{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:07:28Z","timestamp":1789639648049,"version":"4.0.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00404-020-05766-1","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T15:04:23Z","timestamp":1599145463000},"page":"455-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The first thrombotic event in purely obstetric antiphospholipid syndrome patients and in antiphospholipid antibody carriers: comparison of incidence and characteristics"],"prefix":"10.1007","volume":"303","author":[{"given":"Marta","family":"Tonello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Calligaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Favaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Del Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Veronese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Salvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Gervasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-9828","authenticated-orcid":false,"given":"Amelia","family":"Ruffatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"5766_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, de Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295\u2013306. https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01753.x","journal-title":"J Thromb Haemost"},{"key":"5766_CR2","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.thromres.2004.08.006","volume":"114","author":"M Lassere","year":"2004","unstructured":"Lassere M, Empson M (2004) Treatment of antiphospholipid syndrome in pregnancy\u2013a systematic review of randomized therapeutic trials. Thromb Res 114:419\u2013426. https:\/\/doi.org\/10.1016\/j.thromres.2004.08.006","journal-title":"Thromb Res"},{"key":"5766_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1055\/s-0038-1632388","volume":"118","author":"A Ruffatti","year":"2018","unstructured":"Ruffatti A, Tonello M, Hoxha A, Sciascia S, Cuadrado MJ, Latino JO, Udry S, Reshetnyak T, Costedoat-Chalumeau N, Morel N, Marozio L, Tincani A, Andreoli L, Haladyj E, Meroni PL, Gerosa M, Alijotas-Reig J, Tenti S, Mayer-Pickel K, Simchen MJ, Bertero MT, De Carolis S, Ramoni V, Mekinian A, Grandone E, Maina A, Serrano F, Pengo V, Khamashta MA (2018) Effect of additional treatments combined with conventional therapies in pregnant patients with high-risk antiphospholipid syndrome: a multicentre study. Thromb Haemost 118:639\u2013646. https:\/\/doi.org\/10.1055\/s-0038-1632388","journal-title":"Thromb Haemost"},{"key":"5766_CR4","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/1529-0131(200106)44:6%3C1466::aid-art242%3E3.0.co;2-c","volume":"44","author":"D Erkan","year":"2001","unstructured":"Erkan D, Merrill JT, Yazici Y, Sammaritano L, Buyon JP, Lockshin MD (2001) High thrombosis rate after fetal loss in antiphospholipid syndrome: effective prophylaxis with aspirin. Arthritis Rheum 44:1466\u20131467. https:\/\/doi.org\/10.1002\/1529-0131(200106)44:6%3C1466:aid-art242%3E3.0.co;2-c","journal-title":"Arthritis Rheum"},{"key":"5766_CR5","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1002\/art.10165","volume":"46","author":"A Tincani","year":"2002","unstructured":"Tincani A, Taglietti M, Biasini C, Frassi M, Gorla R, Balestrieri G (2002) Thromboembolicevents after fetal loss in patients with antiphospholipid syndrome: comment on the article by Erkan et al. Arthritis Rheum 46:1126\u20131127. https:\/\/doi.org\/10.1002\/art.10165","journal-title":"Arthritis Rheum"},{"key":"5766_CR6","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1093\/humrep\/deh844","volume":"20","author":"S Quenby","year":"2005","unstructured":"Quenby S, Farquharson RG, Dawood F, Hughes AM, Topping J (2005) Recurrent miscarriage and long-term thrombosis risk: a case-control study. Hum Reprod 20:1729\u20131732. https:\/\/doi.org\/10.1093\/humrep\/deh844","journal-title":"Hum Reprod"},{"key":"5766_CR7","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1177\/0961203310397080","volume":"20","author":"G Lef\u00e8vre","year":"2011","unstructured":"Lef\u00e8vre G, Lambert M, Bacri JL, Dubucquoi S, Quemeneur T, Caron C, Launay