{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:00:05Z","timestamp":1780581605274,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH124"],"award-info":[{"award-number":["ZR2021QH124"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-022-06748-1","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T17:02:49Z","timestamp":1661446969000},"page":"1115-1123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Human papillomavirus (HPV) integration signature in cervical lesions: identification of MACROD2 gene as HPV hot spot integration site"],"prefix":"10.1007","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-6278","authenticated-orcid":false,"given":"Junwei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"6748_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin 71:209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"6748_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12985-022-01775-5","volume":"19","author":"D Feng","year":"2022","unstructured":"Feng D, Wei S, Chen J, Yu Z, Lhamo Y et al (2022) Human papillomavirus prevalence and genotype distribution landscapes in Shannan City, Tibet Tibetan Autonomous Region. China Virol J 19:46","journal-title":"China Virol J"},{"key":"6748_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/vaccines10020188","volume":"10","author":"M Onuki","year":"2022","unstructured":"Onuki M, Yamamoto K, Yahata H, Kanao H, Horie K et al (2022) Changes in HPV16\/18 prevalence among unvaccinated women with cervical intraepithelial neoplasia in Japan: assessment of herd effects following the HPV vaccination program. Vaccines (Basel) 10:188","journal-title":"Vaccines (Basel)"},{"key":"6748_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.785169","volume":"11","author":"X Xu","year":"2021","unstructured":"Xu X, Han Z, Ruan Y, Liu M, Cao G et al (2021) HPV16-LINC00393 integration alters local 3D genome architecture in cervical cancer cells. Front Cell Infect Microbiol 11:785169","journal-title":"Front Cell Infect Microbiol"},{"key":"6748_CR5","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.7314\/APJCP.2013.14.6.3837","volume":"14","author":"L Wang","year":"2013","unstructured":"Wang L, Dai SZ, Chu HJ, Cui HF, Xu XY (2013) Integration sites and genotype distributions of human papillomavirus in cervical intraepithelial neoplasia. Asian Pac J Cancer Prev 14:3837\u20133841","journal-title":"Asian Pac J Cancer Prev"},{"key":"6748_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.798608","volume":"12","author":"S Yang","year":"2021","unstructured":"Yang S, Zhao Q, Tang L, Chen Z, Wu Z et al (2021) Whole genome assembly of human papillomavirus by nanopore long-read sequencing. Front Genet 12:798608","journal-title":"Front Genet"},{"key":"6748_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006211","volume":"13","author":"AA McBride","year":"2017","unstructured":"McBride AA, Warburton A (2017) The role of integration in oncogenic progression of HPV-associated cancers. PLoS Pathog 13:e1006211","journal-title":"PLoS Pathog"},{"key":"6748_CR8","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/ijc.30243","volume":"139","author":"C Bodelon","year":"2016","unstructured":"Bodelon C, Untereiner ME, Machiela MJ, Vinokurova S, Wentzensen N (2016) Genomic characterization of viral integration sites in HPV-related cancers. Int J Cancer 139:2001\u20132011","journal-title":"Int J Cancer"},{"key":"6748_CR9","doi-asserted-by":"publisher","first-page":"8877","DOI":"10.18632\/oncotarget.12830","volume":"8","author":"M Tuna","year":"2017","unstructured":"Tuna M, Amos CI (2017) Next generation sequencing and its applications in HPV-associated cancers. Oncotarget 8:8877\u20138889","journal-title":"Oncotarget"},{"key":"6748_CR10","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/ng.3178","volume":"47","author":"Z Hu","year":"2015","unstructured":"Hu Z, Zhu D, Wang W, Li W, Jia W et al (2015) Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet 47:158\u2013163","journal-title":"Nat Genet"},{"key":"6748_CR11","first-page":"6242173","volume":"2018","author":"W Li","year":"2018","unstructured":"Li W, Qi Y, Cui X, Huo Q, Zhu L et al (2018) Characteristic of HPV Integration in the genome and transcriptome of cervical cancer tissues. Biomed Res Int 2018:6242173","journal-title":"Biomed Res Int"},{"key":"6748_CR12","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1186\/s12864-016-3203-3","volume":"17","author":"R Jackson","year":"2016","unstructured":"Jackson R, Rosa BA, Lameiras S, Cuninghame S, Bernard J et al (2016) Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology. BMC Genomics 17:851","journal-title":"BMC Genomics"},{"key":"6748_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.virol.2014.05.026","volume":"462\u2013463","author":"J Chen","year":"2014","unstructured":"Chen J, Xue Y, Poidinger M, Lim T, Chew SH et al (2014) Mapping of HPV transcripts in four human cervical lesions using RNAseq suggests quantitative rearrangements during carcinogenic progression. Virology 462\u2013463:14\u201324","journal-title":"Virology"},{"key":"6748_CR14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s41416-020-01153-4","volume":"124","author":"M Kamal","year":"2021","unstructured":"Kamal M, Lameiras S, Deloger M, Morel A, Vacher S et al (2021) Human papilloma virus (HPV) integration signature in cervical cancer: identification of MACROD2 gene as HPV hot spot integration site. Br J Cancer 124:777\u2013785","journal-title":"Br J Cancer"},{"key":"6748_CR15","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research N, Albert Einstein College of M, Analytical Biological S, Barretos Cancer H, Baylor College of M et al. (2017) Integrated genomic and