{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:41:03Z","timestamp":1781376063789,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00404-021-06015-9","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T16:03:17Z","timestamp":1617206597000},"page":"1599-1606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Identification of potential biomarkers and metabolic pathways based on integration of metabolomic and transcriptomic data in the development of breast cancer"],"prefix":"10.1007","volume":"303","author":[{"given":"Yifei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-0083","authenticated-orcid":false,"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"issue":"1","key":"6015_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s10926-018-9762-1","volume":"29","author":"SX Luo","year":"2019","unstructured":"Luo SX, Liu JE, Cheng ASK, Xiao SQ, Su YL, Feuerstein M (2019) Breast cancer survivors report similar concerns related to return to work in developed and developing nations. J Occup Rehabil 29(1):42\u201351. https:\/\/doi.org\/10.1007\/s10926-018-9762-1","journal-title":"J Occup Rehabil"},{"issue":"10099","key":"6015_CR2","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","volume":"390","author":"CE Coles","year":"2017","unstructured":"Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, Bhattacharya IS, Brunt AM, Ciurlionis L, Chan C, Donovan EM, Emson MA, Harnett AN, Haviland JS, Hopwood P, Jefford ML, Kaggwa R, Sawyer EJ, Syndikus I, Tsang YM, Wheatley DA, Wilcox M, Yarnold JR, Bliss JM (2017) Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. Lancet 390(10099):1048\u20131060. https:\/\/doi.org\/10.1016\/S0140-6736(17)31145-5","journal-title":"Lancet"},{"key":"6015_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-319-70197-4_7","volume":"173","author":"MS Moran","year":"2018","unstructured":"Moran MS (2018) Advancements and personalization of breast cancer treatment strategies in radiation therapy. Cancer Treat Res 173:89\u2013119. https:\/\/doi.org\/10.1007\/978-3-319-70197-4_7","journal-title":"Cancer Treat Res"},{"issue":"1","key":"6015_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1023\/B:BREA.0000018424.43445.f3","volume":"84","author":"M Lin","year":"2004","unstructured":"Lin M, van Golen KL (2004) Rho-regulatory proteins in breast cancer cell motility and invasion. Breast Cancer Res Treat 84(1):49\u201360. https:\/\/doi.org\/10.1023\/B:BREA.0000018424.43445.f3","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"6015_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/ijc.11186","volume":"106","author":"CL Carpenter","year":"2003","unstructured":"Carpenter CL, Ross RK, Paganini-Hill A, Bernstein L (2003) Effect of family history, obesity and exercise on breast cancer risk among postmenopausal women. Int J Cancer 106(1):96\u2013102. https:\/\/doi.org\/10.1002\/ijc.11186","journal-title":"Int J Cancer"},{"issue":"5","key":"6015_CR6","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3390\/ijms18051101","volume":"18","author":"J Ettlin","year":"2017","unstructured":"Ettlin J, Clementi E, Amini P, Malbon A, Markkanen E (2017) Analysis of gene expression signatures in cancer-associated stroma from canine mammary tumours reveals molecular homology to human breast carcinomas. Int J Mol Sci 18(5):1101. https:\/\/doi.org\/10.3390\/ijms18051101","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6015_CR7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cels.2017.12.001","volume":"6","author":"D Schulz","year":"2018","unstructured":"Schulz D, Zanotelli VRT, Fischer JR, Schapiro D, Engler S, Lun XK, Jackson HW, Bodenmiller B (2018) Simultaneous multiplexed imaging of mRNA and proteins with subcellular resolution in breast cancer tissue samples by mass cytometry. Cell Syst 6(1):25-36. e25. https:\/\/doi.org\/10.1016\/j.cels.2017.12.001","journal-title":"Cell Syst"},{"issue":"11","key":"6015_CR8","doi-asserted-by":"publisher","first-page":"6698","DOI":"10.1093\/nar\/gkx187","volume":"45","author":"JF