{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:44:03Z","timestamp":1793133843022,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002954","name":"Universit\u00e0 degli Studi di Milano - Bicocca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Samples from the unclamped cord alter the acid\u2013base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-021-06076-w","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T14:02:36Z","timestamp":1621692156000},"page":"1493-1499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of clamped and unclamped umbilical cord samples on blood gas analysis"],"prefix":"10.1007","volume":"304","author":[{"given":"Elisabetta","family":"Colciago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-8429","authenticated-orcid":false,"given":"Simona","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ciarmoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Antolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Nespoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Andrea","family":"Mastrolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Emilio","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Manganini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"issue":"3 Pt 1","key":"6076_CR1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1053\/ob.1996.v175.a74401","volume":"175","author":"JA Thorp","year":"1996","unstructured":"Thorp JA, Dildy GA, Yeomans ER, Meyer BA, Parisi VM (1996) Umbilical cord blood gas analysis at delivery. Am J Obstet Gynecol 175(3 Pt 1):517\u2013522","journal-title":"Am J Obstet Gynecol"},{"key":"6076_CR2","doi-asserted-by":"publisher","first-page":"F430","DOI":"10.1136\/adc.2006.099846","volume":"92","author":"L Armstrong","year":"2007","unstructured":"Armstrong L, Stenson BJ (2007) Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Child Fetal Neonatal Ed 92:F430\u2013F434","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"6076_CR3","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1159\/000240487","volume":"20","author":"BD Ackerman","year":"1972","unstructured":"Ackerman BD, Sosna MM, Ullrich JR (1972) A technique for serial sampling of umbilical artery blood at birth. Biol Neonate 20:458\u2013465","journal-title":"Biol Neonate"},{"key":"6076_CR4","first-page":"628","volume":"102","author":"GDV Hankins","year":"2003","unstructured":"Hankins GDV, Speer M (2003) Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy. Obstet Gynecol 102:628\u2013636","journal-title":"Obstet Gynecol"},{"key":"6076_CR5","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ebch.1965","volume":"9","author":"SJ McDonald","year":"2014","unstructured":"McDonald SJ, Middleton P, Dowswell T, Morris PS (2014) Cochrane in context: effect of timing of umbilical cord clamping in term infants on maternal and neonatal outcomes: Commentary. Evid Based Child Health 9:398\u2013400","journal-title":"Evid Based Child Health"},{"key":"6076_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/ebch.1971","volume":"9","author":"SJ McDonald","year":"2014","unstructured":"McDonald SJ, Middleton P, Dowswell T, Morris PS (2014) Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Evid Based Child Health 9:303\u2013397","journal-title":"Evid Based Child Health"},{"key":"6076_CR7","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1440-1754.1997.tb01606.x","volume":"33","author":"M McDonnell","year":"1997","unstructured":"McDonnell M, Henderson-Smart D (1997) Delayed umbilical cord clamping in preterm infants: a feasibility study. J Paediatr Child Health 33:308\u2013310","journal-title":"J Paediatr Child Health"},{"key":"6076_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/aogs.13233","volume":"97","author":"S Xodo","year":"2018","unstructured":"Xodo S, Xodo L, Berghella V (2018) Delayed cord clamping and cord gas analysis at birth. Acta Obst Gynecol Scand 97:7\u201312","journal-title":"Acta Obst Gynecol Scand"},{"key":"6076_CR9","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00404-010-1516-z","volume":"283","author":"C De Paco","year":"2011","unstructured":"De Paco C, Florido J, Garrido MC, Prados S, Navarrete L (2011) Umbilical cord blood acid\u2013base and gas analysis after early versus delayed cord clamping in neonates at term. Arch Gynecol Obstet 283:1011\u20131014","journal-title":"Arch Gynecol Obstet"},{"key":"6076_CR10","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1097\/AOG.0000000000001860","volume":"129","author":"American College of Obstetricians and Gynecologists","year":"2017","unstructured":"American College of Obstetricians and Gynecologists (2017) Committee Opinion No. 684: delayed umbilical cord clamping after birth. Obstet Gynecol 129:e5\u2013e10","journal-title":"Obstet Gynecol"},{"key":"6076_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ijgo.2015.06.018","volume":"131","author":"D Ayres-de-Campos","year":"2015","unstructured":"Ayres-de-Campos D, Arulkumaran S, FIGO (2015) Intrapartum Fetal Monitoring Expert Consensus Panel. FIGO