{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:38:29Z","timestamp":1740109109948,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00404-020-05834-6","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T18:02:58Z","timestamp":1603130578000},"page":"803-810","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the prognostic significance of preoperative high normocalcemia in epithelial ovarian carcinoma"],"prefix":"10.1007","volume":"303","author":[{"given":"Hyun-Woong","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Taek","family":"Ouh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-6403","authenticated-orcid":false,"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"5834_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2016.08.006","volume":"41","author":"PM Webb","year":"2017","unstructured":"Webb PM, Jordan SJ (2017) Epidemiology of epithelial ovarian cancer. Best Pract Res Clin Obstet Gynaecol 41:3\u201314. https:\/\/doi.org\/10.1016\/j.bpobgyn.2016.08.006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"5834_CR2","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1002\/cncr.11347","volume":"97","author":"MT Goodman","year":"2003","unstructured":"Goodman MT, Correa CN, Tung KH, Roffers SD, Cheng WuX, Young JL Jr, Wilkens LR, Carney ME, Howe HL (2003) Stage at diagnosis of ovarian cancer in the United States, 1992\u20131997. Cancer 97:2648\u20132659. https:\/\/doi.org\/10.1002\/cncr.11347","journal-title":"Cancer"},{"key":"5834_CR3","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1158\/1055-9965.Epi-15-0443","volume":"24","author":"MG Kelly","year":"2015","unstructured":"Kelly MG, Winkler SS, Lentz SS, Berliner SH, Swain MF, Skinner HG, Schwartz GG (2015) Serum calcium and serum albumin are biomarkers that can discriminate malignant from benign pelvic masses. Cancer Epidemiol Biomarkers Prev 24:1593\u20131598. https:\/\/doi.org\/10.1158\/1055-9965.Epi-15-0443","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"5834_CR4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1089\/jwh.2011.3053","volume":"20","author":"SL Stewart","year":"2011","unstructured":"Stewart SL, Rim SH, Richards TB (2011) Gynecologic oncologists and ovarian cancer treatment: avenues for improved survival. J Womens Health (Larchmt) 20:1257\u20131260. https:\/\/doi.org\/10.1089\/jwh.2011.3053","journal-title":"J Womens Health (Larchmt)"},{"key":"5834_CR5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.ygyno.2014.01.010","volume":"132","author":"KA So","year":"2014","unstructured":"So KA, Hong JH, Jin HM, Kim JW, Song JY, Lee JK, Lee NW (2014) The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: a retrospective cohort study. Gynecol Oncol 132:551\u2013555. https:\/\/doi.org\/10.1016\/j.ygyno.2014.01.010","journal-title":"Gynecol Oncol"},{"key":"5834_CR6","doi-asserted-by":"publisher","first-page":"9548","DOI":"10.1038\/s41598-017-10328-8","volume":"7","author":"W Zhang","year":"2017","unstructured":"Zhang W, Ye B, Liang W, Ren Y (2017) Preoperative prognostic nutritional index is a powerful predictor of prognosis in patients with stage III ovarian cancer. Sci Rep 7:9548. https:\/\/doi.org\/10.1038\/s41598-017-10328-8","journal-title":"Sci Rep"},{"key":"5834_CR7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1200\/jop.2016.011155","volume":"12","author":"W Goldner","year":"2016","unstructured":"Goldner W (2016) Cancer-related hypercalcemia. J Oncol Pract 12:426\u2013432. https:\/\/doi.org\/10.1200\/jop.2016.011155","journal-title":"J Oncol Pract"},{"key":"5834_CR8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/0002-9343(56)90081-X","volume":"21","author":"A Gellhorn","year":"1956","unstructured":"Gellhorn A, Plimpton CH (1956) Hypercalcemia in malignant disease without evidence of bone destruction. Am J Med 21:750\u2013759","journal-title":"Am J Med"},{"key":"5834_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ygyno.2012.12.046","volume":"129","author":"GG Schwartz","year":"2013","unstructured":"Schwartz GG, Skinner HG (2013) Prospective studies of total and ionized serum calcium in relation to incident and fatal ovarian cancer. Gynecol Oncol 129:169\u2013172. https:\/\/doi.org\/10.1016\/j.ygyno.2012.12.046","journal-title":"Gynecol Oncol"},{"key":"5834_CR10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.canep.2017.07.004","volume":"49","author":"GG Schwartz","year":"2017","unstructured":"Schwartz GG, Tretli S, Vos L, Robsahm TE (2017) Prediagnostic serum calcium and albumin and ovarian cancer: a nested case\u2013control study in the Norwegian