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Cases were compared according to their prenatal findings and outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>36 cases of multisystem ciliopathies were diagnosed. Meckel-Gruber syndrome (MKS) was the most common ciliopathy (<jats:italic>n<\/jats:italic>\u2009=\u200919\/36, 52.8%), followed by disorders that belong to the group of short-rib thoracic dysplasia (SRTD, <jats:italic>n<\/jats:italic>\u2009=\u200910\/36, 27.8%) McKusick\u2013Kaufmann syndrome (MKKS, <jats:italic>n<\/jats:italic>\u2009=\u20094\/36, 11.1%), Bardet\u2013Biedl syndrome (BBS, <jats:italic>n<\/jats:italic>\u2009=\u20092\/36, 5.5%) and Joubert syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091\/36, 2.8%). All cases showed abnormalities of the kidneys, most often hyperechogenic parenchyma (<jats:italic>n<\/jats:italic>\u2009=\u200926\/36, 72.2%), cystic dysplasia (<jats:italic>n<\/jats:italic>\u2009=\u200924\/36, 66.7%), and\/or bilateral kidney enlargement (<jats:italic>n<\/jats:italic>\u2009=\u200922\/36, 61.1%). Oligohydramnios was mainly present in fetuses with MKS. Polydactyly (<jats:italic>n<\/jats:italic>\u2009=\u200918\/36), abnormalities of the CNS (<jats:italic>n<\/jats:italic>\u2009=\u200925\/36), and heart defects (<jats:italic>n<\/jats:italic>\u2009=\u200910\/36) were associated in 50%, 69.4%, and 27.8%, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Prenatal detection of renal abnormalities associated with skeletal or brain abnormalities should raise the suspicion for multisystem ciliopathies. Prenatal ultrasound can help to differentiate between different diseases and pave the way for subsequent targeted genetic testing.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-021-06265-7","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T07:12:42Z","timestamp":1633072362000},"page":"71-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fetal ciliopathies: a retrospective observational single-center study"],"prefix":"10.1007","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-3691","authenticated-orcid":false,"given":"Corinna","family":"Simonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Floeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"issue":"2","key":"6265_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/GCO.0000000000000348","volume":"29","author":"KO Kagan","year":"2017","unstructured":"Kagan KO, Dufke A, Gembruch U (2017) Renal cystic disease and associated ciliopathies. 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