{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:25:24Z","timestamp":1792189524946,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-023-06981-2","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T04:10:37Z","timestamp":1677989437000},"page":"1625-1631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effects of Covid-19 mRNA vaccine on adolescence gynecological well-being"],"prefix":"10.1007","volume":"307","clinical-trial-number":[{"clinical-trial-number":"nct04748172","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-3041","authenticated-orcid":false,"given":"Aya","family":"Mohr-Sasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigal","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Sivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoni","family":"Zehori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Orvieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaron","family":"Rabinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"issue":"11","key":"6981_CR1","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1051\/medsci\/2020203","volume":"36","author":"E Billon-Denis","year":"2020","unstructured":"Billon-Denis E, Tournier JN (2020) COVID-19 and vaccination: a global disruption. Med Sci (Paris) 36(11):1034\u20131037","journal-title":"Med Sci (Paris)"},{"issue":"2","key":"6981_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/cei.13517","volume":"202","author":"JS Tregoning","year":"2020","unstructured":"Tregoning JS, Brown ES, Cheeseman HM, Flight KE, Higham SL, Lemm NM et al (2020) Vaccines for COVID-19. Clin Exp Immunol 202(2):162\u2013192","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"6981_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/vaccines10010081","volume":"10","author":"M Stein","year":"2022","unstructured":"Stein M, Ashkenazi-Hoffnung L, Greenberg D, Dalal I, Livni G, Chapnick G et al (2022) The Burden of COVID-19 in children and its prevention by vaccination: a joint statement of the Israeli Pediatric Association and the Israeli Society for pediatric infectious diseases. Vaccines (Basel). 10(1):81","journal-title":"Vaccines (Basel)."},{"issue":"7","key":"6981_CR4","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00431-020-03684-7","volume":"179","author":"I Liguoro","year":"2020","unstructured":"Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A et al (2020) SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr 179(7):1029\u20131046","journal-title":"Eur J Pediatr"},{"issue":"36","key":"6981_CR5","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.15585\/mmwr.mm7036e2","volume":"70","author":"MJ Delahoy","year":"2021","unstructured":"Delahoy MJ, Ujamaa D, Whitaker M, O\u2019Halloran A, Anglin O, Burns E et al (2021) Hospitalizations associated with COVID-19 among children and adolescents\u2014COVID-NET, 14 States, March 1, 2020-August 14, 2021. MMWR Morb Mortal Wkly Rep 70(36):1255\u20131260","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"6981_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1056\/NEJMoa2107456","volume":"385","author":"RW Frenck","year":"2021","unstructured":"Frenck RW, Klein NP, Kitchin N, Gurtman A, Absalon J, Lockhart S et al (2021) Safety, immunogenicity, and efficacy of the BNT162b2 Covid-19 vaccine in adolescents. N Engl J Med 385(3):239\u2013250","journal-title":"N Engl J Med"},{"issue":"6 Suppl 4","key":"6981_CR7","doi-asserted-by":"publisher","first-page":"S391","DOI":"10.1016\/j.amepre.2015.06.009","volume":"49","author":"DA Salmon","year":"2015","unstructured":"Salmon DA, Dudley MZ, Glanz JM, Omer SB (2015) Vaccine hesitancy: causes, consequences, and a call to action. Am J Prev Med 49(6 Suppl 4):S391\u2013S398","journal-title":"Am J Prev Med"},{"issue":"8","key":"6981_CR8","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.4161\/hv.24657","volume":"9","author":"E Dub\u00e9","year":"2013","unstructured":"Dub\u00e9 E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger J (2013) Vaccine hesitancy: an overview. Hum Vaccin Immunother 9(8):1763\u20131773","journal-title":"Hum Vaccin Immunother"},{"issue":"2","key":"6981_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3390\/vaccines9020160","volume":"9","author":"M Sallam","year":"2021","unstructured":"Sallam M (2021) COVID-19 vaccine hesitancy Worldwide: a concise systematic review of vaccine acceptance rates. Vaccines (Basel). 