Janus Serum Bank Cohort. Cancer Epidemiol 49:225\u2013230. https:\/\/doi.org\/10.1016\/j.canep.2017.07.004","journal-title":"Cancer Epidemiol"},{"key":"5834_CR11","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1016\/j.ejca.2010.05.019","volume":"46","author":"AT Toriola","year":"2010","unstructured":"Toriola AT, Surcel HM, Calypse A, Grankvist K, Luostarinen T, Lukanova A, Pukkala E, Lehtinen M (2010) Independent and joint effects of serum 25-hydroxyvitamin D and calcium on ovarian cancer risk: a prospective nested case\u2013control study. Eur J Cancer 46:2799\u20132805. https:\/\/doi.org\/10.1016\/j.ejca.2010.05.019","journal-title":"Eur J Cancer"},{"key":"5834_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/nu9070679","volume":"9","author":"X Song","year":"2017","unstructured":"Song X, Li Z, Ji X, Zhang D (2017) Calcium intake and the risk of ovarian cancer: a meta-analysis. Nutrients 9:679. https:\/\/doi.org\/10.3390\/nu9070679","journal-title":"Nutrients"},{"key":"5834_CR13","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/bjc.2016.289","volume":"115","author":"B Qin","year":"2016","unstructured":"Qin B, Moorman PG, Alberg AJ et al (2016) Dairy, calcium, vitamin D and ovarian cancer risk in African\u2013American women. Br J Cancer 115:1122\u20131130. https:\/\/doi.org\/10.1038\/bjc.2016.289","journal-title":"Br J Cancer"},{"key":"5834_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/excr.2000.4910","volume":"258","author":"SA Hobson","year":"2000","unstructured":"Hobson SA, McNeil SE, Lee F, Rodland KD (2000) Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells. Exp Cell Res 258:1\u201311. https:\/\/doi.org\/10.1006\/excr.2000.4910","journal-title":"Exp Cell Res"},{"key":"5834_CR15","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.bbamcr.2015.11.017","volume":"1863","author":"S Tennakoon","year":"2016","unstructured":"Tennakoon S, Aggarwal A, K\u00e1llay E (2016) The calcium-sensing receptor and the hallmarks of cancer. Biochim Biophys Acta 1863:1398\u20131407. https:\/\/doi.org\/10.1016\/j.bbamcr.2015.11.017","journal-title":"Biochim Biophys Acta"},{"key":"5834_CR16","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1210\/endo.141.11.7875","volume":"141","author":"K Akino","year":"2000","unstructured":"Akino K, Ohtsuru A, Kanda K, Yasuda A, Yamamoto T, Akino Y, Naito S, Kurokawa M, Iwahori N, Yamashita S (2000) Parathyroid hormone-related peptide is a potent tumor angiogenic factor. Endocrinology 141:4313\u20134316. https:\/\/doi.org\/10.1210\/endo.141.11.7875","journal-title":"Endocrinology"},{"key":"5834_CR17","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/sj.bjc.6600757","volume":"88","author":"RP Hoey","year":"2003","unstructured":"Hoey RP, Sanderson C, Iddon J, Brady G, Bundred NJ, Anderson NG (2003) The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br J Cancer 88:567\u2013573. https:\/\/doi.org\/10.1038\/sj.bjc.6600757","journal-title":"Br J Cancer"},{"key":"5834_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/s0090-4295(96)00182-3","volume":"48","author":"M Iwamura","year":"1996","unstructured":"Iwamura M, Hellman J, Cockett AT, Lilja H, Gershagen S (1996) Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen. Urology 48:317\u2013325. https:\/\/doi.org\/10.1016\/s0090-4295(96)00182-3","journal-title":"Urology"},{"key":"5834_CR19","first-page":"3059","volume":"51","author":"GJ Powell","year":"1991","unstructured":"Powell GJ, Southby J, Danks JA, Stillwell RG, Hayman JA, Henderson MA, Bennett RC, Martin TJ (1991) Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 51:3059\u20133061","journal-title":"Cancer Res"},{"key":"5834_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1196\/annals.1402.046","volume":"1117","author":"M Nishihara","year":"2007","unstructured":"Nishihara M, Kanematsu T, Taguchi T, Razzaque MS (2007) PTHrP and tumorigenesis: is there a role in prognosis? Ann N Y Acad Sci 1117:385\u2013392. https:\/\/doi.org\/10.1196\/annals.1402.046","journal-title":"Ann N Y Acad Sci"},{"key":"5834_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.regpep.2006.12.017","volume":"141","author":"X Shen","year":"2007","unstructured":"Shen X, Mula RV, Evers BM, Falzon M (2007) Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. Regul Pept 141:61\u201372. https:\/\/doi.org\/10.1016\/j.regpep.2006.12.017","journal-title":"Regul Pept"},{"key":"5834_CR22","doi-asserted-by":"publisher","first-page":"826","DOI":"10.4065\/78.7.826","volume":"78","author":"RJ Singh","year":"2003","unstructured":"Singh RJ, Kumar R (2003) Fibroblast