{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:01:32Z","timestamp":1776920492490,"version":"3.51.2"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To determine if blastocyst trophectoderm biopsy for PGT-A is associated with an increased rate of live birth per embryo in good prognosis IVF patients at a single center.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a retrospective cohort study of good prognosis embryo transfer cycles at a single center from 1\/1\/2017 to 12\/31\/2019. We evaluated the rate of live birth per embryo with and without PGT-A for transfer of embryos in two groups of good prognosis patients: embryos from donor oocytes and embryos from autologous oocytes with maternal age less than 35\u00a0years at oocyte retrieval. Two-sided Fisher\u2019s exact tests were used for comparisons between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After transfer of embryos created from donor oocytes the live birth rate per euploid embryo was 70.6% (24\/34) compared to 34.3% (35\/102) for untested embryos for a rate difference of 36.3% (95% CI 18.4\u201354.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). After transfer of embryos created from autologous oocytes with maternal age less than 35\u00a0years at oocyte retrieval the live birth rate per euploid embryo was 70.0% (49\/70) compared to 52.5% (53\/101) for untested embryos for a rate difference of 17.5% (95% CI 3.0\u201332.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In good prognosis patients at our center the live birth rate per euploid blastocyst was higher than for untested blastocysts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06679-x","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T21:12:03Z","timestamp":1657660323000},"page":"1321-1327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of trophectoderm biopsy for PGT-A on live birth rate per embryo in good prognosis patients"],"prefix":"10.1007","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-7434","authenticated-orcid":false,"given":"Michael S.","family":"Awadalla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-3067","authenticated-orcid":false,"given":"Ravi","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-2981","authenticated-orcid":false,"given":"Jacqueline R.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-9655","authenticated-orcid":false,"given":"Lynda K.","family":"McGinnis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-9450","authenticated-orcid":false,"given":"Ali","family":"Ahmady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"6679_CR1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.fertnstert.2020.07.052","volume":"115","author":"AW Tiegs","year":"2021","unstructured":"Tiegs AW, Tao X, Zhan Y et al (2021) A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy. 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