{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:17:44Z","timestamp":1793035064676,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00404-020-05888-6","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:02:51Z","timestamp":1605600171000},"page":"1009-1016","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective effect of edaravone against radiation-induced ovarian injury: a histopathological and immunohistochemical evaluation in an experimental rat model"],"prefix":"10.1007","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-7863","authenticated-orcid":false,"given":"\u00dclk\u00fc","family":"Mete Ural","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beril","family":"G\u00fcrlek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Alver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"5888_CR1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/cncr.21324","volume":"104","author":"G Delaney","year":"2005","unstructured":"Delaney G, Jacob S, Featherstone C, Barton M (2005) The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 104:1129\u20131137","journal-title":"Cancer"},{"key":"5888_CR2","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00404-015-3924-6","volume":"293","author":"M Kececi","year":"2016","unstructured":"Kececi M, Akpolat M, Gulle K, Gencer E, Sahbaz A (2016) Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries. Arch Gynecol Obstet 293:1255\u20131262","journal-title":"Arch Gynecol Obstet"},{"key":"5888_CR3","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.fertnstert.2008.07.1714","volume":"92","author":"JS Stroud","year":"2009","unstructured":"Stroud JS, Mutch D, Rader J, Powell M, Thaker PH, Grigsby PW (2009) Effects of cancer treatment on ovarian function. Fertil Steril 92:417\u2013427","journal-title":"Fertil Steril"},{"key":"5888_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1191\/0960327102ht216oa","volume":"21","author":"LE Feinendegen","year":"2002","unstructured":"Feinendegen LE (2002) Reactive oxygen species in cell responses to toxic agents. Hum Exp Toxicol 21:85\u201390","journal-title":"Hum Exp Toxicol"},{"key":"5888_CR5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1582-4934.2001.tb00158.x","volume":"5","author":"N Shinomiya","year":"2001","unstructured":"Shinomiya N (2001) New concepts in radiation-induced apoptosis: \u2018premitotic apoptosis\u2019 and \u2018postmitotic apoptosis.\u2019 J Cell Mol Med 5:240\u2013253","journal-title":"J Cell Mol Med"},{"key":"5888_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1179\/135100005X70224","volume":"10","author":"K England","year":"2005","unstructured":"England K, Cotter TG (2005) Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis. Redox Rep 10:237\u2013245","journal-title":"Redox Rep"},{"key":"5888_CR7","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1210\/jc.2006-0020","volume":"91","author":"W Chemaitilly","year":"2006","unstructured":"Chemaitilly W, Mertens AC, Mitby P, Whitton J, Stovall M, Yasui Y et al (2006) Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab 91:1723\u20131728","journal-title":"J Clin Endocrinol Metab"},{"key":"5888_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jns.2004.03.002","volume":"221","author":"K Toyoda","year":"2004","unstructured":"Toyoda K, Fujii K, Kamouchi M, Nakane H, Arihiro S, Okada Y et al (2004) Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci 221:11\u201317","journal-title":"J Neurol Sci"},{"key":"5888_CR9","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","volume":"16","author":"Writing Group. Edaravone (MCI-186) ALS 19 Study Group","year":"2017","unstructured":"Writing Group. Edaravone (MCI-186) ALS 19 Study Group (2017) Safety and efficacy of edaravone in well-defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16:505\u2013512","journal-title":"Lancet Neurol"},{"key":"5888_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.atherosclerosis.2006.05.040","volume":"191","author":"H Xi","year":"2007","unstructured":"Xi H, Akishita M, Nagai K, Yu W, Hasegawa H, Eto M et al (2007) Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. Atherosclerosis 191:281\u2013289","journal-title":"Atherosclerosis"},{"key":"5888_CR11","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1073\/pnas.1422998112","volume":"112","author":"SS Jiao","year":"2015","unstructured":"Jiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ et al (2015) Edaravone alleviates Alzheimer\u2019s disease-type pathologies and cognitive deficits. Proc Natl Acad Sci USA 112:5225\u20135230","journal-title":"Proc Natl Acad Sci USA"},{"key":"5888_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.physbeh.2015.10.029","volume":"154","author":"CS Sriram","year":"2016","unstructured":"Sriram CS, Jangra A, Gurjar SS, Mohan P, Bezbaruah BK (2016) Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1. Physiol Behav 154:135\u2013144","journal-title":"Physiol Behav"},{"key":"5888_CR13","doi-asserted-by":"publisher","first-page":"e20677","DOI":"10.1371\/journal.pone.0020677","volume":"6","author":"N Xiong","year":"2011","unstructured":"Xiong