{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:40:14Z","timestamp":1778820014050,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902643"],"award-info":[{"award-number":["81902643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00404-020-05803-z","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:05:56Z","timestamp":1601366756000},"page":"541-546","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical characteristics and risk factors of invasion in extramammary Paget\u2019s disease of the vulva"],"prefix":"10.1007","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2807-367X","authenticated-orcid":false,"given":"Shanhui","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-5093","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-8610","authenticated-orcid":false,"given":"Huaying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-9949","authenticated-orcid":false,"given":"Yulan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"5803_CR1","unstructured":"Kurman RJ, Carcangiu ML, Herrington CS (2014) Tumors of the vulva. In: (IARC) international agency for research on cancer. eds. WHO classification of tumors of female reproductive organs. 4th ed. Lyon, France; World Health Organization 236\u2013237"},{"key":"5803_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.critrevonc.2016.03.008","volume":"101","author":"M van der Linden","year":"2016","unstructured":"van der Linden M, Meeuwis KA, Bulten J et al (2016) Paget disease of the vulva. Crit Rev Oncol Hematol 101:60\u201374","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"5803_CR3","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1097\/IGC.0000000000001189","volume":"28","author":"R Nitecki","year":"2018","unstructured":"Nitecki R, Davis M, Watkins JC et al (2018) Extramammary Paget disease of the vulva: a case series examining treatment, recurrence, and malignant transformation. Int J Gynecol Cancer 28(3):632\u2013638","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"5803_CR4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.ygyno.2013.02.029","volume":"129","author":"Y Cai","year":"2013","unstructured":"Cai Y, Sheng W, Xiang L et al (2013) Primary extramammary Paget\u2019s disease of the vulva: the clinicopathological features and treatment outcomes in a series of 43 patients. Gynecol Oncol 129(2):412\u2013416","journal-title":"Gynecol Oncol"},{"issue":"1","key":"5803_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejogrb.2009.11.003","volume":"149","author":"R Shaco-Levy","year":"2010","unstructured":"Shaco-Levy R, Bean SM, Vollmer RT et al (2010) Paget disease of the vulva: a study of 56 cases. Eur J Obstet Gynecol Reprod Biol 149(1):86\u201391","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"5803_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.gore.2016.12.010","volume":"19","author":"CO Onaiwu","year":"2016","unstructured":"Onaiwu CO, Salcedo MP, Pessini SA et al (2016) Paget\u2019s disease of the vulva: a review of 89 cases. Gynecol Oncol Rep 19:46\u201349","journal-title":"Gynecol Oncol Rep"},{"issue":"2","key":"5803_CR7","first-page":"313","volume":"158","author":"N Hatta","year":"2008","unstructured":"Hatta N, Yamada M, Hirano T et al (2008) Extramammary Paget\u2019s disease: treatment, prognostic factors and outcome in 76 patients. Br J Dermatol 158(2):313\u2013318","journal-title":"Br J Dermatol"},{"issue":"5","key":"5803_CR8","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1053\/hupa.2002.124788","volume":"33","author":"EJ Wilkinson","year":"2002","unstructured":"Wilkinson EJ, Brown HM (2002) Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. Hum Pathol 33(5):549\u2013554","journal-title":"Hum Pathol"},{"issue":"1","key":"5803_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1440-0960.2012.00898.x","volume":"54","author":"ES Delport","year":"2013","unstructured":"Delport ES (2013) Extramammary Paget's disease of the vulva: an annotated review of the current literature. Australas J Dermatol 54(1):9\u201321","journal-title":"Australas J Dermatol"},{"issue":"1","key":"5803_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/IGC.0000000000001131","volume":"28","author":"C Borghi","year":"2018","unstructured":"Borghi C, Bogani G, Ditto A et al (2018) Invasive Paget disease of the Vulva. Int J Gynecol Cancer 28(1):176\u2013182","journal-title":"Int J Gynecol Cancer"},{"issue":"4","key":"5803_CR11","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1097\/00003081-197821040-00014","volume":"21","author":"CA