consensus guidelines on intrapartum fetal monitoring: Physiology of fetal oxygenation and the main goals of intrapartum fetal monitoring. Int J Gynaecol Obstet 131:5\u20138","journal-title":"Int J Gynaecol Obstet"},{"key":"6076_CR12","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1097\/01.AOG.0000445580.65983.d2","volume":"123","author":"American College of Obstetricians and Gynecologists","year":"2014","unstructured":"American College of Obstetricians and Gynecologists (2014) Executive summary: neonatal encephalopathy and neurologic outcome, second edition. Obstet Gynecol 123:896\u2013901","journal-title":"Obstet Gynecol"},{"key":"6076_CR13","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1600-0412.2012.01530.x","volume":"92","author":"O Andersson","year":"2013","unstructured":"Andersson O, Hellstr\u00f6m-Westas L, Andersson D, Clausen J, Domell\u00f6f M (2013) Effects of delayed compared with early umbilical cord clamping on maternal postpartum hemorrhage and cord blood gas sampling: a randomized trial. Acta Obstet Gynecol Scand 92:567\u2013574. https:\/\/doi.org\/10.1111\/j.1600-0412.2012.01530.x","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"6076_CR14","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/AOG.0000000000003663","volume":"135","author":"APA Nudelman","year":"2020","unstructured":"Nudelman APA, Matthew JR, Belogolovsky E, Jegatheesan P, Govindaswami B, Song D (2020) Effect of delayed cord clamping on umbilical blood gas values in term newborns. Obstetr Gynecol 135(3):576\u2013582. https:\/\/doi.org\/10.1097\/AOG.0000000000003663","journal-title":"Obstetr Gynecol"},{"key":"6076_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ejogrb.2012.01.020","volume":"162","author":"J Valero","year":"2012","unstructured":"Valero J, Desantes D, Perales-Puchalt A, Rubio J, Diago Almela VJ, Perales A (2012) Effect of delayed umbilical cord clamping on blood gas analysis. Eur J Obstet Gynecol Reprod Biol 162:21\u201323","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"6076_CR16","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1471-0528.2008.01708.x","volume":"115","author":"N Wiberg","year":"2008","unstructured":"Wiberg N, K\u00e4ll\u00e9n K, Olofsson P (2008) Delayed umbilical cord clamping at birth has effects on arterial and venous blood gases and lactate concentrations. BJOG 115:697\u2013703","journal-title":"BJOG"},{"key":"6076_CR17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.earlhumdev.2014.03.010","volume":"90","author":"M Di Tommaso","year":"2014","unstructured":"Di Tommaso M, Seravalli V, Martini I, La Torre P, Dani C (2014) Blood gas values in clamped and unclamped umbilical cord at birth. Early Hum Dev 90:523\u2013525","journal-title":"Early Hum Dev"},{"key":"6076_CR18","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/aogs.13445","volume":"97","author":"S Xodo","year":"2018","unstructured":"Xodo S, Xodo L, Berghella V (2018) Timing of cord clamping for blood gas analysis is of paramount importance. Acta Obst Gynecol Scand 97:1533\u20131533","journal-title":"Acta Obst Gynecol Scand"},{"key":"6076_CR19","first-page":"1","volume-title":"Common problems in the newborn nursery","author":"SM Guiles","year":"2019","unstructured":"Guiles SM, Goldsmith JP (2019) Post-resuscitation care of the depressed newborn. In: Martin GI, Rosenfeld W (eds) Common problems in the newborn nursery. Springer International Publishing, Cham, pp 1\u201312"},{"key":"6076_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S1526-9523(99)00004-5","volume":"45","author":"JS Mercer","year":"2000","unstructured":"Mercer JS, Nelson CC, Skovgaard RL (2000) Umbilical cord clamping: beliefs and practices of American nurse-midwives. J Midw Women\u2019s Health 45:58\u201366","journal-title":"J Midw Women\u2019s Health"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06076-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-021-06076-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06076-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T15:10:56Z","timestamp":1635433856000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-021-06076-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6076"],"URL":"https:\/\/doi.org\/10.1007\/s00404-021-06076-w","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,22]]},"assertion":[{"value":"16 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have stated explicitly that there are no conflict of interest in connection with this article. The authors alone are responsible for the content and writing of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Authors and data retrieval assistants attended \u201cGood Clinical Practice\u201d training on ethical and organizational standards. The study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"IRB Ethical approval"}},{"value":"Not applicable. All data were anonymised and the study do not include any informations to enable the identification of participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}