N, Xiong J, Khare G, Chen C, Huang J, Zhao Y et al (2011) Edaravone guards dopamine neurons in a rotenone model for Parkinson\u2019s disease. PLoS ONE 6:e20677","journal-title":"PLoS ONE"},{"key":"5888_CR14","first-page":"104","volume":"21","author":"M Nagase","year":"2016","unstructured":"Nagase M, Yamamoto Y, Miyazaki Y, Yoshino H (2016) Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration. Redox Rep 21:104\u2013112","journal-title":"Redox Rep"},{"key":"5888_CR15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","volume":"12","author":"H Yoshida","year":"2006","unstructured":"Yoshida H, Yanai H, Namiki Y, Fukatsu-Sasaki K, Furutani N, Tada N (2006) Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 12:9\u201320","journal-title":"CNS Drug Rev"},{"key":"5888_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1742-7843.2011.00763.x","volume":"110","author":"K Srinivasan","year":"2012","unstructured":"Srinivasan K, Sharma SS (2012) Edaravone offers neuroprotection in a diabetic stroke model via inhibition of endoplasmic reticulum stress. Basic Clin Pharmacol Toxicol 110:133\u2013140","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"5888_CR17","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1016\/j.bmcl.2016.03.024","volume":"26","author":"N Polkam","year":"2016","unstructured":"Polkam N, Ramaswamy VR, Rayam P, Allaka TR, Anantaraju HS, Dharmarajan S et al (2016) Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives. Bioorg Med Chem Lett 26:2562\u20132568","journal-title":"Bioorg Med Chem Lett"},{"key":"5888_CR18","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s11255-015-1070-5","volume":"47","author":"L Liu","year":"2015","unstructured":"Liu L, Song Y, Zhao M, Yi Z, Zeng Q (2015) Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis. Int Urol Nephrol 47:1745\u20131752","journal-title":"Int Urol Nephrol"},{"key":"5888_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0014-2999(03)01463-8","volume":"465","author":"Y Okatani","year":"2003","unstructured":"Okatani Y, Wakatsuki A, Enzan H, Miyahara Y (2003) Edaravone protects against ischemia\/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 465:163\u2013170","journal-title":"Eur J Pharmacol"},{"key":"5888_CR20","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1269\/jrr.45.319","volume":"45","author":"K Anzai","year":"2004","unstructured":"Anzai K, Furuse M, Yoshida A, Matsuyama A, Moritake T, Tsuboi K et al (2004) In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug. J Radiat Res 45:319\u2013323","journal-title":"J Radiat Res"},{"key":"5888_CR21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/jcb.29382","volume":"121","author":"X Zhang","year":"2020","unstructured":"Zhang X, Ye G, Wu Z, Zou K, He X, Xu X et al (2020) The therapeutic effects of edaravone on collagen-induced arthritis in rats. J Cell Biochem 121:1463\u20131474","journal-title":"J Cell Biochem"},{"key":"5888_CR22","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jphs.2015.02.001","volume":"127","author":"N Nakajima","year":"2015","unstructured":"Nakajima N, Watanabe S, Kiyoi T, Tanaka A, Suemaru K, Araki H (2015) Evaluation of edaravone against radiation-induced oral mucositis in mice. J Pharmacol Sci 127:339\u2013343","journal-title":"J Pharmacol Sci"},{"key":"5888_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mrfmmm.2009.05.002","volume":"669","author":"N Camats","year":"2009","unstructured":"Camats N, Garc\u00eda F, Parrilla JJ, Calaf J, Mart\u00edn-Mateo M, Cald\u00e9s MG (2009) The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats. Mutat Res 669:67\u201379","journal-title":"Mutat Res"},{"key":"5888_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.mrfmmm.2005.05.019","volume":"578","author":"CJ Lee","year":"2005","unstructured":"Lee CJ, Yoon YD (2005) Gamma-radiation-induced follicular degeneration in the prepubertal mouse ovary. Mutat Res 578:247\u2013255","journal-title":"Mutat Res"},{"key":"5888_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.reprotox.2013.11.005","volume":"43","author":"RS Said","year":"2014","unstructured":"Said RS, Badr AM, Nada AS, El-Demerdash E (2014) Sodium selenite treatment restores long-lasting ovarian damage induced by irradiation in rats: impact on oxidative stress and apoptosis. Reprod Toxicol 43:85\u201393","journal-title":"Reprod Toxicol"},{"key":"5888_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5653\/cerm.2019.00143","volume":"46","author":"B Wiweko","year":"2019","unstructured":"Wiweko B, Soebijanto S, Boediono A, Mansyur M, Siregar NC, Suryandari DA et al (2019) Survival of isolated human preantral follicles after vitrification: analyses of morphology and fas ligand and caspase-3 mRNA expression. Clin Exp Reprod Med 46:152\u2013165","journal-title":"Clin Exp Reprod Med"},{"key":"5888_CR27","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/1933719115620493","volume":"23","author":"LL Damous","year":"2016","unstructured":"Damous LL, Silva SM, Carbonel AA, Sim\u00f5es Mde J, Baracat EC, Montero EF (2016) Progressive evaluation of apoptosis, proliferation, and