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Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background\/purpose<\/jats:title>\n                <jats:p>This study aims to investigate whether women with cervical dysplasia after LEEP have an increased risk of pregnancy\/childbirth complications or recurrence of dysplasia in an upcoming pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data from 240 women after LEEP were analysed retrospectively. The reference group consisted of 956 singleton births. Fisher\u2019s and Wilcoxon rank tests were used to detect differences between groups. Using logistic regressions, we analysed the effect of surgery-specific aspects of LEEP on pregnancy\/childbirth complications and the frequency of CIN recurrences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found that tissue-preserving LEEP did not lead to premature birth or miscarriage and did not increase the likelihood of CIN recurrence.<\/jats:p>\n                <jats:p>We did not observe differences regarding preterm birth [&lt;\u200937 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.28)\u2009&lt;\u200934 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.31),\u2009&lt;\u200932\u00a0weeks of gestation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.11)] or birth weight (&lt;\u20092500\u00a0g (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.54),\u2009&lt;\u20092000\u00a0g (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.77) between groups. However, women after LEEP exhibit a higher risk of premature rupture of membranes (PROM) at term (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.009) and vaginal infections (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.06). Neither volume nor depth of the removed tissue nor an additional endocervical resection seems to influence the likelihood of premature birth or early miscarriage. Performing an endocervical resection protects against CIN recurrence (OR 0.0881, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.003).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>After tissue-preserving LEEP, there is an increased risk of vaginal infections and PROM at term in consecutive pregnancy. LEEP does not affect prematurity or miscarriage. The removal of additional endocervical tissue appears to be a protective factor against recurrence of CIN.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-022-06760-5","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T03:19:39Z","timestamp":1662520779000},"page":"1137-1143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pregnancy outcome and risk of recurrence after tissue-preserving loop electrosurgical excision procedure (LEEP)"],"prefix":"10.1007","volume":"307","author":[{"given":"Jule Alena","family":"Lieb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja Natascha","family":"Fehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-5891","authenticated-orcid":false,"given":"Monika","family":"Hampl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"6760_CR1","unstructured":"S3-Leitlinie: https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/032-033OL.html"},{"issue":"9509","key":"6760_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0140-6736(06)68181-6","volume":"367","author":"M Kyrgiou","year":"2006","unstructured":"Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Arbyn M, Prendiville W, Paraskevaidis E (2006) Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis. 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Monika Hampl received honoraria for lectures and travel support from Astra Zeneca, Amedes, MSD, Sanofi Aventis, Exeltis, and Gedeon Richter.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the institutional ethic board at the University of D\u00fcsseldorf; date of approval: 28.10.2015; reference number: 5262. All patients had given written informed consent and approved their clinical history for the purpose of research and publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All co-authors have seen and agreed with the contents of the manuscript. If the manuscript is accepted, all authors agree to publish it.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}