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All women recruited underwent serial bedside measurements of the main hemodynamic parameters using a non-invasive ultrasound system (USCOM-1A). Total vascular resistances (TVR), heart rate (HR), stroke volume (SV), cardiac output (CO) and arterial blood pressure were measured before epidural administration (T0), after 5\u00a0min 5 (T1) from epidural bolus and at the end of the first stage of labor (T2). FHR was continuously recorded through computerized cardiotocography before and after the procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The starting CO was significantly higher in a subgroup of women with low TVR than in women with high-TVR group. After the bolus of epidural analgesia in the low-TVR group there was a significant reduction in CO and then increased again at the end of the first stage, in the high-TVR group the CO increased insignificantly after the anesthesia bolus, while it increased significantly in the remaining part of the first stage of labor. On the other hand, CO was inversely correlated with the number of decelerations detected on cCTG in the 1\u00a0hour after the epidural bolus while the short-term variation was significantly lower in the group with high-TVR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Maternal hemodynamic status at the onset of labor can make a difference in fetal response to the administration of epidural analgesia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06658-2","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T14:02:56Z","timestamp":1655301776000},"page":"1789-1794","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal hemodynamics and computerized cardiotocography during labor with epidural analgesia"],"prefix":"10.1007","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-1391","authenticated-orcid":false,"given":"Stefano Raffaele","family":"Giannubilo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirco","family":"Amici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Simonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"6658_CR1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000101980.34587.66","author":"M Van de Velde","year":"2004","unstructured":"Van de Velde M, Teunkens A, Hanssens M, Vandermeersch E, Verhaeghe J (2004) Intrathecal sufentanil and fetal heart rate abnormalities a double-blind, double placebo controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor. 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