{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:37:56Z","timestamp":1773416276343,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-022-06755-2","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T02:02:41Z","timestamp":1661047361000},"page":"1761-1769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genital tract dysbiosis in infertile women with a history of repeated implantation failure and pilot study for reproductive outcomes following oral enteric coating lactoferrin supplementation"],"prefix":"10.1007","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-3139","authenticated-orcid":false,"given":"Kotaro","family":"Kitaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomoto","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"issue":"Suppl 1","key":"6755_CR1","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1073\/pnas.1002611107","volume":"108","author":"J Ravel","year":"2011","unstructured":"Ravel J, Gajer P, Abdo Z et al (2011) Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A 108(Suppl 1):4680\u20134687","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"6755_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12934-020-01464-4","volume":"19","author":"WJY Chee","year":"2020","unstructured":"Chee WJY, Chew SY, Than LT (2020) Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact 19(1):203","journal-title":"Microb Cell Fact"},{"issue":"5","key":"6755_CR3","doi-asserted-by":"publisher","first-page":"611.e1","DOI":"10.1016\/j.ajog.2014.11.043","volume":"212","author":"CM Mitchell","year":"2015","unstructured":"Mitchell CM, Haick A, Nkwopara E et al (2015) Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol 212(5):611.e1\u20139","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"6755_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10815-015-0614-z","volume":"33","author":"JM Franasiak","year":"2016","unstructured":"Franasiak JM, Werner MD, Juneau CR et al (2016) Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit. J Assist Reprod Genet 33(1):129\u2013136","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"6755_CR5","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","volume":"215","author":"I Moreno","year":"2016","unstructured":"Moreno I, Codo\u00f1er FM, Vilella F et al (2016) Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol 215(6):684\u2013703","journal-title":"Am J Obstet Gynecol"},{"key":"6755_CR6","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1602","volume":"4","author":"H Verstraelen","year":"2016","unstructured":"Verstraelen H, Vilchez-Vargas R, Desimpel F et al (2016) Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1\u20132 region of the 16S rRNA gene. Peer J 4:e1602","journal-title":"Peer J"},{"issue":"1","key":"6755_CR7","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","volume":"8","author":"C Chen","year":"2017","unstructured":"Chen C, Song X, Wei W et al (2017) The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun 8(1):875","journal-title":"Nat Commun"},{"issue":"1","key":"6755_CR8","doi-asserted-by":"publisher","first-page":"9905","DOI":"10.1038\/s41598-019-46173-0","volume":"9","author":"AD Winters","year":"2019","unstructured":"Winters AD, Romero R, Gervasi MT et al (2019) Does the endometrial cavity have a molecular microbial signature? Sci Rep 9(1):9905","journal-title":"Sci Rep"},{"issue":"4","key":"6755_CR9","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/biom10040593","volume":"10","author":"NM Molina","year":"2020","unstructured":"Molina NM, Sola-Leyva A, Saez-Lara MJ et al (2020) New opportunities for endometrial health by modifying uterine microbial composition: present or future? Biomolecules 10(4):593","journal-title":"Biomolecules"},{"key":"6755_CR10","doi-asserted-by":"publisher","first-page":"4893437","DOI":"10.1155\/2019\/4893437","volume":"2019","author":"K Kitaya","year":"2019","unstructured":"Kitaya K, Nagai Y, Arai W et al (2019) Characterization of microbiota in endometrial fluid and vaginal secretions in infertile women with repeated implantation failure. Mediators Inflamm 2019:4893437","journal-title":"Mediators Inflamm"},{"issue":"4","key":"6755_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/pathogens8040205","volume":"8","author":"I Garcia-Grau","year":"2019","unstructured":"Garcia-Grau I, Perez-Villaroya D, Bau D et al (2019) Taxonomical and functional assessment of the endometrial microbiota in a context of recurrent reproductive failure: a case report. Pathogens 8(4):205","journal-title":"Pathogens"},{"issue":"3","key":"6755_CR12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.repbio.2020.07.001","volume":"20","author":"D Kadogami","year":"2020","unstructured":"Kadogami D, Nakaoka