{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:29:19Z","timestamp":1793780959019,"version":"4.6.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00404-021-06236-y","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T07:02:41Z","timestamp":1631689361000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Methotrexate versus expectant management in ectopic pregnancy: a meta-analysis"],"prefix":"10.1007","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4215-0600","authenticated-orcid":false,"given":"Ahmed Kunwer","family":"Naveed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umair","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumbal Nasir","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"issue":"3","key":"6236_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1517\/14656566.2.3.409","volume":"2","author":"K Barnhart","year":"2001","unstructured":"Barnhart K, Coutifaris C, Esposito M (2001) The pharmacology of methotrexate. Expert Opin Pharmacother 2(3):409\u2013417","journal-title":"Expert Opin Pharmacother"},{"issue":"3","key":"6236_CR2","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.fertnstert.2010.09.006","volume":"95","author":"K Barnhart","year":"2011","unstructured":"Barnhart K, van Mello NM, Bourne T, Kirk E, Van Calster B, Bottomley C et al (2011) Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome. Fertil Steril 95(3):857\u2013866","journal-title":"Fertil Steril"},{"issue":"12","key":"6236_CR3","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1093\/humrep\/17.12.3224","volume":"17","author":"J Bouyer","year":"2002","unstructured":"Bouyer J, Coste J, Fernandez H, Pouly JL, Job-Spira N (2002) Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Human Reprod (Oxford, England) 17(12):3224\u20133230","journal-title":"Human Reprod (Oxford, England)"},{"issue":"8","key":"6236_CR4","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1093\/oxfordjournals.humrep.a138246","volume":"8","author":"WM Ankum","year":"1993","unstructured":"Ankum WM, der Veen FV, Hamerlynck JVTH, Lammes FB (1993) Pregnancy: laparoscopy: a dispensable tool in the diagnosis of ectopic pregnancy? Hum Reprod 8(8):1301\u20131306","journal-title":"Hum Reprod"},{"issue":"9485","key":"6236_CR5","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0140-6736(05)67103-6","volume":"366","author":"CM Farquhar","year":"2005","unstructured":"Farquhar CM (2005) Ectopic pregnancy. Lancet (London, England) 366(9485):583\u2013591","journal-title":"Lancet (London, England)"},{"issue":"5","key":"6236_CR6","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/S0015-0282(98)00278-7","volume":"70","author":"BW Mol","year":"1998","unstructured":"Mol BW, Hajenius PJ, Engelsbel S, Ankum WM, Van der Veen F, Hemrika DJ et al (1998) Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive. Fertil Steril 70(5):972\u2013981","journal-title":"Fertil Steril"},{"issue":"4","key":"6236_CR7","first-page":"778","volume":"101","author":"KT Barnhart","year":"2003","unstructured":"Barnhart KT, Gosman G, Ashby R, Sammel M (2003) The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens. Obstet Gynecol 101(4):778\u2013784","journal-title":"Obstet Gynecol"},{"issue":"3","key":"6236_CR8","first-page":"407","volume":"95","author":"RJ Morlock","year":"2000","unstructured":"Morlock RJ, Lafata JE, Eisenstein D (2000) Cost-effectiveness of single-dose methotrexate compared with laparoscopic treatment of ectopic pregnancy. Obstet Gynecol 95(3):407\u2013412","journal-title":"Obstet Gynecol"},{"issue":"1","key":"6236_CR9","first-page":"70","volume":"62","author":"J Lund","year":"1955","unstructured":"Lund J (1955) Early ectopic pregnancy; comments on conservative treatment. J Obstet Gynaecol Br Emp 62(1):70\u201376","journal-title":"J Obstet Gynaecol Br Emp"},{"issue":"3 Pt 1","key":"6236_CR10","first-page":"345","volume":"80","author":"P Yl\u00f6stalo","year":"1992","unstructured":"Yl\u00f6stalo P, Cacciatore B, Sj\u00f6berg J, K\u00e4\u00e4ri\u00e4inen M, Tenhunen A, Stenman UH (1992) Expectant management of ectopic pregnancy. Obstet Gynecol 80(3 Pt 1):345\u2013348","journal-title":"Obstet Gynecol"},{"issue":"6","key":"6236_CR11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1590\/S1516-31802006000600004","volume":"124","author":"J Elito Junior","year":"2006","unstructured":"Elito Junior J, Camano L (2006) Unruptured tubal pregnancy: different treatments for early and late diagnosis. Sao Paulo Med J\u00a0=\u00a0Revista paulista de medicina 124(6):321\u20134","journal-title":"Sao Paulo Med J\u00a0=\u00a0Revista paulista de medicina"},{"issue":"4","key":"6236_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1056\/NEJMcp0810384","volume":"361","author":"KT Barnhart","year":"2009","unstructured":"Barnhart KT (2009) Clinical practice. Ectopic pregnancy. N Engl J Med 361(4):379\u201387","journal-title":"N Engl J Med"},{"issue":"2","key":"6236_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0020-7292(99)00114-9","volume":"67","author":"J Elito Jr","year":"1999","unstructured":"Elito J Jr, Reichmann AP, Uchiyama MN, Camano L (1999) Predictive score for the systemic treatment of unruptured ectopic pregnancy