{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:40:42Z","timestamp":1790811642761,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00404-021-05980-5","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T05:59:29Z","timestamp":1612850369000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis"],"prefix":"10.1007","volume":"304","author":[{"given":"Cui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Zhong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-5153","authenticated-orcid":false,"given":"Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"issue":"24","key":"5980_CR1","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1001\/jama.2018.17953","volume":"320","author":"AN Peiris","year":"2018","unstructured":"Peiris AN, Chaljub E, Medlock D (2018) Endometriosis [J]. JAMA 320(24):2608","journal-title":"JAMA"},{"issue":"3","key":"5980_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/AOG.0000000000002469","volume":"131","author":"T Falcone","year":"2018","unstructured":"Falcone T, Flyckt R (2018) Clinical management of endometriosis [J]. Obstet Gynecol 131(3):557\u2013571","journal-title":"Obstet Gynecol"},{"issue":"3","key":"5980_CR3","first-page":"273","volume":"23","author":"MGD Broi","year":"2019","unstructured":"Broi MGD, Ferriani RA, Navarro PA (2019) Ethiopathogenic mechanisms of endometriosis-related infertility [J]. JBRA Assist Reprod 23(3):273\u2013280","journal-title":"JBRA Assist Reprod"},{"issue":"11","key":"5980_CR4","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","volume":"15","author":"C Chapron","year":"2019","unstructured":"Chapron C, Marcellin L, Borghese B et al (2019) Rethinking mechanisms, diagnosis and management of endometriosis [J]. Nat Rev Endocrinol 15(11):666\u2013682","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"5980_CR5","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","volume":"98","author":"RO Burney","year":"2012","unstructured":"Burney RO, Giudice LC (2012) Pathogenesis and pathophysiology of endometriosis [J]. Fertil Steril 98(3):511\u2013519","journal-title":"Fertil Steril"},{"issue":"11","key":"5980_CR6","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1177\/1933719115584448","volume":"22","author":"C Yildiz","year":"2015","unstructured":"Yildiz C, Kacan T, Akkar OB et al (2015) Effects of pazopanib, sunitinib, and sorafenib, anti-vegf agents, on the growth of experimental endometriosis in rats [J]. Reprod Sci 22(11):1445\u20131451","journal-title":"Reprod Sci"},{"issue":"5 Suppl","key":"5980_CR7","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.fertnstert.2007.06.060","volume":"89","author":"A Salmassi","year":"2008","unstructured":"Salmassi A, Acil Y, Schmutzler AG et al (2008) Differential interleukin-6 messenger ribonucleic acid expression and its distribution pattern in eutopic and ectopic endometrium [J]. Fertil Steril 89(5 Suppl):1578\u20131584","journal-title":"Fertil Steril"},{"issue":"2","key":"5980_CR8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1530\/jrf.0.1010421","volume":"101","author":"DS Charnock-Jones","year":"1994","unstructured":"Charnock-Jones DS, Sharkey AM, Fenwick P et al (1994) Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time[J]. J Reprod Fertil 101(2):421\u2013426","journal-title":"J Reprod Fertil"},{"issue":"7","key":"5980_CR9","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1161\/ATVBAHA.107.143081","volume":"27","author":"G Rega","year":"2007","unstructured":"Rega G, Kaun C, Demyanets S et al (2007) Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin-6 and oncostatin m in human adipose tissue in vitro and in murine adipose tissue in vivo [J]. Arterioscler Thromb Vasc Biol 27(7):1587\u20131595","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5980_CR10","unstructured":"Endometriosis Collaborative Group, Obstetrics and Gynecology Branch, Chinese Medical Association. Guidelines for the diagnosis and treatment of endometriosis [J]. 