{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:38:16Z","timestamp":1761514696570,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00404-020-05914-7","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T23:02:40Z","timestamp":1609628560000},"page":"1255-1261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single- versus multiple-dose methotrexate in cesarean scar pregnancies management: treatment and reproductive outcomes"],"prefix":"10.1007","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1282-5379","authenticated-orcid":false,"given":"Gabriel","family":"Levin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Shai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri P.","family":"Dior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Gilad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher","family":"Shushan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Benshushan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Or","family":"Tuval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Ben-David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Mashiach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raanan","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"5914_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/uog.56","volume":"21","author":"D Jurkovic","year":"2003","unstructured":"D Jurkovic K Hillaby B Woelfer A Lawrence R Salim CJ Elson 2003 First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment Cesarean section scar Ultrasound Obstet Gynecol 21 220 227","journal-title":"Ultrasound Obstet Gynecol"},{"key":"5914_CR2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/uog.974","volume":"23","author":"KM Seow","year":"2004","unstructured":"KM Seow LW Huang YH Lin MY Lin YL Tsai JL Hwang 2004 Cesarean scar pregnancy: issues in management Ultrasound Obstet Gynecol 23 247 253","journal-title":"Ultrasound Obstet Gynecol"},{"key":"5914_CR3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1471-0528.2006.01237.x","volume":"114","author":"A Ash","year":"2007","unstructured":"A Ash A Smith D Maxwell 2007 Caesarean scar pregnancy BJOG 114 253 263","journal-title":"BJOG"},{"key":"5914_CR4","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/01.AOG.0000218690.24494.ce","volume":"107","author":"MA Rotas","year":"2006","unstructured":"MA Rotas S Haberman M Levgur 2006 Cesarean scar ectopic pregnancies: etiology, diagnosis, and management Obstet Gynecol 107 1373 1381","journal-title":"Obstet Gynecol"},{"key":"5914_CR5","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1097\/AOG.0000000000002560","volume":"131","author":"ACOG Practice Bulletin No. 193","year":"2018","unstructured":"ACOG Practice Bulletin No. 193 2018 Tubal ectopic pregnancy Obstet Gynecol 131 e91 e103","journal-title":"Obstet Gynecol"},{"key":"5914_CR6","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jogc.2017.01.027","volume":"39","author":"J Papillon-Smith","year":"2017","unstructured":"J Papillon-Smith ML Sobel KM Niles MJ Solnik A Murji 2017 Surgical management algorithm for caesarean scar pregnancy J Obstet Gynaecol Can 39 619 626","journal-title":"J Obstet Gynaecol Can"},{"key":"5914_CR7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1067\/mob.2002.125998","volume":"187","author":"DL Fylstra","year":"2002","unstructured":"DL Fylstra T Pound-Chang MG Miller A Cooper KM Miller 2002 Ectopic pregnancy within a cesarean delivery scar: a case report Am J Obstet Gynecol 187 302 304","journal-title":"Am J Obstet Gynecol"},{"key":"5914_CR8","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.rbmo.2019.05.015","volume":"39","author":"G Levin","year":"2019","unstructured":"G Levin R Zigron UP Dior  2019 Conservative management of Caesarean scar pregnancies with systemic multidose methotrexate: predictors of treatment failure and reproductive outcomes Reprod Biomed Online 39 827 834","journal-title":"Reprod Biomed Online"},{"key":"5914_CR9","doi-asserted-by":"publisher","first-page":"B2","DOI":"10.1016\/j.ajog.2020.01.030","volume":"222","author":"R Miller","year":"2020","unstructured":"R Miller IE Timor-Tritsch C Gyamfi-Bannerman pubs@smfm.org SfM-FMSEa 2020 Society for Maternal-Fetal Medicine (SMFM) Consult Series #49: Cesarean scar pregnancy Am J Obstet Gynecol 222 B2 B14","journal-title":"Am J Obstet Gynecol"},{"key":"5914_CR10","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.fertnstert.2015.12.130","volume":"105","author":"K Birch Petersen","year":"2016","unstructured":"K Birch Petersen E Hoffmann C Rifbjerg Larsen NH Svarre 2016 Cesarean scar pregnancy: a systematic review of treatment studies Fertil Steril 105 958 967","journal-title":"Fertil Steril"},{"issue":"356","key":"5914_CR11","first-page":"e1","volume":"211","author":"J Xiao","year":"2014","unstructured":"J Xiao S Zhang F Wang  2014 Cesarean scar pregnancy: noninvasive and effective treatment with high-intensity focused ultrasound Am J Obstet Gynecol 211 356 e1 7","journal-title":"Am J Obstet Gynecol"},{"key":"5914_CR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ajog.2012.03.007","volume":"207","author":"IE Timor-Tritsch","year":"2012","unstructured":"IE Timor-Tritsch A Monteagudo 2012 Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review