D, Houfflin-Debarge V, Hachulla E, Kyndt X, Subtil D, Hatron PY (2011) Thrombotic events during long-term follow-up of obstetric antiphospholipid syndrome patients. Lupus 20:861\u2013865. https:\/\/doi.org\/10.1177\/0961203310397080","journal-title":"Lupus"},{"key":"5766_CR8","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1160\/TH11-05-0340","volume":"106","author":"JC Gris","year":"2011","unstructured":"Gris JC, Chauleur C, Molinari N, Mar\u00e8s P, Fabbro-Peray P, Qu\u00e9r\u00e9 I, Lefrant JY, Haddad B, Dauzat M (2011) Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. Thromb Haemost 106:1053\u20131061. https:\/\/doi.org\/10.1160\/TH11-05-0340","journal-title":"Thromb Haemost"},{"key":"5766_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/ard.2011.153817","volume":"71","author":"MA Martinez-Zamora","year":"2012","unstructured":"Martinez-Zamora MA, Peralta S, Creus M, Tassies D, Reverter JC, Espinosa G, Cervera R, Carmona F, Balasch J (2012) Risk of thromboembolic events after recurrent spontaneous abortion in antiphospholipid syndrome: a case-control study. Ann Rheum Dis 71:61\u201366. https:\/\/doi.org\/10.1136\/ard.2011.153817","journal-title":"Ann Rheum Dis"},{"key":"5766_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11239-017-1526-9","volume":"44","author":"G Drozdinsky","year":"2017","unstructured":"Drozdinsky G, Hadar E, Shmueli A, Gabbay-Benziv R, Shiber S (2017) Obstetric antiphospholipid syndrome and long term arterial thrombosis risk. J Thromb Thrombolys 44:371\u2013375. https:\/\/doi.org\/10.1007\/s11239-017-1526-9","journal-title":"J Thromb Thrombolys"},{"key":"5766_CR11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/1471-0528.15469","volume":"126","author":"GR de Jes\u00fas","year":"2019","unstructured":"de Jes\u00fas GR, Sciascia S, Andrade D, Barbhaiya M, Tektonidou M, Banzato A, Pengo V, Ji L, Meroni PL, Ugarte A, Cohen H, Branch DW, Andreoli L, Belmont HM, Fortin PR, Petri M, Rodriguez E, Cervera R, Knight JS, Atsumi T, Willis R, Nascimento IS, Rosa R, Erkan D, Levy RA, APS ACTION (2019) Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study. BJOG 126:656\u2013661. https:\/\/doi.org\/10.1111\/1471-0528.15469","journal-title":"BJOG"},{"key":"5766_CR12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1111\/j.1538-7836.2008.03121.x","volume":"6","author":"A Ruffatti","year":"2008","unstructured":"Ruffatti A, Olivieri S, Tonello M, Bortolati M, Bison E, Salvan E, Facchinetti M, Pengo V (2008) Influence of different IgG anticardiolipin antibody cut-off values on antiphospholipid syndrome classification. J Thromb Haemost 6:1693\u20131696. https:\/\/doi.org\/10.1111\/j.1538-7836.2008.03121.x","journal-title":"J Thromb Haemost"},{"key":"5766_CR13","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","volume":"7","author":"V Pengo","year":"2009","unstructured":"Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, de Groot PG (2009) Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 7:1737\u20131740. https:\/\/doi.org\/10.1111\/j.1538-7836.2009.03555.x","journal-title":"J Thromb Haemost"},{"key":"5766_CR14","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1093\/rheumatology\/ker139","volume":"50","author":"A Ruffatti","year":"2011","unstructured":"Ruffatti A, Tonello M, Visentin MS, Bontadi A, Hoxha A, De Carolis S, Botta A, Salvi S, Nuzzo M, Rovere-Querini P, Canti V, Mosca M, Mitic G, Bertero MT, Pengo V, Boffa MC, Tincani A (2011) Risk factors for pregnancy failure in patients with antiphospholipid syndrome treated with conventional therapies: a multicentre, case-control study. Rheumatology 50:1684\u20131689. https:\/\/doi.org\/10.1093\/rheumatology\/ker139","journal-title":"Rheumatology"},{"key":"5766_CR15","doi-asserted-by":"publisher","first-page":"525e1","DOI":"10.1016\/j.ajog.2017.01.026","volume":"216","author":"G Saccone","year":"2017","unstructured":"Saccone G, Berghella V, Maruotti GM, Ghi T, Rizzo G, Simonazzi G, Rizzo N, Facchinetti F, Dall\u2019Asta A, Visentin S, Sarno L, Xodo S, Bernabini D, Monari F, Roman A, Eke AC, Hoxha A, Ruffatti A, Schuit E, Martinelli P, PREGNANTS (PREGNancy in women with