{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:41:41Z","timestamp":1765827701907,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81571397","31770989"],"award-info":[{"award-number":["81571397","31770989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shanghai Ninth People\u2019s Hospital Foundation of China","award":["JYLJ030"],"award-info":[{"award-number":["JYLJ030"]}]},{"name":"the Nature Science Foundation of Shanghai","award":["16ZR1419500"],"award-info":[{"award-number":["16ZR1419500"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00404-018-4870-x","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T21:10:45Z","timestamp":1534972245000},"page":"833-840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The risk of birth defects among children born after vitrified blastocyst transfers and those born after fresh and vitrified cleavage-stage embryo transfers"],"prefix":"10.1007","volume":"298","author":[{"given":"Qianqian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-3598","authenticated-orcid":false,"given":"Yanping","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"issue":"suppl 1","key":"4870_CR1","doi-asserted-by":"publisher","first-page":"i72","DOI":"10.1093\/humrep\/des230","volume":"27","author":"T Hardarson","year":"2012","unstructured":"Hardarson T, Van Landuyt L, Jones G (2012) The blastocyst. Hum Reprod 27(suppl 1):i72\u2013i91. \n                    https:\/\/doi.org\/10.1093\/humrep\/des230","journal-title":"Hum Reprod"},{"issue":"3","key":"4870_CR2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/humupd\/dmu001","volume":"20","author":"S Dar","year":"2014","unstructured":"Dar S, Lazer T, Shah PS, Librach CL (2014) Neonatal outcomes among singleton births after blastocyst vs. cleavage stage embryo transfer: a systematic review and meta-analysis. Hum Reprod Update 20(3):439\u2013448. \n                    https:\/\/doi.org\/10.1093\/humupd\/dmu001","journal-title":"Hum Reprod Update"},{"issue":"4","key":"4870_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.fertnstert.2015.07.1130","volume":"104","author":"GM Chambers","year":"2015","unstructured":"Chambers GM, Chughtai AA, Farquhar CM, Wang YA (2015) Risk of preterm birth after blastocyst embryo transfer: a large population study using contemporary registry data from Australia and New Zealand. Fertil Steril 104(4):997\u20131003. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2015.07.1130","journal-title":"Fertil Steril"},{"issue":"1","key":"4870_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.fertnstert.2013.09.025","volume":"101","author":"I Osamu","year":"2014","unstructured":"Osamu I, Ryuichiro A, Akira K, Atsuo I, Hidekazu S, David AG (2014) Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 101(1):128\u2013133. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2013.09.025","journal-title":"Fertil Steril"},{"issue":"5","key":"4870_CR5","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1016\/j.fertnstert.2009.12.027","volume":"94","author":"KL Bengt","year":"2010","unstructured":"Bengt KL, Orvar FM, Anna L, Emma N, Karl-G Sta N, Petra Otterbla O (2010) Blastocyst vs. cleavage stage transfer in in\u00a0vitro fertilization: differences in neonatal outcome?. Fertil Steril 94(5):1680\u20131683. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2009.12.027","journal-title":"Fertil Steril"},{"issue":"4","key":"4870_CR6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1093\/humrep\/des448","volume":"28","author":"S Dar","year":"2013","unstructured":"Dar S, Librach C, Gunby J, Bissonnette F, Cowan L (2013) Increased risk of preterm birth in singleton pregnancies after blastocyst vs. day 3 embryo transfer: canadian ART Register (CARTR) analysis. Hum Reprod 28(4):924\u2013928","journal-title":"Hum Reprod"},{"issue":"5","key":"4870_CR7","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.fertnstert.2015.02.020","volume":"103","author":"H Chen","year":"2015","unstructured":"Chen H, Wang Y, Lyu Q, Ai A, Fu Y, Tian H, Cai R, Hong Q, Chen Q, Shoham Z, Kuang Y (2015) Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in\u00a0vitro fertilization and vitrified embryo transfer cycles. Fertil Steril 103(5):1194\u20131201. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2015.02.020","journal-title":"Fertil Steril"},{"issue":"10","key":"4870_CR8","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1111\/1471-0528.14365","volume":"124","author":"MJ Davies","year":"2017","unstructured":"Davies MJ, Rumbold AR, Marino JL, Willson K, Giles LC, Whitrow MJ, Scheil W, Moran LJ, Thompson JG, Lane M, Moore VM (2017) Maternal factors and the risk of birth defects after IVF and ICSI: a whole of population cohort study. BJOG 124(10):1537\u20131544","journal-title":"BJOG"},{"issue":"6","key":"4870_CR9","doi-asserted-by":"publisher","first-page":"e154934","DOI":"10.1001\/jamapediatrics.2015.4934","volume":"170","author":"SL Boulet","year":"2016","unstructured":"Boulet SL, Kirby RS, Reefhuis J, Zhang Y, Sunderam S, Cohen B, Bernson D, Copeland G, Bailey MA, Jamieson MA, Jamieson DJ, Kissin DM (2016) Assisted reproductive technology and birth defects among liveborn infants in Florida, Massachusetts, and Michigan, 2000\u20132010. JAMA Pediatr 170(6):e154934","journal-title":"JAMA Pediatr"},{"issue":"3","key":"4870_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.siny.2014.01.001","volume":"19","author":"JL Simpson","year":"2014","unstructured":"Simpson JL (2014) Birth defects and assisted reproductive technologies. Semin Fetal Neonatal Med 19(3):177\u2013182","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"4870_CR11","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.fertnstert.2010.08.024","volume":"95","author":"J Yan","year":"2011","unstructured":"Yan J, Huang G, Sun Y, Zhao X, Chen S, Zou S, Hao C, Quan S, Chen ZJ (2011) Birth defects after assisted reproductive tech -nologies in China: analysis of 15,405 ofspring in seven centers (2004\u20132008). Fertil Steril 95(1):458\u2013460. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2010.08.024","journal-title":"Fertil Steril"},{"issue":"6","key":"4870_CR12","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.fertnstert.2012.02.051","volume":"97","author":"W Shi","year":"2012","unstructured":"Shi W, Xue X, Zhang S, Zhao W, Liu S, Zhou H, Wang M, Shi J (2012) Perinatal and neonatal outcomes of 494 babies delivered from 972 vitrifed embryo transfers. Fertil Steril 97(6):1338\u20131342. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2012.02.051","journal-title":"Fertil Steril"},{"issue":"7","key":"4870_CR13","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1093\/humrep\/dew103","volume":"31","author":"F Belva","year":"2016","unstructured":"Belva F, Bonduelle M, Roelants M, Verheyen G, Van Landuyt L (2016) Neonatal health including congenital malformation risk of 1072 children born after vitrifed embryo transfer. Hum Reprod 31(7):1610\u20131620. \n                    https:\/\/doi.org\/10.1093\/humrep\/dew103","journal-title":"Hum Reprod"},{"issue":"1","key":"4870_CR14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ejogrb.2011.12.005","volume":"161","author":"O Kato","year":"2012","unstructured":"Kato O, Kawasaki N, Bodri D, Kuroda T, Kawachiya S, Kato K, Takehara Y (2012) Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified vs. fresh single embryo transfer. Eur J Obstet Gynecol Reprod Biol 161(1):46\u201350","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"4870_CR15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.fertnstert.2016.06.029","volume":"106","author":"D Glujovsky","year":"2016","unstructured":"Glujovsky D, Farquhar C (2016) Cleavage-stage or blastocyst transfer: what are the benefits and harms? Fertil Steril 106(2):244\u2013250. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2016.06.029","journal-title":"Fertil Steril"},{"issue":"3","key":"4870_CR16","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.fertnstert.2013.01.087","volume":"99","author":"PCOT Technology","year":"2013","unstructured":"PCOT Technology (2013) Blastocyst culture and transfer in clinical-assisted reproduction: a committee opinion. Fertil Steril 99(3):667","journal-title":"Fertil Steril"},{"issue":"1","key":"4870_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/humrep\/dem339","volume":"23","author":"EG Papanikolaou","year":"2008","unstructured":"Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, Devroey P (2008) Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 23(1):91\u201399. \n                    https:\/\/doi.org\/10.1093\/humrep\/dem339","journal-title":"Hum Reprod"},{"issue":"11","key":"4870_CR18","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1056\/NEJMoa053524","volume":"354","author":"EG Papanikolaou","year":"2006","unstructured":"Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteghem A, Devroey P (2006) In vitro fertilization with single blastocyst-stage vs. single cleavage-stage embryos. New Engl J Med 354(11):1139\u20131146. \n                    https:\/\/doi.org\/10.1056\/NEJMoa053524","journal-title":"New Engl J Med"},{"issue":"2","key":"4870_CR19","doi-asserted-by":"publisher","first-page":"D2118","DOI":"10.1002\/14651858.CD002118","volume":"7","author":"DB Embryologist","year":"2002","unstructured":"Embryologist DB, Proctor M, Johnson N, Olive D (2002) Cleavage stage vs. blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst Rev 7(2):D2118. \n                    https:\/\/doi.org\/10.1002\/14651858.CD002118","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"4870_CR20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.rbmo.2015.09.016","volume":"32","author":"A Maheshwari","year":"2016","unstructured":"Maheshwari A, Hamilton M, Bhattacharya S (2016) Should we be promoting embryo transfer at blastocyst stage? Reprod Biomed Online 32(2):142\u2013146","journal-title":"Reprod Biomed Online"},{"issue":"6","key":"4870_CR21","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S1472-6483(10)62088-3","volume":"7","author":"P Lonergan","year":"2003","unstructured":"Lonergan P, Rizos D, Gutierrez-Adan A, Fair T, Boland MP (2003) Effect of culture environment on embryo quality and gene expression\u2014experience from animal studies. Reprod Biomed Online 7(6):657\u2013663","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"4870_CR22","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.theriogenology.2011.07.016","volume":"77","author":"A Calle","year":"2012","unstructured":"Calle A, Fernandez-Gonzalez R, Ramos-Ibeas P, Laguna-Barraza R, Perez-Cerezales S, Bermejo-Alvarez P, Ramirez MA, Gutierrez-Adan A (2012) Long-term and transgenerational effects of in vitro culture on mouse embryos. Theriogenology 77(4):785\u2013793. \n                    https:\/\/doi.org\/10.1016\/j.theriogenology.2011.07.016","journal-title":"Theriogenology"},{"issue":"1","key":"4870_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.fertnstert.2004.12.051","volume":"84","author":"T Katsuhiko","year":"2005","unstructured":"Katsuhiko T, Tetsunori M, Tetsuya G, Chikahiro O (2005) Perinatal outcome of blastocyst transfer with vitrification using cryoloop: a 4-year follow-up study. Fertil Steril 84(1):88\u201392. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2004.12.051","journal-title":"Fertil Steril"},{"issue":"7","key":"4870_CR24","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1093\/humrep\/deq117","volume":"25","author":"M Wikland","year":"2010","unstructured":"Wikland M, Hardarson T, Hillensj\u00f6 T, Westin C, Westlander G, Wood M, Wennerholm UB (2010) Obstetric outcomes after transfer of vitrified blastocysts. Hum Reprod 25(7):1699","journal-title":"Hum Reprod"},{"issue":"3","key":"4870_CR25","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1093\/humrep\/deq374","volume":"26","author":"LL Van","year":"2011","unstructured":"Van LL, Stoop D, Verheyen G, Verpoest W, Camus M, Van DVH, Devroey P, Van DAE (2011) Outcome of closed blastocyst vitrification in relation to blastocyst quality: evaluation of 759 warming cycles in a single-embryo transfer policy. Hum Reprod 26(3):527\u2013534","journal-title":"Hum Reprod"},{"issue":"1","key":"4870_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.fertnstert.2008.05.014","volume":"92","author":"RG Rama","year":"2009","unstructured":"Rama RG, Jaya PG, Murali KK, Madan K (2009) Neonatal outcome after vitrified day 3 embryo transfers: a preliminary study. Fertil Steril 92(1):143\u2013148. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2008.05.014","journal-title":"Fertil Steril"},{"issue":"8","key":"4870_CR27","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1093\/humrep\/det104","volume":"28","author":"SY Liu","year":"2013","unstructured":"Liu SY, Teng B, Fu J, Li X, Zheng Y, Sun XX (2013) Obstetric and neonatal outcomes after transfer of vitrified early cleavage embryos. Hum Reprod 28(8):2093\u20132100. \n                    https:\/\/doi.org\/10.1093\/humrep\/det104","journal-title":"Hum Reprod"},{"key":"4870_CR28","doi-asserted-by":"publisher","first-page":"574513","DOI":"10.1155\/2012\/574513","volume":"2012","author":"B Samadirad","year":"2012","unstructured":"Samadirad B, Khamnian Z, Hosseini MB, Dastgiri S (2012) Congenital anomalies and termination of pregnancy in Iran. J Pregnancy 2012:574513. \n                    https:\/\/doi.org\/10.1155\/2012\/574513","journal-title":"J Pregnancy"},{"issue":"6","key":"4870_CR29","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/EDE.0000000000000163","volume":"25","author":"E Svensson","year":"2014","unstructured":"Svensson E, Ehrenstein V, Norgaard M, Bakketeig LS, Rothman KJ, Sorensen HT, Pedersen L (2014) Estimating the proportion of all observed birth defects occurring in pregnancies terminated by a second-trimester abortion. Epidemiology 25(6):866\u2013871. \n                    https:\/\/doi.org\/10.1097\/EDE.0000000000000163","journal-title":"Epidemiology"},{"issue":"5","key":"4870_CR30","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/humupd\/dmr022","volume":"17","author":"A Hackshaw","year":"2011","unstructured":"Hackshaw A, Rodeck C, Boniface S (2011) Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls. Hum Reprod Update 17(5):589\u2013604. \n                    https:\/\/doi.org\/10.1093\/humupd\/dmr022","journal-title":"Hum Reprod Update"},{"issue":"4","key":"4870_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/pd.4516","volume":"35","author":"C Deng","year":"2015","unstructured":"Deng C, Yi L, Mu Y, Zhu J, Qin Y, Fan X, Wang Y, Li Q, Dai L (2015) Recent trends in the birth prevalence of down syndrome in China: impact of prenatal diagnosis and subsequent terminations. Prenat Diagn 35(4):311\u2013318. \n                    https:\/\/doi.org\/10.1002\/pd.4516","journal-title":"Prenat Diagn"},{"issue":"10","key":"4870_CR32","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/bdra.2335","volume":"103","author":"CM Rocheleau","year":"2015","unstructured":"Rocheleau CM, Bertke SJ, Lawson CC, Romitti PA, Sanderson WT, Malik S, Lupo PJ, Desrosiers TA, Bell E, Druschel C, Correa A, Reefhuis J (2015) Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol 103(10):823\u2013833. \n                    https:\/\/doi.org\/10.1002\/bdra.2335","journal-title":"Birth Defects Res A Clin Mol Teratol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-018-4870-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-4870-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-4870-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T19:09:54Z","timestamp":1566500994000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-018-4870-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["4870"],"URL":"https:\/\/doi.org\/10.1007\/s00404-018-4870-x","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"type":"print","value":"0932-0067"},{"type":"electronic","value":"1432-0711"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"11 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants gave written informed consent for this research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}