molecular characterization of cervical cancer. Nature 543:378-384","DOI":"10.1038\/nature21386"},{"key":"6748_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41525-021-00264-y","volume":"6","author":"A Warburton","year":"2021","unstructured":"Warburton A, Markowitz TE, Katz JP, Pipas JM, McBride AA (2021) Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs. NPJ Genom Med 6:101","journal-title":"NPJ Genom Med"},{"key":"6748_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/gcc.22415","volume":"56","author":"G Gao","year":"2017","unstructured":"Gao G, Johnson SH, Vasmatzis G, Pauley CE, Tombers NM et al (2017) Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. Genes Chromosomes Cancer 56:59\u201374","journal-title":"Genes Chromosomes Cancer"},{"key":"6748_CR18","doi-asserted-by":"publisher","first-page":"E447","DOI":"10.1111\/1469-0691.12233","volume":"19","author":"A Gradissimo Oliveira","year":"2013","unstructured":"Gradissimo Oliveira A, Delgado C, Verdasca N, Pista A (2013) Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia. Clin Microbiol Infect 19:E447-450","journal-title":"Clin Microbiol Infect"},{"key":"6748_CR19","doi-asserted-by":"publisher","first-page":"813","DOI":"10.2147\/JIR.S278911","volume":"13","author":"L Chen","year":"2020","unstructured":"Chen L, Dong B, Gao H, Xue H, Pan D et al (2020) HPV-16 E2\/E6 and POU5F1B as biomarkers to determine cervical high-grade squamous lesions and more. J Inflamm Res 13:813\u2013821","journal-title":"J Inflamm Res"},{"key":"6748_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103675","volume":"174","author":"R Bhattacharjee","year":"2022","unstructured":"Bhattacharjee R, Das SS, Biswal SS, Nath A, Das D et al (2022) Mechanistic role of HPV-associated early proteins in cervical cancer: molecular pathways and targeted therapeutic strategies. Crit Rev Oncol Hematol 174:103675","journal-title":"Crit Rev Oncol Hematol"},{"key":"6748_CR21","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1038\/s41467-020-15927-0","volume":"11","author":"DW Zheng","year":"2020","unstructured":"Zheng DW, Gao F, Cheng Q, Bao P, Dong X et al (2020) A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat Commun 11:1985","journal-title":"Nat Commun"},{"key":"6748_CR22","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fgene.2019.00489","volume":"10","author":"J Shen-Gunther","year":"2019","unstructured":"Shen-Gunther J, Cai H, Zhang H, Wang Y (2019) Abundance of HPV L1 intra-genotype variants with capsid epitopic modifications found within low- and high-grade pap smears with potential implications for vaccinology. Front Genet 10:489","journal-title":"Front Genet"},{"key":"6748_CR23","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.7150\/jca.31450","volume":"10","author":"W Li","year":"2019","unstructured":"Li W, Tian S, Wang P, Zang Y, Chen X et al (2019) The characteristics of HPV integration in cervical intraepithelial cells. J Cancer 10:2783\u20132787","journal-title":"J Cancer"},{"key":"6748_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13219","author":"J Mainguene","year":"2022","unstructured":"Mainguene J, Vacher S, Kamal M, Hamza A, Masliah-Planchon J et al (2022) Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma. Mol Oncol. https:\/\/doi.org\/10.1002\/1878-0261.13219","journal-title":"Mol Oncol"},{"key":"6748_CR25","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3390\/cancers12030604","volume":"12","author":"KLH Feijs","year":"2020","unstructured":"Feijs KLH, Cooper CDO, Zaja R (2020) The controversial roles of ADP-ribosyl hydrolases MACROD1, MACROD2 and TARG1 in carcinogenesis. Cancers (Basel) 12:604","journal-title":"Cancers (Basel)"},{"key":"6748_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41525-020-0122-7","volume":"5","author":"ZJ Zhou","year":"2020","unstructured":"Zhou ZJ, Luo CB, Xin HY, Hu ZQ, Zhu GQ et al (2020) MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3beta\/beta-catenin signaling. NPJ Genom Med 5:15","journal-title":"NPJ Genom Med"},{"key":"6748_CR27","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1158\/2159-8290.CD-17-0909","volume":"8","author":"A Sakthianandeswaren","year":"2018","unstructured":"Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B et al (2018) MACROD2 haploinsufficiency impairs catalytic activity of PARP1 and promotes chromosome instability and growth of intestinal tumors. Cancer Discov 8:988\u20131005","journal-title":"Cancer Discov"},{"key":"6748_CR28","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1158\/2159-8290.CD-18-0674","volume":"8","author":"N Jin","year":"2018","unstructured":"Jin N, Burkard ME (2018) MACROD2, an original cause of CIN? Cancer Discov 8:921\u2013923","journal-title":"Cancer Discov"},{"key":"6748_CR29","doi-asserted-by":"publisher","first-page":"17606","DOI":"10.1073\/pnas.1408650111","volume":"111","author":"M Mohseni","year":"2014","unstructured":"Mohseni M, Cidado J, Croessmann S, Cravero K, Cimino-Mathews A et al (2014) MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. Proc Natl Acad Sci USA 111:17606\u201317611","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-022-06748-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T08:05:56Z","timestamp":1679040356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-022-06748-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["6748"],"URL":"https:\/\/doi.org\/10.1007\/s00404-022-06748-1","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,25]]},"assertion":[{"value":"24 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by our institutional ethical review board. Informed consent had been obtained from the reported patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}