2015(3):161\u2013169"},{"issue":"4","key":"5980_CR11","first-page":"280","volume":"21","author":"SQ Chen","year":"2012","unstructured":"Chen SQ, Jin WY, Huang JM et al (2012) Isolation and culture of human endometrial cells by modified screen method [J]. Progress Modern Obstetrics Gynecol 21(4):280\u2013285","journal-title":"Progress Modern Obstetrics Gynecol"},{"issue":"35","key":"5980_CR12","first-page":"4905","volume":"44","author":"Y Liu","year":"2015","unstructured":"Liu Y, Li WH, Wei WY (2015) Isolation and identification of primary human endometrial cells [J]. Chongqing Med 44(35):4905","journal-title":"Chongqing Med"},{"key":"5980_CR13","unstructured":"Wang X (2005) Effects of interleukin-6 cytokines on proliferation and differentiation of adult myoblasts [D]. PLA Academy of Military Medical Sciences; PLA Academy of Military Medical Sciences"},{"issue":"1","key":"5980_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.rbmo.2017.09.015","volume":"36","author":"G Benagiano","year":"2018","unstructured":"Benagiano G, Guo SW, Puttemans P et al (2018) Progress in the diagnosis and management of adolescent endometriosis: an opinion [J]. Reprod Biomed Online 36(1):102\u2013114","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"5980_CR15","doi-asserted-by":"publisher","first-page":"386","DOI":"10.2174\/1567201816666181227112421","volume":"16","author":"M Ilhan","year":"2019","unstructured":"Ilhan M, G\u00fcra\u011fa\u00e7Dereli FT, Akkol EK (2019) Novel drug targets with traditional herbal medicines for overcoming endometriosis [J]. Curr Drug Deliv 16(5):386\u2013399","journal-title":"Curr Drug Deliv"},{"key":"5980_CR16","first-page":"577","volume":"4","author":"M Lin","year":"2014","unstructured":"Lin M, Wang Y, Dong K, Yang HH, Lv JQ (2014) Expression of nuclear factor kappaB, MCP-1 and RANTES concentration in peritoneal fluid in women with endometriosis [J]. J Practical Med 4:577\u2013579","journal-title":"J Practical Med"},{"issue":"3","key":"5980_CR17","first-page":"455","volume":"17","author":"XY Gong","year":"2019","unstructured":"Gong XY, Xu P, Ge CY et al (2019) Research progress on IL-6 in ovarian cancer [J]. Appl J General Practice 17(3):455\u2013458","journal-title":"Appl J General Practice"},{"issue":"001","key":"5980_CR18","first-page":"53","volume":"30","author":"DJ Zhu","year":"2019","unstructured":"Zhu DJ, Ye M (2019) The clinical value of IL-6, IL-8, MCP-1 and TNF-\u03b1 in the diagnosis of endometriosis [J]. Chinese J Reprod Health 30(001):53\u201356","journal-title":"Chinese J Reprod Health"},{"issue":"2","key":"5980_CR19","first-page":"945","volume":"43","author":"J Cheng","year":"2019","unstructured":"Cheng J, Yang HL, Gu CJ et al (2019) Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1\u03b1\/ROS\/VEGF [J]. Int J Mol Med 43(2):945\u2013955","journal-title":"Int J Mol Med"},{"issue":"006","key":"5980_CR20","first-page":"569","volume":"035","author":"SJ Jiang","year":"2019","unstructured":"Jiang SJ, Liang SR, Zhang XQ et al (2019) Research progress of IL-6\/IL-6 receptor axis and its targeted inhibitors [J]. Chinese J Cell Mol Immunol 035(006):569\u2013574","journal-title":"Chinese J Cell Mol Immunol"},{"key":"5980_CR21","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.12659\/MSM.905226","volume":"23","author":"S Li","year":"2017","unstructured":"Li S, Fu X, Wu T et al (2017) Role of interleukin-6 and its receptor in endometriosis [J]. Med Sci Monit 23:3801\u20133807","journal-title":"Med Sci Monit"},{"issue":"1","key":"5980_CR22","first-page":"57","volume":"16","author":"HY Xu","year":"2007","unstructured":"Xu HY, Cao YM, Li JX et al (2007) Study on the relationship between IL-6 and the pathogenesis of endometriosis [J]. Progress Modern Obstetrics Gynecol 16(1):57\u201359","journal-title":"Progress Modern Obstetrics Gynecol"},{"issue":"21","key":"5980_CR23","first-page":"3025","volume":"25","author":"YH Pan","year":"2010","unstructured":"Pan YH, Tao DY, Niu ZH et al (2010) Study on the correlation between the expression of LIF in endometrium and follicular fluid and pregnancy outcome in patients with endometriosis during IVF treatment cycle [J]. Maternal Child Health Care China 25(21):3025\u20133025","journal-title":"Maternal Child Health Care China"},{"issue":"01","key":"5980_CR24","first-page":"7","volume":"22","author":"Y