Y, Morimoto Y (2020) Use of a vaginal probiotic suppository and antibiotics to influence the composition of the endometrial microbiota. Reprod Biol 20(3):307\u2013314","journal-title":"Reprod Biol"},{"issue":"3","key":"6755_CR13","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03242-19","volume":"11","author":"M Fu","year":"2020","unstructured":"Fu M, Zhang X, Liang Y et al (2020) Alterations in vaginal microbiota and associated metabolome in women with recurrent implantation failure. MBio 11(3):e03242-19","journal-title":"MBio"},{"issue":"3","key":"6755_CR14","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/rmb2.12389","volume":"20","author":"T Ichiyama","year":"2021","unstructured":"Ichiyama T, Kuroda K, Nagai Y et al (2021) Analysis of vaginal and endometrial microbiota communities in infertile women with a history of repeated implantation failure. Reprod Med Biol 20(3):334\u2013344","journal-title":"Reprod Med Biol"},{"issue":"3","key":"6755_CR15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/GCO.0000000000000698","volume":"33","author":"P Pirtea","year":"2021","unstructured":"Pirtea P, Scott RT Jr, de Ziegler D et al (2021) Recurrent implantation failure: how common is it? Curr Opin Obstet Gynecol 33(3):207\u2013212","journal-title":"Curr Opin Obstet Gynecol"},{"key":"6755_CR16","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1951155","author":"Y Li","year":"2021","unstructured":"Li Y, Tan Y, Xia G et al (2021) Effects of probiotics, prebiotics, and synbiotics on polycystic ovary syndrome: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. https:\/\/doi.org\/10.1080\/10408398.2021.1951155","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"6755_CR17","doi-asserted-by":"publisher","first-page":"7976","DOI":"10.1038\/s41598-020-64705-x","volume":"10","author":"EFM Oerlemans","year":"2020","unstructured":"Oerlemans EFM, Bellen G, Claes I et al (2020) Impact of a Lactobacilli-containing gel on vulvovaginal candidosis and the vaginal microbiome. Sci Rep 10(1):7976","journal-title":"Sci Rep"},{"issue":"1","key":"6755_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1469-0691.2008.02112.x","volume":"15","author":"P Mastromarino","year":"2009","unstructured":"Mastromarino P, Macchia S, Meggiorini L et al (2009) Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 15(1):67\u201374","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"6755_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034540","volume":"7","author":"CS Bradshaw","year":"2012","unstructured":"Bradshaw CS, Pirotta M, De Guingand D et al (2012) Efficacy of oral metronidazole with vaginal clindamycin or vaginal probiotic for bacterial vaginosis: randomised placebo-controlled double-blind trial. PLoS ONE 7(4):e34540","journal-title":"PLoS ONE"},{"issue":"1","key":"6755_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1472-6483(10)61301-6","volume":"11","author":"Y Gilboa","year":"2005","unstructured":"Gilboa Y, Bar-Hava I, Fisch B et al (2005) Does intravaginal probiotic supplementation increase the pregnancy rate in IVF-embryo transfer cycles? Reprod Biomed Online 11(1):71\u201375","journal-title":"Reprod Biomed Online"},{"issue":"7","key":"6755_CR21","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.3390\/jcm10071461","volume":"10","author":"A L\u00f3pez-Moreno","year":"2021","unstructured":"L\u00f3pez-Moreno A, Aguilera M (2021) Vaginal probiotics for reproductive health and related dysbiosis: systematic review and meta-analysis. J Clin Med 10(7):1461","journal-title":"J Clin Med"},{"issue":"7","key":"6755_CR22","first-page":"55","volume":"23","author":"M Sorensen","year":"1940","unstructured":"Sorensen M, Sorensen SPL (1940) The proteins in whey. Compte Rendu Des Trav Lab Carlsberg Ser Chim 23(7):55\u201399","journal-title":"Compte Rendu Des Trav Lab Carlsberg Ser Chim"},{"issue":"8","key":"6755_CR23","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.3390\/nu13082492","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Lu C, Zhang J (2021) Lactoferrin and its detection methods: a review. Nutrients 13(8):2492","journal-title":"Nutrients"},{"issue":"6","key":"6755_CR24","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","volume":"73","author":"DK Gardner","year":"2000","unstructured":"Gardner DK, Lane M, Stevens J et al (2000) Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 73(6):1155\u20131158","journal-title":"Fertil Steril"},{"issue":"9","key":"6755_CR25","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/modpathol.3880405","volume":"14","author":"IB Bayer-Garner","year":"2001","unstructured":"Bayer-Garner IB, Korourian S (2001) Plasma cells in chronic endometritis are easily identified when stained