{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:10:36Z","timestamp":1789470636361,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In adults and fetuses, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a marker of cardiac failure and myocardial remodelling. We examined the effect of anemia and intrauterine transfusion (IUT) on NT-proBNP concentrations in fetuses with anemia and established gestational age-dependent reference values of a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed NT-proBNP levels in anemic fetuses that underwent serial intrauterine transfusions (IUT), focusing on different causes and severity of anemia and comparing the results to a non-anemic control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the control group, the average NT-proBNP concentration was 1339\u2009\u00b1\u2009639\u00a0pg\/ml, decreasing significantly with increasing gestational age (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u2212\u00a074.04,\n                      <jats:italic>T<\/jats:italic>\n                      \u2009=\u2009\u2212\u00a03.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Subjects had significantly higher NT-proBNP concentrations before initiation of IUT therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), showing fetuses with parvovirus B19 (PVB19) infection having the highest concentrations. Hydropic fetuses also showed an increased NT-proBNP concentration compared to non-hydropic fetuses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). During the course of therapy, NT-proBNP concentration before subsequent IUT decreased significantly from pathologically high levels, while MoM-Hb and MoM-MCA-PSV remained pathological.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NT-pro BNP levels in non-anemic fetuses are higher than in postnatal life, decreasing with ongoing pregnancy. Anemia is a hyperdynamic state and its severity correlates with circulating NT-proBNP levels. Highest concentrations occur in fetuses with hydrops and with PVB19 infection, respectively. Treatment by IUT leads to a normalisation of NT-proBNP concentrations, so the measurement of its levels may be useful in therapy monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-023-07006-8","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T08:02:26Z","timestamp":1679817746000},"page":"1341-1351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fetal NT-proBNP levels and their course in severe anemia during intrauterine treatment"],"prefix":"10.1007","volume":"309","author":[{"given":"Pauline","family":"Siebers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waltraut Maria","family":"Merz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Recker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6633-8464","authenticated-orcid":false,"given":"Eva Christin","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"7006_CR1","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0140-6736(88)91896-X","volume":"331","author":"KH Nicolaides","year":"1988","unstructured":"Nicolaides KH, Clewell WH, Mibashan RS et al (1988) Fetal haemoglobin measurement in the assessment of red cell isoimmunisation. Lancet 331:1073\u20131075. https:\/\/doi.org\/10.1016\/S0140-6736(88)91896-X","journal-title":"Lancet"},{"key":"7006_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bpobgyn.2019.01.001","volume":"58","author":"F Prefumo","year":"2019","unstructured":"Prefumo F, Fichera A, Fratelli N, Sartori E (2019) Fetal anemia: diagnosis and management. Best Pract Res Clin Obstet Gynaecol 58:2\u201314. https:\/\/doi.org\/10.1016\/j.bpobgyn.2019.01.001","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"7006_CR3","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/uog.82","volume":"21","author":"AA Baschat","year":"2003","unstructured":"Baschat AA, Muench MV, Gembruch U (2003) Coronary artery blood flow velocities in various fetal conditions: fetal coronary blood flow. Ultrasound Obstet Gynecol 