{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:14:43Z","timestamp":1793222083498,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T016701\/1"],"award-info":[{"award-number":["MR\/T016701\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To evaluate the relationship between maternal left ventricular systolic function, utero-placental circulation, and risk of adverse neonatal outcomes in women with cardiac disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>119 women managed in the pregnancy heart clinic (2019\u20132021) were identified. Women were classified by their primary cardiac condition. Adverse neonatal outcomes were: low birth weight (&lt;\u20092500\u00a0g), small-for-gestational-age (&lt;\u200910th birth-weight centile), pre-term delivery (&lt;\u200937\u00a0weeks\u2019 gestation), and fetal demise (&gt;\u200920\u00a0weeks\u2019 gestation). Parameters of left ventricular systolic function (global longitudinal strain, radial strain, ejection fraction, average S\u2019, and cardiac output) were calculated and pulsatility index was recorded from last growth scan.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Adverse neonatal outcomes occurred in 28 neonates (24%); most frequently in valvular heart disease (<jats:italic>n<\/jats:italic>\u2009=\u20098) and cardiomyopathy (<jats:italic>n<\/jats:italic>\u2009=\u20097). Small-for-gestational-age neonates were most common in women with cardiomyopathy (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). Early pregnancy average S\u2019 (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), late pregnancy average S\u2019 (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), and late pregnancy cardiac output (<jats:italic>p<\/jats:italic>\u2009=\u20090.008) were significantly lower in women with adverse neonatal outcomes than in those with healthy neonates. There was a significant association between neonatal birth-weight centile and global longitudinal strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and cardiac output (<jats:italic>p<\/jats:italic>\u2009=\u20090.0002) in late pregnancy. Pulsatility index was highest in women with cardiomyopathy (<jats:italic>p<\/jats:italic>\u2009=\u20090.007), and correlated with average S\u2019 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and global longitudinal strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) in late pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Women with cardiac disease may not tolerate cardiovascular adaptations required during pregnancy to support fetal growth. Adverse neonatal outcomes were associated with reduced left ventricular systolic function and higher pulsatility index. The association between impaired systolic function and reduced fetal growth is supported by insufficient utero-placental circulation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06635-9","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T07:04:03Z","timestamp":1654239843000},"page":"1431-1439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal left ventricular function and adverse neonatal outcomes in women with cardiac disease"],"prefix":"10.1007","volume":"307","author":[{"given":"Elizabeth J.","family":"Eggleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona J.","family":"Bhagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte J.","family":"Patient","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Belham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Pickett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-5626","authenticated-orcid":false,"given":"Catherine E.","family":"Aiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"6635_CR1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1161\/CIRCULATIONAHA.114.009029","volume":"130","author":"M Sanghavi","year":"2014","unstructured":"Sanghavi M, Rutherford JD (2014) Cardiovascular physiology of pregnancy. Circulation 130:1003\u20131008. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.009029","journal-title":"Circulation"},{"key":"6635_CR2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s11886-016-0760-7","volume":"18","author":"S Liu","year":"2016","unstructured":"Liu S, Elkayam U, Naqvi TZ (2016) Echocardiography in pregnancy: part 1. Curr Cardiol Rep 18:92. https:\/\/doi.org\/10.1007\/s11886-016-0760-7","journal-title":"Curr Cardiol Rep"},{"key":"6635_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/01.AOG.0000128170.15161.1d","volume":"104","author":"DK Desai","year":"2004","unstructured":"Desai DK, Moodley J, Naidoo DP (2004) Echocardiographic assessment of cardiovascular hemodynamics in normal pregnancy. Obstet Gynecol 104:20\u201329. https:\/\/doi.org\/10.1097\/01.AOG.0000128170.15161.1d","journal-title":"Obstet Gynecol"},{"key":"6635_CR4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/uog.12296","volume":"41","author":"ME