{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:54:04Z","timestamp":1758815644938,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00404-018-5015-y","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:51:19Z","timestamp":1546563079000},"page":"1345-1351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma"],"prefix":"10.1007","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-2989","authenticated-orcid":false,"given":"Maria","family":"Lagerstedt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Huotari-Orava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nissinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Farshchian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-L.","family":"Laasanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Snellman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. U.","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.-M.","family":"K\u00e4h\u00e4ri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"5015_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1097\/PAS.0000000000000454","volume":"39","author":"F Dong","year":"2015","unstructured":"Dong F, Kojiro S, Darrell RB, Growdon WB, Oliva E (2015) Squamous cell carcinoma of the vulva: a subclassification of 97 cases by clinicopathologic, immunohistochemical, and molecular features (p16, p53, and EGFR). Am J Surg Pathol 39:1045\u20131053","journal-title":"Am J Surg Pathol"},{"key":"5015_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/his.12034","volume":"62","author":"M Pino Del","year":"2013","unstructured":"Del Pino M, Rodriguez-Carunchio L, Ordi J (2013) Pathways of vulvar intraepithelial neoplacia and squamous cell carcinoma. Histopathology 62:161\u2013175","journal-title":"Histopathology"},{"key":"5015_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/PAS.0000000000000291","volume":"39","author":"N Singh","year":"2015","unstructured":"Singh N, Leen SL, Han G, Faruqi A, Kokka F, Rosenthal A et al (2015) Expanding the morphologic spectrum of differentiated VIN (dVIN) through detailed mapping of cases with p53 loss. Am J Surg Pathol 39:52\u201360","journal-title":"Am J Surg Pathol"},{"key":"5015_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/PGP.0000000000000263","volume":"35","author":"AS Cheng","year":"2016","unstructured":"Cheng AS, Karnezis AN, Jordan S, Sighn N, McAlpine JN, Gilks CG (2016) p16 immunostaining allows for accurate subclassification of vulvar squamous cell carcinoma into HPV associated and HPV independent cases. Int J Gynecol Pathol 35:385\u2013393","journal-title":"Int J Gynecol Pathol"},{"key":"5015_CR5","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.juro.2013.01.102","volume":"190","author":"BC Carlson","year":"2013","unstructured":"Carlson BC, Hofer MD, Ballek N, Yang XJ, Meeks JJ, Gonzalez CM (2013) Protein markers of malignant potential in penile and vulvar lichen sclerosus. J Urol 190:399\u2013406","journal-title":"J Urol"},{"key":"5015_CR6","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1038\/bjc.2014.490","volume":"111","author":"CH Kwon","year":"2014","unstructured":"Kwon CH, Park HJ, Lee JR, Kim HK, Jeon TY, Jo HJ et al (2014) Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer. Br J Cancer 111:1993\u20132002","journal-title":"Br J Cancer"},{"key":"5015_CR7","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1515\/hsz-2014-0161","volume":"10","author":"MR Ehlers","year":"2014","unstructured":"Ehlers MR (2014) Immuno-modulating effects of alpha-1 antitrypsin. Biol Chem 10:1187\u20131193","journal-title":"Biol Chem"},{"key":"5015_CR8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00441-016-2457-z","volume":"365","author":"L Nissinen","year":"2016","unstructured":"Nissinen L, Farshchian M, Riihil\u00e4 P, K\u00e4h\u00e4ri VM (2016) New perspectives on role of tumor microenviroment in progression of cutaneus squamous cell carcinoma. Cell Tissue Res 365:691\u2013702","journal-title":"Cell Tissue Res"},{"key":"5015_CR9","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/bjc.1992.60","volume":"65","author":"M Higashiyama","year":"1992","unstructured":"Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R (1992) An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis. Br J Cancer 65:300\u2013302","journal-title":"Br J Cancer"},{"key":"5015_CR10","doi-asserted-by":"crossref","first-page":"20312","DOI":"10.18632\/oncotarget.3964","volume":"6","author":"CH Kwon","year":"2015","unstructured":"Kwon CH, Park HJ, Choi JH, Lee JR, Kim HK, Jo HJ et al (2015) Snail and Serpin A1 promote tumor progression and