21:426\u2013429. https:\/\/doi.org\/10.1002\/uog.82","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7006_CR4","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1034\/j.1600-0412.2001.080008726.x","volume":"80","author":"K Sohan","year":"2001","unstructured":"Sohan K, Carroll SG, De La Fuente S et al (2001) Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment: Hydrops fetalis. Acta Obstet Gynecol Scand 80:726\u2013730. https:\/\/doi.org\/10.1034\/j.1600-0412.2001.080008726.x","journal-title":"Acta Obstet Gynecol Scand"},{"key":"7006_CR5","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37:2129\u20132200. https:\/\/doi.org\/10.1093\/eurheartj\/ehw128","journal-title":"Eur Heart J"},{"key":"7006_CR6","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/pr.2012.53","volume":"72","author":"WM Merz","year":"2012","unstructured":"Merz WM, K\u00fcbler K, Fimmers R et al (2012) Circulating N-terminal pro-B-type natriuretic peptide in fetal anemia before and after treatment. Pediatr Res 72:174\u2013178. https:\/\/doi.org\/10.1038\/pr.2012.53","journal-title":"Pediatr Res"},{"key":"7006_CR7","doi-asserted-by":"publisher","first-page":"654356","DOI":"10.3389\/fphys.2021.654356","volume":"12","author":"T Miyoshi","year":"2021","unstructured":"Miyoshi T, Hosoda H, Minamino N (2021) Significance of atrial and brain natriuretic peptide measurements in fetuses with heart failure. Front Physiol 12:654356. https:\/\/doi.org\/10.3389\/fphys.2021.654356","journal-title":"Front Physiol"},{"key":"7006_CR8","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1210\/en.2003-0127","volume":"144","author":"VA Cameron","year":"2003","unstructured":"Cameron VA, Ellmers LJ (2003) Minireview: natriuretic peptides during development of the fetal heart and circulation. Endocrinology 144:2191\u20132194. https:\/\/doi.org\/10.1210\/en.2003-0127","journal-title":"Endocrinology"},{"key":"7006_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00246-008-9258-4","volume":"30","author":"A Nir","year":"2009","unstructured":"Nir A, Lindinger A, Rauh M et al (2009) NT-Pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies. Pediatr Cardiol 30:3\u20138. https:\/\/doi.org\/10.1007\/s00246-008-9258-4","journal-title":"Pediatr Cardiol"},{"key":"7006_CR10","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.clinbiochem.2009.11.012","volume":"43","author":"WM Merz","year":"2010","unstructured":"Merz WM, K\u00fcbler K, Albers E et al (2010) Reference values for N-terminal pro-B-type natriuretic peptide in fetal circulation between 20 and 34 weeks of gestation. Clin Biochem 43:519\u2013521. https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.11.012","journal-title":"Clin Biochem"},{"key":"7006_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00392-011-0366-4","volume":"101","author":"WM Merz","year":"2012","unstructured":"Merz WM, K\u00fcbler K, Albers E et al (2012) N-terminal pro-B-type natriuretic peptide in the circulation of fetuses with cardiac malformations. Clin Res Cardiol 101:73\u201379. https:\/\/doi.org\/10.1007\/s00392-011-0366-4","journal-title":"Clin Res Cardiol"},{"key":"7006_CR12","doi-asserted-by":"publisher","first-page":"e63664","DOI":"10.1371\/journal.pone.0063664","volume":"8","author":"WM Merz","year":"2013","unstructured":"Merz WM, K\u00fcbler K, Fimmers R et al (2013) Cardiorenal syndrome is present in human fetuses with severe, isolated urinary tract malformations. PLoS ONE 8:e63664. https:\/\/doi.org\/10.1371\/journal.pone.0063664","journal-title":"PLoS ONE"},{"key":"7006_CR13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1515\/jpm.2011.065","volume":"39","author":"F Bahlmann","year":"2011","unstructured":"Bahlmann F, Krummenauer F, Spahn S et al (2011) Natriuretic peptide levels in intrauterine growth-restricted fetuses with absent and reversed end-diastolic flow of the umbilical artery in relation to ductus venosus flow velocities. J Perinat Med 39:529\u2013537. https:\/\/doi.org\/10.1515\/jpm.2011.065","journal-title":"J Perinat Med"},{"key":"7006_CR14","first-page":"657","volume":"32","author":"K Luterek","year":"2011","unstructured":"Luterek