":"Colazingari S, Treglia M, Najjar R, Bevilacqua A (2013) The combined therapy myo-inositol plus d-chiro-inositol, rather than d-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Arch Gynecol Obstet 288:1405\u20131411. \n                    https:\/\/doi.org\/10.1007\/s00404-013-2855-3","journal-title":"Arch Gynecol Obstet"},{"key":"4861_CR12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3109\/09513590.2015.1101444","volume":"32","author":"A Pacchiarotti","year":"2016","unstructured":"Pacchiarotti A, Carlomagno G, Antonini G, Pacchiarotti A (2016) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol 32:69\u201373. \n                    https:\/\/doi.org\/10.3109\/09513590.2015.1101444","journal-title":"Gynecol Endocrinol"},{"key":"4861_CR13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.rbmo.2017.07.005","volume":"35","author":"N Mendoza","year":"2017","unstructured":"Mendoza N, P\u00e9rez L, Simoncini T, Genazzani A (2017) Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials. Reprod Biomed Online 35:529\u2013535. \n                    https:\/\/doi.org\/10.1016\/j.rbmo.2017.07.005","journal-title":"Reprod Biomed Online"},{"key":"4861_CR14","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. \n                    https:\/\/doi.org\/10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"4861_CR15","unstructured":"Higgins JPT, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from \n                    http:\/\/handbook.cochrane.org"},{"key":"4861_CR16","first-page":"555","volume":"14","author":"P Rizzo","year":"2010","unstructured":"Rizzo P, Raffone E, Benedetto V (2010) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol 14:555\u2013561","journal-title":"Eur Rev Med Pharmacol"},{"key":"4861_CR17","first-page":"509","volume":"15","author":"L Ciotta","year":"2011","unstructured":"Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F (2011) Effects of Myo-Inositol supplementation on oocyte\u2019s quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci 15:509\u2013514","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4861_CR18","first-page":"452","volume":"15","author":"V Unfer","year":"2011","unstructured":"Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S (2011) Myo-inositol rather than d-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Eur Rev Med Pharmacol Sci 15:452\u2013457","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4861_CR19","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1016\/j.fertnstert.2012.07.270","volume":"98","author":"G Carlomagno","year":"2012","unstructured":"Carlomagno G, Oliva MM, Roseff SJ, Unfer V (2012) Myo-inositol: ovarian stimulation and IVF outcomes. Fertil Steril 98:S74\u2013S75. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2012.07.270","journal-title":"Fertil Steril"},{"key":"4861_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1477-7827-10-52","volume":"10","author":"F Lisi","year":"2012","unstructured":"Lisi F, Carfagna P, Oliva MM, Rago R, Lisi R, Poverini R, Manna C, Vaquero E, Caserta D, Raparelli V, Marci R, Moscarini M (2012) Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reprod Biol Endocrinol 10:52. \n                    https:\/\/doi.org\/10.1186\/1477-7827-10-52","journal-title":"Reprod Biol Endocrinol"},{"key":"4861_CR21","first-page":"38","volume":"21","author":"R Schillaci","year":"2012","unstructured":"Schillaci R, Mangione D, Lo Monte G, Vassiliadis A (2012) Inositol supplementation and IVF outcome: preliminary data. Ital J Gynaecol Obstet 21:38\u201344","journal-title":"Ital J Gynaecol Obstet"},{"key":"4861_CR22","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3109\/09513590.2012.743020","volume":"29","author":"PG Artini","year":"2013","unstructured":"Artini PG, Di Berardino OM, Papini F, Genazzani AD, Simi G, Ruggiero M, Cela V (2013) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study. Gynecol Endocrinol 29:375\u2013379. \n                    https:\/\/doi.org\/10.3109\/09513590.2012.743020","journal-title":"Gynecol Endocrinol"},{"key":"4861_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13048-015-0167-x","volume":"8","author":"F Caprio","year":"2015","unstructured":"Caprio F, D\u2019Eufemia MD, Trotta C, Campitiello MR, Ianniello R, Mele D, Colacurci N (2015) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial. J