with syndecan-1. Mod Pathol 14(9):877\u2013879","journal-title":"Mod Pathol"},{"issue":"5","key":"6755_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12719","volume":"78","author":"K Kitaya","year":"2017","unstructured":"Kitaya K, Matsubayashi H, Takaya Y et al (2017) Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. Am J Reprod Immunol 78(5):e12719","journal-title":"Am J Reprod Immunol"},{"issue":"12","key":"6755_CR27","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1093\/humrep\/des323","volume":"27","author":"K Kitaya","year":"2012","unstructured":"Kitaya K, Tada Y, Taguchi S et al (2012) Local mononuclear cell infiltrates in infertile patients with endometrial macropolyps versus micropolyps. Hum Reprod 27(12):3474\u20133480","journal-title":"Hum Reprod"},{"issue":"1","key":"6755_CR28","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.fertnstert.2019.03.004","volume":"112","author":"E Cicinelli","year":"2019","unstructured":"Cicinelli E, Vitagliano A, Kumar A, International Working Group for Standardization of Chronic Endometritis Diagnosis et al (2019) Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Fertil Steril 112(1):162\u2013173","journal-title":"Fertil Steril"},{"key":"6755_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1875036201307010001","volume":"7","author":"E Aronesty","year":"2013","unstructured":"Aronesty E (2013) Comparison of sequencing utility programs. The Open Bioinformatics J 7:1\u20138","journal-title":"The Open Bioinformatics J"},{"issue":"16","key":"6755_CR30","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","volume":"27","author":"RC Edgar","year":"2011","unstructured":"Edgar RC, Haas BJ, Clemente JC et al (2011) UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 27(16):2194\u20132200","journal-title":"Bioinformatics"},{"issue":"5","key":"6755_CR31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J et al (2010) QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7(5):335\u2013336","journal-title":"Nat Methods"},{"issue":"3","key":"6755_CR32","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/ismej.2011.139","volume":"6","author":"D McDonald","year":"2012","unstructured":"McDonald D, Price MN, Goodrich J et al (2012) An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. ISME J 6(3):610\u2013618","journal-title":"ISME J"},{"issue":"1","key":"6755_CR33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1139\/bcb-2016-0051","volume":"95","author":"K Otsuki","year":"2017","unstructured":"Otsuki K, Imai N (2017) Effects of lactoferrin in 6 patients with refractory bacterial vaginosis. Biochem Cell Biol 95(1):31\u201333","journal-title":"Biochem Cell Biol"},{"issue":"3","key":"6755_CR34","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.fertnstert.2018.04.012","volume":"110","author":"K Kitaya","year":"2018","unstructured":"Kitaya K, Takeuchi T, Mizuta S et al (2018) Endometritis: new time, new concepts. Fertil Steril 110(3):344\u2013350","journal-title":"Fertil Steril"},{"issue":"1","key":"6755_CR35","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.fertnstert.2018.03.017","volume":"110","author":"A Vitagliano","year":"2018","unstructured":"Vitagliano A, Saccardi C, Noventa M et al (2018) Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis. Fertil Steril 110(1):103-112.e1","journal-title":"Fertil Steril"},{"issue":"6","key":"6755_CR36","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1093\/humrep\/dez065","volume":"34","author":"R Koedooder","year":"2019","unstructured":"Koedooder R, Singer M, Schoenmakers S et al (2019) The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study. Hum Reprod 34(6):1042\u20131054","journal-title":"Hum Reprod"},{"issue":"6","key":"6755_CR37","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.rbmo.2020.08.015","volume":"41","author":"MH Saxtorph","year":"2020","unstructured":"Saxtorph MH, Hallager T, Persson G et al (2020) Assessing endometrial receptivity after recurrent implantation failure: a prospective controlled cohort study. Reprod Biomed Online 41(6):998\u20131006","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"6755_CR38","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1093\/humrep\/deaa372","volume":"36","author":"A Sola-Leyva","year":"2021","unstructured":"Sola-Leyva A, Andr\u00e9s-Le\u00f3n E, Molina NM et al (2021) Mapping the entire functionally active endometrial microbiota. Hum Reprod 36(4):1021\u20131031","journal-title":"Hum Reprod"},{"issue":"2","key":"6755_CR39","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/aogs.14297","volume":"101","author":"K L\u00fcll","year":"2022","unstructured":"L\u00fcll K, Saare M, Peter M et al (2022) Differences in microbial profile of