{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:08:07Z","timestamp":1781291287266,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>It is still not clear whether to screen women with primary premature ovarian insufficiency for autoimmunity. Moreover, a possible association of autoimmunity with decreased bone mass density in premature ovarian insufficiency patients has not been evaluated. Thus, the objectives of this study were to review our experience with the use of an autoimmune screening panel in premature ovarian insufficiency women and to focus on bone mass density.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a retrospective cohort study, 76 chromosomally normal women with primary premature ovarian insufficiency were included. The main outcome parameters were the results of an autoimmune screening panel and of dual-energy X-ray absorptiometry.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median age was 33\u00a0years. Sixty percent of premature ovarian insufficiency patients revealed abnormal dual-energy X-ray absorptiometry results (minimal T-score\u2009&lt;\u2009\u22121.0). Any signs of autoimmunity were found in 21 women (36.2%). The most frequent abnormal results were increased thyroperoxidase antibodies (24.1%) and thyroglobulin antibodies (20.7%). A longer duration of amenorrhea (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.015; <jats:italic>p<\/jats:italic>\u2009=\u20090.007), any abnormality during autoimmune screening (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009\u22120.940; <jats:italic>p<\/jats:italic>\u2009=\u20090.010), and a lower body mass index (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.057; <jats:italic>p<\/jats:italic>\u2009=\u20090.036) were associated with a lower minimal T-score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In chromosomally normal women with primary premature ovarian insufficiency, the prevalence of autoimmunity and decreased bone mass density seem high. Our data highlight the association between autoimmune abnormalities and decreased dual-energy X-ray absorptiometry results.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-020-05860-4","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T19:03:44Z","timestamp":1604948624000},"page":"1109-1115","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Autoimmunological serum parameters and bone mass density in premature ovarian insufficiency: a retrospective cohort study"],"prefix":"10.1007","volume":"303","author":[{"given":"Klara","family":"Beitl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Rosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Poetsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Seifried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mayrhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrig","family":"Marculescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"issue":"9","key":"5860_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s40618-016-0467-z","volume":"39","author":"A Podfigurna-Stopa","year":"2016","unstructured":"Podfigurna-Stopa A, Czyzyk A, Grymowicz M, Smolarczyk R, Katulski K, Czajkowski K, Meczekalski B (2016) Premature ovarian insufficiency: the context of long-term effects. J Endocrinol Invest 39(9):983\u2013990. https:\/\/doi.org\/10.1007\/s40618-016-0467-z","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"5860_CR2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s40618-014-0231-1","volume":"38","author":"S Luisi","year":"2015","unstructured":"Luisi S, Orlandini C, Regini C, Pizzo A, Vellucci F, Petraglia F (2015) Premature ovarian insufficiency: from pathogenesis to clinical management. J Endocrinol Invest 38(6):597\u2013603. https:\/\/doi.org\/10.1007\/s40618-014-0231-1","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"5860_CR3","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/humrep\/dew027","volume":"31","author":"L Webber","year":"2016","unstructured":"Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B, Cifkova R, de Muinck K-S, Hogervorst E, Janse F, Liao L, Vlaisavljevic V, Zillikens C, Vermeulen N (2016) ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod 31(5):926\u2013937. https:\/\/doi.org\/10.1093\/humrep\/dew027","journal-title":"Hum Reprod"},{"issue":"1","key":"5860_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.maturitas.2010.04.011","volume":"67","author":"S Vujovic","year":"2010","unstructured":"Vujovic S, Brincat M, Erel T, Gambacciani M, Lambrinoudaki I, Moen