Estensen","year":"2013","unstructured":"Estensen ME, Beitnes JO, Grindheim G, Aaberge L, Smiseth OA, Henriksen T, Aakhus S (2013) Altered maternal left ventricular contractility and function during normal pregnancy. Ultrasound Obstet Gynecol 41:659\u2013666. https:\/\/doi.org\/10.1002\/uog.12296","journal-title":"Ultrasound Obstet Gynecol"},{"key":"6635_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ogrm.2021.11.001","volume":"32","author":"R Chattopadhyay","year":"2021","unstructured":"Chattopadhyay R, Olwell B, Bhagra CJ (2021) Maternal cardiac disease in pregnancy. Obstet Gynaecol Reprod Med 32:1\u20137. https:\/\/doi.org\/10.1016\/j.ogrm.2021.11.001","journal-title":"Obstet Gynaecol Reprod Med"},{"key":"6635_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10554-016-0977-y","volume":"33","author":"SP Sengupta","year":"2017","unstructured":"Sengupta SP, Bansal M, Hofstra L, Sengupta PP, Narula J (2017) Gestational changes in left ventricular myocardial contractile function: new insights from two-dimensional speckle tracking echocardiography. Int J Cardiovasc Imaging 33:69\u201382. https:\/\/doi.org\/10.1007\/s10554-016-0977-y","journal-title":"Int J Cardiovasc Imaging"},{"key":"6635_CR7","doi-asserted-by":"publisher","first-page":"4139635","DOI":"10.1155\/2017\/4139635","volume":"2017","author":"S Visentin","year":"2017","unstructured":"Visentin S, Palermo C, Camerin M, Daliento L, Muraru D, Cosmi E, Badano LP (2017) Echocardiographic techniques of deformation imaging in the evaluation of maternal cardiovascular system in patients with complicated pregnancies. Biomed Res Int 2017:4139635. https:\/\/doi.org\/10.1155\/2017\/4139635","journal-title":"Biomed Res Int"},{"key":"6635_CR8","first-page":"169","volume":"6","author":"N Keser","year":"2006","unstructured":"Keser N (2006) Echocardiography in pregnant women. Anadolu Kardiyol Derg 6:169\u2013173","journal-title":"Anadolu Kardiyol Derg"},{"key":"6635_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.14797\/mdcj-13-4-209","volume":"13","author":"K Adam","year":"2017","unstructured":"Adam K (2017) Pregnancy in women with cardiovascular diseases. Method Debakey Cardiovasc J 13:209\u2013215. https:\/\/doi.org\/10.14797\/mdcj-13-4-209","journal-title":"Method Debakey Cardiovasc J"},{"key":"6635_CR10","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1093\/eurheartj\/ehy340","volume":"7","author":"V Regitz-Zagrosek","year":"2018","unstructured":"Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomstr\u00f6m-Lungqvist C, C\u00edfkov\u00e1 R, De Bonis M, Lung B et al (2018) 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J 7:3165\u20133241. https:\/\/doi.org\/10.1093\/eurheartj\/ehy340","journal-title":"Eur Heart J"},{"key":"6635_CR11","doi-asserted-by":"publisher","DOI":"10.21542\/GCSP.2021.5","volume":"2021","author":"S Kotit","year":"2021","unstructured":"Kotit S, Yacoub M (2021) Cardiovascular adverse events in pregnancy: a global perspective. Glob Cardiol Sci Pract 2021:e202105. https:\/\/doi.org\/10.21542\/GCSP.2021.5","journal-title":"Glob Cardiol Sci Pract"},{"key":"6635_CR12","unstructured":"Knight M, Bunch K, Tuffnell D, Shakespeare J, Kotnis R, Kenyon S, Kurinczuk JJ (Eds.) on behalf of MBRRACE-UK. Saving lives, improving mothers\u2019 care\u2014lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2015\u201317. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2019"},{"key":"6635_CR13","unstructured":"Building US. Capacity to Review and Prevent Maternal Deaths (2018) Report from nine maternal mortality review committees. Retrieved from http:\/\/reviewtoaction.org\/Report_from_Nine_MMRCs"},{"key":"6635_CR14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009395","volume":"7","author":"A Owens","year":"2018","unstructured":"Owens A, Yang J, Nie L, Lima F, Avila C, Stergiopoulos K (2018) Neonatal and maternal outcomes in pregnant women with cardiac disease. J Am Heart Assoc 7:e009395. https:\/\/doi.org\/10.1161\/JAHA.118.009395","journal-title":"J Am Heart Assoc"},{"key":"6635_CR15","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/eurheartj\/ehs270","volume":"34","author":"JW Roos-Hesselink","year":"2013","unstructured":"Roos-Hesselink JW, Ruys TPE, Stein JI, Thil\u00e9n U, Webb GB, Niwa K, Kaemmerer H et al (2013) Outcome of pregnancy in patients with structural or ischaemic heart disease: results of a registry of the European Society of Cardiology. Eur Heart J 34:657\u2013665. https:\/\/doi.org\/10.1093\/eurheartj\/ehs270","journal-title":"Eur Heart J"},{"key":"6635_CR16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.amjcard.2015.04.063","volume":"116","author":"P Koutrolou-Sotiropoulou","year":"2015","unstructured":"Koutrolou-Sotiropoulou P, Parikh PB, Miller C, Lima FV, Butler J, Stergiopoulos K (2015) Impact of heart disease on maternal and fetal outcomes in