K, Szymusik I, Bartkowiak R et al (2011) N-terminal pro-B-type natriuretic peptide: a potential marker of fetal heart failure in hemolytic disease. Neuro Endocrinol Lett 32:657\u2013662","journal-title":"Neuro Endocrinol Lett"},{"key":"7006_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/uog.13443","volume":"44","author":"WM Merz","year":"2014","unstructured":"Merz WM, Gembruch U (2014) Old tool\u2014new application: NT-proBNP in fetal medicine. Ultrasound Obstet Gynecol 44:377\u2013385. https:\/\/doi.org\/10.1002\/uog.13443","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7006_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1203\/PDR.0b013e3181b3aee4","volume":"66","author":"E Lechner","year":"2009","unstructured":"Lechner E, Wiesinger-Eidenberger G, Wagner O et al (2009) Amino terminal pro B-type natriuretic peptide levels are elevated in the cord blood of neonates with congenital heart defect. Pediatr Res 66:466\u2013469. https:\/\/doi.org\/10.1203\/PDR.0b013e3181b3aee4","journal-title":"Pediatr Res"},{"key":"7006_CR17","doi-asserted-by":"publisher","first-page":"e0177253","DOI":"10.1371\/journal.pone.0177253","volume":"12","author":"C Leufgen","year":"2017","unstructured":"Leufgen C, Gembruch U, Stoffel-Wagner B et al (2017) N-terminal pro-B-type natriuretic peptide in amniotic fluid of fetuses with known or suspected cardiac load. PLoS ONE 12:e0177253. https:\/\/doi.org\/10.1371\/journal.pone.0177253","journal-title":"PLoS ONE"},{"key":"7006_CR18","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1056\/NEJMoa052855","volume":"355","author":"D Oepkes","year":"2006","unstructured":"Oepkes D, Seaward PG, Vandenbussche FPHA et al (2006) Doppler ultrasonography versus amniocentesis to predict fetal anemia. N Engl J Med 355:156\u2013164. https:\/\/doi.org\/10.1056\/NEJMoa052855","journal-title":"N Engl J Med"},{"key":"7006_CR19","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1067\/mob.2001.118161","volume":"185","author":"L Detti","year":"2001","unstructured":"Detti L, Oz U, Guney I et al (2001) Doppler ultrasound velocimetry for timing the second intrauterine transfusion in fetuses with anemia from red cell alloimmunization. Am J Obstet Gynecol 185:1048\u20131051. https:\/\/doi.org\/10.1067\/mob.2001.118161","journal-title":"Am J Obstet Gynecol"},{"key":"7006_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00404-022-06517-0","volume":"307","author":"L Vonzun","year":"2022","unstructured":"Vonzun L, Ochsenbein-K\u00f6lble N, Balsyte D et al (2022) Second systolic peak in fetal middle cerebral artery Doppler after intrauterine transfusion. Arch Gynecol Obstet 307:241\u2013248. https:\/\/doi.org\/10.1007\/s00404-022-06517-0","journal-title":"Arch Gynecol Obstet"},{"key":"7006_CR21","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1373\/clinchem.2005.048892","volume":"51","author":"B Bar-Oz","year":"2005","unstructured":"Bar-Oz B, Lev-Sagie A, Arad I et al (2005) N-terminal pro-B-type natriuretic peptide concentrations in mothers just before delivery, in cord blood, and in newborns. Clin Chem 51:926\u2013927. https:\/\/doi.org\/10.1373\/clinchem.2005.048892","journal-title":"Clin Chem"},{"key":"7006_CR22","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.144","author":"G Fortunato","year":"2006","unstructured":"Fortunato G, CarandenteGiarrusso P, Martinelli P et al (2006) Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates. Clin Chem Lab Med (CCLM). https:\/\/doi.org\/10.1515\/CCLM.2006.144","journal-title":"Clin Chem Lab Med (CCLM)"},{"key":"7006_CR23","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/s0008-6363(00)00303-5","volume":"49","author":"T Walther","year":"2001","unstructured":"Walther T, Stepan H, Faber R (2001) Dual natriuretic peptide response to volume load in the fetal circulation. Cardiovasc Res 49:817\u2013819. https:\/\/doi.org\/10.1016\/s0008-6363(00)00303-5","journal-title":"Cardiovasc Res"},{"key":"7006_CR24","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00404-009-1253-3","volume":"281","author":"WJ Seong","year":"2010","unstructured":"Seong WJ, Yoon DH, Chong GO et al (2010) Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery. Arch Gynecol Obstet 281:907\u2013912. https:\/\/doi.org\/10.1007\/s00404-009-1253-3","journal-title":"Arch Gynecol Obstet"},{"key":"7006_CR25","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1373\/clinchem.2004.040253","volume":"50","author":"J Bakker","year":"2004","unstructured":"Bakker J, Gies I, Slavenburg B et al (2004) Reference values for N-terminal pro-B-type natriuretic peptide in umbilical cord blood. Clin Chem 50:2465. https:\/\/doi.org\/10.1373\/clinchem.2004.040253","journal-title":"Clin Chem"},{"key":"7006_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","volume":"79","author":"B Swynghedauw","year":"1999","unstructured":"Swynghedauw B (1999) Molecular mechanisms of myocardial remodeling. Physiol Rev 79:215\u2013262. https:\/\/doi.org\/10.1152\/physrev.1999.79.1.215","journal-title":"Physiol Rev"},{"key":"7006_CR27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00392-005-0246-x","volume":"94","author":"L Schwachtgen","year":"2005","unstructured":"Schwachtgen L, Herrmann M, Georg T et al (2005) Reference values of NT-proBNP serum concentrations in the umbilical cord blood and in healthy neonates and children. Z Kardiol 94:399\u2013404. https:\/\/doi.org\/10.1007\/s00392-005-0246-x","journal-title":"Z Kardiol"},{"key":"7006_CR28","doi-asserted-by":"publisher","first-page":"273.e1","DOI":"10.1016\/j.ajog.2008.10.009","volume":"200","author":"RD Kocylowski","year":"2009","unstructured":"Kocylowski RD, Dubiel M, Gudmundsson S et al (2009) Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood. Am J Obstet Gynecol 200:273.e1-273.e25. https:\/\/doi.org\/10.1016\/j.ajog.2008.10.009","journal-title":"Am J Obstet Gynecol"},{"key":"7006_CR29","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s13224-018-1180-y","volume":"69","author":"V Yadav","year":"2019","unstructured":"Yadav V, Deka D, Aparna S, Dadhwal V (2019) NT-proBNP: a useful biochemical marker for prognosis in Rh-isoimmunized pregnancies. J Obstet Gynaecol India 69:128\u2013132. https:\/\/doi.org\/10.1007\/s13224-018-1180-y","journal-title":"J Obstet Gynaecol India"},{"key":"7006_CR30","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/s0140-6736(88)91332-3","volume":"1","author":"HJ Porter","year":"1988","unstructured":"Porter HJ, Quantrill AM, Fleming KA (1988) B19 parvovirus infection of myocardial cells. Lancet 1:535\u2013536. https:\/\/doi.org\/10.1016\/s0140-6736(88)91332-3","journal-title":"Lancet"},{"key":"7006_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1056\/NEJMra030840","volume":"350","author":"NS Young","year":"2004","unstructured":"Young NS, Brown KE (2004) Parvovirus B19. N Engl J Med 350:586\u2013597. https:\/\/doi.org\/10.1056\/NEJMra030840","journal-title":"N Engl J Med"},{"key":"7006_CR32","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/uog.3934","volume":"29","author":"A Girsen","year":"2007","unstructured":"Girsen A, Ala-Kopsala M, M\u00e4kikallio K et al (2007) Cardiovascular hemodynamics and umbilical artery N-terminal peptide of proB-type natriuretic peptide in human fetuses with growth restriction. Ultrasound Obstet Gynecol 29:296\u2013303. https:\/\/doi.org\/10.1002\/uog.3934","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7006_CR33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1128\/CMR.15.3.485-505.2002","volume":"15","author":"ED Heegaard","year":"2002","unstructured":"Heegaard ED, Brown KE (2002) Human parvovirus B19. Clin Microbiol Rev 15:485\u2013505. https:\/\/doi.org\/10.1128\/CMR.15.3.485-505.2002","journal-title":"Clin Microbiol Rev"},{"key":"7006_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06712-z","author":"P Kosian","year":"2022","unstructured":"Kosian P, Hellmund A, Geipel A et al (2022) Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study. Arch Gynecol Obstet. https:\/\/doi.org\/10.1007\/s00404-022-06712-z","journal-title":"Arch Gynecol