MH, Schenck-Gustafsson K, Tremollieres F, Rozenberg S, Rees M (2010) EMAS position statement: managing women with premature ovarian failure. Maturitas 67(1):91\u201393. https:\/\/doi.org\/10.1016\/j.maturitas.2010.04.011","journal-title":"Maturitas"},{"issue":"4","key":"5860_CR5","first-page":"604","volume":"67","author":"CB Coulam","year":"1986","unstructured":"Coulam CB, Adamson SC, Annegers JF (1986) Incidence of premature ovarian failure. Obstet Gynecol 67(4):604\u2013606","journal-title":"Obstet Gynecol"},{"issue":"3","key":"5860_CR6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5114\/pm.2018.78552","volume":"17","author":"A Szeliga","year":"2018","unstructured":"Szeliga A, Maciejewska-Jeske M, Meczekalski B (2018) Bone health and evaluation of bone mineral density in patients with premature ovarian insufficiency. Menopause Rev 17(3):112\u2013116. https:\/\/doi.org\/10.5114\/pm.2018.78552","journal-title":"Menopause Rev"},{"issue":"1","key":"5860_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/s0029-7844(97)00583-8","volume":"91","author":"JN Anasti","year":"1998","unstructured":"Anasti JN, Kalantaridou SN, Kimzey LM, Defensor RA, Nelson LM (1998) Bone loss in young women with karyotypically normal spontaneous premature ovarian failure. Obstet Gynecol 91(1):12\u201315. https:\/\/doi.org\/10.1016\/s0029-7844(97)00583-8","journal-title":"Obstet Gynecol"},{"issue":"7","key":"5860_CR8","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1210\/jc.2008-1878","volume":"94","author":"VB Popat","year":"2009","unstructured":"Popat VB, Calis KA, Vanderhoof VH, Cizza G, Reynolds JC, Sebring N, Troendle JF, Nelson LM (2009) Bone mineral density in estrogen-deficient young women. J Clin Endocrinol Metab 94(7):2277\u20132283. https:\/\/doi.org\/10.1210\/jc.2008-1878","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"5860_CR9","doi-asserted-by":"publisher","first-page":"101323","DOI":"10.1016\/j.beem.2019.101323","volume":"33","author":"K Sharif","year":"2019","unstructured":"Sharif K, Watad A, Bridgewood C, Kanduc D, Amital H, Shoenfeld Y (2019) Insights into the autoimmune aspect of premature ovarian insufficiency. Best Pract Res Clin Endocrinol Metab 33(6):101323. https:\/\/doi.org\/10.1016\/j.beem.2019.101323","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"8","key":"5860_CR10","first-page":"461","volume":"13","author":"M Ebrahimi","year":"2015","unstructured":"Ebrahimi M, Akbari Asbagh F (2015) The role of autoimmunity in premature ovarian failure. Iranian J Rep Med 13(8):461\u2013472","journal-title":"Iranian J Rep Med"},{"key":"5860_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2172-15-11","volume":"15","author":"X Zhen","year":"2014","unstructured":"Zhen X, Qiao J, Li R, Wang L, Liu P (2014) Serologic autoimmunologic parameters in women with primary ovarian insufficiency. BMC Immunol 15:11. https:\/\/doi.org\/10.1186\/1471-2172-15-11","journal-title":"BMC Immunol"},{"issue":"6","key":"5860_CR12","doi-asserted-by":"publisher","first-page":"e0196113","DOI":"10.1371\/journal.pone.0196113","volume":"13","author":"C Mendoza-Pinto","year":"2018","unstructured":"Mendoza-Pinto C, Rojas-Villarraga A, Molano-Gonzalez N, Jimenez-Herrera EA, Leon-Vazquez ML, Montiel-Jarquin A, Garcia-Carrasco M, Cervera R (2018) Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: a systematic review and meta-regression. PLoS ONE 13(6):e0196113. https:\/\/doi.org\/10.1371\/journal.pone.0196113","journal-title":"PLoS ONE"},{"issue":"1","key":"5860_CR13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.14310\/horm.2002.1719","volume":"16","author":"SP Polovina","year":"2017","unstructured":"Polovina SP, Miljic D, Zivojinovic S, Milic N, Micic D, Brkic VP (2017) The impact of thyroid autoimmunity (TPOAb) on bone density and fracture risk in postmenopausal women. Hormones (Athens, Greece) 16(1):54\u201361. https:\/\/doi.org\/10.14310\/horm.2002.1719","journal-title":"Hormones (Athens, Greece)"},{"issue":"1","key":"5860_CR14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cgh.2019.05.043","volume":"18","author":"T Schmidt","year":"2020","unstructured":"Schmidt T, Schmidt C, Strahl A, Mussawy H, Rolvien T, Jandl NM, Casar C, Oheim R, Schinke T, Lohse AW, Amling M, Schramm C, Barvencik F (2020) A system to determine risk of osteoporosis in patients with autoimmune hepatitis. Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc 18(1):226-233.e223. https:\/\/doi.org\/10.1016\/j.cgh.2019.05.043","journal-title":"Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc"},{"key":"5860_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bonr.2017.10.003","volume":"7","author":"RA Iseme","year":"2017","unstructured":"Iseme RA, McEvoy M, Kelly B, Agnew L, Walker FR, Attia J (2017) Is osteoporosis an autoimmune mediated disorder? Bone Rep 7:121\u2013131. https:\/\/doi.org\/10.1016\/j.bonr.2017.10.003","journal-title":"Bone Rep"},{"issue":"1","key":"5860_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/09513599809024966","volume":"12","author":"N Doldi","year":"1998","unstructured":"Doldi N, Belvisi L, Bassan M, Fusi FM, Ferrari A (1998) Premature ovarian failure: steroid synthesis and autoimmunity. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol 12(1):23\u201328. https:\/\/doi.org\/10.3109\/09513599809024966","journal-title":"Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol"},{"key":"5860_CR17","doi-asserted-by":"publisher","unstructured":"Crosbie D, Black C, McIntyre L, Royle PL, Thomas S (2007) Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst Rev 4:Cd005114. doi:https:\/\/doi.org\/10.1002\/14651858.CD005114.pub2","DOI":"10.1002\/14651858.CD005114.pub2"},{"issue":"1","key":"5860_CR18","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3109\/13697137.2013.800040","volume":"17","author":"J Ott","year":"2014","unstructured":"Ott J, Pecnik P, Promberger R, Pils S, Seemann R, Hermann M, Frigo P (2014) Dehydroepiandrosterone in women with premature ovarian failure and Hashimoto\u2019s thyroiditis. Clim J Int Menopause Soc 17(1):92\u201396. https:\/\/doi.org\/10.3109\/13697137.2013.800040","journal-title":"Clim J Int Menopause Soc"},{"issue":"1","key":"5860_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13052-017-0355-y","volume":"43","author":"C Ciaccio","year":"2017","unstructured":"Ciaccio C, Fontana L, Milani D, Tabano S, Miozzo M, Esposito S (2017) Fragile X syndrome: a review of clinical and molecular diagnoses. Italian J Pediatrics 43(1):39. https:\/\/doi.org\/10.1186\/s13052-017-0355-y","journal-title":"Italian J Pediatrics"},{"issue":"12","key":"5860_CR20","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1172\/jci63141","volume":"122","author":"C Bagni","year":"2012","unstructured":"Bagni C, Tassone F, Neri G, Hagerman R (2012) Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics. J Clin Investig 122(12):4314\u20134322. https:\/\/doi.org\/10.1172\/jci63141","journal-title":"J Clin Investig"},{"key":"5860_CR21","unstructured":"Prevention and management of osteoporosis (2003) World Health Organization technical report series, vol 921, pp 1\u2013164, back cover"},{"issue":"4","key":"5860_CR22","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.ogc.2012.09.007","volume":"39","author":"S Rafique","year":"2012","unstructured":"Rafique S, Sterling EW, Nelson LM (2012) A new approach to primary ovarian insufficiency. Obstet Gynecol Clin North Am 39(4):567\u2013586. https:\/\/doi.org\/10.1016\/j.ogc.2012.09.007","journal-title":"Obstet Gynecol Clin North Am"},{"key":"5860_CR23","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2147\/vhrm.s9252","volume":"6","author":"MM Ciccone","year":"2010","unstructured":"Ciccone MM, Aquilino A, Cortese F, Scicchitano P, Sassara M, Mola E, Rollo R, Caldarola P, Giorgino F, Pomo V, Bux F (2010) Feasibility and effectiveness of a disease and care management model in the primary health care system for patients with heart failure and diabetes (Project Leonardo). Vasc Health Risk Manag 6:297\u2013305. https:\/\/doi.org\/10.2147\/vhrm.s9252","journal-title":"Vasc Health Risk Manag"},{"issue":"10","key":"5860_CR24","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1001\/archinte.164.10.1108","volume":"164","author":"ES Siris","year":"2004","unstructured":"Siris ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, Berger ML (2004) Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med 164(10):1108\u20131112. https:\/\/doi.org\/10.1001\/archinte.164.10.1108","journal-title":"Arch Intern Med"},{"issue":"3","key":"5860_CR25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1056\/NEJMoa1107142","volume":"366","author":"ML Gourlay","year":"2012","unstructured":"Gourlay ML, Fine JP, Preisser JS, May RC, Li C, Lui LY, Ransohoff DF, Cauley JA, Ensrud KE (2012) Bone-density testing interval and transition to osteoporosis in older women. N Eng J Med 366(3):225\u2013233. https:\/\/doi.org\/10.1056\/NEJMoa1107142","journal-title":"N Eng J Med"},{"issue":"1","key":"5860_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00404-005-0029-7","volume":"273","author":"D