endometrial fluid and tissue samples in women with in vitro fertilization failure are driven by Lactobacillus abundance. Acta Obstet Gynecol Scand 101(2):212\u2013220","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"6755_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01184-w","volume":"10","author":"I Moreno","year":"2022","unstructured":"Moreno I, Garcia-Grau I, Perez-Villaroya D et al (2022) Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome 10(1):1","journal-title":"Microbiome"},{"issue":"1","key":"6755_CR41","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3390\/ijms23010180","volume":"23","author":"SG Vitale","year":"2021","unstructured":"Vitale SG, Ferrari F, Ciebiera M et al (2021) The role of genital tract microbiome in fertility: a systematic review. Int J Mol Sci 23(1):180","journal-title":"Int J Mol Sci"},{"issue":"4","key":"6755_CR42","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/diagnostics12040878","volume":"12","author":"SE Tanaka","year":"2022","unstructured":"Tanaka SE, Sakuraba Y, Kitaya K et al (2022) Differential vaginal microbiota profiling in lactic-acid-producing bacteria between infertile women with and without chronic endometritis. Diagnostics 12(4):878","journal-title":"Diagnostics"},{"issue":"4","key":"6755_CR43","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1093\/humrep\/deab009","volume":"36","author":"NM Molina","year":"2021","unstructured":"Molina NM, Sola-Leyva A, Haahr T et al (2021) Analysing endometrial microbiome: methodological considerations and recommendations for good practice. Hum Reprod 36(4):859\u2013879","journal-title":"Hum Reprod"},{"issue":"8","key":"6755_CR44","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1093\/humrep\/deab156","volume":"36","author":"KA Wyatt","year":"2021","unstructured":"Wyatt KA, Filby CE, Davies-Tuck ML et al (2021) Menstrual fluid endometrial stem\/progenitor cell and supernatant protein content: cyclical variation and indicative range. Hum Reprod 36(8):2215\u20132229","journal-title":"Hum Reprod"},{"issue":"5","key":"6755_CR45","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/humrep\/det016","volume":"28","author":"CM Zumoffen","year":"2013","unstructured":"Zumoffen CM, Gil R, Caille AM et al (2013) A protein isolated from human oviductal tissue in vitro secretion, identified as human lactoferrin, interacts with spermatozoa and oocytes and modulates gamete interaction. Hum Reprod 28(5):1297\u20131308","journal-title":"Hum Reprod"},{"issue":"2","key":"6755_CR46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.fertnstert.2006.06.025","volume":"87","author":"A Yanaihara","year":"2007","unstructured":"Yanaihara A, Mitsukawa K, Iwasaki S et al (2007) High concentrations of lactoferrin in the follicular fluid correlate with embryo quality during in vitro fertilization cycles. Fertil Steril 87(2):279\u2013282","journal-title":"Fertil Steril"},{"issue":"1","key":"6755_CR47","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1139\/bcb-2020-0098","volume":"99","author":"E Massa","year":"2021","unstructured":"Massa E, Pelusa F, Lo Celso A et al (2021) Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients - correlation with IVF parameters. Biochem Cell Biol 99(1):91\u201396","journal-title":"Biochem Cell Biol"},{"issue":"1","key":"6755_CR48","first-page":"1357417","volume":"28","author":"A Pino","year":"2017","unstructured":"Pino A, Giunta G, Randazzo CL et al (2017) Bacterial biota of women with bacterial vaginosis treated with lactoferrin: an open prospective randomized trial. Microb Ecol Health Dis 28(1):1357417","journal-title":"Microb Ecol Health Dis"},{"issue":"1","key":"6755_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3920\/BM2018.0075","volume":"10","author":"R Russo","year":"2019","unstructured":"Russo R, Karadja E, De Seta F (2019) Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. Benef Microbes 10(1):19\u201326","journal-title":"Benef Microbes"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06755-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-022-06755-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-022-06755-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T04:09:40Z","timestamp":1664338180000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-022-06755-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,21]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["6755"],"URL":"https:\/\/doi.org\/10.1007\/s00404-022-06755-2","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,21]]},"assertion":[{"value":"24 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no financial interests and\/or competing interests in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}