{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:39:23Z","timestamp":1794271163736,"version":"4.9.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Promedon GmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Uterine-preserving techniques are becoming increasingly popular in the last decade. This investigation evaluates a novel hysteropexy technique using a mesh in sling-alike configuration [Splentis (Promedon, Argentina)] which is attached anteriorly to the cervix and suspended to the sacrospinous ligaments bilaterally via the vaginal route in women undergoing surgery for uterine prolapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center cohort study, evaluating women who underwent transvaginal hysteropexy with Splentis for primary uterine descent. Data have been collected prospectively as part of the quality assurance system. Primary endpoint was treatment success, defined as a combined endpoint including the absence of a vaginal bulge symptom and no retreatment of apical prolapse. A validated questionnaire to evaluate quality-of-life and prolapse symptoms was utilized. Descriptive analysis was applied. Wilcoxon signed-rank test was performed to compare paired samples. The significance level was set at 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 103 women with a median age of 68.0 [IQR 11.5] years with a median apical POP-Q stage of 3 were included. The median surgery time was 22 [IQR 12] minutes and no intraoperative complication occurred. After a median follow-up time of 17\u00a0months, treatment success was achieved in 91 (89.2%) patients and quality of life and patient report outcomes improved significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mesh exposure occurred in 3 (2.9%) patients. Of these, two patients required surgical revision, and one patient was treated conservatively. One patient required partial mesh removal due to dyspareunia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bilateral sacrospinous hysteropexy with Splentis offers an efficacious and safe alternative for apical compartment repair, incorporating the advantages of pelvic floor reconstruction via the vaginal route.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-022-06486-4","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T16:03:16Z","timestamp":1647273796000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A novel bilateral anterior sacrospinous hysteropexy technique for apical pelvic organ prolapse repair via the vaginal route: a cohort study"],"prefix":"10.1007","volume":"306","clinical-trial-number":[{"clinical-trial-number":"drks00018990","registry":"10.18810\/drks"}],"author":[{"given":"Gert","family":"Naumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"B\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena-Johanna","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"H\u00fcsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"6486_CR1","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/s0140-6736(07)60462-0","volume":"369","author":"JE Jelovsek","year":"2007","unstructured":"Jelovsek JE, Maher C, Barber MD (2007) Pelvic organ prolapse. 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Schr\u00f6der declare that they have no conflicts of interest. T. H\u00fcsch declares personal fees Photocure GmbH outside the submitted work. G. Naumann declares participation in clinical trials and consultancy for Promedon, Member of Advisory Board, at Dr. Pfleger GmbH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest statement"}},{"value":"The protocol was approved by the ethics committee of the medical association of Thuringia, Germany (vote number: 60750\/2020\/26), informed consent was obtained by the patients and the trial has been registered at the German Clinical Trials Register (number: DRKS00018990) 16.03.2021 retrospectively registered,","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}