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We used pregnancy outcome record to evaluate a complete data set of single nucleotide polymorphism-based test results performed by a Swiss genetics center.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>The Panorama<jats:sup>\u00ae<\/jats:sup> test assesses the risk of fetal trisomies (21, 18 and 13), gonosomal aneuploidy (GAN), triploidy or vanishing twins (VTT) and five different microdeletions (MD). We evaluated all 7549 test results meeting legal and quality requirements taken in women with nondonor singleton pregnancies between April 2013 and September 2016 classifying them as high or low risk. Follow-up ended after 9\u00a0months, data collection 7\u00a0months later.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The Panorama<jats:sup>\u00ae<\/jats:sup> test provided conclusive results in 96.1% of cases, detecting 153 FCA: T21 <jats:italic>n<\/jats:italic>\u2009=\u200976, T18 <jats:italic>n<\/jats:italic>\u2009=\u200919, T13 <jats:italic>n<\/jats:italic>\u2009=\u200915, GAN <jats:italic>n<\/jats:italic>\u2009=\u200919, VTT <jats:italic>n<\/jats:italic>\u2009=\u200913 and MD <jats:italic>n<\/jats:italic>\u2009=\u200911 (overall prevalence 2.0%). Pregnancy outcome record was available for 68.6% of conclusive laboratory results, including 2.0% high-risk cases. In this cohort the Panorama<jats:sup>\u00ae<\/jats:sup> test exhibited 99.90% sensitivity for each trisomy; specificity was 99.90% for T21, 99.98% for T18 and 99.94% for T13. False positive rate was 0.10% for T21, 0.02% for T18 and 0.06% for T13.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>SNP-based testing by a Swiss genetics center confirms the expected accuracy of NIPT in FCA detection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-021-06203-7","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T06:04:19Z","timestamp":1631858659000},"page":"1185-1192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Audit of the first\u2009&gt;\u20097500 noninvasive prenatal aneuploidy tests in a Swiss genetics center"],"prefix":"10.1007","volume":"305","author":[{"given":"Anahita","family":"Bajka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-6257","authenticated-orcid":false,"given":"Michael","family":"Bajka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Chablais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-9973","authenticated-orcid":false,"given":"Tilo","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"6203_CR1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/pd.4136","volume":"33","author":"LS Chitty","year":"2013","unstructured":"Chitty LS, Bianchi DW (2013) Noninvasive prenatal testing: the paradigm is shifting rapidly. 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Chablais is an employee of Genetica AG. M. Bajka, A. Bajka and T. Burkhardt report no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Zurich institutional review board (KEK-ZH-No.2016-00672).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}