Li","year":"2016","unstructured":"Li Y, Zhu J (2016) Expression of iNOS and VEGF in endometriosis [J]. Hebei Med 22(01):7\u20139","journal-title":"Hebei Med"},{"issue":"01","key":"5980_CR25","first-page":"34","volume":"24","author":"CF Yu","year":"2016","unstructured":"Yu CF, Ye LJ, Duan DR et al (2016) Expression and significance of MMP-2, MMP-9 and VEGF in endometriosis [J]. Chinese J Birth Health Heredity 24(01):34\u201335","journal-title":"Chinese J Birth Health Heredity"},{"key":"5980_CR26","unstructured":"Wang XF (2009) Expression of MIP-1\u03b2 and LIF in the endometrium during window period of endometriosis [D]. Central South University"},{"issue":"4","key":"5980_CR27","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/1933719115607978","volume":"23","author":"I Filippi","year":"2016","unstructured":"Filippi I, Carrarelli P, Luisi S et al (2016) Different expression of hypoxic and angiogenic factors in human endometriotic lesions [J]. Reprod Sci 23(4):492\u2013497","journal-title":"Reprod Sci"},{"issue":"11","key":"5980_CR28","doi-asserted-by":"publisher","first-page":"e0166658","DOI":"10.1371\/journal.pone.0166658","volume":"11","author":"S Liu","year":"2016","unstructured":"Liu S, Xin X, Hua T et al (2016) Efficacy of anti-VEGF\/VEGFR agents on animal models of endometriosis: a systematic review and Meta-analysis [J]. PLoS ONE 11(11):e0166658","journal-title":"PLoS ONE"},{"issue":"03","key":"5980_CR29","first-page":"243","volume":"29","author":"CD Feng","year":"2013","unstructured":"Feng CD, Wang FL, Yuan F et al (2013) Expression of IL-17, IL-6 and TGF-\u03b2 in tissues of patients with endometriosis [J]. Chinese J Immunol 29(03):243\u2013246","journal-title":"Chinese J Immunol"},{"issue":"003","key":"5980_CR30","first-page":"338","volume":"028","author":"Q Hu","year":"2020","unstructured":"Hu Q, Xu L (2020) Expression of miR-223-3p and LIF in endometrial tissue of infertile patients with endometriosis [J]. Chinese J Family Planning 028(003):338\u2013341","journal-title":"Chinese J Family Planning"},{"issue":"11","key":"5980_CR31","first-page":"1946","volume":"22","author":"ZH Chen","year":"2018","unstructured":"Chen ZH, Li AJ, Bai J et al (2018) Expression and significance of serum VEGF, HE4 and MMP-9 in patients with endometriosis [J]. Chinese J Lab Diag 22(11):1946\u20131948","journal-title":"Chinese J Lab Diag"},{"issue":"6","key":"5980_CR32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/molehr\/gal041","volume":"12","author":"I Velasco","year":"2006","unstructured":"Velasco I, Rueda J, Aci\u00e9n P (2006) Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis [J]. Mol Hum Reprod 12(6):377\u2013381","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"5980_CR33","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s13075-014-0416-1","volume":"16","author":"AL Binch","year":"2014","unstructured":"Binch AL, Cole AA, Breakwell LM et al (2014) Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [J]. Arthritis Res Ther 16(5):416","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"5980_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ni.3153","volume":"16","author":"CA Hunter","year":"2015","unstructured":"Hunter CA, Jones SA (2015) IL-6 as a keystone cytokine in health and disease [J]. Nat Immunol 16(5):448\u2013457","journal-title":"Nat Immunol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-05980-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-021-05980-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-05980-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T11:06:07Z","timestamp":1622286367000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-021-05980-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,8]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["5980"],"URL":"https:\/\/doi.org\/10.1007\/s00404-021-05980-5","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,8]]},"assertion":[{"value":"29 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Ethics Committee of Linyi Central Hospital (No.LY19-208). Written informed consent was obtained from all the study subjects before enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}