Gregori","year":"1978","unstructured":"Gregori CA, Smith CI, Breen JL (1978) Extramammary Paget\u2019s disease. Clin Obstet Gynecol 21(4):1107\u20131115","journal-title":"Clin Obstet Gynecol"},{"issue":"4","key":"5803_CR12","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.jaad.2018.11.016","volume":"81","author":"M van der Linden","year":"2019","unstructured":"van der Linden M, Oonk MHM, van Doorn HC et al (2019) Vulvar Paget disease: a national retrospective cohort study. J Am Acad Dermatol 81(4):956\u2013962","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"5803_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/LGT.0b013e3182a64a58","volume":"18","author":"G Liu","year":"2014","unstructured":"Liu G, Yuan B, Wang Y et al (2014) Clinicopathologic study of vulvar Paget\u2019s disease in China. J Low Genit Tract Dis 18(3):281\u2013284","journal-title":"J Low Genit Tract Dis"},{"issue":"3","key":"5803_CR14","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ygyno.2006.09.017","volume":"104","author":"D Black","year":"2007","unstructured":"Black D, Tornos C, Soslow RA et al (2007) The outcomes of patients with positive margins after excision for intraepithelial Paget's disease of the vulva. Gynecol Oncol 104(3):547\u2013550","journal-title":"Gynecol Oncol"},{"issue":"19","key":"5803_CR15","first-page":"31638","volume":"S0090\u20138258","author":"D Nasioudis","year":"2019","unstructured":"Nasioudis D, Bhadra M, Ko EM (2019) Extramammary Paget disease of the vulva: management and prognosis. Gynecol Oncol S0090\u20138258(19):31638\u201331645","journal-title":"Gynecol Oncol"},{"issue":"1","key":"5803_CR16","first-page":"34","volume":"35","author":"KY Lee","year":"2009","unstructured":"Lee KY, Roh MR, Chung WG et al (2009) Comparison of Mohs micrographic surgery and wide excision for extramammary Paget\u2019s disease: Korean experience. Dermatol Surg 35(1):34\u201340","journal-title":"Dermatol Surg"},{"issue":"5","key":"5803_CR17","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1365-4632.2010.04661.x","volume":"50","author":"SJ Lee","year":"2011","unstructured":"Lee SJ, Choe YS, Jung HD et al (2011) A multicenter study on extramammary Paget\u2019s disease in Korea. Int J Dermatol 50(5):508\u2013515","journal-title":"Int J Dermatol"},{"issue":"2","key":"5803_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/LGT.0000000000000191","volume":"20","author":"F Sopracordevole","year":"2016","unstructured":"Sopracordevole F, Di Giuseppe J, De Piero G et al (2016) Surgical treatment of paget disease of the vulva: prognostic significance of stromal invasion and surgical margin status. J Low Genit Tract Dis 20(2):184\u2013188","journal-title":"J Low Genit Tract Dis"},{"issue":"1","key":"5803_CR19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/PGP.0b013e3181b1cc5e","volume":"29","author":"R Shaco-Levy","year":"2010","unstructured":"Shaco-Levy R, Bean SM, Vollmer RT et al (2010) Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course. Int J Gynecol Pathol 29(1):69\u201378","journal-title":"Int J Gynecol Pathol"},{"issue":"1","key":"5803_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1072-7515(02)01619-8","volume":"196","author":"JP Pierie","year":"2003","unstructured":"Pierie JP, Choudry U, Muzikansky A et al (2003) Prognosis and management of extramammary Paget\u2019s disease and the association with secondary malignancies. J Am Coll Surg 196(1):45\u201350","journal-title":"J Am Coll Surg"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05803-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-020-05803-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05803-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:04:28Z","timestamp":1632873868000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-020-05803-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["5803"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05803-z","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"assertion":[{"value":"10 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study protocol was approved by the Ethical Committee of Fudan University Shanghai Cancer Center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Patients were contacted by telephone to obtain verbal informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agreed to publish the submitted article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}