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All patients had been treated by VFR and no participant had received adjuvant radiotherapy. The gynecologic cancer lymphedema questionnaire (GCLQ) was used to determine the presence of lymphedema. Structured telephone interviews were conducted to assess postoperative sequelae and long-term complications.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Forty-three VFR patients (median age 63\u00a0years) were available for QoL assessment. Thirty-eight (88%) had received inguinal lymph-node dissection in addition to VFR. Mean global QoL (global health status) rating among all patients was 66.1 (\u00b1\u200925.5) on a scale from 0 to 100 with higher scores indicating better QoL. Higher GCLQ scores were significantly associated with lower global QoL scores (Spearman's rank correlation <jats:italic>\u03c1<\/jats:italic>\u2009=\u2212\u00a00.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The presence of preoperative co-morbidities and postoperative wound-healing complications were also linked to reduced QoL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for both). In a multivariable regression model, there was a significant interaction between preoperative co-morbidities and wound-healing complications with regard to global QoL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Overall, VFR patients exhibit good quality of life postoperatively. The presence of lymphedema, wound-healing complications, and preoperative morbidities were associated with reduced QoL. Prospective longitudinal studies have to confirm our findings in the future.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00404-020-05584-5","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:03:44Z","timestamp":1589889824000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quality of life and associated factors after surgical treatment of vulvar cancer by vulvar field resection (VFR)"],"prefix":"10.1007","volume":"302","author":[{"given":"Sophia","family":"Trott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"H\u00f6ckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Dornh\u00f6fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Geue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahriye","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-5198","authenticated-orcid":false,"given":"Benjamin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"issue":"1","key":"5584_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD (2017) Jemal A (2017) Cancer Statistics. 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Aktas has received personal fees from Novartis Pharma, AstraZeneca, Amgen, and Roche Pharma outside the submitted work. N. Dorh\u00f6fer has received personal fees from Roche Pharma, AstraZeneca, and Tesaro\u00a0outside the submitted work. B. Wolf and M. H\u00f6ckel were supported by a grant from Stiftung Gyn\u00e4kologische Onkologie.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}