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Before the end of pneumoperitoneum, patients were laparoscopically administered an intraperitoneal infusion of 0.25% ropivacaine 40\u00a0ml (R group) or 0.25% ropivacaine combined with 1 \u00b5g\/kg dexmedetomidine 40\u00a0ml (RD group). The primary outcome was QoR-40, which was assessed before surgery and 24\u00a0h after surgery. Secondary outcomes included postoperative NRS scores, postoperative anesthetic dosage, the time to ambulation, urinary catheter removal, and anal exhaust. The incidence of dizziness, nausea, and vomiting was also analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 109 women were recruited. The RD group had higher QoR scores than the R group at 24\u00a0h after surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Compared with the R group, NRS scores in the RD group decreased at 2, 6, 12, and 24\u00a0h after surgery (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the RD group, the time to the first dosage of postoperative opioid was longer and the cumulative and effective times of PCA compression were less than those in the R group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Simultaneously, the time to ambulation (<jats:italic>p<\/jats:italic>\u2009=\u20090.033), anal exhaust (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and urethral catheter removal (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) was shortened in the RD group. The RD group had a lower incidence of dizziness, nausea, and vomiting (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Intraperitoneal infusion of ropivacaine combined with dexmedetomidine improved the quality of recovery in patients undergoing TLH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ChiCTR2000033209, Registration Date: May 24, 2020.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-023-07020-w","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:57:57Z","timestamp":1680501477000},"page":"1387-1393","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of intraperitoneal infusion of ropivacaine combined with dexmedetomidine in patients undergoing total laparoscopic hysterectomy: a single-center randomized double-blinded controlled trial"],"prefix":"10.1007","volume":"309","author":[{"given":"Liyan","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denggui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"7020_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12876-015-0277-3","volume":"15","author":"T Jaschinski","year":"2015","unstructured":"Jaschinski T, Mosch C, Eikermann M, Neugebauer EA (2015) Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. 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This study was approved by the Ethics Committee of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University (Ref. 2020YJ164), and individual informed consent was provided by each participant. The study was carried out by the applicable guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}