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Although being a target of diabetes complications, the influence of high glucose on this compartment has been poorly investigated. Both miRNAs and IGF1R are associated with diabetic complications in different tissues. Herein, we examined the effects of high glucose on the expression of miRNAs and IGF1R signaling pathway in the human myometrium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Human myometrial explants were cultivated for 48\u00a0h under either high or low glucose conditions. Thereafter, the conditioned medium was collected for biochemical analyses and the myometrial samples were processed for histological examination as well as miRNA and mRNA expression profiling by qPCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Myometrial structure and morphology were well preserved after 48\u00a0h of cultivation in both high and low glucose conditions. Levels of lactate, creatinine, LDH and estrogen in the supernatant were similar between groups. An explorative screening by qPCR arrays revealed that 6 out of 754 investigated miRNAs were differentially expressed in the high glucose group. Data validation by single qPCR assays confirmed diminished expression of miR-215-5p and miR-296-5p, and also revealed reduced miR-497-3p levels. Accordingly, mRNA levels of <jats:italic>IGF1R<\/jats:italic> and its downstream mediators <jats:italic>FOXO3<\/jats:italic> and <jats:italic>PDCD4,<\/jats:italic> which are potentially targeted by miR-497-3p, were elevated under high glucose conditions. In contrast, mRNA expression of <jats:italic>IGF1<\/jats:italic>, <jats:italic>PTEN, and GLUT1<\/jats:italic> was unchanged.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The human myometrium responds to short-term exposure (48\u00a0h) to high glucose concentrations by regulating the expression of miRNAs, <jats:italic>IGF1R<\/jats:italic> and its downstream targets.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-020-05940-5","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T19:08:10Z","timestamp":1613070490000},"page":"1513-1522","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of high glucose in the expression of miRNAs and IGF1R signaling pathway in human myometrial explants"],"prefix":"10.1007","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-5921","authenticated-orcid":false,"given":"Rodolfo R.","family":"Favaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Morales-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Sonnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Schleussner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo R.","family":"Markert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telma M. 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