{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:46:41Z","timestamp":1778906801344,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["Society (CAN2017\/594"],"award-info":[{"award-number":["Society (CAN2017\/594"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["201346 PjF"],"award-info":[{"award-number":["201346 PjF"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003744","name":"Stiftelsen Handlanden Hjalmar Svenssons","doi-asserted-by":"publisher","award":["(HJSV2019058)"],"award-info":[{"award-number":["(HJSV2019058)"]}],"id":[{"id":"10.13039\/501100003744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005009","name":"Stiftelsen Assar Gabrielssons Fond","doi-asserted-by":"publisher","award":["FB17-65"],"award-info":[{"award-number":["FB17-65"]}],"id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","award":["689021\/17"],"award-info":[{"award-number":["689021\/17"]}],"id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish state","award":["ALFGBG-813171\/965702"],"award-info":[{"award-number":["ALFGBG-813171\/965702"]}]},{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to explore how patients treated for endometrial cancer (EC) with robotic surgery are affected in symptoms of anxiety and depression and HRQoL in the long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women scheduled for primary robotic surgery for EC were included (<jats:italic>n<\/jats:italic>\u2009=\u200964), in this single-center study. Socioeconomic variables were obtained at baseline. The European Organization for Research and Treatment of Cancers Quality of Life Questionnaire Core 30 (QLQ-C30), its module for EC (EN24), the Generalized Anxiety Disorder Scale (GAD-7), and the Patient Health Questionnaire Depression Scale (PHQ-9) were followed prospectively from baseline to 2\u00a0weeks, 3\u00a0months and 1\u00a0year postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of patients scoring above the clinical threshold for anxiety decreased from 17 (27.0%) at baseline to 4 (7.0%) at 2\u00a0weeks (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). Depressive symptoms were reported in 20% of patients at baseline and did not change significantly during the one-year follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.58). A significant decrease in Global health status was seen at 2\u00a0weeks (from 69.8 to 62.7;<jats:italic>p<\/jats:italic>\u2009=\u20090.048), with return to baseline levels after 3\u00a0months (68.5;<jats:italic>p<\/jats:italic>\u2009=\u20090.32) and stable at 1\u00a0year. Unemployment, low income, and adjuvant therapy correlated with lower Global health status at 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The significant proportion of patients with anxiety symptoms preoperatively reduced prompt after surgery, while the proportion with depression remained constant, indicating that the primary treatment has no long-term negative effect on patients\u2019 mental health. At 3\u00a0months, there is no obvious remaining negative impact on patients\u2019 HRQoL, and these results are consistent after 1\u00a0year.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00404-023-06917-w","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T04:41:26Z","timestamp":1674621686000},"page":"515-525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Health-related quality of life after robotic surgery for endometrial cancer: a prospective longitudinal one-year follow-up study"],"prefix":"10.1007","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-4406","authenticated-orcid":false,"given":"Anna","family":"Lindfors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"J\u00e4rvholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernilla","family":"Dahm-K\u00e4hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"issue":"9","key":"6917_CR1","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1097\/IGC.0000000000000299","volume":"24","author":"F Joly","year":"2014","unstructured":"Joly F, McAlpine J, Nout R, Avall-Lundqvist E, Shash E, Friedlander M (2014) Quality of life and patient-reported outcomes in endometrial cancer clinical trials: a call for action! Int J Gynecol Cancer 24(9):1693\u20131699","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"6917_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.ygyno.2017.11.007","volume":"148","author":"R Shisler","year":"2018","unstructured":"Shisler R, Sinnott JA, Wang V, Hebert C, Salani R, Felix AS (2018) Life after endometrial cancer: a systematic review of patient-reported outcomes. Gynecol Oncol 148(2):403\u2013413","journal-title":"Gynecol Oncol"},{"key":"6917_CR3","unstructured":"Cancercentrum R. Nationellt v\u00e5rdprogram livmoderkroppscancer: Regionala Cancercentrum i samverkan (2018) [updated 2018\u201306\u201327]"},{"key":"6917_CR4","unstructured":"SEER Stat Fact Sheets. Endometrial Cancers National Cancer Institute: American National Cancer Institute, Surveillance, Epidemiology and End Results Program 