Am J Obstet Gynecol 207 14 29","journal-title":"Am J Obstet Gynecol"},{"key":"5914_CR13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/OGX.0000000000000561","volume":"73","author":"TL Glenn","year":"2018","unstructured":"TL Glenn J Bembry AD Findley  2018 Cesarean scar ectopic pregnancy: current management strategies Obstet Gynecol Surv 73 293 302","journal-title":"Obstet Gynecol Surv"},{"key":"5914_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/01443615.2018.1499714","volume":"39","author":"AE Tahaoglu","year":"2019","unstructured":"AE Tahaoglu Y Dogan MS Bakir  2019 A single centre's experience of caesarean scar pregnancy and proposal of a management algorithm J Obstet Gynaecol 39 259 264","journal-title":"J Obstet Gynaecol"},{"key":"5914_CR15","first-page":"18972","volume":"8","author":"M Wang","year":"2015","unstructured":"M Wang Z Yang Y Li  2015 Conservative management of cesarean scar pregnancies: a prospective randomized controlled trial at a single center Int J Clin Exp Med 8 18972 18980","journal-title":"Int J Clin Exp Med"},{"issue":"44","key":"5914_CR16","first-page":"e1","volume":"207","author":"IE Timor-Tritsch","year":"2012","unstructured":"IE Timor-Tritsch A Monteagudo R Santos T Tsymbal G Pineda AA Arslan 2012 The diagnosis, treatment, and follow-up of cesarean scar pregnancy Am J Obstet Gynecol 207 44 e1 13","journal-title":"Am J Obstet Gynecol"},{"key":"5914_CR17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.rbmo.2017.01.004","volume":"34","author":"C Yang","year":"2017","unstructured":"C Yang J Cai Y Geng Y Gao 2017 Multiple-dose and double-dose versus single-dose administration of methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis Reprod Biomed Online 34 383 391","journal-title":"Reprod Biomed Online"},{"key":"5914_CR18","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1080\/13625187.2017.1412426","volume":"22","author":"G Levin","year":"2017","unstructured":"G Levin HH Chill A Rottenstreich 2017 Transverse myelitis following methotrexate treatment of ectopic pregnancy: a case report Eur J Contracept Reprod Health Care 22 476 478","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"5914_CR19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.7863\/ultra.34.4.601","volume":"34","author":"IE Timor-Tritsch","year":"2015","unstructured":"IE Timor-Tritsch N Khatib A Monteagudo J Ramos R Berg S Kov\u00e1cs 2015 Cesarean scar pregnancies: experience of 60 cases J Ultrasound Med 34 601 610","journal-title":"J Ultrasound Med"},{"key":"5914_CR20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jmig.2015.04.008","volume":"22","author":"VY Cheung","year":"2015","unstructured":"VY Cheung 2015 Local methotrexate injection as the first-line treatment for cesarean scar pregnancy: review of the literature J Minim Invasive Gynecol 22 753 758","journal-title":"J Minim Invasive Gynecol"},{"key":"5914_CR21","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1097\/AOG.0000000000002940","volume":"132","author":"O Grechukhina","year":"2018","unstructured":"O Grechukhina U Deshmukh L Fan  2018 Cesarean Scar pregnancy, incidence, and recurrence: five-year experience at a single tertiary care referral center Obstet Gynecol 132 1285 1295","journal-title":"Obstet Gynecol"},{"key":"5914_CR22","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1093\/humrep\/dem078","volume":"22","author":"J Ben Nagi","year":"2007","unstructured":"J Ben Nagi S Helmy D Ofili-Yebovi J Yazbek E Sawyer D Jurkovic 2007 Reproductive outcomes of women with a previous history of Caesarean scar ectopic pregnancies Hum Reprod 22 2012 2015","journal-title":"Hum Reprod"},{"key":"5914_CR23","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1111\/jog.12414","volume":"40","author":"MS Kutuk","year":"2014","unstructured":"MS Kutuk G Uysal M Dolanbay MT Ozgun 2014 Successful medical treatment of cesarean scar ectopic pregnancies with systemic multidose methotrexate: single-center experience J Obstet Gynaecol Res 40 1700 1706","journal-title":"J Obstet Gynaecol Res"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05914-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-020-05914-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-020-05914-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T14:07:38Z","timestamp":1618668458000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-020-05914-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,2]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["5914"],"URL":"https:\/\/doi.org\/10.1007\/s00404-020-05914-7","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"type":"print","value":"0932-0067"},{"type":"electronic","value":"1432-0711"}],"subject":[],"published":{"date-parts":[[2021,1,2]]},"assertion":[{"value":"25 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study, formal consent is not required and was waived by the institutional review board approval. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"IRB approval of Hadassah Medical Center and Chaim Sheba Medical Centers were obtained for this study. Informed consent was waved by authorization by both IRBs (5663-18-SMC and 0154\u201016\u2010HMO).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}