predict prognosis in colorectal cancer. Oncotarget 6:20312\u201320326","journal-title":"Oncotarget"},{"key":"5015_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10585-009-9303-6","volume":"27","author":"K Normandin","year":"2010","unstructured":"Normandin K, P\u00e9ant B, Le Page C, de Ladurantaye M, Ouellet V, Tonin PN et al (2010) Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. Clin Exp Metastasis 27:55\u201369","journal-title":"Clin Exp Metastasis"},{"key":"5015_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/path.2347","volume":"215","author":"JN Kloth","year":"2008","unstructured":"Kloth JN, Gorter A, Fleuren GJ, Oosting J, Uljee S, ter Haar N et al (2008) Elevated expression of Serpin A1 and Serpin A3 in HLA-positive cervical carcinoma. J Pathol 215:222\u2013230","journal-title":"J Pathol"},{"key":"5015_CR13","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.ajpath.2011.05.012","volume":"179","author":"M Farshchian","year":"2011","unstructured":"Farshchian M, Kivisaari A, Ala-aho R, Riihil\u00e4 P, Kallajoki M, Gr\u00e9nman R et al (2011) Serpin peptidase inhibitor clade A member 1 (Serpin A1) is a novel biomarker for progression of cutaneous squamous cell carcinoma. Am J Pathol 179:1110\u20131119","journal-title":"Am J Pathol"},{"key":"5015_CR14","doi-asserted-by":"publisher","first-page":"6851","DOI":"10.1158\/0008-5472.CAN-06-0662","volume":"6","author":"N Joshi","year":"2006","unstructured":"Joshi N, Johnson LL, Wei WQ, Abnet CC, Dong ZW, Taylor PR et al (2006) Gene expression differences in normal esophageal mucosa associated with regression amd progression of mild and moderate squamous dysplasia in a high-risk Chinese population. Cancer Res 6:6851\u20136860","journal-title":"Cancer Res"},{"key":"5015_CR15","first-page":"1535","volume":"8","author":"J Zhao","year":"2015","unstructured":"Zhao J, Fan YX, Yang Y, Liu DL, Wu K, Wen FB et al (2015) Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method. Int J Exp Pathol 8:1535\u20131544","journal-title":"Int J Exp Pathol"},{"key":"5015_CR16","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1007\/s13277-015-3163-2","volume":"36","author":"J Yang","year":"2010","unstructured":"Yang J, Xiong X, Wang X, Guo B, He K, Huang C (2010) Identification of peptide regions of SERPINA1 and ENOSF1 and their protein expression as potential serum biomarkers for gastric cancer. Tumor Biol 36:5109\u20135118","journal-title":"Tumor Biol"},{"key":"5015_CR17","first-page":"482","volume":"29","author":"ZJ El-Akawi","year":"2008","unstructured":"El-Akawi ZJ, Al-Hindawi FK, Bashir NA (2008) Alpha-1 antitrypsin (alpha1-AT) plasma levels in lung, prostate and breast cancer patients. Neuro Endocrinol Lett 29:482\u2013484","journal-title":"Neuro Endocrinol Lett"},{"key":"5015_CR18","first-page":"672","volume":"16","author":"A Topic","year":"2011","unstructured":"Topic A, Ljujic M, Petrovic-Stanojevic N, Dopudja-Pantic V, Radojkovic D (2011) Phenotypes and serum levels of alpha-1-antitrypsin in lung cancer. J BUON 16:672\u2013676","journal-title":"J BUON"},{"key":"5015_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1186\/1471-2407-14-355","volume":"14","author":"S P\u00e9rez-Holanda","year":"2014","unstructured":"P\u00e9rez-Holanda S, Blanco I, Men\u00e9ndez M, Rodrigo L (2014) Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls. BMC Cancer 14:355","journal-title":"BMC Cancer"},{"key":"5015_CR20","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/sj.leu.2404352","volume":"20","author":"MM Duplantier","year":"2006","unstructured":"Duplantier MM, Lamant L, Sabourdy F, de Reynies A, Delsol G, Espinos E (2006) Serpin A1 is overexpressed in ALK+ anaplastic large cell lymphoma and its expression correlates with extranodal dissemination. Leukemia 20:1848\u20131854","journal-title":"Leukemia"},{"key":"5015_CR21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/S0901-5027(87)80096-6","volume":"16","author":"K Shirasuna","year":"1987","unstructured":"Shirasuna K, Sugiyama M, Watatani K, Morioka S, Havashido Y (1987) Serum alpha-1-antitrypsin in patients with malignant tumors occurring in the oral region. Int J Oral Maxillofac Surg 16:516\u2013520","journal-title":"Int J Oral Maxillofac Surg"},{"key":"5015_CR22","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S1470-2045(04)01414-7","volume":"5","author":"Z Sun","year":"2004","unstructured":"Sun Z, Yang P (2004) Role of imbalance between neutrofil elastase and \u03b11-antitrypsin in cancer development and progression. Lancet Oncol 5:182\u2013190","journal-title":"Lancet