{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:01:21Z","timestamp":1785834081879,"version":"3.56.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Finnish government","award":["Research funds from specified government transfers"],"award-info":[{"award-number":["Research funds from specified government transfers"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Cohort study of 2411 pregnant women recruited from maternity health care clinics. The severity of NVP was categorized according to Pregnancy-Unique Quantification of Emesis (PUQE) questionnaire into no\/mild\/moderate\/severe NVP. History of nausea was assessed in connection with motion sickness, seasickness, migraine or other kinds of headache, after anesthesia, related to the use of contraceptives, and other kinds of nausea. History of NVP in relatives was categorized into first-degree (mother\/sister) and second-degree relatives (more distant).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In multivariable analysis including previous personal history of nausea, motion sickness (OR 3.17, 95% CI 1.81\u20135.56, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and nausea in migraine (OR 3.18, 95% CI 1.86\u20135.45, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were associated with severe NVP. History of nausea in other kinds of headache was associated with moderate NVP (OR 1.91, 95% CI 1.34\u20132.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Women with affected first-degree relatives had higher odds for moderate (OR 3.84, 95% CI 2.72\u20135.40) and severe (OR 3.19, 95% CI 1.92\u20135.28) NVP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). All these results remained significant after adjusting for parity, body mass index, smoking, employment and age.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Women with personal history of nausea or family history of NVP have an increased susceptibility of NVP. This information is useful in pre-pregnancy counselling.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-020-05683-3","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T06:02:33Z","timestamp":1594447353000},"page":"947-955","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives"],"prefix":"10.1007","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-4714","authenticated-orcid":false,"given":"Linda","family":"Laitinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-4860","authenticated-orcid":false,"given":"Miina","family":"Nurmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-7762","authenticated-orcid":false,"given":"Pauliina","family":"Ellil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-1327","authenticated-orcid":false,"given":"P\u00e4ivi","family":"Rautava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-1427","authenticated-orcid":false,"given":"Mari","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-0306","authenticated-orcid":false,"given":"P\u00e4ivi","family":"Polo-Kantola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"issue":"2","key":"5683_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.gtc.2011.03.009","volume":"40","author":"NM Lee","year":"2011","unstructured":"Lee NM, Saha S (2011) Nausea and vomiting of pregnancy. Gastroenterol Clin North Am 40(2):309\u2013334","journal-title":"Gastroenterol Clin North Am"},{"issue":"3\u20134","key":"5683_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000477853","volume":"100","author":"V London","year":"2017","unstructured":"London V, Grube S, Sherer DM, Abulafia O (2017) Hyperemesis gravidarum: a review of recent literature. Pharmacology 100(3\u20134):161\u2013171","journal-title":"Pharmacology"},{"issue":"2","key":"5683_CR3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.wombi.2012.10.001","volume":"26","author":"H Wood","year":"2013","unstructured":"Wood H, McKellar LV, Lightbody M (2013) Nausea and vomiting in pregnancy: blooming or bloomin\u2019 awful? A review of the literature. Women and Birth 26(2):100\u2013104","journal-title":"Women and Birth"},{"key":"5683_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.autneu.2016.07.003","volume":"202","author":"CD Balaban","year":"2017","unstructured":"Balaban CD, Yates BJ (2017) What is nausea? a historical analysis of changing views. Auton Neurosci 202:5\u201317","journal-title":"Auton Neurosci"},{"key":"5683_CR5","doi-asserted-by":"publisher","first-page":"S184","DOI":"10.1067\/mob.2002.122592","volume":"186","author":"TM Goodwin","year":"2002","unstructured":"Goodwin TM (2002) Nausea and vomiting of pregnancy: An obstetric syndrome. Am J Obstet Gynecol 186:S184\u2013S189","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"5683_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41572-019-0110-3","volume":"125","author":"MS Fejzo","year":"2019","unstructured":"Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes \u00c5, Painter RC, Mullin PM (2019) Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers 125(1):62. https:\/\/doi.org\/10.1038\/s41572-019-0110-3","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"5683_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/WCO.0000000000000163","volume":"28","author":"JF Golding","year":"2015","unstructured":"Golding JF, Gresty MA (2015) Pathophysiology and treatment of motion sickness. Curr Opin Neurol 28(1):83\u201388","journal-title":"Curr Opin Neurol"},{"key":"5683_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fneur.2016.00014","volume":"7","author":"G Bertolini","year":"2016","unstructured":"Bertolini G, Straumann D (2016) Moving in a moving world: a review on vestibular motion sickness. Front Neurol 7:14","journal-title":"Front Neurol"},{"key":"5683_CR9","doi-asserted-by":"publisher","first-page":"S215","DOI":"10.1067\/mob.2002.123053","volume":"186","author":"L Heinrichs","year":"2002","unstructured":"Heinrichs L (2002) Linking olfaction with nausea and vomiting of pregnancy, recurrent abortion, hyperemesis gravidarum, and migraine headache. Am J Obstet Gynecol 186:S215","journal-title":"Am J Obstet Gynecol"},{"issue":"8","key":"5683_CR10","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/head.12150","volume":"53","author":"DC Buse","year":"2013","unstructured":"Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM et al (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American migraine prevalence and prevention (AMPP) study. Headache 53(8):1278\u20131299","journal-title":"Headache"},{"issue":"6","key":"5683_CR11","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1097\/01.AOG.0000260956.61835.6d","volume":"109","author":"C Moreau","year":"2007","unstructured":"Moreau C, Trussell J, Gilbert F, Bajos N, Bouyer J (2007) Oral contraceptive tolerance: does the type of pill matter? Obs Gynecol 109(6):1277\u20131285","journal-title":"Obs Gynecol"},{"key":"5683_CR12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejphar.2013.10.037","volume":"722","author":"CC Horn","year":"2014","unstructured":"Horn CC, Wallisch WJ, Homanics GE, Williams JP (2014) Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol 722:55\u201366","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"5683_CR13","doi-asserted-by":"publisher","first-page":"230.e1","DOI":"10.1016\/j.ajog.2010.09.018","volume":"204","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Cantor RM, Macgibbon K, Romero R, Goodwin TM, Mullin PM et al (2011) Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol 204(3):230.e1\u20137","journal-title":"Am J Obstet Gynecol"},{"key":"5683_CR14","first-page":"c2050","volume":"340","author":"A Vikanes","year":"2010","unstructured":"Vikanes A, Skjaerven R, Grjibovski AM, Gunnes N, Vangen S, Magnus P (2010) Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ 340:c2050","journal-title":"BMJ"},{"issue":"1","key":"5683_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ejogrb.2008.07.003","volume":"141","author":"MS Fejzo","year":"2008","unstructured":"Fejzo MS, Ingles SA, Wilson M, Wang W, MacGibbon K, Romero R et al (2008) High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals. Eur J Obstet Gynecol Reprod Biol 141(1):13\u201317","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"5683_CR16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s10519-016-9781-7","volume":"46","author":"L Colodro-Conde","year":"2016","unstructured":"Colodro-Conde L, Jern P, Johansson A, S\u00e1nchez-Romera JF, Lind PA, Painter JN et al (2016) Nausea and vomiting during pregnancy is highly heritable. Behav Genet 46(4):481\u2013491","journal-title":"Behav Genet"},{"issue":"1","key":"5683_CR17","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","volume":"9","author":"MS Fejzo","year":"2018","unstructured":"Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgr\u00edmsd\u00f3ttir IB, Vacic V, MacGibbon KW et al (2018) Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun 9(1):1178","journal-title":"Nat Commun"},{"issue":"3","key":"5683_CR18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1080\/01443610500060651","volume":"25","author":"G Koren","year":"2005","unstructured":"Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A et al (2005) Validation studies of the pregnancy unique-quantification of emesis (PUQE) scores. J Obstet Gynaecol 25(3):241\u2013244","journal-title":"J Obstet Gynaecol"},{"key":"5683_CR19","unstructured":"Gissler M. Perinatal statistics: parturients, deliveries and newborns 2014\u20132015. Finnish National Institute for Health and Welfare. Available at: https:\/\/urn.fi\/URN:NBN:fi-fe2015093014230. Accessed 15 Oct 2019"},{"issue":"1","key":"5683_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1213\/ANE.0000000000000002","volume":"118","author":"TJ Gan","year":"2014","unstructured":"Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA et al (2014) Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 118(1):85\u2013113","journal-title":"Anesth Analg"},{"issue":"3","key":"5683_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1526-4610.2006.00370.x","volume":"46","author":"VT Martin","year":"2006","unstructured":"Martin VT, Behbehani M (2006) Ovarian Hormones and Migraine