Tien","year":"2017","unstructured":"Tien JF, Mazloomian A, Cheng S-WG, Hughes CS, Chow CC, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J (2017) CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion. Nucleic Acids Res 45(11):6698\u20136716. https:\/\/doi.org\/10.1093\/nar\/gkx187","journal-title":"Nucleic Acids Res"},{"key":"6015_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41523-017-0027-5","volume":"3","author":"CH O'Flanagan","year":"2017","unstructured":"O\u2019Flanagan CH, Rossi EL, McDonell SB, Chen X, Tsai Y-H, Parker JS, Usary J, Perou CM, Hursting SD (2017) Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer. NPJ Breast Cancer 3:26. https:\/\/doi.org\/10.1038\/s41523-017-0027-5","journal-title":"NPJ Breast Cancer"},{"issue":"4","key":"6015_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cmet.2010.09.002","volume":"12","author":"LJ Eichner","year":"2010","unstructured":"Eichner LJ, Perry M-C, Dufour CR, Bertos N, Park M, St-Pierre J, Gigu\u00e8re V (2010) miR-378(\u2217) mediates metabolic shift in breast cancer cells via the PGC-1\u03b2\/ERR\u03b3 transcriptional pathway. Cell Metab 12(4):352\u2013361. https:\/\/doi.org\/10.1016\/j.cmet.2010.09.002","journal-title":"Cell Metab"},{"issue":"8","key":"6015_CR11","doi-asserted-by":"publisher","first-page":"13021","DOI":"10.1002\/jcp.27973","volume":"234","author":"X Luo","year":"2019","unstructured":"Luo X, Yu H, Song Y, Sun T (2019) Integration of metabolomic and transcriptomic data reveals metabolic pathway alteration in breast cancer and impact of related signature on survival. J Cell Physiol 234(8):13021\u201313031. https:\/\/doi.org\/10.1002\/jcp.27973","journal-title":"J Cell Physiol"},{"key":"6015_CR12","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/1471-2164-13-334","volume":"13","author":"J Budczies","year":"2012","unstructured":"Budczies J, Denkert C, M\u00fcller BM, Brockm\u00f6ller SF, Klauschen F, Gy\u00f6rffy B, Dietel M, Richter-Ehrenstein C, Marten U, Salek RM (2012) Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue\u2014a GC-TOFMS based metabolomics study. BMC Genomics 13:334. https:\/\/doi.org\/10.1186\/1471-2164-13-334","journal-title":"BMC Genomics"},{"key":"6015_CR13","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3389\/fonc.2020.00804","volume":"10","author":"MA Hassan","year":"2020","unstructured":"Hassan MA, Al-Sakkaf K, Shait Mohammed MR, Dallol A, Al-Maghrabi J, Aldahlawi A, Ashoor S, Maamra M, Ragoussis J, Wu W, Khan MI, Al-Malki AL, Choudhry H (2020) Integration of transcriptome and metabolome provides unique insights to pathways associated with obese breast cancer patients. Front Oncol 10:804. https:\/\/doi.org\/10.3389\/fonc.2020.00804","journal-title":"Front Oncol"},{"key":"6015_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fbioe.2015.00038","volume":"3","author":"T Ara","year":"2015","unstructured":"Ara T, Enomoto M, Arita M, Ikeda C, Kera K, Yamada M, Nishioka T, Ikeda T, Nihei Y, Shibata D, Kanaya S, Sakurai N (2015) Metabolonote: a wiki-based database for managing hierarchical metadata of metabolome analyses. Front Bioeng Biotechnol 3:38. https:\/\/doi.org\/10.3389\/fbioe.2015.00038","journal-title":"Front Bioeng Biotechnol"},{"issue":"Database","key":"6015_CR15","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1093\/nar\/gkl887","volume":"35","author":"T Barrett","year":"2007","unstructured":"Barrett T, Troup D, Wilhite S, Ledoux P, Rudnev D, Evangelista C, Kim I, Soboleva A, Tomashevsky M, Edgar R (2007) NCBI GEO: mining tens of millions of expression profiles\u2013database and tools update. Nucleic Acids Res 35(Database):760\u2013765. https:\/\/doi.org\/10.1093\/nar\/gkl887","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"6015_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","volume":"20","author":"L Gautier","year":"2004","unstructured":"Gautier L, Cope L, Bolstad B, Irizarry R (2004) affy\u2013analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20(3):307\u2013315. https:\/\/doi.org\/10.1093\/bioinformatics\/btg405","journal-title":"Bioinformatics"},{"issue":"7","key":"6015_CR17","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"M Ritchie","year":"2015","unstructured":"Ritchie M, Phipson B, Wu D, Hu Y, Law C, Shi W, Smyth G (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"6015_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12859-018-2085-6","volume":"19","author":"JK Siddiqui","year":"2018","unstructured":"Siddiqui JK, Baskin E, Liu M, Cantemir-Stone CZ, Zhang B, Bonneville R, McElroy JP, Coombes KR, Mathe EA (2018) IntLIM: integration using linear models of metabolomics and gene expression data. BMC Bioinformatics 19(1):81. https:\/\/doi.org\/10.1186\/s12859-018-2085-6","journal-title":"BMC Bioinformatics"},{"issue":"20","key":"6015_CR19","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1093\/bioinformatics\/btr499","volume":"27","author":"A Kamburov","year":"2011","unstructured":"Kamburov A, Cavill R, Ebbels TMD, Herwig R, Keun HC (2011) Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA. Bioinformatics 27(20):2917\u20132918. https:\/\/doi.org\/10.1093\/bioinformatics\/btr499","journal-title":"Bioinformatics"},{"issue":"21\u201322","key":"6015_CR20","doi-asserted-by":"publisher","first-page":"e1900042","DOI":"10.1002\/pmic.201900042","volume":"19","author":"A Kumar","year":"2019","unstructured":"Kumar A, Misra BB (2019) Challenges and opportunities in cancer metabolomics. Proteomics 19(21\u201322):e1900042. https:\/\/doi.org\/10.1002\/pmic.201900042","journal-title":"Proteomics"},{"issue":"18","key":"6015_CR21","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1158\/1078-0432.ccr-13-0209","volume":"19","author":"G Zhang","year":"2013","unstructured":"Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP (2013) Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res 19(18):4983\u20134993. https:\/\/doi.org\/10.1158\/1078-0432.ccr-13-0209","journal-title":"Clin Cancer Res"},{"issue":"17","key":"6015_CR22","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.1158\/0008-5472.can-16-0562","volume":"76","author":"Y Teng","year":"2016","unstructured":"Teng Y, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ, Cowell JK (2016) The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis. Cancer Res 76(17):5133\u20135142. https:\/\/doi.org\/10.1158\/0008-5472.can-16-0562","journal-title":"Cancer Res"},{"issue":"1","key":"6015_CR23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2121-6-11","volume":"6","author":"CF Stovold","year":"2005","unstructured":"Stovold CF, Millard TH, Machesky LM (2005) Inclusion of Scar\/WAVE3 in a similar complex to Scar\/WAVE1 and 2. BMC Cell Biol 6(1):11. https:\/\/doi.org\/10.1186\/1471-2121-6-11","journal-title":"BMC Cell Biol"},{"issue":"3","key":"6015_CR24","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.devcel.2009.08.012","volume":"17","author":"RH Insall","year":"2009","unstructured":"Insall RH, Machesky LM (2009) Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell 17(3):310\u2013322. https:\/\/doi.org\/10.1016\/j.devcel.2009.08.012","journal-title":"Dev Cell"},{"issue":"4","key":"6015_CR25","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1158\/0008-5472.can-15-1680","volume":"76","author":"Y Teng","year":"2016","unstructured":"Teng Y, Bahassan A, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell JK (2016) Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion. Cancer Res 76(4):965\u2013973. https:\/\/doi.org\/10.1158\/0008-5472.can-15-1680","journal-title":"Cancer Res"},{"issue":"35","key":"6015_CR26","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/onc.2015.527","volume":"35","author":"Y Teng","year":"2016","unstructured":"Teng Y, Pi W, Wang Y, Cowell JK (2016) WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2\/HER3 signaling. Oncogene 