{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:21:34Z","timestamp":1793650894399,"version":"4.5.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>Due to modern and individualised treatments, women at reproductive age have a high survival rate after cancer therapy. What are pregnancy and birth rates of women after cancer and how often do they use cryopreserved ovarian tissue or gametes?<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>From 2007 to 2015, 162 women aged 26.7\u00a0\u00b1\u00a06.9\u00a0years were counselled for fertility preservation at a single University Fertility Centre. A questionnaire study was performed in average 3 and 6\u00a0years after the diagnosis of cancer. The women were asked about their fertility, partnership, family planning, and pregnancy history. 72 women (51%) answered a written questionnaire in 2016. 59 women were reached again by phone in 2019 (82%).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The preferred method of fertility preservation was ovarian tissue cryopreservation (<jats:italic>n<\/jats:italic>\u2009=\u200936, 50%); none of the women had ovarian hyperstimulation in order to cryopreserve oocytes. About 3\u00a0years after treatment, 37 women of 72 women (51%) of the women with a mean age of 29.9\u00a0years had a strong wish to conceive. 21\/72 (29%) had actively tried to conceive after successful cancer treatment; eight women (11%) were already pregnant or had children. Six years after cancer diagnosis 16\/59 (27%) women had ongoing anticancer treatment. 12\/59 (20%) were pregnant or had children, while 39% (23\/59) had no menstrual cycle. Only one woman used her cryopreserved ovarian tissue, but did not become pregnant.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>After cancer and gonadotoxic treatment, women\u2019s desire to have a child is substantial. In this study, the rate of spontaneous pregnancies and births was 20% 6\u00a0years after gonadotoxic therapies. Not every woman, however, has the opportunity to conceive: factors impairing fertility include ongoing cancer treatment or persistent disease, no partner, no menstrual cycle, as well as other reasons for infertility.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00404-020-05563-w","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T16:04:01Z","timestamp":1588781041000},"page":"1579-1588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Motherhood after cancer: fertility and utilisation of fertility-preservation methods"],"prefix":"10.1007","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-2424","authenticated-orcid":false,"given":"Maren","family":"Goeckenjan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Freis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gla\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Trinkaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Torka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wimberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Germeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"5563_CR1","unstructured":"Website of the German network for fertility preservation. https:\/\/fertiprotekt.com\/fertiprotektnetwork. 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Germeyer\u2014Director of the board of Fertiprotekt e.V. No potential conflicts of interest with direct of potential influence or bias on the work: M. Goeckenjan, A. Freis, K. Gla\u00df, J. Schaar, I. Trinkaus, S. Torka, and P. Wimberger.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the local ethics committee. All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study (EK 314072015).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}