ANTiphospholipid Syndrome) working group (2017) Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study. Am J Obstet Gynecol 216:525e1\u2013525e12. https:\/\/doi.org\/10.1016\/j.ajog.2017.01.026","journal-title":"Am J Obstet Gynecol"},{"key":"5766_CR16","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1002\/art.34402","volume":"64","author":"MD Lockshin","year":"2012","unstructured":"Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, Petri M, Porter TF, Sammaritano L, Stephenson MD, Buyon J, Salmon JE (2012) Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum 64:2311\u20132318. https:\/\/doi.org\/10.1002\/art.34402","journal-title":"Arthritis Rheum"},{"key":"5766_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11926-010-0149-3","volume":"13","author":"M Barbhaiya","year":"2011","unstructured":"Barbhaiya M, Erkan D (2011) Primary thrombosis prophylaxis in antiphospholipid antibody-positive patients: where do we stand? Curr Rheumatol Rep 13:59\u201369. https:\/\/doi.org\/10.1007\/s11926-010-0149-3","journal-title":"Curr Rheumatol Rep"},{"key":"5766_CR18","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1136\/ard.2010.142042","volume":"70","author":"A Ruffatti","year":"2011","unstructured":"Ruffatti A, Del Ross T, Ciprian M, Bertero MT, Sciascia S, Scarpato S, Montecucco C, Rossi S, Caramaschi P, Biasi D, Doria A, Rampudda M, Monica N, Fischetti F, Picillo U, Brucato A, Salvan E, Vittorio P, Meroni P, Tincani A (2011) Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. Ann Rheum Dis 70:1083\u20131086. https:\/\/doi.org\/10.1136\/ard.2010.142042","journal-title":"Ann Rheum Dis"},{"key":"5766_CR19","doi-asserted-by":"publisher","first-page":"4714","DOI":"10.1182\/blood-2011-03-340232","volume":"118","author":"V Pengo","year":"2011","unstructured":"Pengo V, Ruffatti A, Legnani C, Testa S, Fierro T, Marongiu F, De Micheli V, Gresele P, Tonello M, Ghirarduzzi A, Bison E, Denas G, Banzato A, Padayattil Jose S, Iliceto S (2011) Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood 118:4714\u20134718. https:\/\/doi.org\/10.1182\/blood-2011-03-340232","journal-title":"Blood"},{"key":"5766_CR20","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S1474-4422(09)70239-X","volume":"8","author":"RT Urbanus","year":"2009","unstructured":"Urbanus RT, Siegerink B, Roest M, Rosendaal FR, de Groot PG, Algra A (2009) Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study. Lancet Neurol 8:998\u20131005. https:\/\/doi.org\/10.1016\/S1474-4422(09)70239-X","journal-title":"Lancet Neurol"},{"key":"5766_CR21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s11239-018-1672-8","volume":"46","author":"A Rottenstreich","year":"2018","unstructured":"Rottenstreich A, Arad A, Terespolsky H, Elchalal U, Amsalm H, Roth B, Kalish Y (2018) Antiphospholipid antibody profile-based outcome of purely vascular and purely obstetric antiphospholipid syndrome. J Thromb Thrombolys 46:166\u2013173. https:\/\/doi.org\/10.1007\/s11239-018-1672-8","journal-title":"J Thromb Thrombolys"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05766-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-020-05766-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05766-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T22:28:10Z","timestamp":1630708090000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-020-05766-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["5766"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05766-1","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"9 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All the authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the study were in accordance with the ethical standards of the institutional review board for observational studies and the audit committee of the University Hospital of Padua (No 6894) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All the subjects were provided information about the study\u2019s modality and objectives and were asked to sign statements consenting to participate in the study and authorizing the publication of their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}