2016"},{"issue":"1","key":"6917_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","volume":"31","author":"N Concin","year":"2021","unstructured":"Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S et al (2021) ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer 31(1):12\u201339","journal-title":"Int J Gynecol Cancer"},{"issue":"9","key":"6917_CR6","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.ejso.2016.06.400","volume":"42","author":"DA Park","year":"2016","unstructured":"Park DA, Lee DH, Kim SW, Lee SH (2016) Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: a systematic review and meta-analysis. Eur J Surg Oncol 42(9):1303\u20131314","journal-title":"Eur J Surg Oncol"},{"issue":"9","key":"6917_CR7","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1097\/IGC.0000000000000245","volume":"24","author":"JN McAlpine","year":"2014","unstructured":"McAlpine JN, Greimel E, Brotto LA, Nout RA, Shash E, Avall-Lundqvist E et al (2014) Quality of life research in endometrial cancer: what is needed to advance progress in this disease site? Methodological considerations from the gynecologic cancer intergroup symptom benefit working group brainstorming session, Leiden 2012. Int J Gynecol Cancer 24(9):1686\u20131692","journal-title":"Int J Gynecol Cancer"},{"key":"6917_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1415","volume":"361","author":"A Pitman","year":"2018","unstructured":"Pitman A, Suleman S, Hyde N, Hodgkiss A (2018) Depression and anxiety in patients with cancer. BMJ 361:k1415","journal-title":"BMJ"},{"issue":"12","key":"6917_CR9","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1080\/0284186X.2018.1521987","volume":"57","author":"S Salehi","year":"2018","unstructured":"Salehi S, Brandberg Y, \u00c5vall-Lundqvist E, Suzuki C, Johansson H, Legerstam B et al (2018) Long-term quality of life after comprehensive surgical staging of high-risk endometrial cancer - results from the RASHEC trial. Acta Oncol 57(12):1671\u20131676","journal-title":"Acta Oncol"},{"issue":"3","key":"6917_CR10","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.ygyno.2014.03.015","volume":"133","author":"G Ferrandina","year":"2014","unstructured":"Ferrandina G, Petrillo M, Mantegna G, Fuoco G, Terzano S, Venditti L et al (2014) Evaluation of quality of life and emotional distress in endometrial cancer patients: a 2-year prospective, longitudinal study. Gynecol Oncol 133(3):518\u2013525","journal-title":"Gynecol Oncol"},{"issue":"2","key":"6917_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ijgo.2009.02.010","volume":"105","author":"W Creasman","year":"2009","unstructured":"Creasman W (2009) Revised FIGO staging for carcinoma of the endometrium. Int J Gynaecol Obstet 105(2):109","journal-title":"Int J Gynaecol Obstet"},{"key":"6917_CR12","unstructured":"System SP. \u00c4ldre med l\u00e5ga inkomster [Pdf report]. Pensionsmyndigheten; (2018) Available from: https:\/\/www.pensionsmyndigheten.se\/nyheter-och-press\/nyheter\/andelen-aldre-med-relativt-lag-ekonomisk-standard"},{"issue":"9","key":"6917_CR13","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","volume":"16","author":"K Kroenke","year":"2001","unstructured":"Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16(9):606\u2013613","journal-title":"J Gen Intern Med"},{"issue":"10","key":"6917_CR14","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","volume":"166","author":"RL Spitzer","year":"2006","unstructured":"Spitzer RL, Kroenke K, Williams JB, L\u00f6we B (2006) A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166(10):1092\u20131097","journal-title":"Arch Intern Med"},{"issue":"4","key":"6917_CR15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.genhosppsych.2010.03.006","volume":"32","author":"K Kroenke","year":"2010","unstructured":"Kroenke K, Spitzer RL, Williams JB, L\u00f6we B (2010) The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry 32(4):345\u2013359","journal-title":"Gen Hosp Psychiatry"},{"issue":"5","key":"6917_CR16","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u2013376","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"6917_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ejca.2010.08.014","volume":"47","author":"E Greimel","year":"2011","unstructured":"Greimel E, Nordin A, Lanceley A, Creutzberg CL, van de Poll-Franse LV, Radisic VB et al (2011) Psychometric validation of the European organisation for research and treatment of cancer quality of life questionnaire-endometrial cancer module (EORTC QLQ-EN24). Eur J Cancer 47(2):183\u2013190","journal-title":"Eur J Cancer"},{"issue":"1","key":"6917_CR18","doi-asserted-by":"publisher","first-page":"e12639","DOI":"10.1111\/ecc.12639","volume":"27","author":"M Stukan","year":"2018","unstructured":"Stukan M, Zalewski K, Mardas M, Filarska D, Szajewski M, Kmie\u0107 A et al (2018) Independent psychometric validation of European organization for research and treatment of cancer quality of life questionnaire-endometrial cancer module (EORTC QLQ-EN24). Eur J Cancer Care (Engl) 27(1):e12639","journal-title":"Eur