{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:50:07Z","timestamp":1782967807875,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To explore whether epidemiological shifts regarding reproduction and pregnancy have influenced the spectrum of indications for late termination of singleton pregnancies (TOP) above 17\u00a0weeks of gestation and to evaluate temporal changes in maternal demographics and fetal indications over the last 16\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective single-center cohort study involving all late TOPs preceded by feticide between 1 January 2004 and 31 December 2019 at a tertiary referral hospital in Austria. Outcome variables were retrieved and a time trend assessed between two 8-year intervals (2004\u20132011 versus 2012\u20132019).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Between January 2004 and December 2019, a total of 209 singleton pregnancies (50.7% male; 46.9% female fetuses, 2.4% no disclosed sex) were terminated medically at a median gestational age of 25<jats:sup>+1<\/jats:sup> (17<jats:sup>+3<\/jats:sup>\u201337<jats:sup>+1<\/jats:sup>) weeks at our institution. Predominant conditions legally justifying the late medical abortion were abnormaltities of the brain\/central nervous system (<jats:italic>n<\/jats:italic>\u2009=\u200983; 39.7%), chromosomal aberrations (<jats:italic>n<\/jats:italic>\u2009=\u200933; 15.8%), complex malformations (<jats:italic>n<\/jats:italic>\u2009=\u200931; 4.8%) and abnormaltities of the musculosceletal system including diaphragmatic hernias (<jats:italic>n<\/jats:italic>\u2009=\u200918; 8.6%), as reflected by the <jats:italic>ICD-10-<\/jats:italic>categories \u201cC<jats:italic>ongenital malformation of the central nervous system\u201d<\/jats:italic>, \u201c<jats:italic>Other congenital malformations<\/jats:italic>\u201d and \u201c<jats:italic>Chromosomal abnormalities<\/jats:italic>\u201d. No changes were observed with regards to maternal age (30.1\u2009\u00b1\u20095.9 vs. 31.0\u2009\u00b1\u20096.0\u00a0years; \u2009<jats:italic>p<\/jats:italic> =\u20090.315) nor frequency of assisted reproductive technologies (7.0% vs. 8.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.550). Despite a 2.5-fold increase in incidence of late TOPs, no epidemiological changes in maternal or fetal characteristics were observed over the last 16\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Population profile and indications for late TOPs followed by feticide remain unchanged over time.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-021-06042-6","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T13:02:32Z","timestamp":1617368552000},"page":"935-942","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Temporal changes in epidemiological profile and fetal indications for late termination of pregnancy: a retrospective single-center study"],"prefix":"10.1007","volume":"304","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-4817","authenticated-orcid":false,"given":"Dana Ana\u00efs","family":"Muin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Otte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Scharrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kasprian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Husslein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Bettelheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"6042_CR1","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1111\/j.1471-0528.2009.02228.x","volume":"116","author":"M Habiba","year":"2009","unstructured":"Habiba M, Da Fr\u00e8 M, Taylor DJ et al (2009) Late termination of pregnancy: a comparison of obstetricians\u2019 experience in eight European countries. BJOG Int J Obstet Gynaecol 116:1340\u20131349","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"6042_CR2","unstructured":"Strafgesetzbuch (2018) \u00a7 97 StGB Straflosigkeit des Schwangerschaftsabbruchs"},{"issue":"560","key":"6042_CR3","first-page":"e561","volume":"201","author":"FA Chervenak","year":"2009","unstructured":"Chervenak FA, Mccullough LB (2009) An ethically justified practical approach to offering, recommending, performing, and referring for induced abortion and feticide. Am J Obstet Gynecol 201(560):e561-566","journal-title":"Am J Obstet Gynecol"},{"key":"6042_CR4","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1471-0528.2011.03189.x","volume":"119","author":"M Gissler","year":"2012","unstructured":"Gissler M, Fronteira I, Jahn A et al (2012) Terminations of pregnancy in the European Union. BJOG Int J Obstet Gynaecol 119:324\u2013332","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"6042_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1749-6632.2000.tb05163.x","volume":"913","author":"RJ Cook","year":"2000","unstructured":"Cook RJ (2000) Developments in abortion laws. Comparative and international perspectives. Ann N Y Acad Sci 913:74\u201387","journal-title":"Ann N Y Acad Sci"},{"key":"6042_CR6","first-page":"3","volume":"23","author":"RJ Cook","year":"1989","unstructured":"Cook RJ, Dickens BM (1989) International developments in abortion laws: 1977\u201388. IPPF Med Bull 23:3\u20134","journal-title":"IPPF Med Bull"},{"key":"6042_CR7","unstructured":"Centre for Reproductive Rights (2020) Wyrok Trybuna\u0142u Konstytucyjnego z dnia 22 pa\u017adziernika 2020 r. sygn. akt K 1\/20"},{"key":"6042_CR8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1471-0528.2010.02531.x","volume":"117","author":"E Garne","year":"2010","unstructured":"Garne E, Khoshnood B, Loane M et al (2010) Termination of pregnancy for fetal anomaly after 23 weeks of gestation: a European register-based study. BJOG Int J Obstet Gynaecol 117:660\u2013666","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"6042_CR9","doi-asserted-by":"crossref","unstructured":"Sunderam S, Kissin DM, Zhang Y et al. (2019) Assisted Reproductive Technology Surveillance\u2014United States, 2016. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C, 2002) 68:1\u201323","DOI":"10.15585\/mmwr.ss6804a1"},{"key":"6042_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1017\/S002193202000005X","volume":"53","author":"J Kocourkov\u00e1","year":"2021","unstructured":"Kocourkov\u00e1 J, \u0160\u0165astn\u00e1 A (2021) The realization of fertility intentions in the context of childbearing postponement: comparison of transitional and post-transitional populations. J Biosoc Sci 53:82\u201397","journal-title":"J Biosoc Sci"},{"key":"6042_CR11","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s13524-020-00929-w","volume":"57","author":"CS Hartnett","year":"2020","unstructured":"Hartnett CS, Gemmill A (2020) Recent trends in U.S. childbearing intentions. Demography 57:2035\u20132045","journal-title":"Demography"},{"key":"6042_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.fertnstert.2020.05.023","volume":"114","author":"Z Blumenfeld","year":"2020","unstructured":"Blumenfeld Z (2020) Possible impact of COVID-19 on fertility and assisted reproductive technologies. Fertil Steril 114:56\u201357","journal-title":"Fertil Steril"},{"key":"6042_CR13","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/humupd\/dmt006","volume":"19","author":"M Hansen","year":"2013","unstructured":"Hansen M, Kurinczuk JJ, Milne E et al (2013) Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update 19:330\u2013353","journal-title":"Hum Reprod Update"},{"key":"6042_CR14","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","volume":"366","author":"MJ Davies","year":"2012","unstructured":"Davies MJ, Moore VM, Willson KJ et al (2012) Reproductive technologies and the risk of birth defects. N Engl J Med 366:1803\u20131813","journal-title":"N Engl J Med"},{"key":"6042_CR15","volume-title":"Classification of diseases (ICD)","author":"World Health Organization","year":"2020","unstructured":"World Health Organization (2020) Classification of diseases (ICD). World Health Organization, Geneva"},{"key":"6042_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0003-3995(02)01130-9","volume":"45","author":"C Stoll","year":"2002","unstructured":"Stoll C, Alembik Y, Dott B et al (2002) Impact of prenatal diagnosis on livebirth prevalence of children with congenital anomalies. Ann Genet 45:115\u2013121","journal-title":"Ann Genet"},{"key":"6042_CR17","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/jech.48.3.290","volume":"48","author":"C Julian-Reynier","year":"1994","unstructured":"Julian-Reynier C, Philip N, Scheiner C et al (1994) Impact of prenatal diagnosis by ultrasound on the prevalence of congenital anomalies at birth in southern France. J Epidemiol Community Health 48:290\u2013296","journal-title":"J Epidemiol Community Health"},{"key":"6042_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5152\/jtgga.2012.09","volume":"13","author":"A Corbacioglu","year":"2012","unstructured":"Corbacioglu A, Aslan H, Aydin S et al (2012) Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre. J Turk Ger Gynecol Assoc 13:85\u201390","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"6042_CR19","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1080\/14767058.2017.1297406","volume":"31","author":"N Feldman","year":"2018","unstructured":"Feldman N, Melcer Y, Hod E et al (2018) Termination of pregnancy due to fetal abnormalities performed after 32 weeks\u2019 gestation: survey of 57 fetuses from a single medical center. J Maternal-fetal Neonatal Med 31:740\u2013746","journal-title":"J Maternal-fetal Neonatal Med"},{"key":"6042_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00404-018-4836-z","volume":"298","author":"Y Melcer","year":"2018","unstructured":"Melcer Y, Maymon R, Krajden Haratz K et al (2018) Termination of pregnancy due to fetal central nervous system abnormalities performed after 24 weeks\u2019 gestation: survey of 57 fetuses from a single medical center. Arch Gynecol Obstet 298:551\u2013559","journal-title":"Arch Gynecol Obstet"},{"key":"6042_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/pd.2188","volume":"29","author":"O Barel","year":"2009","unstructured":"Barel O, Vaknin Z, Smorgick N et al (2009) Fetal abnormalities leading to third trimester abortion: nine-year experience from a single medical center. Prenat Diagn 29:223\u2013228","journal-title":"Prenat Diagn"},{"key":"6042_CR22","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/pd.1531","volume":"26","author":"Z Vaknin","year":"2006","unstructured":"Vaknin Z, Ben-Ami I, Reish O et al (2006) Fetal abnormalities leading to termination of singleton pregnancy: the 7-year experience of a single medical center. Prenat Diagn 26:938\u2013943","journal-title":"Prenat Diagn"},{"key":"6042_CR23","first-page":"135","volume":"3","author":"B De Keersmaecker","year":"2011","unstructured":"De Keersmaecker B, Claus F, De Catte L (2011) Imaging the fetal central nervous system. Facts Views Vis Obgyn 3:135\u2013149","journal-title":"Facts Views Vis Obgyn"},{"key":"6042_CR24","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/j.1471-0528.2006.01144.x","volume":"113","author":"H Statham","year":"2006","unstructured":"Statham H, Solomou W, Green J (2006) Late termination of pregnancy: law, policy and decision making in four English fetal medicine units. BJOG Int J Obstet Gynaecol 113:1402\u20131411","journal-title":"BJOG Int J Obstet Gynaecol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06042-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-021-06042-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06042-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T15:12:02Z","timestamp":1631200322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-021-06042-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["6042"],"URL":"https:\/\/doi.org\/10.1007\/s00404-021-06042-6","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,2]]},"assertion":[{"value":"9 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study complied with the principles outlined in the Helsinki Declaration of 1975, as revised in 2013, and was approved by the institutional review board of the Ethics Committee at the Medical University of Vienna (<i>EK Number 1855\/2017<\/i>).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Parents\u2019 written informed consent had been obtained in each case at the time of initial visit as well as for the post-mortem workup.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"As above.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Available upon request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}