9(2):160","journal-title":"Vaccines (Basel)."},{"key":"6981_CR10","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jad.2021.06.003","volume":"292","author":"Y Xu","year":"2021","unstructured":"Xu Y, Zhang R, Zhou Z, Fan J, Liang J, Cai L et al (2021) Parental psychological distress and attitudes towards COVID-19 vaccination: A cross-sectional survey in Shenzhen. China J Affect Disord 292:552\u2013558","journal-title":"China J Affect Disord"},{"key":"6981_CR11","unstructured":"Care H. [Available from: https:\/\/www.muhealth.org\/our-stories\/does-covid-19-vaccine-affect-fertility-heres-what-experts-say."},{"key":"6981_CR12","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3998180","author":"L Trogstad","year":"2022","unstructured":"Trogstad L (2022) Increased occurrence of menstrual disturbances in 18- to 30-year-old women after covid-19 vaccination. SSRN Electron J. https:\/\/doi.org\/10.2139\/ssrn.3998180","journal-title":"SSRN Electron J"},{"issue":"1","key":"6981_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.rbmo.2020.09.020","volume":"42","author":"K Li","year":"2021","unstructured":"Li K, Chen G, Hou H, Liao Q, Chen J, Bai H et al (2021) Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online 42(1):260\u2013267","journal-title":"Reprod Biomed Online"},{"key":"6981_CR14","unstructured":"Katharine MN, Lee EJJ, Urooba A Fatima, Maria L Cox, Kathryn BH Clancy (2022) Characterizing menstrual bleeding changes occurring after SARS-CoV-2 vaccination View ORCID Profile"},{"key":"6981_CR15","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/humrep\/deab282","volume":"37","author":"A Mohr-Sasson","year":"2021","unstructured":"Mohr-Sasson A, Haas J, Abuhasira S, Sivan M, Amdurski HD, Dadon T et al (2021) The effect of Covid-19 mRNA vaccine on serum anti-M\u00fcllerian hormone levels. Hum Reprod 37:534","journal-title":"Hum Reprod"},{"key":"6981_CR16","unstructured":"Coulter B. [Available from: https:\/\/www.beckmancoulter.com\/products\/immunoassay\/access-amh."},{"issue":"6","key":"6981_CR17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1001\/jama.2020.12603","volume":"324","author":"A Carf\u00ec","year":"2020","unstructured":"Carf\u00ec A, Bernabei R, Landi F, Group GAC-P-ACS (2020) Persistent symptoms in patients after acute COVID-19. JAMA 324(6):603\u2013605","journal-title":"JAMA"},{"issue":"8","key":"6981_CR18","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/01443615.2021.1907562","volume":"41","author":"O Demir","year":"2021","unstructured":"Demir O, Sal H, Comba C (2021) Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol 41(8):1257\u20131261","journal-title":"J Obstet Gynaecol"},{"key":"6981_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.642755","volume":"12","author":"N Phelan","year":"2021","unstructured":"Phelan N, Behan LA, Owens L (2021) The impact of the COVID-19 Pandemic on Women\u2019s Reproductive Health. Front Endocrinol (Lausanne) 12:642755","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"6981_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.ajog.2021.09.016","volume":"226","author":"SM Khan","year":"2022","unstructured":"Khan SM, Shilen A, Heslin KM, Ishimwe P, Allen AM, Jacobs ET et al (2022) SARS-CoV-2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT study. Am J Obstet Gynecol 226(2):270\u2013273","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"6981_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11154-012-9223-7","volume":"13","author":"J Evans","year":"2012","unstructured":"Evans J, Salamonsen LA (2012) Inflammation, leukocytes and menstruation. Rev Endocr Metab Disord 13(4):277\u2013288","journal-title":"Rev Endocr Metab Disord"},{"issue":"2","key":"6981_CR22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/irv.12509","volume":"12","author":"KR Talaat","year":"2018","unstructured":"Talaat KR, Halsey NA, Cox AB, Coles CL, Durbin AP, Ramakrishnan A et al (2018) Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination. Influenza Other Respir Viruses 12(2):202\u2013210","journal-title":"Influenza Other Respir Viruses"},{"issue":"4","key":"6981_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2217\/WHE.13.32","volume":"9","author":"M Berbic","year":"2013","unstructured":"Berbic M, Fraser IS (2013) Immunology of normal and abnormal menstruation. Womens Health (Lond) 9(4):387\u2013395","journal-title":"Womens Health (Lond)"},{"issue":"Suppl 2","key":"6981_CR24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3109\/13697137.2014.963964","volume":"17","author":"M Berbic","year":"2014","unstructured":"Berbic M, Ng CH, Fraser IS (2014) Inflammation and endometrial bleeding. Climacteric 17(Suppl 2):47\u201353","journal-title":"Climacteric"},{"issue":"1","key":"6981_CR25","doi-asserted-by":"publisher","first-page":"10762","DOI":"10.1038\/s41598-020-67668-1","volume":"10","author":"L Gong","year":"2020","unstructured":"Gong L, Ji HH, Tang XW, Pan LY, Chen X, Jia YT (2020) Human papillomavirus vaccine-associated premature ovarian insufficiency and related adverse events: data mining of Vaccine Adverse Event Reporting System. Sci Rep 10(1):10762","journal-title":"Sci Rep"},{"key":"6981_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pvr.2018.02.002","volume":"5","author":"S Suzuki","year":"2018","unstructured":"Suzuki S, Hosono A (2018) No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study. Papillomavirus Res 5:96\u2013103","journal-title":"Papillomavirus Res"},{"key":"6981_CR27","doi-asserted-by":"crossref","unstructured":"Toshimitsu Shingu TU, Masuji Nishi, Kazuo Hayashida, Seizaburo Kashiwagi, Jun Hayashi, Masaro Kaji (1982) Menstrual abnormalities after hepatitis B vaccine. Kurume Med J 1982; 29:123\u2013125","DOI":"10.2739\/kurumemedj.29.123"},{"issue":"1","key":"6981_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/path.2162","volume":"212","author":"I Hamming","year":"2007","unstructured":"Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD et al (2007) The emerging role of ACE2 in physiology and disease. J Pathol 212(1):1\u201311","journal-title":"J Pathol"},{"issue":"1","key":"6981_CR29","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.fertnstert.2010.06.060","volume":"95","author":"FM Reis","year":"2011","unstructured":"Reis FM, Bouissou DR, Pereira VM, Camargos AF, dos Reis AM, Santos RA (2011) Angiotensin-(1\u20137), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary. Fertil Steril 95(1):176\u2013181","journal-title":"Fertil Steril"},{"issue":"1","key":"6981_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12958-021-00757-6","volume":"19","author":"R Orvieto","year":"2021","unstructured":"Orvieto R, Noach-Hirsh M, Segev-Zahav A, Haas J, Nahum R, Aizer A (2021) Does mRNA SARS-CoV-2 vaccine influence patients\u2019 performance during IVF-ET cycle? Reprod Biol Endocrinol 19(1):69","journal-title":"Reprod Biol Endocrinol"},{"issue":"9","key":"6981_CR31","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1093\/humrep\/deab182","volume":"36","author":"Y Bentov","year":"2021","unstructured":"Bentov Y, Beharier O, Moav-Zafrir A, Kabessa M, Godin M, Greenfield CS et al (2021) Ovarian follicular function is not altered by SARS-CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination. Hum Reprod 36(9):2506\u20132513","journal-title":"Hum Reprod"},{"key":"6981_CR32","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0943","author":"AL Naleway","year":"2018","unstructured":"Naleway AL, Mittendorf KF, Irving SA, Henninger ML, Crane B, Smith N et al (2018) Primary ovarian insufficiency and adolescent vaccination. Pediatrics. https:\/\/doi.org\/10.1542\/peds.2018-0943","journal-title":"Pediatrics"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-06981-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-023-06981-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-06981-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T17:10:15Z","timestamp":1681751415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-023-06981-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,5]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["6981"],"URL":"https:\/\/doi.org\/10.1007\/s00404-023-06981-2","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,5]]},"assertion":[{"value":"1 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the \u201cSheba Medical Center\u201d Ethical Committee Review Board (ID 8121-21-SMC) on the 8th of February 2021 and was registered at the National Institutes of Health (NCT04748172).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent statement was requested by the ethical committee and signed by all participants or their legal apotropos.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors gave consent for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}