with a single dose of methotrexate. Int J Gynaecol Obstet 67(2):75\u201379","journal-title":"Int J Gynaecol Obstet"},{"issue":"6","key":"6236_CR14","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","volume":"85","author":"A Alleyassin","year":"2006","unstructured":"Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Hamed EA (2006) Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril 85(6):1661\u20131666","journal-title":"Fertil Steril"},{"issue":"4","key":"6236_CR15","first-page":"64S","volume":"105","author":"CK Klauser","year":"2005","unstructured":"Klauser CK, May WL, Johnson VK, Cowan BD, Hines RS (2005) Methotrexate for ectopic pregnancy: a randomized \u201csingle dose\u201d compared with \u201cmultidose\u201d trial. Obstet Gynecol 105(4):64S","journal-title":"Obstet Gynecol"},{"issue":"2","key":"6236_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ajog.2019.01.002","volume":"221","author":"S Alur-Gupta","year":"2019","unstructured":"Alur-Gupta S, Cooney LG, Senapati S, Sammel MD, Barnhart KT (2019) Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis. Am J Obstet Gynecol 221(2):95-108.e2","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"6236_CR17","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00404-014-3513-0","volume":"291","author":"PM Silva","year":"2015","unstructured":"Silva PM, Araujo J\u00fanior E, Cecchino GN, Elito J\u00fanior J, Camano L (2015) Effectiveness of expectant management versus methotrexate in tubal ectopic pregnancy: a double-blind randomized trial. Arch Gynecol Obstet 291(4):939\u2013943","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"6236_CR18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/humrep\/des373","volume":"28","author":"NM van Mello","year":"2013","unstructured":"van Mello NM, Mol F, Verhoeve HR, van Wely M, Adriaanse AH, Boss EA et al (2013) Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison. Human Reprod (Oxford, England) 28(1):60\u201367","journal-title":"Human Reprod (Oxford, England)"},{"issue":"2","key":"6236_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/uog.17329","volume":"49","author":"D Jurkovic","year":"2017","unstructured":"Jurkovic D, Memtsa M, Sawyer E, Donaldson AN, Jamil A, Schramm K et al (2017) Single-dose systemic methotrexate vs expectant management for treatment of tubal ectopic pregnancy: a placebo-controlled randomized trial. Ultrasound Obstet Gynecol 49(2):171\u2013176","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"6236_CR20","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/0029-7844(96)00293-1","volume":"88","author":"J Korhonen","year":"1996","unstructured":"Korhonen J, Stenman U-H, Yl\u00f6stalo P (1996) Low-dose oral methotrexate with expectant management of ectopic pregnancy. Obstet Gynecol 88(5):775\u2013778","journal-title":"Obstet Gynecol"},{"issue":"2","key":"6236_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/GRF.0b013e3182510a73","volume":"55","author":"EA Bachman","year":"2012","unstructured":"Bachman EA, Barnhart K (2012) Medical management of ectopic pregnancy: a comparison of regimens. Clin Obstet Gynecol 55(2):440\u2013447","journal-title":"Clin Obstet Gynecol"},{"issue":"4","key":"6236_CR22","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0002-9378(99)70665-4","volume":"180","author":"N Job-Spira","year":"1999","unstructured":"Job-Spira N, Fernandez H, Bouyer J, Pouly JL, Germain E, Coste J (1999) Ruptured tubal ectopic pregnancy: risk factors and reproductive outcome: results of a population-based study in France. Am J Obstet Gynecol 180(4):938\u2013944","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"6236_CR23","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0015-0282(16)57410-X","volume":"63","author":"D Trio","year":"1995","unstructured":"Trio D, Strobelt N, Picciolo C, Lapinski RH, Ghidini A (1995) Prognostic factors for successful expectant management of ectopic pregnancy. Fertil Steril 63(3):469\u2013472","journal-title":"Fertil Steril"},{"issue":"4","key":"6236_CR24","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0015-0282(16)56638-2","volume":"61","author":"J Korhonen","year":"1994","unstructured":"Korhonen J, Stenman UH, Yl\u00f6stalo P (1994) Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy. Fertil Steril 61(4):632\u2013636","journal-title":"Fertil Steril"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06236-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-021-06236-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-021-06236-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T13:13:16Z","timestamp":1647090796000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-021-06236-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["6236"],"URL":"https:\/\/doi.org\/10.1007\/s00404-021-06236-y","relation":{},"ISSN":["0932-0067","1432-0711"],"issn-type":[{"value":"0932-0067","type":"print"},{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"19 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"IRB ethical approval"}},{"value":"All the RCT selected for this meta-analysis had taken consent form their respective patient population.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}