Obstet"},{"key":"7006_CR35","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jcv.2010.07.014","volume":"49","author":"M Enders","year":"2010","unstructured":"Enders M, Klingel K, Weidner A et al (2010) Risk of fetal hydrops and non-hydropic late intrauterine fetal death after gestational parvovirus B19 infection. J Clin Virol 49:163\u2013168. https:\/\/doi.org\/10.1016\/j.jcv.2010.07.014","journal-title":"J Clin Virol"},{"key":"7006_CR36","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/0140-6736(91)93435-c","volume":"337","author":"AL Morey","year":"1991","unstructured":"Morey AL, Nicolini U, Welch CR et al (1991) Parvovirus B19 infection and transient fetal hydrops. Lancet 337:496. https:\/\/doi.org\/10.1016\/0140-6736(91)93435-c","journal-title":"Lancet"},{"key":"7006_CR37","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1046\/j.1365-2141.1999.01241.x","volume":"104","author":"F Forestier","year":"1999","unstructured":"Forestier F, Tissot JD, Vial Y et al (1999) Haematological parameters of parvovirus B19 infection in 13 fetuses with hydrops foetalis. Br J Haematol 104:925\u2013927. https:\/\/doi.org\/10.1046\/j.1365-2141.1999.01241.x","journal-title":"Br J Haematol"},{"key":"7006_CR38","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1067\/mob.2002.128024","volume":"187","author":"E Cosmi","year":"2002","unstructured":"Cosmi E, Mari G, DelleChiaie L et al (2002) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. Am J Obstet Gynecol 187:1290\u20131293. https:\/\/doi.org\/10.1067\/mob.2002.128024","journal-title":"Am J Obstet Gynecol"},{"key":"7006_CR39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000236353","volume":"26","author":"SA Pasman","year":"2009","unstructured":"Pasman SA, van den Brink CPB, Kamping MA et al (2009) Total blood volume is maintained in nonhydropic fetuses with severe hemolytic anemia. Fetal Diagn Ther 26:10\u201315. https:\/\/doi.org\/10.1159\/000236353","journal-title":"Fetal Diagn Ther"},{"key":"7006_CR40","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1067\/mob.2001.116690","volume":"185","author":"IL van Kamp","year":"2001","unstructured":"van Kamp IL, Klumper FJ, Bakkum RS et al (2001) The severity of immune fetal hydrops is predictive of fetal outcome after intrauterine treatment. Am J Obstet Gynecol 185:668\u2013673. https:\/\/doi.org\/10.1067\/mob.2001.116690","journal-title":"Am J Obstet Gynecol"},{"key":"7006_CR41","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/uog.17319","volume":"50","author":"C Zwiers","year":"2017","unstructured":"Zwiers C, Lindenburg ITM, Klumper FJ et al (2017) Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures. Ultrasound Obstet Gynecol 50:180\u2013186. https:\/\/doi.org\/10.1002\/uog.17319","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7006_CR42","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1113\/expphysiol.2009.049379","volume":"95","author":"SS Jonker","year":"2010","unstructured":"Jonker SS, Giraud MK, Giraud GD et al (2010) Cardiomyocyte enlargement, proliferation and maturation during chronic fetal anaemia in sheep. Exp Physiol 95:131\u2013139. https:\/\/doi.org\/10.1113\/expphysiol.2009.049379","journal-title":"Exp Physiol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-07006-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-023-07006-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-07006-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T10:04:08Z","timestamp":1708769048000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-023-07006-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,26]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["7006"],"URL":"https:\/\/doi.org\/10.1007\/s00404-023-07006-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2347669\/v1","asserted-by":"object"}]},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,26]]},"assertion":[{"value":"10 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Approval was granted by the Ethics Committee of the University of Bonn (Study ID 208\/08).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}