Ovarian Res 8:37. \n                    https:\/\/doi.org\/10.1186\/s13048-015-0167-x","journal-title":"J Ovarian Res"},{"key":"4861_CR24","doi-asserted-by":"publisher","first-page":"4378507","DOI":"10.1155\/2016\/4378507","volume":"2016","author":"B Lesoine","year":"2016","unstructured":"Lesoine B, Regidor PA (2016) Prospective randomized study on the influence of myoinositol in PCOS women undergoing IVF in the improvement of oocyte quality, fertilization rate, and embryo quality. Int J Endocrinol 2016:4378507. \n                    https:\/\/doi.org\/10.1155\/2016\/4378507","journal-title":"Int J Endocrinol"},{"key":"4861_CR25","first-page":"19","volume":"81","author":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19\u201325","journal-title":"Fertil Steril"},{"key":"4861_CR26","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3109\/09513590.2011.650660","volume":"28","author":"V Unfer","year":"2012","unstructured":"Unfer V, Carlomagno G, Dante G, Facchinetti F (2012) Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol Endocrinol 28:509\u2013515. \n                    https:\/\/doi.org\/10.3109\/09513590.2011.650660","journal-title":"Gynecol Endocrinol"},{"key":"4861_CR27","doi-asserted-by":"publisher","first-page":"1849162","DOI":"10.1155\/2016\/1849162","volume":"2016","author":"V Unfer","year":"2016","unstructured":"Unfer V, Nestler JE, Kamenov ZA, Prapas N, Facchinetti F (2016) Effects of Inositol(s) in women with PCOS: a systematic review of randomized controlled trials. Int J Endocrinol 2016:1849162. \n                    https:\/\/doi.org\/10.1155\/2016\/1849162","journal-title":"Int J Endocrinol"},{"key":"4861_CR28","doi-asserted-by":"publisher","first-page":"e8842","DOI":"10.1097\/MD.0000000000008842","volume":"96","author":"X Zheng","year":"2017","unstructured":"Zheng X, Lin D, Zhang Y, Lin Y, Song J, Li S, Sun Y (2017) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET. Medicine (Baltimore) 96:e8842. \n                    https:\/\/doi.org\/10.1097\/MD.0000000000008842","journal-title":"Medicine (Baltimore)"},{"key":"4861_CR29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/humrep\/deu319","volume":"30","author":"A Busnelli","year":"2015","unstructured":"Busnelli A, Papaleo E, Del Prato D, La Vecchia I, Iachini E, Paffoni A, Candiani M, Somigliana E (2015) A retrospective evaluation of prognosis and cost-effectiveness of IVF in poor responders according to the Bologna criteria. Hum Reprod 30:315\u2013322. \n                    https:\/\/doi.org\/10.1093\/humrep\/deu319","journal-title":"Hum Reprod"},{"key":"4861_CR30","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1055\/s-0030-1265669","volume":"28","author":"E Zivi","year":"2010","unstructured":"Zivi E, Simon A, Laufer N (2010) Ovarian hyperstimulation syndrome: definition, incidence, and classification. Semin Reprod Med 28:441\u2013447. \n                    https:\/\/doi.org\/10.1055\/s-0030-1265669","journal-title":"Semin Reprod Med"},{"key":"4861_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.fertnstert.2008.09.054","volume":"93","author":"JM Csokmay","year":"2010","unstructured":"Csokmay JM, Yauger BJ, Henne MB, Armstrong AY, Queenan JT, Segars JH (2010) Cost analysis model of outpatient management of ovarian hyperstimulation syndrome with paracentesis: \u201cTap early and often\u201d versus hospitalization. Fertil Steril 93:167\u2013173. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2008.09.054","journal-title":"Fertil Steril"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-018-4861-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-4861-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-4861-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T19:26:25Z","timestamp":1564860385000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-018-4861-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["4861"],"URL":"https:\/\/doi.org\/10.1007\/s00404-018-4861-y","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,4]]},"assertion":[{"value":"22 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no proprietary, financial, professional, or other personal interest of any nature in any product, service, or company. The authors alone are responsible for the content and writing of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}