35(35):4633\u20134640. https:\/\/doi.org\/10.1038\/onc.2015.527","journal-title":"Oncogene"},{"issue":"3","key":"6015_CR27","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.bbrc.2004.04.115","volume":"318","author":"M Yang","year":"2004","unstructured":"Yang M, Chen T, Han C, Li N, Wan T, Cao X (2004) Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. Biochem Biophys Res Commun 318(3):792\u2013799. https:\/\/doi.org\/10.1016\/j.bbrc.2004.04.115","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"6015_CR28","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1002\/jnr.24034","volume":"95","author":"H Wen","year":"2017","unstructured":"Wen H, Zhan L, Chen S, Long L, Xu E (2017) Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy. J Neurosci Res 95(10):1993\u20132004. https:\/\/doi.org\/10.1002\/jnr.24034","journal-title":"J Neurosci Res"},{"issue":"1","key":"6015_CR29","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41467-018-02823-x","volume":"9","author":"P Ebner","year":"2018","unstructured":"Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F (2018) The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun 9(1):599. https:\/\/doi.org\/10.1038\/s41467-018-02823-x","journal-title":"Nat Commun"},{"key":"6015_CR30","doi-asserted-by":"publisher","first-page":"e922217","DOI":"10.12659\/msm.922217","volume":"26","author":"H Liu","year":"2020","unstructured":"Liu H, Xu J, Yao Q, Zhang Z, Guo Q, Lin J (2020) Rab7is associated with poor prognosis of gastric cancer and promotes proliferation, invasion, and migration of gastric cancer cells. Med Sci Monit 26:e922217. https:\/\/doi.org\/10.12659\/msm.922217","journal-title":"Med Sci Monit"},{"issue":"11","key":"6015_CR31","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.18632\/aging.103268","volume":"12","author":"C Sun","year":"2020","unstructured":"Sun C, Wang P, Dong W, Liu H, Sun J, Zhao L (2020) LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer. Aging (Albany NY) 12(11):10427\u201310440. https:\/\/doi.org\/10.18632\/aging.103268","journal-title":"Aging (Albany NY)"},{"key":"6015_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ejphar.2017.08.022","volume":"813","author":"X Kou","year":"2017","unstructured":"Kou X, Yang Y, Jiang X, Liu H, Sun F, Wang X, Liu L, Liu H, Lin Z, Jiang L (2017) Vorinostat and Simvastatin have synergistic effects on triple-negative breast cancer cells via abrogating Rab7 prenylation. Eur J Pharmacol 813:161\u2013171. https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.022","journal-title":"Eur J Pharmacol"},{"issue":"21","key":"6015_CR33","doi-asserted-by":"publisher","first-page":"34652","DOI":"10.18632\/oncotarget.16147","volume":"8","author":"S Zhou","year":"2017","unstructured":"Zhou S, Shen Y, Zheng M, Wang L, Che R, Hu W, Li P (2017) DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer. Oncotarget 8(21):34652\u201334660. https:\/\/doi.org\/10.18632\/oncotarget.16147","journal-title":"Oncotarget"},{"issue":"1","key":"6015_CR34","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ygyno.2020.01.013","volume":"157","author":"F Jun","year":"2020","unstructured":"Jun F, Peng Z, Zhang Y, Shi D (2020) Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma. Gynecol Oncol 157(1):268\u2013279. https:\/\/doi.org\/10.1016\/j.ygyno.2020.01.013","journal-title":"Gynecol Oncol"},{"key":"6015_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-3-319-47656-8_9","volume":"965","author":"EG Armitage","year":"2017","unstructured":"Armitage EG, Ciborowski M (2017) Applications of metabolomics in cancer studies. Adv Exp Med Biol 965:209\u2013234. https:\/\/doi.org\/10.1007\/978-3-319-47656-8_9","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"6015_CR36","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/15384101.2018.1444305","volume":"17","author":"X Mu","year":"2018","unstructured":"Mu X, Shi W, Xu Y, Xu C, Zhao T, Geng B, Yang J, Pan J, Hu S, Zhang C, Zhang J, Wang C, Shen J, Che Y, Liu Z, Lv Y, Wen H, You Q (2018) Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK\/STAT3 signaling pathway in breast