growth factor 23 concentrations in humoral hypercalcemia of malignancy and hyperparathyroidism. Mayo Clin Proc 78:826\u2013829. https:\/\/doi.org\/10.4065\/78.7.826","journal-title":"Mayo Clin Proc"},{"key":"5834_CR23","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/s0025-6196(11)61528-0","volume":"80","author":"PJ Tebben","year":"2005","unstructured":"Tebben PJ, Kalli KR, Cliby WA, Hartmann LC, Grande JP, Singh RJ, Kumar R (2005) Elevated fibroblast growth factor 23 in women with malignant ovarian tumors. Mayo Clin Proc 80:745\u2013751. https:\/\/doi.org\/10.1016\/s0025-6196(11)61528-0","journal-title":"Mayo Clin Proc"},{"key":"5834_CR24","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/ijms20030695","volume":"20","author":"A Mansinho","year":"2019","unstructured":"Mansinho A, Ferreira AR, Casimiro S et al (2019) Levels of circulating fibroblast growth factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci 20:695. https:\/\/doi.org\/10.3390\/ijms20030695","journal-title":"Int J Mol Sci"},{"key":"5834_CR25","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s12032-011-0019-5","volume":"29","author":"V Asher","year":"2012","unstructured":"Asher V, Lee J, Bali A (2012) Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer. Med Oncol 29:2005\u20132009. https:\/\/doi.org\/10.1007\/s12032-011-0019-5","journal-title":"Med Oncol"},{"key":"5834_CR26","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/j.1471-0528.1994.tb13550.x","volume":"101","author":"D Parker","year":"1994","unstructured":"Parker D, Bradley C, Bogle SM, Lay J, Masood M, Hancock AK, Naylor B, Price JJ (1994) Serum albumin and CA125 are powerful predictors of survival in epithelial ovarian cancer. Br J Obstet Gynaecol 101:888\u2013893","journal-title":"Br J Obstet Gynaecol"},{"key":"5834_CR27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/0885066613507530","volume":"30","author":"JD Maier","year":"2015","unstructured":"Maier JD, Levine SN (2015) Hypercalcemia in the intensive care unit: a review of pathophysiology, diagnosis, and modern therapy. J Intensive Care Med 30:235\u2013252. https:\/\/doi.org\/10.1177\/0885066613507530","journal-title":"J Intensive Care Med"},{"key":"5834_CR28","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1210\/jc.2012-1429","volume":"97","author":"GS Ong","year":"2012","unstructured":"Ong GS, Walsh JP, Stuckey BG, Brown SJ, Rossi E, Ng JL, Nguyen HH, Kent GN, Lim EM (2012) The importance of measuring ionized calcium in characterizing calcium status and diagnosing primary hyperparathyroidism. J Clin Endocrinol Metab 97:3138\u20133145. https:\/\/doi.org\/10.1210\/jc.2012-1429","journal-title":"J Clin Endocrinol Metab"},{"key":"5834_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3109\/00365518809085762","volume":"48","author":"A Sorva","year":"1988","unstructured":"Sorva A, Elfving S, Pohja P, Tilvis RS (1988) Assessment of calcaemic status in geriatric hospital patients: serum ionized calcium versus albumin-adjusted total calcium. Scand J Clin Lab Invest 48:489\u2013494","journal-title":"Scand J Clin Lab Invest"},{"key":"5834_CR30","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/00000478-199411000-00004","volume":"18","author":"RH Young","year":"1994","unstructured":"Young RH, Oliva E, Scully RE (1994) Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol 18:1102\u20131116","journal-title":"Am J Surg Pathol"},{"issue":"229\u2013234","key":"5834_CR31","first-page":"277","volume":"147","author":"B Piura","year":"2008","unstructured":"Piura B (2008) Hypercalcemia in malignancies of the female genital tract. Harefuah 147(229\u2013234):277","journal-title":"Harefuah"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05834-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-020-05834-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05834-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T05:57:41Z","timestamp":1634623061000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-020-05834-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["5834"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05834-6","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"type":"print","value":"0932-0067"},{"type":"electronic","value":"1432-0711"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Boards of Korea University Medical Center (KUGH17256). Institutional Review Boards of Korea University Medical Center allows the use of medical record without informed consent where data are fully anonymized.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}