Oncol"},{"key":"5015_CR23","doi-asserted-by":"crossref","first-page":"25815","DOI":"10.18632\/oncotarget.4441","volume":"6","author":"HJ Chan","year":"2015","unstructured":"Chan HJ, Li H, Liu Z, Yuan YC, Mortimer J, Chen S (2015) SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients. Oncotarget 6:25815\u201325827","journal-title":"Oncotarget"},{"key":"5015_CR24","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.3892\/ijo.2017.3962","volume":"50","author":"Y Li","year":"2017","unstructured":"Li Y, Miao L, Yu M, Shi M, Wang Y, Yang J et al (2017) \u03b11-antitrypsin promotes lung adenocarcinoma metastasis through upregulating fibronectin expression. Int J Oncol 50:1955\u20131964","journal-title":"Int J Oncol"},{"key":"5015_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/ijc.28364","volume":"15","author":"C Bodelon","year":"2014","unstructured":"Bodelon C, Madeleine MM, Johnson LG, Du Q, Galloway DA, Malkki M et al (2014) Genetic variation in the TLR and NF-\u03baB genetic pathways and cervical and vulvar cancer risk: a population-based case\u2013control study. Int J Cancer 15:437\u2013444","journal-title":"Int J Cancer"},{"key":"5015_CR26","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/jid.2011.369","volume":"132","author":"A Terlou","year":"2012","unstructured":"Terlou A, Santegoets LA, van der Meijden WI, Heijmans-Antonissen C, Swagemakers SM, van der Spek PJ et al (2012) An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. J Invest Dermatol 132:658\u2013666","journal-title":"J Invest Dermatol"},{"key":"5015_CR27","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jamadermatol.2015.0643","volume":"151","author":"A Lee","year":"2015","unstructured":"Lee A, Bradford J, Fischer G (2015) Long-term management of adult vulvar lichen sclerosus: a prospective cohort study of 507 women. JAMA Dermatol 151:1061\u20131067","journal-title":"JAMA Dermatol"},{"key":"5015_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cytogfr.2016.03.007","volume":"30","author":"G Mangino","year":"2016","unstructured":"Mangino G, Chiantore MV, Iuliano M, Fiorucci G, Romeo G (2016) Inflammatory microenvironment and human papilloma-induced carcinogenesis. Cytokine Growth Factor Rev 30:103\u2013111","journal-title":"Cytokine Growth Factor Rev"},{"key":"5015_CR29","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.1038\/onc.2017.66","volume":"36","author":"R Shakya","year":"2017","unstructured":"Shakya R, Tarulli GA, Sheng L, Lokman NA, Ricciardelli C, Pishas KI et al (2017) Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer. Oncogene 36:4469\u20134480","journal-title":"Oncogene"},{"key":"5015_CR30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1136\/jclinpath-2011-200103","volume":"64","author":"JC Sadalla","year":"2011","unstructured":"Sadalla JC, Louren\u00e7o SV, Sotto MN, Baracat EC, Carvalho JP (2011) Claudin and p53 expression in vulvar lichen sclerosus and squamous-cell carcinoma. J Clin Pathol 64:853\u2013857","journal-title":"J Clin Pathol"},{"key":"5015_CR31","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1365-2559.2005.02321.x","volume":"48","author":"B Liegl","year":"2006","unstructured":"Liegl B, Regauer S (2006) p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN). Histopathology 48:268\u2013274","journal-title":"Histopathology"},{"key":"5015_CR32","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.1158\/1078-0432.CCR-17-1302","volume":"23","author":"LS Nooij","year":"2017","unstructured":"Nooij LS, ter Haar NT, Ruano D, Rakislova N, van Wezel T, Smit VT et al (2017) Genomic characterization of vulvar (pre) cancers identifies distinct molecular subtypes with prognostic significance. Clin Cancer Res 23:6781\u20136789","journal-title":"Clin Cancer Res"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-5015-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-018-5015-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-018-5015-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T15:03:15Z","timestamp":1605970995000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-018-5015-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["5015"],"URL":"https:\/\/doi.org\/10.1007\/s00404-018-5015-y","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"type":"print","value":"0932-0067"},{"type":"electronic","value":"1432-0711"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"22 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving were in accordance with the ethical standards of the institutional research committee (R11026) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}