Uygur","year":"2005","unstructured":"Uygur D, Seng\u00fcl O, Bayar D, Erdin\u00e7 S, Batio\u011flu S, Mollamahmutoglu L (2005) Bone loss in young women with premature ovarian failure. Arch Gynecol Obstet 273(1):17\u201319. https:\/\/doi.org\/10.1007\/s00404-005-0029-7","journal-title":"Arch Gynecol Obstet"},{"key":"5860_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13060544","author":"A Palermo","year":"2016","unstructured":"Palermo A, Tuccinardi D, Defeudis G, Watanabe M, D\u2019Onofrio L, Lauria Pantano A, Napoli N, Pozzilli P, Manfrini S (2016) BMI and BMD: the potential interplay between obesity and bone fragility. Int J Environ Res Public Health. https:\/\/doi.org\/10.3390\/ijerph13060544","journal-title":"Int J Environ Res Public Health"},{"issue":"11","key":"5860_CR28","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1007\/s00198-005-1863-y","volume":"16","author":"C De Laet","year":"2005","unstructured":"De Laet C, Kanis JA, Od\u00e9n A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteop Int J 16(11):1330\u20131338. https:\/\/doi.org\/10.1007\/s00198-005-1863-y","journal-title":"Osteop Int J"},{"issue":"5","key":"5860_CR29","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1365-2265.1993.tb02403.x","volume":"39","author":"J F\u00f6ldes","year":"1993","unstructured":"F\u00f6ldes J, Tarj\u00e1n G, Szathmari M, Varga F, Krasznai I, Horvath C (1993) Bone mineral density in patients with endogenous subclinical hyperthyroidism: is this thyroid status a risk factor for osteoporosis? Clin Endocrinol 39(5):521\u2013527. https:\/\/doi.org\/10.1111\/j.1365-2265.1993.tb02403.x","journal-title":"Clin Endocrinol"},{"key":"5860_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041034","author":"AP Delitala","year":"2020","unstructured":"Delitala AP, Scuteri A, Doria C (2020) Thyroid hormone diseases and osteoporosis. J Clin Med. https:\/\/doi.org\/10.3390\/jcm9041034","journal-title":"J Clin Med"},{"issue":"1","key":"5860_CR31","first-page":"27","volume":"66","author":"MM Alper","year":"1985","unstructured":"Alper MM, Garner PR (1985) Premature ovarian failure: its relationship to autoimmune disease. Obstet Gynecol 66(1):27\u201330","journal-title":"Obstet Gynecol"},{"issue":"2","key":"5860_CR32","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/s0015-0282(16)58095-9","volume":"65","author":"GS Conway","year":"1996","unstructured":"Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS (1996) Characterization of idiopathic premature ovarian failure. Fertil Steril 65(2):337\u2013341. https:\/\/doi.org\/10.1016\/s0015-0282(16)58095-9","journal-title":"Fertil Steril"},{"issue":"4","key":"5860_CR33","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.sram.2004.11.010","volume":"2","author":"D Lebovic","year":"2004","unstructured":"Lebovic D, Rajesh N (2004) Premature ovarian failure: \u2018think, autoimmune disorder.\u2019 Sex Rep Menopause 2(4):230\u2013233","journal-title":"Sex Rep Menopause"},{"issue":"4","key":"5860_CR34","first-page":"281","volume":"7","author":"R Ko\u0161ir Poga\u010dnik","year":"2014","unstructured":"Ko\u0161ir Poga\u010dnik R, Meden Vrtovec H, Vizjak A, Ur\u0161ula Levi\u010dnik A, Slabe N, Ihan A (2014) Possible role of autoimmunity in patients with premature ovarian insufficiency. Int J Fert Ster 7(4):281\u2013290","journal-title":"Int J Fert Ster"},{"issue":"11","key":"5860_CR35","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1007\/s10815-019-01572-0","volume":"36","author":"M Kirshenbaum","year":"2019","unstructured":"Kirshenbaum M, Orvieto R (2019) Premature ovarian insufficiency (POI) and autoimmunity\u2014an update appraisal. J Assist Reprod Genet 36(11):2207\u20132215. https:\/\/doi.org\/10.1007\/s10815-019-01572-0","journal-title":"J Assist Reprod Genet"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05860-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-020-05860-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05860-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:04:14Z","timestamp":1616418254000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-020-05860-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["5860"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05860-4","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]},"assertion":[{"value":"14 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data will be provided if necessary.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}