angiogenesis in fresh rat ovarian autografts under remote \u0131schemic preconditioning. Reprod Sci 23:803\u2013811","journal-title":"Reprod Sci"},{"key":"5888_CR28","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/80442","volume":"6","author":"Y Morita","year":"2000","unstructured":"Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A et al (2000) Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med 6:1109\u20131114","journal-title":"Nat Med"},{"key":"5888_CR29","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jpag.2012.04.001","volume":"25","author":"Y Simsek","year":"2012","unstructured":"Simsek Y, Gurocak S, Turkoz Y, Akpolat N, Celik O, Ozer A et al (2012) Ameliorative effects of resveratrol on acute ovarian toxicity induced by total body irradiation in young adult rats. J Pediatr Adolesc Gynecol 25:262\u2013266","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"5888_CR30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.canlet.2009.12.020","volume":"293","author":"N Sasano","year":"2010","unstructured":"Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A et al (2010) Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. Cancer Lett 293:52\u201357","journal-title":"Cancer Lett"},{"key":"5888_CR31","doi-asserted-by":"publisher","first-page":"105967","DOI":"10.1016\/j.intimp.2019.105967","volume":"77","author":"C Bailly","year":"2019","unstructured":"Bailly C (2019) Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. Int Immunopharmacol 77:105967","journal-title":"Int Immunopharmacol"},{"key":"5888_CR32","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.bmcl.2014.01.045","volume":"24","author":"E Kamogawa","year":"2014","unstructured":"Kamogawa E, Sueishi Y (2014) A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. Bioorg Med Chem Lett 24:1376\u20131379","journal-title":"Bioorg Med Chem Lett"},{"key":"5888_CR33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jns.2014.05.051","volume":"343","author":"B Cheng","year":"2014","unstructured":"Cheng B, Guo Y, Li C, Ji B, Pan Y, Chen J et al (2014) Edaravone protected PC12 cells against MPP(+)-cytoxicity via inhibiting oxidative stress and up-regulating heme oxygenase-1 expression. J Neurol Sci 343:115\u2013119","journal-title":"J Neurol Sci"},{"key":"5888_CR34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1527-3466.2008.00041.x","volume":"26","author":"T Watanabe","year":"2008","unstructured":"Watanabe T, Tahara M, Todo S (2008) The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 26:101\u2013114","journal-title":"Cardiovasc Ther"},{"key":"5888_CR35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1080\/17482960600881870","volume":"7","author":"H Yoshino","year":"2006","unstructured":"Yoshino H, Kimura A (2006) Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study). Amyotroph Lateral Scler 7:241\u2013245","journal-title":"Amyotroph Lateral Scler"},{"key":"5888_CR36","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1227\/01.NEU.0000338067.83059.EB","volume":"64","author":"A Munakata","year":"2009","unstructured":"Munakata A, Ohkuma H, Nakano T, Shimamura N, Asano K, Naraoka M (2009) Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. Neurosurgery 64:428\u2013429","journal-title":"Neurosurgery"},{"key":"5888_CR37","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1177\/1753944716630653","volume":"10","author":"MQ Hassan","year":"2016","unstructured":"Hassan MQ, Akhtar MS, Akhtar M, Ali J, Haque SE, Najmi AK (2016) Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage. Ther Adv Cardiovasc Dis 10:214\u2013223","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"5888_CR38","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.ajem.2016.06.084","volume":"34","author":"T Qin","year":"2016","unstructured":"Qin T, Lei LY, Li N, Shi FR, Chen MH, Xie L (2016) Edaravone improves survival and neurological outcomes after CPR in a ventricular fibrillation model of rats. Am J Emerg Med 34:1944\u20131949","journal-title":"Am J Emerg Med"},{"key":"5888_CR39","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1139\/cjpp-2015-0587","volume":"94","author":"L Ji","year":"2016","unstructured":"Ji L, Liu Y, Zhang Y, Chang W, Gong J, Wei S et al (2016) The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts. Can J Physiol Pharmacol 94:996\u20131006","journal-title":"Can J Physiol Pharmacol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05888-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00404-020-05888-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05888-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:04:52Z","timestamp":1616418292000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00404-020-05888-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["5888"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05888-6","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"18 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The approval of the local ethics committee for animal experiments was obtained before the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}