{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:41:32Z","timestamp":1789792892744,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20<jats:sup>+0<\/jats:sup>\u00a0weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19<jats:sup>+3<\/jats:sup> (13<jats:sup>+0<\/jats:sup>\u201331<jats:sup>+4<\/jats:sup>) weeks of gestation. IUFD occurred in 16\/103 fetuses (15.5%). Overall survival was 84.5% (87\/103). Hydrops (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), lower mean hemoglobin at first IUT (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and low platelets (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20<jats:sup>+0<\/jats:sup>\u00a0weeks of gestation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20\u00a0weeks is not related to worse perinatal outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06712-z","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T14:06:08Z","timestamp":1659449168000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. 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