headache: understanding Mechanisms and pathogenesis-Part 2. Headache J Head Face Pain 46(3):365\u2013386","journal-title":"Headache J Head Face Pain"},{"issue":"6","key":"5683_CR22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0010-7824(99)00109-2","volume":"60","author":"MJ Rosenberg","year":"1999","unstructured":"Rosenberg MJ, Meyers A, Roy V (1999) Efficacy, cycle control, and side effects of low- and lower-dose oral contraceptives: a randomized trial of 20 micrograms and 35 micrograms estrogen preparations. Contraception 60(6):321\u2013329","journal-title":"Contraception"},{"issue":"3","key":"5683_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ogc.2008.04.002","volume":"35","author":"TM Goodwin","year":"2008","unstructured":"Goodwin TM (2008) Hyperemesis gravidarum. Obstet Gynecol Clin North Am 35(3):401\u2013417","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"4","key":"5683_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1159\/000299031","volume":"19","author":"A J\u00e4rnfelt-Samsioe","year":"1985","unstructured":"J\u00e4rnfelt-Samsioe A, Eriksson B, Waldenstr\u00f6m J, Samsioe G (1985) Some new aspects on emesis gravidarum: relations to clinical data, serum electrolytes, total protein and creatinine. Gynecol Obstet Invest 19(4):174\u2013186","journal-title":"Gynecol Obstet Invest"},{"issue":"6","key":"5683_CR25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3109\/01443619209025932","volume":"12","author":"S Whitehead","year":"1992","unstructured":"Whitehead S, Andrews P, Chamberlain G (1992) Characterisation of nausea and vomiting in early pregnancy: a survey of 1000 women. J Obstet Gynecol 12(6):364\u2013369","journal-title":"J Obstet Gynecol"},{"issue":"2","key":"5683_CR26","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000291833","volume":"43","author":"R Gadsby","year":"1997","unstructured":"Gadsby R, Barnie-Adshead A, Jagger C (1997) Pregnancy nausea related to women\u2019s obstetric and personal histories. Gynecol Obstet Invest 43(2):108\u2013111","journal-title":"Gynecol Obstet Invest"},{"issue":"4","key":"5683_CR27","doi-asserted-by":"publisher","first-page":"417.e1","DOI":"10.1016\/j.ajog.2008.07.003","volume":"199","author":"TM Goodwin","year":"2008","unstructured":"Goodwin TM, Nwankwo OA, O\u2019Leary LD, O\u2019Leary D, Romero R, Korst LM (2008) The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway. Am J Obstet Gynecol 199(4):417.e1\u20139","journal-title":"Am J Obstet Gynecol"},{"key":"5683_CR28","doi-asserted-by":"publisher","first-page":"S204","DOI":"10.1067\/mob.2002.122602","volume":"186","author":"FO Black","year":"2002","unstructured":"Black FO (2002) Maternal susceptibility to nausea and vomiting of pregnancy: Is the vestibular system involved? Am J Obstet Gynecol 186:S204\u2013S209","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"5683_CR29","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/j.1526-4610.2011.01900.x","volume":"51","author":"BL Peterlin","year":"2011","unstructured":"Peterlin BL, Gupta S, Ward TN, MacGregor A (2011) Sex matters: evaluating sex and gender in migraine and headache research. Headache 51(6):839\u2013842","journal-title":"Headache"},{"issue":"4","key":"5683_CR30","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1080\/01443610701327362","volume":"27","author":"TR Einarson","year":"2007","unstructured":"Einarson TR, Navioz Y, Maltepe C, Einarson A, Koren G (2007) Existence and severity of nausea and vomiting in pregnancy (NVP) with different partners. J Obstet Gynaecol 27(4):360\u2013362","journal-title":"J Obstet Gynaecol"},{"issue":"12","key":"5683_CR31","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1111\/j.1471-0528.2005.00765.x","volume":"112","author":"LIS Trogstad","year":"2005","unstructured":"Trogstad LIS, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM (2005) Recurrence risk in hyperemesis gravidarum. BJOG An Int J Obstet Gynaecol 112(12):1641\u20131645","journal-title":"BJOG An Int J Obstet Gynaecol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05683-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-020-05683-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05683-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T23:20:46Z","timestamp":1625959246000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-020-05683-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,11]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["5683"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05683-3","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,11]]},"assertion":[{"value":"24 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors disclose no conflicts of interest pertaining to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study had approval from the Joint Ethics Committees of University of Turku and Turku University Central Hospital, Turku, Finland (43\/180\/2011). This study has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants of this study gave their informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}