cancer. Cell Cycle 17(4):428\u2013438. https:\/\/doi.org\/10.1080\/15384101.2018.1444305","journal-title":"Cell Cycle"},{"issue":"42","key":"6015_CR37","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1038\/onc.2009.229","volume":"28","author":"Y Zhao","year":"2009","unstructured":"Zhao Y, Zhou M, Liu H, Ding Y, Khong H, Yu D, Fodstad O, Tan M (2009) Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene 28(42):3689\u20133701. https:\/\/doi.org\/10.1038\/onc.2009.229","journal-title":"Oncogene"},{"issue":"1","key":"6015_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-016-3794-z","volume":"157","author":"F Martel","year":"2016","unstructured":"Martel F, Guedes M, Keating E (2016) Effect of polyphenols on glucose and lactate transport by breast cancer cells. Breast Cancer Res Treat 157(1):1\u201311. https:\/\/doi.org\/10.1007\/s10549-016-3794-z","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"6015_CR39","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1073\/pnas.1614035114","volume":"114","author":"P Chen","year":"2017","unstructured":"Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y (2017) Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A 114(3):580\u2013585. https:\/\/doi.org\/10.1073\/pnas.1614035114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7750","key":"6015_CR40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41586-019-0977-x","volume":"568","author":"I Elia","year":"2019","unstructured":"Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, van Gorsel M, Boon R, Escalona-Noguero C, Torrekens S, Verfaillie C, Verbeken E, Carmeliet G, Fendt SM (2019) Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. Nature 568(7750):117\u2013121. https:\/\/doi.org\/10.1038\/s41586-019-0977-x","journal-title":"Nature"},{"issue":"27","key":"6015_CR41","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1038\/onc.2017.6","volume":"36","author":"L Jin","year":"2017","unstructured":"Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S (2017) Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene 36(27):3797\u20133806. https:\/\/doi.org\/10.1038\/onc.2017.6","journal-title":"Oncogene"},{"issue":"4","key":"6015_CR42","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2018.07.030","volume":"174","author":"MP Murphy","year":"2018","unstructured":"Murphy MP, O\u2019Neill LA (2018) Krebs cycle reimagined: the emerging roles of succinate and itaconate as signal transducers. Cell 174(4):780\u2013784. https:\/\/doi.org\/10.1016\/j.cell.2018.07.030","journal-title":"Cell"},{"key":"6015_CR43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.biochi.2017.02.008","volume":"135","author":"K Sajnani","year":"2017","unstructured":"Sajnani K, Islam F, Smith RA, Gopalan V, Lam AK-Y (2017) Genetic alterations in Krebs cycle and its impact on cancer pathogenesis. Biochimie 135:164\u2013172. https:\/\/doi.org\/10.1016\/j.biochi.2017.02.008","journal-title":"Biochimie"},{"issue":"1","key":"6015_CR44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13058-018-0953-7","volume":"20","author":"WS Liu","year":"2018","unstructured":"Liu WS, Chan SH, Chang HT, Li GC, Tu YT, Tseng HH, Fu TY, Chang HY, Liou HH, Ger LP, Tsai KW (2018) Isocitrate dehydrogenase 1-snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability. Breast Cancer Res 20(1):25. https:\/\/doi.org\/10.1186\/s13058-018-0953-7","journal-title":"Breast Cancer Res"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06015-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-021-06015-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06015-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T08:13:14Z","timestamp":1619770394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-021-06015-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["6015"],"URL":"https:\/\/doi.org\/10.1007\/s00404-021-06015-9","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,31]]},"assertion":[{"value":"28 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}