J Cancer Care (Engl)"},{"key":"6917_CR19","first-page":"2001","volume-title":"The EORTC QLQ-C30 scoring manual (3rd Edition)","author":"PMAN Fayers","year":"2001","unstructured":"Fayers PMAN, Bjordal K, Groenvold M, Curran D, Bottomley A, on behalf of the EORTC Quality of Life Group (2001) The EORTC QLQ-C30 scoring manual (3rd Edition). European Organisation for Research and Treatment of Cancer, Brussels, p 2001"},{"issue":"11","key":"6917_CR20","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.ejca.2012.02.059","volume":"48","author":"K Cocks","year":"2012","unstructured":"Cocks K, King MT, Velikova G, de Castro G, Martyn St-James M, Fayers PM et al (2012) Evidence-based guidelines for interpreting change scores for the European organisation for the research and treatment of cancer quality of life questionnaire core 30. Eur J Cancer 48(11):1713\u20131721","journal-title":"Eur J Cancer"},{"key":"6917_CR21","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.98","volume":"1","author":"R Johansson","year":"2013","unstructured":"Johansson R, Carlbring P, Heedman \u00c5, Paxling B, Andersson G (2013) Depression, anxiety and their comorbidity in the Swedish general population: point prevalence and the effect on health-related quality of life. PeerJ 1:e98","journal-title":"PeerJ"},{"issue":"2","key":"6917_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","volume":"12","author":"AJ Mitchell","year":"2011","unstructured":"Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C et al (2011) Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol 12(2):160\u2013174","journal-title":"Lancet Oncol"},{"issue":"1","key":"6917_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ygyno.2015.10.024","volume":"140","author":"SF Herling","year":"2016","unstructured":"Herling SF, Moller AM, Palle C, Thomsen T (2016) Health-related quality of life after robotic-assisted laparoscopic hysterectomy for women with endometrial cancer\u2013a prospective cohort study. Gynecol Oncol 140(1):107\u2013113","journal-title":"Gynecol Oncol"},{"key":"6917_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejca.2018.11.024","volume":"107","author":"S Nolte","year":"2019","unstructured":"Nolte S, Liegl G, Petersen MA, Aaronson NK, Costantini A, Fayers PM et al (2019) General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States. Eur J Cancer 107:153\u2013163","journal-title":"Eur J Cancer"},{"key":"6917_CR25","doi-asserted-by":"crossref","first-page":"e1312","DOI":"10.1002\/cnr2.1312","volume":"4","author":"SK Ramasubbu","year":"2020","unstructured":"Ramasubbu SK, Pasricha RK, Nath UK, Rawat VS, Das B (2020) Quality of life and factors affecting it in adult cancer patients undergoing cancer chemotherapy in a tertiary care hospital. Cancer Rep (Hoboken, NJ) 4:e1312","journal-title":"Cancer Rep (Hoboken, NJ)"},{"issue":"3","key":"6917_CR26","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s11764-019-00767-9","volume":"13","author":"JA McDougall","year":"2019","unstructured":"McDougall JA, Blair CK, Wiggins CL, Goodwin MB, Chiu VK, Rajput A et al (2019) Socioeconomic disparities in health-related quality of life among colorectal cancer survivors. J Cancer Surviv 13(3):459\u2013467","journal-title":"J Cancer Surviv"},{"issue":"12","key":"6917_CR27","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1080\/00016340701743116","volume":"86","author":"T Rannestad","year":"2007","unstructured":"Rannestad T, Skjeldestad FE (2007) Pain and quality of life among long-term gynecological cancer survivors: a population-based case-control study. Acta Obstet Gynecol Scand 86(12):1510\u20131516","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"11","key":"6917_CR28","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.ejca.2011.11.014","volume":"48","author":"RA Nout","year":"2012","unstructured":"Nout RA, Putter H, J\u00fcrgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM et al (2012) Five-year quality of life of endometrial cancer patients treated in the randomised post operative radiation therapy in endometrial cancer (PORTEC-2) trial and comparison with norm data. Eur J Cancer 48(11):1638\u20131648","journal-title":"Eur J Cancer"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-06917-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-023-06917-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-06917-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T15:10:21Z","timestamp":1701789021000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-023-06917-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["6917"],"URL":"https:\/\/doi.org\/10.1007\/s00404-023-06917-w","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"assertion":[{"value":"30 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the regional ethical review board of Gothenburg (Dnr: 874-15).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Participants gave oral and written informed consent to be included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}