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Survival analysis was used to assess CSH and CIF for MA, stratified for FIGO-2015 pathologic CTG and relevant covariates.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>FIGO-2015 pathological CTG with expedited operative delivery or urgent cesarean section within 10 or 20\u00a0min from diagnosis, respectively occurred in 282\/3459 (8.20%). The rate of MA at delivery was 3.32% (115\/3459). The spline of CSH for MA showed a direct correlation with the duration of 2STG always presenting higher values and greater slope in the presence of pathologic CTG, with plateau between 60 and 120\u00a0min and rapid increase after 120\u00a0min. The CIF at 180\u00a0min in the 2STG was 2.67% for nonpathological and 10.63% for pathological CTG_RED. Nulliparity, pathological CTG, and meconium-stained amniotic fluid resulted significant predictors of MA in our multivariable model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The risk for MA increases moderately across the 2STG with nonpathological CTG and quadruples with pathological CTG_RED. Adjustment for other predictors of MA including meconium-stained amniotic fluid and nulliparity reveals a significant hazard increase for MA associated with pathologic CTG_RED.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06594-1","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T13:04:22Z","timestamp":1653138262000},"page":"1225-1232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hazard and cumulative incidence of umbilical cord metabolic acidemia at birth in fetuses experiencing the second stage of labor and pathologic intrapartum fetal heart rate requiring expedited delivery"],"prefix":"10.1007","volume":"307","author":[{"given":"Paolo Ivo","family":"Cavoretto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Seidenari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1810","authenticated-orcid":false,"given":"Antonio","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"6594_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ajog.2019.07.032","volume":"222","author":"JM Turner","year":"2020","unstructured":"Turner JM, Mitchell MD, Kumar SS (2020) The physiology of intrapartum fetal compromise at term. 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