pregnant women. Am J Cardiol 116:474\u2013480. https:\/\/doi.org\/10.1016\/j.amjcard.2015.04.063","journal-title":"Am J Cardiol"},{"key":"6635_CR17","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/heartjnl-2018-313551","volume":"105","author":"M Cauldwell","year":"2019","unstructured":"Cauldwell M, Steer P, Sterrenburg M, Wallace S, Malin G, Ulivi G, Everett T et al (2019) Birth weight in pregnancies complicated by maternal heart disease. Heart 105:391\u2013398. https:\/\/doi.org\/10.1136\/heartjnl-2018-313551","journal-title":"Heart"},{"key":"6635_CR18","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1016\/j.amjcard.2017.02.003","volume":"119","author":"FV Lima","year":"2017","unstructured":"Lima FV, Yang J, Xu J, Stergiopoulos K (2017) National trends and in-hospital outcomes in pregnant women with heart disease in the United States. Am J Cardiol 119:1694\u20131700. https:\/\/doi.org\/10.1016\/j.amjcard.2017.02.003","journal-title":"Am J Cardiol"},{"key":"6635_CR19","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/j.amjcard.2019.03.012","volume":"123","author":"F Lima","year":"2019","unstructured":"Lima F, Nie L, Yang J, Owens A, Dianati-Maleki N, Avila C, Stergiopoulos K (2019) Postpartum cardiovascular outcomes among women with heart disease from a nationwide study. Am J Cardiol 123:2006\u20132014. https:\/\/doi.org\/10.1016\/j.amjcard.2019.03.012","journal-title":"Am J Cardiol"},{"key":"6635_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.115.002414","volume":"4","author":"RM Wald","year":"2015","unstructured":"Wald RM, Silversides CK, Kingdom J, Toi A, Lau C, Mason J, Colamn JM et al (2015) Maternal cardiac output and fetal doppler predict adverse neonatal outcomes in pregnant women with heart disease. J Am Heart Assoc 4:1\u201311. https:\/\/doi.org\/10.1161\/JAHA.115.002414","journal-title":"J Am Heart Assoc"},{"key":"6635_CR21","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1471-0528.2006.00945.x","volume":"113","author":"JEAK Bamfo","year":"2006","unstructured":"Bamfo JEAK, Kametas NA, Turan O, Khaw A, Nicolaides KH (2006) Maternal cardiac function in fetal growth restriction. BJOG An Int J Obstet Gynaecol 113:784\u2013791. https:\/\/doi.org\/10.1111\/j.1471-0528.2006.00945.x","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"6635_CR22","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.ijcard.2012.10.005","volume":"168","author":"J Cornette","year":"2013","unstructured":"Cornette J, Ruys TPE, Rossi A, Rizopoulos D, Takkenberg JJM, Karamermer Y, Opi\u0107 P et al (2013) Hemodynamic adaptation to pregnancy in women with structural heart disease. Int J Cardiol 168:825\u2013831. https:\/\/doi.org\/10.1016\/j.ijcard.2012.10.005","journal-title":"Int J Cardiol"},{"key":"6635_CR23","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1161\/CIRCULATIONAHA.113.002810","volume":"128","author":"PG Pieper","year":"2013","unstructured":"Pieper PG, Balci A, Aarnoudse JG, Kampman MAM, Sollie KM, Groen H, Mulder BJM et al (2013) Uteroplacental blood flow, cardiac function, and pregnancy outcome in women with congenital heart disease. Circulation 128:2478\u20132487. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.002810","journal-title":"Circulation"},{"key":"6635_CR24","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s10554-015-0659-1","volume":"31","author":"GD Cole","year":"2015","unstructured":"Cole GD, Dhutia NM, Shun-Shin MJ, Willson K, Harrison J, Raphael CE, Zolgharni M et al (2015) Defining the real-world reproducibility of visual grading of left ventricular function and visual estimation of left ventricular ejection fraction: impact of image quality, experience and accreditation. Int J Cardiovasc Imaging 31:1303\u20131314. https:\/\/doi.org\/10.1007\/s10554-015-0659-1","journal-title":"Int J Cardiovasc Imaging"},{"key":"6635_CR25","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1136\/hrt.2007.141002","volume":"96","author":"H Blessberger","year":"2010","unstructured":"Blessberger H, Binder T (2010) Two dimensional speckle tracking echocardiography: basic principles. Heart 96:716\u2013722. https:\/\/doi.org\/10.1136\/hrt.2007.141002","journal-title":"Heart"},{"key":"6635_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","volume":"16","author":"JU Voigt","year":"2014","unstructured":"Voigt JU, Pedrizzetti G, Lysyansky P, Marwick TH, Houle H, Baumann R, Pedri S et al (2014) Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging 16:1\u201311. https:\/\/doi.org\/10.1093\/ehjci\/jeu184","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"25","key":"6635_CR27","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1016\/j.jacc.2014.01.073","volume":"63","author":"P Thavendiranathan","year":"2014","unstructured":"Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH (2014) Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol 63(25):2751\u20132768. https:\/\/doi.org\/10.1016\/j.jacc.2014.01.073","journal-title":"J Am Coll Cardiol"},{"key":"6635_CR28","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.jacc.2018.08.2162","volume":"72","author":"TH Marwick","year":"2018","unstructured":"Marwick TH (2018) Ejection fraction pros and cons: JACC state-of-the-art review. J Am Coll Cardiol 72:2360\u20132379. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.2162","journal-title":"J Am Coll Cardiol"},{"key":"6635_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1161\/CIRCIMAGING.111.970012","volume":"5","author":"O Savu","year":"2012","unstructured":"Savu O, Jurcu\u0163 R, Giu\u015fc\u01ce S, van Mieghem T, Gussi I, Popescu BA, Ginghina C et al (2012) Morphological and functional adaptation of the maternal heart during pregnancy. Circ Cardiovasc Imaging 5:289\u2013297. https:\/\/doi.org\/10.1161\/CIRCIMAGING.111.970012","journal-title":"Circ Cardiovasc Imaging"},{"key":"6635_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-7120-13-6","volume":"13","author":"J Cong","year":"2015","unstructured":"Cong J, Fan T, Yang X, Squires JW, Cheng G, Zhang L, Zhang Z (2015) Structural and functional changes in maternal left ventricle during pregnancy: a three-dimensional speckle-tracking echocardiography study. Cardiovasc Ultrasound 13:1\u201310. https:\/\/doi.org\/10.1186\/1476-7120-13-6","journal-title":"Cardiovasc Ultrasound"},{"key":"6635_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-019-0785-5","author":"AC O\u2019Kelly","year":"2019","unstructured":"O\u2019Kelly AC, Sharma G, Vaught AJ, Zakaria S (2019) The use of echocardiography and advanced cardiac ultrasonography during pregnancy. Curr Treat Options Cardiovasc Med. https:\/\/doi.org\/10.1007\/s11936-019-0785-5","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"6635_CR32","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(14)61490-2","volume":"384","author":"AT Papageorghiou","year":"2014","unstructured":"Papageorghiou AT, Ohuma EO, Altman DG, Todros T, Ismail LC, Lambert A, Jaffer YA et al (2014) International standards for fetal growth based on serial ultrasound measurements: The Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. Lancet 384:869\u2013879. https:\/\/doi.org\/10.1016\/S0140-6736(14)61490-2","journal-title":"Lancet"},{"key":"6635_CR33","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1530\/ERP-19-0020","volume":"6","author":"C Johnson","year":"2019","unstructured":"Johnson C, Kuyt K, Oxborough D, Stout M (2019) Practical tips and tricks in measuring strain, strain rate and twist for the left and right ventricles. Echo Res Pract 6:R87-98. https:\/\/doi.org\/10.1530\/ERP-19-0020","journal-title":"Echo Res Pract"},{"key":"6635_CR34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2011.01.015","volume":"24","author":"V Mor-Avi","year":"2011","unstructured":"Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M et al (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE\/EAE consensus statement on methodology and indications: Endorsed by the Japanese Society of Echocardiography. J Am Soc Echocardiogr 24:277\u2013313. https:\/\/doi.org\/10.1016\/j.echo.2011.01.015","journal-title":"J Am Soc Echocardiogr"},{"key":"6635_CR35","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","volume":"11","author":"E Potter","year":"2018","unstructured":"Potter E, Marwick TH (2018) Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging 11:260\u2013274. https:\/\/doi.org\/10.1016\/j.jcmg.2017.11.017","journal-title":"JACC Cardiovasc Imaging"},{"key":"6635_CR36","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/AOG.0b013e31820cab69","volume":"117","author":"E Gelson","year":"2011","unstructured":"Gelson E, Curry R, Gatzoulis MA, Swan L, Lupton M, Steer P, Johnson M (2011) Effect of maternal heart disease on fetal growth. Obstet Gynecol 117:886\u2013891. https:\/\/doi.org\/10.1097\/AOG.0b013e31820cab69","journal-title":"Obstet Gynecol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06635-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-022-06635-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06635-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T17:05:11Z","timestamp":1681751111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-022-06635-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["6635"],"URL":"https:\/\/doi.org\/10.1007\/s00404-022-06635-9","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"assertion":[{"value":"4 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institution\u00a0as a retrospective service evaluation (Clinical Project ID: 3420;\u00a0PRN 9402, Approval date 11\/12my\/2020) and supported by HRA approval to analyse predictors of adverse pregnancy outcomes (REC reference 12\/SC\/0344).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}