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The serum levels of sFlt-1 and PlGF were measured by using the BRAHMS Kryptor Compact PLUS. Fetal biometric and Doppler parameters, as well as the sFlt-1\/PlGF ratio, were obtained both upon study inclusion and upon birth.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Various associations between the levels of the biomarkers in maternal blood upon study inclusion and upon birth and sonographic parameters were observed in FGR cases: umbilical artery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), uterine arteries (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), ductus venosus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), cerebroplacental ratio (CPR) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), femur length (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and birth weight (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The higher the sFlt-1\/PlGF ratio upon study inclusion, the shorter the \u201ctime to delivery\u201d (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The multivariate regression analysis showed that the greater the daily percentage increase of the angiogenic markers, the shorter the \u201ctime to delivery\u201d (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The fetal well-being, as measured by feto-maternal Doppler parameters such as CPR and the severity of the placental dysfunction, as measured by the urgency of birth and birth weight, is reflected by the level of the sFlt-1\/PlGF ratio in the maternal serum. A rapid daily increase of the sFlt-1\/PlGF ratio is significantly associated with the clinical progression of the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-021-06186-5","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T09:03:39Z","timestamp":1629882219000},"page":"597-605","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Course of the sFlt-1\/PlGF ratio in fetal growth restriction and correlation with biometric measurements, feto-maternal Doppler parameters and time to delivery"],"prefix":"10.1007","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-186X","authenticated-orcid":false,"given":"A.","family":"Andrikos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Andrikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Birdir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kimmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gellhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"K\u00f6ninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"issue":"Suppl 2","key":"6186_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000053079","volume":"49","author":"HA Wollmann","year":"1998","unstructured":"Wollmann HA (1998) Intrauterine growth restriction: definition and etiology. 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